16 results on '"Stroffolini, Tommaso"'
Search Results
2. THU-378 Prediction of outcomes in patients with HCV compensated liver cirrhosis after SVR: results from 5-years of follow-up
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Morisco, Filomena, primary, Federico, Alessandro, additional, Marignani, Massimo, additional, Lombardo, Flavia L, additional, Cossiga, Valentina, additional, Ranieri, Luisa, additional, Romeo, Mario, additional, Cipullo, Marina, additional, Begini, Paola, additional, Gioli, Federico, additional, and Stroffolini, Tommaso, additional
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- 2024
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3. Prevalence and Modes of Transmission of Hepatitis C Virus Infection: A Historical Worldwide Review.
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Stroffolini, Tommaso and Stroffolini, Giacomo
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HEPATITIS C , *DRUG accessibility , *VIRAL transmission , *LOW-income countries , *DRUG abuse - Abstract
Hepatitis C virus infection affects over 58 million individuals and is responsible for 290,000 annual deaths. The infection spread in the past via blood transfusion and iatrogenic transmission due to the use of non-sterilized glass syringes mostly in developing countries (Cameroon, Central Africa Republic, Egypt) but even in Italy. High-income countries have achieved successful results in preventing certain modes of transmission, particularly in ensuring the safety of blood and blood products, and to a lesser extent, reducing iatrogenic exposure. Conversely, in low-income countries, unscreened blood transfusions and non-sterile injection practices continue to play major roles, highlighting the stark inequalities between these regions. Currently, injection drug use is a major worldwide risk factor, with a growing trend even in low- and middle-income countries (LMICs). Emerging high-risk groups include men who have sex with men (MSM), individuals exposed to tattoo practices, and newborns of HCV-infected pregnant women. The World Health Organization (WHO) has proposed direct-acting antiviral (DAA) therapy as a tool to eliminate infection by interrupting viral transmission from infected to susceptible individuals. However, the feasibility of this ambitious and overly optimistic program generates concern about the need for universal screening, diagnosis, linkage to care, and access to affordable DAA regimens. These goals are very hard to reach, especially in LMICs, due to the cost and availability of drugs, as well as the logistical complexities involved. Globally, only a small proportion of individuals infected with HCV have been tested, and an even smaller fraction of those have initiated DAA therapy. The absence of an effective vaccine is a major barrier to controlling HCV infection. Without a vaccine, the WHO project may remain merely an illusion. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Vaccination in Patients with Liver Cirrhosis: A Neglected Topic.
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Stroffolini, Tommaso and Stroffolini, Giacomo
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VACCINE effectiveness ,VACCINATION coverage ,VACCINE safety ,CIRRHOSIS of the liver ,ANTIBODY formation - Abstract
Patients with liver cirrhosis, due to their weakened innate and adaptive immunity, are more prone to frequent and severe vaccine-preventable infections. Moreover, impaired adaptive immunity results in a limited antibody response to vaccines. Despite this suboptimal antibody response, vaccines have proven to be very effective in reducing severe outcomes and deaths in these patients. In the Western world, regulatory authorities and scientific liver societies (e.g., AASLD and EASL) have recommended vaccinations for cirrhotic patients. However, despite these strong recommendations, vaccine coverage remains suboptimal. Improving vaccine effectiveness and safety information, providing comprehensive counseling to patients, fact-checking to combat fake news and disinformation and removing barriers to vaccination for disadvantaged individuals may help overcome the low coverage rate. In view of this, vaccines should be administered early in the course of chronic liver diseases, as their efficacy declines with the increasing severity of the disease. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Hepatitis B vaccine coverage and risk factors for lack of vaccination in subjects with HBsAg negative liver cirrhosis in Italy: still, much work should be done
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Stroffolini, Tommaso, Lombardi, Anna, Ciancio, Alessia, Fontana, Rosanna, Colloredo, Guido, Marignani, Massimo, Vinci, Maria, Morisco, Filomena, Babudieri, Sergio, Ferrigno, Luigina, and Sagnelli, Evangelista
