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2. Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial

Author

Djillali, ANNANE, Christian, BRUN-BUISSON, Benoit, MISSET, Jean, CHASTRE, François, BRIVET, Julien, BOHE, Carole, SCHWEBEL, Shidasp, SIAMI, Michel, SLAMA, Olivier, LEROY, Gilles, CAPELLIER, Michel, WOLFF, Mohamed, ALI BEN ALI, François, ANTONINI, Jean-François, LORIFERNE, Franck, PETITPAS, Claire, CHARPENTIER, Jean-Michel, CONSTANTIN, Gilles, D'HONNEUR, Bertrand, SOUWEINE, Xavier, FORCEVILLE, Bruno, MEGARBANE, Francois, BAUDIN, Gwenhaël, COLIN, Karim, ASEHNOUNE, Jean-Pierre, QUENOT, Bruno, FRANCOIS, Thierry, BOULAIN, Emmanuelle, MERCIER, Jean, REIGNIER, Roland, AMATHIEU, Fabrice, COOK, Alain, CARIOU, Loic, CHIMOT, Fouad, Fadel, Andrea, Polito, Bernard, Clair, Virginie, Maxime, David, Luis, Tarek, Sharshar, David, Orlikowski, Keyvan, RAZAZI, Nicolas, DE PROST, Guillaume, CARTEAUX, Maité, GARROUSTE ORGEAS, François, Philippart, Alain, Combes, Ania, Nieszkowska, Frederic, Jacobs, Dominique, Prat, Patrick, Lafforgue, Claire, ARA SOMOHANO, Clémence, MINET, Maxime, LUGOSI, Julien, Maizel, Jean Christophe, Navellou, Bruno, Mourvillier, Lila, Bouadma, Jean François, Timsit, Claude Denis, Martin, Julien, Textoris, Sandrine, Wiramus, Clément, BRUN, Benoît, RAGONNET, Ali, Ait-Hssain, Samia, Touati, Jean, Kuba, Vincent, Willems, Pierre, Lahillaire, Mohammed, Lassi, Marion, ANTONA, Alia, MEGHENEM, Marine, DEMESMAY, Eric, Boulet, Olivier, LOUTREL, Romain, DUMONT, Antoine, ROQUILLY, Pierre-Joachim, MAHE, Dominique, DEMEURE dit LATTE, Philippe, CHAMPIN, Jean François, ARNOULD, Raphaël, CINOTTI, Ronan, Le FLOCH, Marc, Clavel, Philippe, Vignon, Nicolas, Pichon, Emmanuelle, BEGOT, Anne-Laure, FEDOU, Catherine, CHAPELLAS, Antoine, GALY, Dalila, Benzekri Lefevre, Armelle, Mathonnet, Anne, Bretagnol, Isabelle, Runge, François, BARBIER, Grégoire, MULLER, Denis, GAROT, Pierre François, DEQUIN, Dominique, PERROTIN, Annick, LEGRAS, Julie, MANKIKIAN, Patrice, TALEC, Stephan, EHRMANN, Aurélie, JORET, Claire, LHOMMET, Emmanuelle, ROUVE, Laetitia, BODET-CONTENTIN, Youenn, JOUAN, Charlotte, SALMONGANDONNIERE, Laurent, MARTIN-LEFEVRE, Matthieu, HENRY-LAGARRIGUE, Aihem, YEHIA, Jean-Baptiste, LASCARROU, Christine, LEBERT, Jean-Claude, LACHERADE, Eric, LEVESQUE, Yen-Lan, NGUYEN, Fabrice, DAVIAUD, Adrien, BOUGLE, Jean Paul, MIRA, Jean Daniel, CHICHE, Frederic, PENE, Tristan, MORICHAU-BEAUCHANT, Guillaume, GERI, Pierre