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This work examined the chiral inversion of 2-arylpropionic acids (2-APAs) under anaerobic conditions and the associated microbial community. The anaerobic condition was simulated by two identical anaerobic digesters. Each digester was fed with the substrate containing 11 either pure (R)- or pure (S)-2-APA enantiomers. Chiral inversion was evidenced by the concentration increase of the other enantiomer in the digestate and the changes in the enantiomeric fraction between the two enantiomers. Both digesters showed similar and poor removal of 2-APAs (≤30%, except for naproxen) and diverse chiral inversion behaviors under anaerobic conditions. Four compounds exhibited (S → R) unidirectional inversion [flurbiprofen, ketoprofen, naproxen, and 2-(4-tert-butylphenyl)propionic acid], and the remaining seven compounds showed bidirectional inversion. Several aerobic and facultative anaerobic bacterial genera (Candidatus Microthrix, Rhodococcus, Mycobacterium, Gordonia, and Sphingobium) were identified in both digesters and predicted to harbor the 2-arylpropionyl-CoA epimerase (enzyme involved in chiral inversion) encoding gene. These genera presented at low abundances

The authors regret that the printed version of the above article contained a transcription error in the m/z 1048 peak area column for the branched GDGTs (Table S2). This error affected the GDGT-inferred summer air temperature presented in Figs. 3, 4 and 5, and some of the calibrations presented Fig. S2. The GDGT-inferred temperatures have been recalculated and are presented below. The authors would like to apologise for any inconvenience caused. The corrected GDGT-inferred summer air temperature (Fig. 3) is largely within the uncertainty of the temperature calibration (2.0 °C RMSE, Pearson et al., 2011). While the pattern of the temperature variations over the last 3500 years remains unchanged, the GDGT-inferred summer air temperature is between 0.4 and 3.3 degrees lower than was originally presented. The interpretations of Thomas et al. (2022) are unaffected, with reconstructed changes in temperature at Club Lake still associated with several other palaeoenvironmental proxies. Section 4.1 “Our reconstruction of MSAT varies between about 13 and 16 °C, and appears to display a long-term increase in temperature averaging ~0.1 °C per century (Fig. 3).” should be “Our reconstruction of MSAT varies between about 10 and 15 °C, and appears to display a long-term increase in temperature averaging ~0.13 °C per century (Fig. 3).” Section 4.2 “The reconstructed temperature of 16.2 ± 1 °C (which is higher than the contemporary Thredbo AWS mean summer temperature) must therefore be treated with caution.” should be “The reconstructed temperature of 15.7 ± 1 °C (which is higher than the contemporary Thredbo AWS mean summer temperature) must therefore be treated with caution.” The updated figures and Supplementary information table and figure related to this corrigendum are presented below. [Figure presented] [Figure presented] [Figure presented]

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science–policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science–policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health., Environmental Sciences Europe, 34 (1), ISSN:2190-4715, ISSN:2190-4707

This study examined the removal and enantio-specific fate of a suite of eleven chiral 2-arylpropionic acids (2-APAs) during biological wastewater treatment simulated in a laboratory-scale membrane bioreactor (MBR). Using pure (R)- and (S)- enantiomers in the MBR influent, chiral inversion was determined through the increase in the concentration of the non-dominant enantiomer and changes in the enantiomeric fraction (EF) between the two enantiomers during the treatment process. Effective (> 90%) and similar removal rates between (R)- and (S)- enantiomers were confirmed for eight 2-APAs. In this study, 2-APAs exhibited diverse and distinctive chiral inversion behaviours: two 2-APAs showed (R→S) unidirectional inversion, three 2-APAs showed (S→R) unidirectional inversion, and six 2-APAs showed bidirectional inversion. This is the first study to report chiral inversion behaviours of a comprehensive suite of 2-APAs with a variety of functional groups substituted onto the aryl ring. A decrease in effluent EF over time was observed for two 2-APAs. This study shows that chiral inversion of 2-APAs varies significantly from compound to compound, despite the high similarity in their chemical structures.

A two-stage hybrid Constructed Wetland (CW) integrated with a microbial fuel cell (MFC), and microbial electrolysis cell (MEC) has been assessed for treatment performance and clogging assessment and further compared with CW. The CW-MEC was operated with applied potential to the working electrode and compared with the performance of naturally adapted redox potential of the CW-MFC system. A complex synthetic municipal wastewater was used during the study, which was composed of trace metals, organics, inorganics, and dye. The study demonstrated that providing a constant potential to the working electrode in CW-MEC has resulted in high treatment performance and reduced sludge generation. The maximum chemical oxygen demand (COD), ammonium(NH4+), and phosphate (PO43−) removal achieved during treatment by CW-MEC at 24 h hydraulic retention time was 89 ± 6%, 72 ± 6% and 93 ± 2%, respectively. ICP-MS results indicated that trace metal removals were also higher in CW-MEC than in CW alone (p