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- 2021
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6. Vaccination Campaign against Hepatitis B Virus in Italy: A History of Successful Achievements
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Stroffolini, Tommaso, primary and Stroffolini, Giacomo, additional
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- 2023
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7. Five Decades of HBV Infection in Italy: A Continuous Challenge
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Stroffolini, Tommaso, primary and Stroffolini, Giacomo, additional
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- 2023
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8. A Historical Overview on the Role of Hepatitis B and C Viruses as Aetiological Factors for Hepatocellular Carcinoma
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Stroffolini, Tommaso, primary and Stroffolini, Giacomo, additional
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- 2023
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9. COVID-19 vaccination among cirrhotics in Italy: High coverage and effectiveness of 3 doses versus 2 in preventing breakthrough infection and hospitalization
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Stroffolini, Tommaso, primary, Ciancio, Alessia, additional, Federico, Alessandro, additional, Benigno, Rosa G., additional, Colloredo, Guido, additional, Lombardi, Anna, additional, Niro, Grazia Anna, additional, Verucchi, Gabriella, additional, Ferrigno, Luigina, additional, Gioli, Federico, additional, and Marignani, Massimo, additional
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- 2022
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10. A Historical Review of Military Medical Strategies for Fighting Infectious Diseases: From Battlefields to Global Health
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Biselli, Roberto, primary, Nisini, Roberto, additional, Lista, Florigio, additional, Autore, Alberto, additional, Lastilla, Marco, additional, De Lorenzo, Giuseppe, additional, Peragallo, Mario Stefano, additional, Stroffolini, Tommaso, additional, and D’Amelio, Raffaele, additional
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- 2022
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11. COVID-19 vaccination among cirrhotics in Italy: High coverage and effectiveness of 3 doses versus 2 in preventing breakthrough infection and hospitalization.
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Stroffolini, Tommaso, Ciancio, Alessia, Federico, Alessandro, Benigno, Rosa G., Colloredo, Guido, Lombardi, Anna, Niro, Grazia Anna, Verucchi, Gabriella, Ferrigno, Luigina, Gioli, Federico, and Marignani, Massimo
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Few reports, all retrospective, have evaluated vaccine coverage against COVID-19 infection in cirrhotic subjects. No data are available for European Countries. We aimed to explore this topic and potential independent predictors of lack of vaccination. Between January 1st and June 30th 2022, 1512 cirrhotic subjects of any etiology were consecutively enrolled in an observational - prospective study in 8 referral centers in Italy. Adjusted Odds Ratios (O.R.) for the association with lack of vaccination and with occurrence of breakthrough infection were evaluated by multiple logistic regression analysis. Overall vaccine coverage was 89.7% (80% among people born abroad). Among the 1358 vaccinated people, 178 (13.1%) had a breakthrough infection; of them 12 (6.7%) were hospitalized, but none died. Independent predictors associated with lack of vaccination were birth abroad, age <65 years and lower years of schooling. Child stage B/C was the only independent predictor of breakthrough infection. Occurrence of breakthrough infection was more likely reported in subjects who received 2 doses of vaccine than in those who received 3 doses (33.9% versus 9.0%; P <0.001). High vaccine coverage against COVID-19 infection is observed among cirrhotic subjects in Italy. Vaccine is effective in preventing severe outcomes. Three doses are more effective than two, even in cirrhotic subjects. This large cohort study evidenced high vaccine coverage against COVID-19 infection among cirrhotic subjects in a European country and the effectiveness of vaccine in preventing severe outcomes. Three doses of vaccine are more effective than two in preventing breakthrough infection and hospitalization. Informative campaigns targeting people younger than 65 years of age and those with lower years of schooling may increase these excellent results. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Acute Delta Hepatitis in Italy spanning three decades (1991–2019): Evidence for the effectiveness of the hepatitis B vaccination campaign.
