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120 results on '"Tamouza Ryad"'

1. Cannabis and schizophrenia: characterisation of a risk factor in a sample of Moroccan patients hospitalised for psychosis

Author

El Hassan Ouanouche, Hicham Elmostafi, Naoufal Amarat, Ouahid Wafaa, Tamouza Ryad, Aboubaker El Hessni, and Abdelhalem Mesfioui

Subjects
Addiction, Cannabis users, Schizophrenia, Disorder and predictivity, Psychiatry, RC435-571
Abstract

Abstract Background In addition to the biological plausibility widely described through a very large number of studies, the causal link between cannabis uses and schizophrenia disorders has become illicit internationally and given the scarcity of similar studies in Morocco. Our study consists of a prospective descriptive study in the psychiatric department of the Moulay ben Abdallah Hospital in Essaouira. The sample consisted of 95 patients diagnosed with schizophrenia according to the DSM5 criteria. The diagnostic assessment included the Positive and Negative Syndrome Scale to assess the severity of positive and negative symptoms of schizophrenia as well as the patient’s general psychopathology, the Clinician-Rated Dimensions of Psychosis Symptom Severity to assess the symptom severity of the psychotic dimensions according, and the Cannabis Abuse Screening Test to assess the extent of cannabis use. Results The mean age of the patients recruited in the study was 33.7 ± 9.37 years with a clear male predominance (p

Published
2022
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2. Suicidal attempt among patients with schizophrenia: A cross-sectional study from Morocco

Author

Yassmine Kassal, Khadija Fritah, Naila Nakidi, Naima Arji, Siham Belbachir, Laboudi Fouad, Mesfioui Abdelhalem, Ouanass Abderrazzak, Tamouza Ryad, and El Hessni Aboubaker

Subjects
suicide attempt, schizophrenia, sociodemographic factors, hallucination, moroccan patients, Environmental sciences, GE1-350
Abstract

Suicide constitutes the greatest risk factor for mortality in individuals with schizophrenia. Although numerous risk factors have been suggested as important predictors of suicidality in schizophrenia, most studies have focused on Caucasian and Chinese patients. This study aimed to examine the prevalence of suicide attempts in schizophrenia patients in Rabat-Sale-Kenitra, Morocco, and to identify associated clinical and sociodemographic characteristics. A cross-sectional study was conducted at the Ar-RAZI Psychiatric Center of Ibn Sina Hospital in Rabat. We examined 175 Moroccan schizophrenic patients. The sociodemographic and clinical variables were analyzed based on the presence or absence of suicide attempts. The prevalence of suicide attempts among patients was 32%. 43% of them had reported multiple suicide attempts. The majority of those who attempted suicide were single, younger, and with a lower economic status. Visual hallucinations were significantly prevalent among attempter patients compared to non-attempters (p =0.032). Consequently, visual hallucinations could be a risk factor for suicide attempts in the Moroccan population. Understanding sociodemographic and clinical characteristics associated with suicide attempts can help identify patients at higher risk and provide appropriate support and interventions to prevent suicide among the Moroccan population.

Published
2023
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5. Diet quality and associations with lactate and metabolic syndrome in bipolar disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J., Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A., Fredembach, B., Suisse, A., Denoual, Q., Polosan, M., Galliot, A.M., Brehon, L., Bonny, G., Durand, L., Feuga, V., Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Samalin, L., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Godin, Ophelia, Choi, Jaehyoung, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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6. B Cell-activating factor (BAFF): A promising trans-nosographic biomarker of inflammation and autoimmunity in bipolar disorder and schizophrenia

Author

Boukouaci, Wahid, Lajnef, Mohamed, Wu, Ching-Lien, Bouassida, Jihène, Saitoh, Kaori, Sugunasabesan, Sobika, Richard, Jean-Romain, Apavou, Maud, Lamy, Anais, Henensal, Adèle, Nkam, Irène, Hasty, Lauren, Sayous, Romain, Bengoufa, Djaouida, Barau, Caroline, Le Corvoisier, Philippe, Honnorat, Jérome, Maskos, Uwe, Yolken, Robert, Leboyer, Marion, and Tamouza, Ryad

Published
2024
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7. Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, PM, Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J, Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A, Fredembach, B., Suisse, A., Denoual, Q, Polosan, M, Galliot, A.M., Brehon, L., Bonny, G, Durand, L, Feuga, V, Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A, Loftus, J., Medecin, I., Samalin, L., Llorca, PM., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Choi, Jaehyoung, Godin, Ophelia, Chernega, Timofei, Kwak, Haejin Angela, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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9. Anti-spike antibody responses to SARS-CoV-2 mRNA vaccines in people with schizophrenia and schizoaffective disorder