Henri, DESSALLES, Yannick, MONSEAU, Mélanie, SAINT-LEGER, Sandrine, BEDON-CARTE, Laetitia, Bodet-Contentin, Walid, Darwiche, Stephan, Ehrmann, Denis, Garot, Antoine, Guillon, Youenn, Jouan, Annick, Legras, Julie, Mankikian, Emmanuelle, Mercier, Marlene, Morisseau, Yonatan, Perez, Emmanuelle, Rouve, Charlotte, Salmon-Gandonniere, Julie, Helms, Hassene, Rahmani, Alexandra, Monnier, Hamid, Merdji, Raphael, Clere-Jehl, Laure, Stiel, Antoine, Studer, Pascal, Andreu, Jean-Baptiste, Roudaut, Marie, Labruyere, Marine, Jacquier, Francois, Barbier, Dalila, Benzekri, Thierry, Boulain, Sophie, Jacquier, Gregoire, Muller, Mai-Anh, Nai, Sophie, Tollec, Damien, Roux, Jonathan, Messika, Constance, Vuillard, Louis-Marie, Dumont, Laura, Federici, Noemie, Zucman, Marc, Amouretti, Djillali, Annane, Pierre, Moine, Paris, Meng, Rania, Bounab, Muriel-Sarah, Fartoukh, Michel, Djibre, Alexandre, Elabbadi, Marie-Ange, Azais, Konstantinos, Bachoumas, Arthur, Bailly, Remi, Bernardon, Gauthier, Blonz, Luc, Desmedt, Brian, Emonet, Maud, Fiancette, Matthieu, Henry, Jean-Claude, Lacherade, Jean-Baptiste, Lascarrou, Christine, Lebert, Julien, Lorber, Laurent Martin-, Lefevre, Caroline, Pouplet, Isabelle, Vinatier, Aihem, Yehia, Sarah, Benghanem, Julien, Charpentier, Clara, Vigneron, Anne-Laure, Fedou, Claire, Mancia, Emmanuelle, Begot, Thomas, Daix, Antoine, Galy, Celine, Gonzalez, Marine, Goudelin, Bruno, Evrard, Arnaud, Desachy, Julien, Vaidie, Guillaume, Gilbert, Cedric, Darreau, Benoit, Derrien, Marjorie, Saint-Martin, Patrice, Tirot, Mickael, Landais, Nicolas, Chudeau, Jean Christophe, Callahan, Dominique, Vivier, Charlene, Le Moal, Pierre-Yves, Olivier, Remy, Marnai, Francis, Schneider, Nicolas, Sedillot, Xavier, Tchenio, Adrien, Robine, Yves, Poncelin, Remi, Bruyere, Heming, Nicholas, Renault, Alain, Kuperminc, Emmanuelle, Brun-Buisson, Christian, Megarbane, Bruno, Quenot, Jean-Pierre, Siami, Shidasp, Cariou, Alain, Forceville, Xavier, Schwebel, Carole, Leone, Marc, Timsit, Jean-Francois, Misset, Benoît, Benali, Mohamed Ali, Colin, Gwenhael, Souweine, Bertrand, Asehnoune, Karim, Mercier, Emmanuelle, Chimot, Loïc, Charpentier, Claire, François, Bruno, Boulain, Thierry, Petitpas, Frank, Constantin, Jean Michel, Dhonneur, Gilles, Baudin, François, Combes, Alain, Bohé, Julien, Loriferne, Jean-François, Cook, Fabrice, Slama, Michel, Leroy, Olivier, Capellier, Gilles, Dargent, Auguste, Hissem, Tarik, Bounab, Rania, Maxime, Virginie, Moine, Pierre, Bellissant, Eric, and Annane, Djillali