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Stroffolini, Tommaso, Morisco, Filomena, Ferrigno, Luigina, Pontillo, Giuseppina, Iantosca, Giuseppina, Cossiga, Valentina, Crateri, Simonetta, Tosti, Maria Elena, Alfonsi, Valeria, D'Angelo, Franca, Zotti, Carla, Rainero, Erika, Marengo, Noemi, Malaspina, Silvana, Gallone, Angela, Castella, Annalisa, Galati, Maria Teresa, Scala, Annamaria, Castagna, Paolo, and Silano, Virginia
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HEPATITIS B vaccines , *HEPATITIS D , *VIRAL hepatitis , *HEPATITIS B , *HUMAN sexuality , *HEPATITIS B virus , *VACCINATION mandates , *COVID-19 - Abstract
Updated incidence data of acute Delta virus hepatitis (HDV) are lacking worldwide. Our aim was to evaluate incidence of and risk factors for acute HDV in Italy after the introduction of the compulsory vaccination against hepatitis B virus (HBV) in 1991. Data were obtained from the National Surveillance System of acute viral hepatitis (SEIEVA). Independent predictors of HDV were assessed by logistic‐regression analysis. The incidence of acute HDV per 1‐million population declined from 3.2 cases in 1987 to 0.04 in 2019, parallel to that of acute HBV per 100,000 from 10.0 to 0.39 cases during the same period. The median age of cases increased from 27 years in the decade 1991–1999 to 44 years in the decade 2010–2019 (p <.001). Over the same period, the male/female ratio decreased from 3.8 to 2.1, the proportion of coinfections increased from 55% to 75% (p =.003) and that of HBsAg positive acute hepatitis tested for by IgM anti‐HDV linearly decreased from 50.1% to 34.1% (p <.001). People born abroad accounted for 24.6% of cases in 2004–2010 and 32.1% in 2011–2019. In the period 2010–2019, risky sexual behaviour (O.R. 4.2; 95%CI: 1.4–12.8) was the sole independent predictor of acute HDV; conversely intravenous drug use was no longer associated (O.R. 1.25; 95%CI: 0.15–10.22) with this. In conclusion, HBV vaccination was an effective measure to control acute HDV. Intravenous drug use is no longer an efficient mode of HDV spread. Testing for IgM‐anti HDV is a grey area requiring alert. Acute HDV in foreigners should be monitored in the years to come. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Effectiveness of Hepatitis B Vaccination Campaign in Italy: Towards the Control of HBV Infection for the First Time in a European Country.
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Stroffolini, Tommaso, Morisco, Filomena, Ferrigno, Luigina, Pontillo, Giuseppina, Iantosca, Giuseppina, Cossiga, Valentina, Crateri, Simonetta, and Tosti, Maria Elena
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HEPATITIS B vaccines , *HEPATITIS B , *INFECTION control , *HEPATITIS B virus , *VIRAL hepatitis , *COVID-19 , *HEPATITIS A - Abstract
Background: In 1991, a mass immunization campaign against the hepatitis B virus (HBV) for children and teenagers was introduced in Italy. This study evaluated the impact of the immunization campaign on the incidence and modes of HBV transmission. Method: Acute HBV cases of viral hepatitis were reported to the National Surveillance System (SEIEVA). Hepatitis A cases reported to the same system were used as controls to calculate the adjusted odds ratios and the population attributable risk for potential risk factors. Results: The incidence of acute HBV declined from 5.0 in 1990 to 0.4 in 2019 per 100,000 population. The fall was almost total in people targeted by the campaign: in 2019, zero cases (100% reduction) in the age-group 0–14 years and 0.1 cases per 100,000 population (99.4% reduction) in the age-group 15–24 years were reported. In the decade 2010–2019, nearly one-fifth (19.3%) of cases occurred in foreigners. Intravenous drug use is no longer a risk factor (OR = 0.7; 95% CI = 0.5–1.02). Beauty treatments, risky sexual exposure, and household contact with an HBsAg carrier were found to be independent predictors of acute hepatitis B. Conclusions: The HB vaccination campaign proved effective in minimising acute HBV in Italy. Control of the infection is close to being reached for the first time in Europe. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Pneumococcal vaccination status among cirrhotic patients in Italy: a neglected topic
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Tommaso Stroffolini, Alessia Ciancio, Alessandro Federico, Rosa G. Benigno, Guido Colloredo, Anna Lombardi, Rosa Cotugno, Gabriella Verucchi, Luigina Ferrigno, Federico Gioli, Massimo Marignani, Yulia Troshina, Mario Romeo, Francesco Di Costanzo, Grazia Anna Niro, Lorenzo Badia, Stroffolini, Tommaso, Ciancio, Alessia, Federico, Alessandro, Benigno, Rosa G, Colloredo, Guido, Lombardi, Anna, Cotugno, Rosa, Verucchi, Gabriella, Ferrigno, Luigina, Gioli, Federico, Marignani, Massimo, Troshina, Yulia, Romeo, Mario, Di Costanzo, Francesco, Niro, Grazia Anna, and Badia, Lorenzo
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Microbiology (medical) ,Infectious Diseases ,Cirrhosi ,Italy ,General Medicine ,Vaccine ,S. pneumoniae - Abstract
To date, few reports have evaluated the pneumococcal vaccination status in cirrhotic patients. No data are available for European countries. We have explored this topic and the potential independent predictors motivating lack of vaccination in Italy. Between January 1st and June 30th 2022, 1419 cirrhotic patients of any etiology were consecutively enrolled in an observational, prospective study at 8 referral centers in Italy. Adjusted odds ratios (ORs) for the association with lack of vaccination were evaluated by multiple logistic regression analysis. Overall vaccine coverage was 17.9% (8.9% in patients < 65 years of age and 27.1% in those aged ≥ 65 years; p < 0.001). Among the 1165 unvaccinated patients, 1068 (91.7%) reported lack of information regarding vaccination as the reason for not having undergone vaccination. Independent predictors associated with lack of vaccination were age < 65 years (OR 3.39, CI 95% 2.41-4.76) and a higher number of schooling years (OR 2.14, CI 95% 1.58-2.91); alcoholic etiology resulted only marginally associated (OR 1.91, CI 95% 1.03-3.52). These findings establish evidence on how pneumococcal vaccination status in Italy is largely suboptimal among cirrhotic patients. These results raise concern, considering the severe outcomes of pneumococcal infection in patients with chronic liver diseases.
