Search

Your search keyword '"Sun, Lili"' showing total 956 results
Start Over Author "Sun, Lili" Publication Year Range Last 3 years
956 results on '"Sun, Lili"'

2. Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma

Author

Bao, Chunyang, Tourdot, Richard W, Brunette, Gregory J, Stewart, Chip, Sun, Lili, Baba, Hideo, Watanabe, Masayuki, Agoston, Agoston T, Jajoo, Kunal, Davison, Jon M, Nason, Katie S, Getz, Gad, Wang, Kenneth K, Imamura, Yu, Odze, Robert, Bass, Adam J, Stachler, Matthew D, and Zhang, Cheng-Zhong

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Human Genome, Rare Diseases, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Humans, Barrett Esophagus, Esophageal Neoplasms, Adenocarcinoma, Chromosomal Instability, Precancerous Conditions, Genomics, Disease Progression
Abstract

The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood. Here we perform haplotype-specific analysis of chromosomal copy-number evolution in the progression of Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) on multiregional whole-genome sequencing data of BE with dysplasia and microscopic EAC foci. We identify distinct patterns of copy-number evolution indicating multigenerational chromosomal instability that is initiated by cell division errors but propagated only after p53 loss. While abnormal mitosis, including whole-genome duplication, underlies chromosomal copy-number changes, segmental alterations display signatures of successive breakage-fusion-bridge cycles and chromothripsis of unstable dicentric chromosomes. Our analysis elucidates how multigenerational chromosomal instability generates copy-number variation in BE cells, precipitates complex alterations including DNA amplifications, and promotes their independent clonal expansion and transformation. In particular, we suggest sloping copy-number variation as a signature of ongoing chromosomal instability that precedes copy-number complexity. These findings suggest copy-number heterogeneity in advanced cancers originates from chromosomal instability in precancerous cells and such instability may be identified from the presence of sloping copy-number variation in bulk sequencing data.

Published
2023

3. Truncated Order Reduction Methods for Discrete Linear Periodic Time-Varying Systems

Author

Sun, Lili, Chen, Jun, Zhang, Xuedong, Meng, Hongbing, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Pei, Yan, editor, Ma, Hao Shang, editor, Chan, Yu-Wei, editor, and Jeong, Hwa-Young, editor

Published
2024
Full Text
View/download PDF

4. Joint Security Protection and Transmission Delay Scheduling Scheme of Voice Switching Network

Author

Tang, Ruilin, Zhai, Hongting, Zhai, Qi, Zhang, Yantong, Bian, Ruochen, Sun, Lili, Zhang, Qingrui, Quan, Weihong, He, Xinxin, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Wang, Wei, editor, Mu, Jiasong, editor, Liu, Xin, editor, and Na, Zhenyu Na, editor

Published
2024
Full Text
View/download PDF

5. A Multidimensional Detection Model of Android Malicious Applications Based on Dynamic and Static Analysis

Author

Zhang, Hao, Liu, Donglan, Liu, Xin, Ma, Lei, Wang, Rui, Zhang, Fangzhe, Sun, Lili, Zhao, Fuhui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Zhang, Yonghong, editor, Qi, Lianyong, editor, Liu, Qi, editor, Yin, Guangqiang, editor, and Liu, Xiaodong, editor

Published
2024
Full Text
View/download PDF

14. Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer

Author

Chiang, Chi-Ling, Ma, Yifan, Hou, Ya-Chin, Pan, Junjie, Chen, Sin-Yu, Chien, Ming-Hsien, Zhang, Zhi-Xuan, Hsu, Wei-Hsiang, Wang, Xinyu, Zhang, Jingjing, Li, Hong, Sun, Lili, Fallen, Shannon, Lee, Inyoul, Chen, Xing-Yu, Chu, Yeh-Shiu, Zhang, Chi, Cheng, Tai-Shan, Jiang, Wen, Kim, Betty Y. S., Reategui, Eduardo, Lee, Robert, Yuan, Yuan, Liu, Hsiao-Chun, Wang, Kai, Hsiao, Michael, Huang, Chi-Ying F., Shan, Yan-Shen, Lee, Andrew S., and James Lee, L.