Published
2024
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3. Relying on pulse oximetry to avoid hypoxaemia and hyperoxia: A multicentre prospective cohort study in patients with circulatory failure

Author

Baudin, Olivier, Calvat, Sylvie, Cracco, Christophe, Desachy, Arnault, Lafon, Charles, Boitrou, Emmanuelle, Follin, Arnaud, Mentec, Hervé, Pajot, Olivier, Plantefève, Gaëtan, Thirion, Marina, Bruyère, Rémi, Quenot, Jean-Pierre, Bachoumas, Konstantinos, Fiancette, Maud, Lacherade, Jean Claude, Lebert, Christine, Martin-Lefèvre, Laurent, Reignier, Jean, Vinatier, Isabelle, Yehia, Aihem, Begot, Emmanuelle, Bellier, Remy, Clavel, Marc, François, Bruno, Galy, Antoine, Pichon, Nicolas, Bardou, Patrick, Bellec, Frédéric, Bonnivard, Michel, Marco, Anne, Roustan, Jérôme, Vimeux, Sylvie, Bretagnol, Anne, Mathonnet, Armelle, Bercault, Nicolas, Kamel, Toufik, Muller, Grégoire, Réminiac, François, Runge, Isabelle, Skarzynski, Marie, Chatellier, Delphine, Coudroy, Rémi, Frat, Jean-Pierre, Goudet, Véronique, Robert, René, Veinstein, Anne, Botoc, Vlad, Chevalier, Stéphanie, Collet, François, Gouello, Jean-Paul, Badin, Julie, Guillon, Antoine, Legras, Annick, Masseret, Elodie, Mercier, Emmanuelle, Talec, Patrice, Boulain, Thierry, Nay, Mai-Anh, Dequin, Pierre-François, Lascarrou, Jean-Baptiste, Vignon, Philippe, and Ehrmann, Stephan

Published
2023
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9. Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial