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- 2023
15. Effectiveness of Hepatitis B Vaccination Campaign in Italy: Towards the Control of HBV Infection for the First Time in a European Country
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Tommaso Stroffolini, Filomena Morisco, Luigina Ferrigno, Giuseppina Pontillo, Giuseppina Iantosca, Valentina Cossiga, Simonetta Crateri, Maria Tosti, null the SEIEVA Collaborating Group, Stroffolini, Tommaso, Morisco, Filomena, Ferrigno, Luigina, Pontillo, Giuseppina, Iantosca, Giuseppina, Cossiga, Valentina, Crateri, Simonetta, Tosti, Maria Elena, and The Seieva Collaborating Group, Null
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Adult ,Male ,Hepatitis B virus ,Adolescent ,Emigrants and Immigrants ,Drug Users ,Young Adult ,Age Distribution ,Virology ,HBV ,Humans ,risk factors ,Child ,intravenous drug user ,Aged ,Aged, 80 and over ,Immunization Programs ,Incidence ,Infant, Newborn ,Infant ,Italy ,epidemiology ,intravenous drug users ,Middle Aged ,Hepatitis B ,Infectious Diseases ,Case-Control Studies ,Child, Preschool ,Female - Abstract
Background: In 1991, a mass immunization campaign against the hepatitis B virus (HBV) for children and teenagers was introduced in Italy. This study evaluated the impact of the immunization campaign on the incidence and modes of HBV transmission. Method: Acute HBV cases of viral hepatitis were reported to the National Surveillance System (SEIEVA). Hepatitis A cases reported to the same system were used as controls to calculate the adjusted odds ratios and the population attributable risk for potential risk factors. Results: The incidence of acute HBV declined from 5.0 in 1990 to 0.4 in 2019 per 100,000 population. The fall was almost total in people targeted by the campaign: in 2019, zero cases (100% reduction) in the age-group 0–14 years and 0.1 cases per 100,000 population (99.4% reduction) in the age-group 15–24 years were reported. In the decade 2010–2019, nearly one-fifth (19.3%) of cases occurred in foreigners. Intravenous drug use is no longer a risk factor (OR = 0.7; 95% CI = 0.5–1.02). Beauty treatments, risky sexual exposure, and household contact with an HBsAg carrier were found to be independent predictors of acute hepatitis B. Conclusions: The HB vaccination campaign proved effective in minimising acute HBV in Italy. Control of the infection is close to being reached for the first time in Europe.