Published
2023
Full Text
View/download PDF

34. Summary of Expansions and Updates in R&D GREET® 2023

Author

Wang, Michael, primary, Elgowainy, Amgad, additional, Lee, Uisung, additional, Baek, Kwang, additional, Balchandani, Sweta, additional, Benavides, Pahola, additional, Burnham, Andrew, additional, Cai, Hao, additional, Chen, Peter, additional, Gan, Yu, additional, Gracida-Alvarez, Ulises, additional, Hawkins, Troy, additional, Huang, Tai-Yuan, additional, Iyer, Rakesh, additional, Kar, Saurajyoti, additional, Kelly, Jarod, additional, Kim, Taemin, additional, Kolodziej, Christopher, additional, Lee, Kyuha, additional, Liu, Xinyu, additional, Lu, Zifeng, additional, Masum, Farhad, additional, Morales, Michele, additional, Ng, Clarence, additional, Ou, Longwen, additional, Poddar, Tuhin, additional, Reddi, Krishna, additional, Shukla, Siddharth, additional, Singh, Udayan, additional, Sun, Lili, additional, Sun, Pingping, additional, Vyawahare, Pradeep, additional, and Zhang, Jingyi, additional

Published
2023
Full Text
View/download PDF

36. Study on Credit Risk Control by Variational Inference

Author

Wang, Kun, Li, Ang, Wang, Xiaokun, Sun, Lili, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Zhang, Feng, editor, Wang, Hua, editor, Barhamgi, Mahmoud, editor, Chen, Lu, editor, and Zhou, Rui, editor

Published
2023
Full Text
View/download PDF

37. A Framework for TLS Implementation Vulnerability Testing in 5G

Author

Wang, Yong, Wang, Rui, Liu, Xin, Liu, Donglan, Zhang, Hao, Ma, Lei, Zhang, Fangzhe, Sun, Lili, Li, Zhenghao, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Zhou, Jianying, editor, Batina, Lejla, editor, Li, Zengpeng, editor, Lin, Jingqiang, editor, Losiouk, Eleonora, editor, Majumdar, Suryadipta, editor, Mashima, Daisuke, editor, Meng, Weizhi, editor, Picek, Stjepan, editor, Rahman, Mohammad Ashiqur, editor, Shao, Jun, editor, Shimaoka, Masaki, editor, Soremekun, Ezekiel, editor, Su, Chunhua, editor, Teh, Je Sen, editor, Udovenko, Aleksei, editor, Wang, Cong, editor, Zhang, Leo, editor, and Zhauniarovich, Yury, editor

Published
2023
Full Text
View/download PDF

44. Abstract 15689: Ablation for Atrial Fibrillation in Patients With Rare Pathogenic Variants in Cardiomyopathy and Arrhythmia Genes

Author

El-Harasis, Majd A, Yoneda, Zachary, Anderson, Katherine, Ye, Fei, Quintana, Joseph, Martinez-Parachini, Jose R, Jackson, Gregory, Varghese, Bibin, Crawford, Diane, Sun, Lili, Williams, Hollie L, OʼNeill, Matthew, Davogustto, Giovanni E, Laws, James L, Murphy, Brittany, Tomasek, Kelsey, Su, Yan Ru, Solem, Emily, Metz, Emma, Smith, Carly, Stubbs, Douglas, Grauherr, Dakota, Wells, Quinn, Michaud, Gregory, saavedra, pablo, Estrada, Juan C, Richardson, Travis, Shen, Sharon, Kanagasundram, Arvindh, Montgomery, Jay A, Tandri, Harikrishna, Ellis, Christopher R, Crossley, George H, Kannankeril, Prince, Stevenson, Lynne W, Stevenson, William G, Lubitz, Steven A, Ellinor, Patrick T, Roden, Dan M, and Shoemaker, Ben B

Published
2023
Full Text
View/download PDF

50. Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis

Author

Hiremath, Girish, Sun, Lili, Collins, Margaret H., Bonis, Peter A., Arva, Nicoleta C., Capocelli, Kelley E., Chehade, Mirna, Davis, Carla M., Falk, Gary W., Gonsalves, Nirmala, Gupta, Sandeep K., Hirano, Ikuo, Leung, John, Khoury, Paneez, Mukkada, Vincent A., Martin, Lisa J., Spergel, Jonathan M., Wechsler, Joshua B., Yang, Guang-Yu, Aceves, Seema S., Furuta, Glenn T., Rothenberg, Marc.E., Koyama, Tatsuki, and Dellon, Evan S.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results