Author

Heming, Nicholas, primary, Renault, Alain, additional, Kuperminc, Emmanuelle, additional, Brun-Buisson, Christian, additional, Megarbane, Bruno, additional, Quenot, Jean-Pierre, additional, Siami, Shidasp, additional, Cariou, Alain, additional, Forceville, Xavier, additional, Schwebel, Carole, additional, Leone, Marc, additional, Timsit, Jean-Francois, additional, Misset, Benoît, additional, Benali, Mohamed Ali, additional, Colin, Gwenhael, additional, Souweine, Bertrand, additional, Asehnoune, Karim, additional, Mercier, Emmanuelle, additional, Chimot, Loïc, additional, Charpentier, Claire, additional, François, Bruno, additional, Boulain, Thierry, additional, Petitpas, Frank, additional, Constantin, Jean Michel, additional, Dhonneur, Gilles, additional, Baudin, François, additional, Combes, Alain, additional, Bohé, Julien, additional, Loriferne, Jean-François, additional, Cook, Fabrice, additional, Slama, Michel, additional, Leroy, Olivier, additional, Capellier, Gilles, additional, Dargent, Auguste, additional, Hissem, Tarik, additional, Bounab, Rania, additional, Maxime, Virginie, additional, Moine, Pierre, additional, Bellissant, Eric, additional, Annane, Djillali, additional, Djillali, ANNANE, additional, Christian, BRUN-BUISSON, additional, Benoit, MISSET, additional, Jean, CHASTRE, additional, François, BRIVET, additional, Julien, BOHE, additional, Carole, SCHWEBEL, additional, Shidasp, SIAMI, additional, Michel, SLAMA, additional, Olivier, LEROY, additional, Gilles, CAPELLIER, additional, Michel, WOLFF, additional, Mohamed, ALI BEN ALI, additional, François, ANTONINI, additional, Jean-François, LORIFERNE, additional, Franck, PETITPAS, additional, Claire, CHARPENTIER, additional, Jean-Michel, CONSTANTIN, additional, Gilles, D'HONNEUR, additional, Bertrand, SOUWEINE, additional, Xavier, FORCEVILLE, additional, Bruno, MEGARBANE, additional, Francois, BAUDIN, additional, Gwenhaël, COLIN, additional, Karim, ASEHNOUNE, additional, Jean-Pierre, QUENOT, additional, Bruno, FRANCOIS, additional, Thierry, BOULAIN, additional, Emmanuelle, MERCIER, additional, Jean, REIGNIER, additional, Roland, AMATHIEU, additional, Fabrice, COOK, additional, Alain, CARIOU, additional, Loic, CHIMOT, additional, Fouad, Fadel, additional, Andrea, Polito, additional, Bernard, Clair, additional, Virginie, Maxime, additional, David, Luis, additional, Tarek, Sharshar, additional, David, Orlikowski, additional, Keyvan, RAZAZI, additional, Nicolas, DE PROST, additional, Guillaume, CARTEAUX, additional, Maité, GARROUSTE ORGEAS, additional, François, Philippart, additional, Alain, Combes, additional, Ania, Nieszkowska, additional, Frederic, Jacobs, additional, Dominique, Prat, additional, Patrick, Lafforgue, additional, Claire, ARA SOMOHANO, additional, Clémence, MINET, additional, Maxime, LUGOSI, additional, Julien, Maizel, additional, Jean Christophe, Navellou, additional, Bruno, Mourvillier, additional, Lila, Bouadma, additional, Jean François, Timsit, additional, Claude Denis, Martin, additional, Julien, Textoris, additional, Sandrine, Wiramus, additional, Clément, BRUN, additional, Benoît, RAGONNET, additional, Ali, Ait-Hssain, additional, Samia, Touati, additional, Jean, Kuba, additional, Vincent, Willems, additional, Pierre, Lahillaire, additional, Mohammed, Lassi, additional, Marion, ANTONA, additional, Alia, MEGHENEM, additional, Marine, DEMESMAY, additional, Eric, Boulet, additional, Olivier, LOUTREL, additional, Romain, DUMONT, additional, Antoine, ROQUILLY, additional, Pierre-Joachim, MAHE, additional, Dominique, DEMEURE dit LATTE, additional, Philippe, CHAMPIN, additional, Jean François, ARNOULD, additional, Raphaël, CINOTTI, additional, Ronan, Le FLOCH, additional, Marc, Clavel, additional, Philippe, Vignon, additional, Nicolas, Pichon, additional, Emmanuelle, BEGOT, additional, Anne-Laure, FEDOU, additional, Catherine, CHAPELLAS, additional, Antoine, GALY, additional, Dalila, Benzekri