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- 2022
16. Acute Delta Hepatitis in Italy spanning three decades (1991-2019): Evidence for the effectiveness of the hepatitis B vaccination campaign
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Tommaso, Stroffolini, Filomena, Morisco, Luigina, Ferrigno, Giuseppina, Pontillo, Giuseppina, Iantosca, Valentina, Cossiga, Simonetta, Crateri, Maria Elena Tosti, Valeria, Alfonsi, Franca, D'Angelo, Zotti, Carla Maria, Rainero, Erika, Marengo, Noemi, Silvana, Malaspina, Angela, Gallone, Annalisa, Castella, Maria Teresa Galati, Annamaria, Scala, Paolo, Castagna, Virginia, Silano, Sebastiano, D'Agosta, Maria Grazia Tacca, Silvia, Iodice, Vilma, Corvi, Maurizio, Oddone, Daniela, Rivetti, Paola, Ravaschietto, Franco, Giovanetti, Teresa, Cappello, Alessandro, Smaniotto, Mario, Ruffier, Marina, Verardo, Maria, Gramegna, Sabrina, Senatore, Danilo, Cereda, Annalisa, Donadini, Carla, Nespoli, Livia, Trezzi, Giorgio, Gennati, Angelo, Monteverdi, Liana, Boldori, Franco Paolo Tortorella, Paola Elvira Merlini, Davide Di Caterina, Marino, Faccini, Anna, Lamberti, Eva, Rossetti, Rita, Brugnoli, Giulia, Mainardi, Alessandra, Vezzoli, Daniela, Caso, Milena, Testa, Alice, Erba, Paola, Senegaglia, Annamaria, Spagna, Silvia, Lodola, Marcello, Tirani, Enza, Giompapa, Luigi Guido Roveri, Gabriele, Guardigli, Vanna, Scalvinoni, Silvia, Spertini, Sabine, Gamper, Andrea, Grünfelder, Barbara, Ploner, Verena, Runggatscher, Silvia, Molinaro, Maria Grazia Zuccali, Silvia, Franchini, Francesca, Russo, Francesca, Zanella, Donatella, Rizzato, Graziella, Carpene, Nadia, Lamonato, Emanuela, Destefani, Alessandra Dal Zotto, Rita Dal Zotto, Paola, Casagrande, Felice, Foglia, Gemma, Zorzi, Ester, Chermaz, Liana, Gava, Luigi, Nicolardi, Lorena, Pavanetto, Cecilia, Battiston, Francesco De Grandi, Laura, Rizzato, Michele, Tonon, Elisabetta, Cannizzo, Maurizio, Foroni, Laura, Colucci, Monica, Barbieri, Rosanna, Ledri, Tolinda, Gallo, Giulio, Rocco, Rossana, Stacul, Ariella, Breda, Andrea, Iob, Simonetta, Micossi, Oriana, Feltrin, Giuseppina, Caernelos, Marco, Mela, Virna, Frumento, Anna, Opisso, Alessandro, Cuccu, Giorgio, Zoppi, Patrizia, Torracca, Armanda, Capellini, Francesco, Maddalo, Giovanna, Mattei, Claudio, Gualanduzzi, Erika, Massimiliani, Anna Rita Sacchi, Laura, Gardenghi, Anna Rosa Gianninoni, Elena Dalle Donne, Roberto, Rangoni, Annalisa, Califano, Chiara, Reali, Emilia, Biguzzi, Barbara, Bondi, Anna, Pecci, Bianca Maria Borrini, Lucia, Pecori, Emanuela, Balocchini, Costanza, Pierozzi, Rosa, Luzzoli, Paola, Marchini, Lara, Lucchesi, Alberto, Tomasi, Elisabetta, Raso, Nadia, Olimpi, Cristiana, Berti, Francesca, Matarazzo, Nicoletta, Galletti, Laura, Puppa, Marinella, Frasca, Alessandro, Barbieri, Chiara, Cinughi, Maria, Bandini, Iorio, Lezzi, Fabrizia, Verdelli, Renzo, Paradisi, Rita, Bindi, Cinzia Monica Sansone, Maria, Rosati, Federica, Zacchini, Simonetta, Baretti, Rossella, Cecconi, Chiara, Staderini, Poalo, Filidei, Elisabetta, Alfaroli, Franco, Barghini, Marina, Cadoni, Anna, Tosti, Giovannini, G, Giovanni, Piattellini, Alessandra, Buscosi, Anna, Pasquale, Carla, Ciani, Maria Claudia Paoloni, Franco, Santocchia, Maria Laura Proietti, Daniel, Fiacchini, Dzenana, Hazurovic, Maria Sole Giamprini, Katia, Gatti, Jacqueline Van Will, Alfredo, Vaccaro, Maria Margherita Sbarbati, Alessandra, Amelio, Daniela, Cimini, Vania, Moroni, Daniela, Francoletti, Federica, Scaccia, Elisabetta, Branchesi, Selena, Saracino, Catia, Mezzanotte, Susanna, Cimica, Vita, Vitale, Franca, Laici, Irene, Petrelli, Barbara, Airini, Gabriella, Passarini, Lucia, Ruffini, Anna