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Your search keyword '"Stazi, M. A."' showing total 4 results
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4 results on '"Stazi, M. A."'

1. An agonist of CXCR4 induces a rapid recovery from the neurotoxic effects of Vipera ammodytes and Vipera aspis venoms.

Author

Stazi, M., Megighian, A., D'Este, G., Negro, S., Ivanušec, A., Lonati, D., Pirazzini, M., Križaj, I., and Montecucco, C.

Subjects
*VENOM, *CXCR4 receptors, *STROMAL cell-derived factor 1, *SNAKEBITES, *SMALL molecules, *MYONEURAL junction, *SCHWANN cells
Abstract

People bitten by Alpine vipers are usually treated with antivenom antisera to prevent the noxious consequences caused by the injected venom. However, this treatment suffers from a number of drawbacks and additional therapies are necessary. The venoms of Vipera ammodytes and of Vipera aspis are neurotoxic and cause muscle paralysis by inducing neurodegeneration of motor axon terminals because they contain a presynaptic acting sPLA2 neurotoxin. We have recently found that any type of damage to motor axons is followed by the expression and activation of the intercellular signaling axis consisting of the CXCR4 receptor present on the membrane of the axon stump and of its ligand, the chemokine CXCL12 released by activated terminal Schwann cells. We show here that also V. ammodytes and V. aspis venoms cause the expression of the CXCL12‐CXCR4 axis. We also show that a small molecule agonist of CXCR4, dubbed NUCC‐390, induces a rapid regeneration of the motor axon terminal with functional recovery of the neuromuscular junction. These findings qualify NUCC‐390 as a promising novel therapeutics capable of improving the recovery from the paralysis caused by the snakebite of the two neurotoxic Alpine vipers. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Age-Related Variations of Genetic and Environmental Contributions to the Covariation of Fear, Distress and Externalizing Symptoms: A Twin Study in Childhood and Adolescence

Author

De Francesco, S, Scaini, S, Alessandri, G, Medda, E, Camoni, L, Stazi, M, Fagnani, C, De Francesco, Stefano, Scaini, Simona, Alessandri, Guido, Medda, Emanuela, Camoni, Laura, Stazi, Maria Antonietta, Fagnani, Corrado, De Francesco, S, Scaini, S, Alessandri, G, Medda, E, Camoni, L, Stazi, M, Fagnani, C, De Francesco, Stefano, Scaini, Simona, Alessandri, Guido, Medda, Emanuela, Camoni, Laura, Stazi, Maria Antonietta, and Fagnani, Corrado

Abstract

The frequency with which Internalizing and Externalizing symptoms co-occur suggests that, behind both domains, there may be a common susceptibility represented by a general psychopathology factor. However, it’s still unclear whether this common susceptibility is affected by age-related variations. Internalizing (i.e., Fear and Distress) and Externalizing symptoms were evaluated in 803 twin pairs from the population-based Italian Twin Registry. Model-fitting analysis was performed separately in the 6–14 and 15–18 age groups to estimate genetic and environmental contributions to the covariance among symptoms. For the 6–14 group, a multivariate Cholesky model best fitted the data, while, for the 15–18 group, the best fit was provided by a Common Pathway model in which nearly 50% of total variance of each trait was mediated by common genetic factors. Our findings support a common susceptibility behind Internalizing and Externalizing symptoms, mainly genetic in origin, that becomes more evident at the beginning of puberty.

Published
2023

4. Age-Related Variations of Genetic and Environmental Contributions to the Covariation of Fear, Distress and Externalizing Symptoms: A Twin Study in Childhood and Adolescence

Author

Stefano De Francesco, Simona Scaini, Guido Alessandri, Emanuela Medda, Laura Camoni, Maria Antonietta Stazi, Corrado Fagnani, De Francesco, S, Scaini, S, Alessandri, G, Medda, E, Camoni, L, Stazi, M, and Fagnani, C

Subjects
Psychiatry and Mental health, Internalization externalization, Latent susceptibility factor, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, Twin study, Children and adolescent
Abstract

The frequency with which Internalizing and Externalizing symptoms co-occur suggests that, behind both domains, there may be a common susceptibility represented by a general psychopathology factor. However, it’s still unclear whether this common susceptibility is affected by age-related variations. Internalizing (i.e., Fear and Distress) and Externalizing symptoms were evaluated in 803 twin pairs from the population-based Italian Twin Registry. Model-fitting analysis was performed separately in the 6–14 and 15–18 age groups to estimate genetic and environmental contributions to the covariance among symptoms. For the 6–14 group, a multivariate Cholesky model best fitted the data, while, for the 15–18 group, the best fit was provided by a Common Pathway model in which nearly 50% of total variance of each trait was mediated by common genetic factors. Our findings support a common susceptibility behind Internalizing and Externalizing symptoms, mainly genetic in origin, that becomes more evident at the beginning of puberty.

Published
2023

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