Lefevre, additional, Armelle, Mathonnet, additional, Anne, Bretagnol, additional, Isabelle, Runge, additional, François, BARBIER, additional, Grégoire, MULLER, additional, Denis, GAROT, additional, Pierre François, DEQUIN, additional, Dominique, PERROTIN, additional, Annick, LEGRAS, additional, Julie, MANKIKIAN, additional, Patrice, TALEC, additional, Stephan, EHRMANN, additional, Aurélie, JORET, additional, Claire, LHOMMET, additional, Emmanuelle, ROUVE, additional, Laetitia, BODET-CONTENTIN, additional, Youenn, JOUAN, additional, Charlotte, SALMONGANDONNIERE, additional, Laurent, MARTIN-LEFEVRE, additional, Matthieu, HENRY-LAGARRIGUE, additional, Aihem, YEHIA, additional, Jean-Baptiste, LASCARROU, additional, Christine, LEBERT, additional, Jean-Claude, LACHERADE, additional, Eric, LEVESQUE, additional, Yen-Lan, NGUYEN, additional, Fabrice, DAVIAUD, additional, Adrien, BOUGLE, additional, Jean Paul, MIRA, additional, Jean Daniel, CHICHE, additional, Frederic, PENE, additional, Tristan, MORICHAU-BEAUCHANT, additional, Guillaume, GERI, additional, Pierre Henri, DESSALLES, additional, Yannick, MONSEAU, additional, Mélanie, SAINT-LEGER, additional, Sandrine, BEDON-CARTE, additional, Laetitia, Bodet-Contentin, additional, Walid, Darwiche, additional, Stephan, Ehrmann, additional, Denis, Garot, additional, Antoine, Guillon, additional, Youenn, Jouan, additional, Annick, Legras, additional, Julie, Mankikian, additional, Emmanuelle, Mercier, additional, Marlene, Morisseau, additional, Yonatan, Perez, additional, Emmanuelle, Rouve, additional, Charlotte, Salmon-Gandonniere, additional, Julie, Helms, additional, Hassene, Rahmani, additional, Alexandra, Monnier, additional, Hamid, Merdji, additional, Raphael, Clere-Jehl, additional, Laure, Stiel, additional, Antoine, Studer, additional, Pascal, Andreu, additional, Jean-Baptiste, Roudaut, additional, Marie, Labruyere, additional, Marine, Jacquier, additional, Francois, Barbier, additional, Dalila, Benzekri, additional, Thierry, Boulain, additional, Sophie, Jacquier, additional, Gregoire, Muller, additional, Mai-Anh, Nai, additional, Sophie, Tollec, additional, Damien, Roux, additional, Jonathan, Messika, additional, Constance, Vuillard, additional, Louis-Marie, Dumont, additional, Laura, Federici, additional, Noemie, Zucman, additional, Marc, Amouretti, additional, Djillali, Annane, additional, Pierre, Moine, additional, Paris, Meng, additional, Rania, Bounab, additional, Muriel-Sarah, Fartoukh, additional, Michel, Djibre, additional, Alexandre, Elabbadi, additional, Marie-Ange, Azais, additional, Konstantinos, Bachoumas, additional, Arthur, Bailly, additional, Remi, Bernardon, additional, Gauthier, Blonz, additional, Luc, Desmedt, additional, Brian, Emonet, additional, Maud, Fiancette, additional, Matthieu, Henry, additional, Jean-Claude, Lacherade, additional, Jean-Baptiste, Lascarrou, additional, Christine, Lebert, additional, Julien, Lorber, additional, Laurent Martin-, Lefevre, additional, Caroline, Pouplet, additional, Isabelle, Vinatier, additional, Aihem, Yehia, additional, Sarah, Benghanem, additional, Julien, Charpentier, additional, Clara, Vigneron, additional, Anne-Laure, Fedou, additional, Claire, Mancia, additional, Emmanuelle, Begot, additional, Thomas, Daix, additional, Antoine, Galy, additional, Celine, Gonzalez, additional, Marine, Goudelin, additional, Bruno, Evrard, additional, Arnaud, Desachy, additional, Julien, Vaidie, additional, Guillaume, Gilbert, additional, Cedric, Darreau, additional, Benoit, Derrien, additional, Marjorie, Saint-Martin, additional, Patrice, Tirot, additional, Mickael, Landais, additional, Nicolas, Chudeau, additional, Jean Christophe, Callahan, additional, Dominique, Vivier, additional, Charlene, Le Moal, additional, Pierre-Yves, Olivier, additional, Remy, Marnai, additional, Francis, Schneider, additional, Nicolas, Sedillot, additional, Xavier, Tchenio, additional, Adrien, Robine, additional, Yves, Poncelin, additional, and Remi, Bruyere, additional