Maria Lambertucci, Annarita, Mogetta, Francesca, Cioccoloni, Giuseppe, Ciarrocchi, Marina, Pistolesi, Erika, Fratello, Francesca, Picciotti, Claudio, Angelini, Paola, Scognamiglio, Francesco, Vairo, Andreina, Ercole, Antonio Salvatore Maglietta, Fabrizio, Magrelli, Fabrizio, Perrelli, Carlo, Cerocchi, Paolo, Grillo, Cristina, Vazzoler, Maria Rosaria Loffredo, Alessio, Pendenza, Maria Rosaria Nappi, Paola, Bueti, Luigi, Santucci, Franca, Mangiagli, Donatella, Varrenti, Silvia, Aquilani, Pietro, Dionette, Daniela, Corpolongo, Giuseppe Di Luzio, Manuela Di Giacomo, Enrico, Giansanti, Cristiana, Mancini, Claudio, Turchi, Carla, Granchelli, Graziella, Soldato, Felesina, D'Eugenio, Ida, Albanesi, Maria Antonietta Ferrara, Annarita, Citarella, Elena, Fossi, Rosa, Alfieri, Milena, Scotto, Anna Luisa Caiazzo, Rosa, Prato, Maria, Chironna, Domenico, Martinelli, Francesca, Fortunato, Maria Giovanna Cappelli, Daniela, Loconsole, Anna, Morea, Giulia Del Matto, Raffaele, Angelillis, Marcello, Antonazzo, Valerio, Aprile, Grazia Maria Avella, Roberta, Cambria, Giovanni, Caputi, Rosati, Cipriani, Carlo De Santis, Francesco, Desiante, Marisa, Ferraro, Vera, Laforgia, Antonino, Madaro, Maria Giuseppina Maluccio, Anna Maria Matera, Stefania, Menolascina, Giuseppina, Moffa, Maria, Nesta, Rita, Olivieri, Onofrio, Pagone, Pasquale, Pedote, Rosella, Squicciarini, Stefano, Termite, Viviana, Vitale, Francesco, Negrone, Manuela, Maldini, Giovanni, Laugello, Teresa, Russo, Anna Domenica Mignuoli, Giuseppe, Afflitto, Benedetto, Caroleo, Maria, Montesanti, Vincenzo De Giorgio, Antonio, Maradei, Rocco Cataldo Romeo, Francesca, Scrivano, Elisa, Lazzarino, Vittoria, Surace, Antonella, Giordano, Alessandro, Bisbano, Anita, Arcuri, Ida, Valentini, Rossana, Mangione, Valentina, Meli, Mario, Cuccia, Elena, Longhitano, Fiorenzo, Delogu, Donatella, Fracasso, Maria Vittoria Marceddu, Antonina, Puggioni, Maria Valentina Eugenua Marras, Rita, Serpi, Simonetta, Santus, Valentina, Marras, Stroffolini, Tommaso, Morisco, Filomena, Ferrigno, Luigina, Pontillo, Giuseppina, Iantosca, Giuseppina, Cossiga, Valentina, Crateri, Simonetta, and Tosti, Maria Elena
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Adult ,Male ,medicine.medical_specialty ,HBsAg ,Hepatitis B virus ,viruses ,Population ,hepatitis delta ,medicine.disease_cause ,Virology ,Internal medicine ,Epidemiology ,medicine ,Humans ,hepatitis B vaccination ,education ,Hepatitis ,education.field_of_study ,Hepatitis B Surface Antigens ,Hepatology ,business.industry ,Immunization Programs ,Incidence (epidemiology) ,virus diseases ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,Hepatitis B ,Hepatitis D ,Vaccination ,Infectious Diseases ,surveillance ,epidemiology ,Female ,Hepatitis Delta Virus ,business ,Viral hepatitis - Abstract
Updated incidence data of acute Delta virus hepatitis (HDV) are lacking worldwide. Our aim was to evaluate incidence of and risk factors for acute HDV in Italy after the introduction of the compulsory vaccination against hepatitis B virus (HBV) in 1991. Data were obtained from the National Surveillance System of acute viral hepatitis (SEIEVA). Independent predictors of HDV were assessed by logistic-regression analysis. The incidence of acute HDV per 1-million population declined from 3.2 cases in 1987 to 0.04 in 2019, parallel to that of acute HBV per 100,000 from 10.0 to 0.39 cases during the same period. The median age of cases increased from 27 years in the decade 1991-1999 to 44 years in the decade 2010-2019 (p
- Published
- 2021
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