Published
2024
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10. Organic Phosphorus Scavenging Supports Efficient Growth of Diazotrophic Cyanobacteria Under Phosphate Depletion

Author

Sophie Rabouille, Lauralie Tournier, Solange Duhamel, Pascal Claquin, Olivier Crispi, Amélie Talec, Angela Landolfi, and Andreas Oschlies

Subjects
Crocosphaera watsonii, marine, oligotrophic, dissolved organic phosphorus, phosphonates, nitrogen fixation, Microbiology, QR1-502
Abstract

Considering the reported significant diazotrophic activities in open-ocean regions where primary production is strongly limited by phosphate, we explored the ability of diazotrophs to use other sources of phosphorus to alleviate the phosphate depletion. We tested the actual efficiency of the open-ocean, N2-fixer Crocosphaera watsonii to grow on organic phosphorus as the sole P source, and observed how the P source affects the cellular C, N, and P composition. We obtained equivalent growth efficiencies on AMP and DL-α-glycerophosphate as compared with identical cultures grown on phosphate, and survival of the population on phytic acid. Our results show that Crocosphaera cannot use all phosphomonoesters with the same efficiency, but it can grow without phosphate, provided that usable DOP and sufficient light energy are available. Also, results point out that organic phosphorus uptake is not proportional to alkaline phosphatase activity, demonstrating that the latter is not a suitable proxy to estimate DOP-based growth yields of organisms, whether in culture experiments or in the natural environment. The growth parameters obtained, as a function of the P source, will be critical to improve and calibrate mathematical models of diazotrophic growth and the distribution of nitrogen fixation in the global ocean.

Published
2022
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11. High proportion of post-migration HIV acquisition in migrant men who have sex with men receiving HIV care in the Paris region, and associations with social disadvantage and sexual behaviours: results of the ANRS-MIE GANYMEDE study, France, 2021 to 2022.

Author

Palich, Romain, Arias-Rodríguez, Andrés, Duracinsky, Martin, Le Talec, Jean-Yves, Torrente, Olivia Rousset, Lascoux-Combe, Caroline, Lacombe, Karine, Ghosn, Jade, Viard, Jean-Paul, Pialoux, Gilles, Ohayon, Michel, Duvivier, Claudine, Velter, Annie, Mechlia, Mohamed Ben, Beniguel, Lydie, Grabar, Sophie, Melchior, Maria, Assoumou, Lambert, and Supervie, Virginie

Published
2024
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13. Recueil des cartes de sensibilité et opérationnelles de l’Atlas POLMAR-Terre à La Réunion – mise à jour 2023

Author

Grondin, Evans, Duval, Magali, Talec, Pascal, Bouilly, Rémi, Grondin, Evans, Duval, Magali, Talec, Pascal, and Bouilly, Rémi

Abstract

Dans le cadre de la convention DEAL/IFREMER et pour le projet Atlas POLMAR-Terre, des mises à jour ponctuelles des couches géographiques dans l’outils SEXTANT sont nécessaires afin d’actualiser l’Atlas intéractif sur le site Polmar. Ces mises à jour nécessitent donc de modifier les produits de cartes de sensibilité et opérationnelles. Cette mise à jour fait suite à celle de 2016.

Published
2023
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17. Les jurys de thèse ont-ils un sexe ? Enquête sur le dispositif « Refusons le 0 % » à l’Université Toulouse III

Author

Chloé Delacroix, Catherine Armengaud, and Jean-Yves Le Talec

Subjects
genre, université, jurys de thèse, égalité femmes-hommes
Abstract

Cette recherche porte sur la composition sexuée des jurys de thèse. En 2016, l’université Toulouse III-Paul Sabatier a mis en place le dispositif « Refusons le 0 % », afin que tous les jurys de thèse locaux soient mixtes (c’est-à-dire qu’ils soient composés d’au moins une personne de chaque sexe). Cette recherche analyse l’effet de cette mesure, en comparant la composition sexuée des jurys de thèse en 2015 et 2016, tout en recueillant les représentations exprimées par une partie des universitaires concerné·e·s. Les résultats de cette enquête ont permis de quantifier les inégalités sexuées dans les jurys de thèse et d’analyser les effets des rapports sociaux de sexe à l’œuvre dans ces jurys. Ils montrent que le dispositif « Refusons le 0 % » s’avère efficace lorsque qu’il est assorti de sanctions en cas de non respect, mais ils indiquent également que s’instaure une forme de « résistance masculine au changement », dans la mesure où l’effectif des jurys tend à augmenter et, qu’en conséquence, le nombre d’hommes ne diminue pas. Les commentaires recueillis auprès des enseignant·e·s-chercheur·e·s soulignent enfin que le sujet de l’égalité femmes-hommes à l’université demeure polémique.

Published
2022

18. Dynamical Darwinian selection of a more productive strain of Tisochrysis lutea

Author

H. Bonnefond, Y. Lie, T. Lacour, B. Saint-Jean, G. Carrier, E. Pruvost, A. Talec, O. Bernard, A. Sciandra, Laboratoire d'océanographie de Villefranche (LOV), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Biological control of artificial ecosystems (BIOCORE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'océanographie de Villefranche (LOV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and ANR-12-BIME-0004,Facteur 4,AMELIORATION NON OGM DES PERFORMANCES DE MICROALGUES(2012)

Subjects
Pigments, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Biomass productivity, ALE, Microalgae, Adaptation, Adaptive laboratory evolution, Agronomy and Crop Science, Selection, ComputingMilieux_MISCELLANEOUS
Abstract

Species domestication and improvement were decisive in increasing agricultural production yields. The microalgae industry must now realize the same accomplishment to boost its development instead of only using wild strains. Although genetically engineering microalgae is a promising path to explore, the artificial modification of the microalgae genome can have adverse side-effects on biomass productivity. Here, we propose a Darwinian method to select and improve microalgal strains, exploiting the competitive exclusion principle in a dynamical environment to drive evolution. Choosing an appropriate selection pressure allows a new adapted population having enhanced properties to emerge. In a natural growing environment, light intensity is consistently changing due to meteorological events, differing microalgae concentration and other exogenous factors. Consequently, the pigmentary profile regulation and the associated genetic mechanism is highly modulable in most microalgae. On top of this, high light intensities are known to elicit strong cellular stresses. For these reasons, a dynamical light regime with high light intensities was deemed a potentially efficient selection factor for the emergence of a new strain adapted to higher irradiance levels. Following 160 days of selection under variable light intensity the biomass productivity of Tisochrysis lutea increased by 77%. Genetic analyses further confirmed the selection protocol's success, with the apparition of 2716 new alleles. To our knowledge, this is the first selection approach allowing a significant biomass productivity increase resulting from an enhanced capacity of microalgae pigment photoadaptation.

Published
2022
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19. Relying on pulse oximetry to avoid hypoxaemia and hyperoxia: A multicentre prospective cohort study in patients with circulatory failure

Author

Boulain, Thierry, primary, Nay, Mai-Anh, additional, Dequin, Pierre-François, additional, Lascarrou, Jean-Baptiste, additional, Vignon, Philippe, additional, Kamel, Toufik, additional, Muller, Grégoire, additional, Ehrmann, Stephan, additional, Baudin, Olivier, additional, Calvat, Sylvie, additional, Cracco, Christophe, additional, Desachy, Arnault, additional, Lafon, Charles, additional, Boitrou, Emmanuelle, additional, Follin, Arnaud, additional, Mentec, Hervé, additional, Pajot, Olivier, additional, Plantefève, Gaëtan, additional, Thirion, Marina, additional, Bruyère, Rémi, additional, Quenot, Jean-Pierre, additional, Bachoumas, Konstantinos, additional, Fiancette, Maud, additional, Lacherade, Jean Claude, additional, Lebert, Christine, additional, Martin-Lefèvre, Laurent, additional, Reignier, Jean, additional, Vinatier, Isabelle, additional, Yehia, Aihem, additional, Begot, Emmanuelle, additional, Bellier, Remy, additional, Clavel, Marc, additional, François, Bruno, additional, Galy, Antoine, additional, Pichon, Nicolas, additional, Bardou, Patrick, additional, Bellec, Frédéric, additional, Bonnivard, Michel, additional, Marco, Anne, additional, Roustan, Jérôme, additional, Vimeux, Sylvie, additional, Bretagnol, Anne, additional, Mathonnet, Armelle, additional, Bercault, Nicolas, additional, Réminiac, François, additional, Runge, Isabelle, additional, Skarzynski, Marie, additional, Chatellier, Delphine, additional, Coudroy, Rémi, additional, Frat, Jean-Pierre, additional, Goudet, Véronique, additional, Robert, René, additional, Veinstein, Anne, additional, Botoc, Vlad, additional, Chevalier, Stéphanie, additional, Collet, François, additional, Gouello, Jean-Paul, additional, Badin, Julie, additional, Guillon, Antoine, additional, Legras, Annick, additional, Masseret, Elodie, additional, Mercier, Emmanuelle, additional, and Talec, Patrice, additional

Published
2022
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22. Relying on pulse oximetry to avoid hypoxaemia and hyperoxia: A multicentre prospective cohort study in patients with circulatory failure

Author

Thierry Boulain, Mai-Anh Nay, Pierre-François Dequin, Jean-Baptiste Lascarrou, Philippe Vignon, Toufik Kamel, Grégoire Muller, Stephan Ehrmann, Olivier Baudin, Sylvie Calvat, Christophe Cracco, Arnault Desachy, Charles Lafon, Emmanuelle Boitrou, Arnaud Follin, Hervé Mentec, Olivier Pajot, Gaëtan Plantefève, Marina Thirion, Rémi Bruyère, Jean-Pierre Quenot, Konstantinos Bachoumas, Maud Fiancette, Jean Claude Lacherade, Christine Lebert, Laurent Martin-Lefèvre, Jean Reignier, Isabelle Vinatier, Aihem Yehia, Emmanuelle Begot, Remy Bellier, Marc Clavel, Bruno François, Antoine Galy, Nicolas Pichon, Patrick Bardou, Frédéric Bellec, Michel Bonnivard, Anne Marco, Jérôme Roustan, Sylvie Vimeux, Anne Bretagnol, Armelle Mathonnet, Nicolas Bercault, François Réminiac, Isabelle Runge, Marie Skarzynski, Delphine Chatellier, Rémi Coudroy, Jean-Pierre Frat, Véronique Goudet, René Robert, Anne Veinstein, Vlad Botoc, Stéphanie Chevalier, François Collet, Jean-Paul Gouello, Julie Badin, Antoine Guillon, Annick Legras, Elodie Masseret, Emmanuelle Mercier, and Patrice Talec

Subjects
Emergency Nursing, Critical Care Nursing
Abstract

The purpose of this study was to assess the predictive performance of pulse oximetry (SpOSpOFive hundred seventy-one patients (mean [standard deviation] Simplified Acute Physiology Score II: 58.7 [20.1]; mechanically ventilated 75.6%) with 2643 available SaO

Published
2022

23. La Liste rouge des espèces menacées en France - Poissons récifaux de La Réunion

Author

Moncorps, Sébastien, Poncet, Laurent, Touroult, Julien, Gigot, Guillaume, Kirchner, Florian, Dumestre, Marielle, Soubeyran, Yohann, Wickel, Julien, Chabanet, Pascale, Durville, Patrick, Roos, David, Rungassamy, Tevamie, Rodicq, Juliette, Fricke, Ronald, Talec, Pascal, Union Internationale pour la Conservation de la Nature (UICN), Patrimoine naturel (PatriNat), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Office français de la biodiversité (OFB), Ecologie marine tropicale dans les Océans Pacifique et Indien (ENTROPIE [Réunion]), Institut de Recherche pour le Développement (IRD)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Staatliches Museum für Naturkunde Stuttgart (SMNS), Ministère de l'environnement, Ministère de l'Environnement, and Comité français de l'UICN, OFB & MNHN

Subjects
[SDE]Environmental Sciences, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Published
2022

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