Author

Nemani, Katlyn, De Picker, Livia, Dickerson, Faith, Leboyer, Marion, Santacatterina, Michele, Ando, Fumika, Capichioni, Gillian, Smith, Thomas E., Kammer, Jamie, El Abdellati, Kawtar, Morrens, Manuel, Coppens, Violette, Katsafanas, Emily, Origoni, Andrea, Khan, Sabahat, Rowe, Kelly, Ziemann, R.Sarah, Tamouza, Ryad, Yolken, Robert H., and Goff, Donald C.

Published
2024
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10. Patients with psychosis spectrum disorders hospitalized during the COVID-19 pandemic unravel overlooked SARS-CoV-2 past infection clustering with HERV-W ENV expression and chronic inflammation

Author

Tamouza, Ryad, Meyer, Urs, Lucas, Alexandre, Richard, Jean Romain, Nkam, Irène, Pinot, Armand, Djonouma, Ndilyam, Boukouaci, Wahid, Charvet, Benjamin, Pierquin, Justine, Brunel, Joanna, Fourati, Slim, Rodriguez, Christophe, Barau, Caroline, Le Corvoisier, Philippe, El Abdellati, Kawtar, De Picker, Livia, Perron, Hervé, and Leboyer, Marion

Published
2023
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11. A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

Author

Lombardi, Laura, Le Clerc, Sigrid, Wu, Ching-Lien, Bouassida, Jihène, Boukouaci, Wahid, Sugusabesan, Sobika, Richard, Jean-Romain, Lajnef, Mohamed, Tison, Maxime, Le Corvoisier, Philippe, Barau, Caroline, Banaschewski, Tobias, Holt, Rosemary, Durston, Sarah, Persico, Antonio M., Oakley, Bethany, Loth, Eva, Buitelaar, Jan, Murphy, Declan, Leboyer, Marion, Zagury, Jean-François, and Tamouza, Ryad

Published
2023
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15. Association of markers of inflammation and intestinal permeability in suicidal patients with major mood disorders

Author

Brouillet, Julie Z., Boltri, Margherita, Lengvenyte, Aiste, Lajnef, Mohamed, Richard, Jean-Romain, Barrau, Caroline, Strumila, Robertas, Coyac, Manon, Wu, Ching-Lien, Boukouaci, Wahid, Sugunasabesan, Sobika, Bouassida, Jihène, Guillaume, Sébastien, Sénèque, Maude, Olié, Emilie, Leboyer, Marion, Courtet, Philippe, and Tamouza, Ryad

Published
2023
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20. Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?

Author

Endres, Dominique, Pollak, Thomas A., Bechter, Karl, Denzel, Dominik, Pitsch, Karoline, Nickel, Kathrin, Runge, Kimon, Pankratz, Benjamin, Klatzmann, David, Tamouza, Ryad, Mallet, Luc, Leboyer, Marion, Prüss, Harald, Voderholzer, Ulrich, Cunningham, Janet L., Domschke, Katharina, Tebartz van Elst, Ludger, and Schiele, Miriam A.

Published
2022
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22. Serum autoantibodies against α7-nicotinic receptors in subgroups of patients with bipolar disorder or schizophrenia: clinical features and link with peripheral inflammation

Author

Darrau, Estelle, primary, Jacquemet, Elise, additional, Pons, Stéphanie, additional, Schlick, Laurène, additional, Zouridakis, Marios, additional, Wu, Ching-Lien, additional, Richard, Jean-Romain, additional, Barau, Caroline, additional, Le Corvoisier, Philippe, additional, Yolken, Robert, additional, Tamouza, Ryad, additional, Leboyer, Marion, additional, and Maskos, Uwe, additional

Published
2024
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23. Low peripheral mitochondrial DNA copy number during manic episodes of bipolar disorders is associated with disease severity and inflammation

Author

Angrand, Loïc, Boukouaci, Wahid, Lajnef, Mohamed, Richard, Jean-Romain, Andreazza, Ana, Wu, Chieng-Lien, Bouassida, Jihène, Rafik, Ismail, Foiselle, Marianne, Mezouad, Esma, Naamoune, Soumia, Chami, Leila, Mihoub, Ons, Salah, Sofiane, Benchaaben, Arij, Le Corvoisier, Philippe, Barau, Caroline, Costes, Bruno, Yolken, Robert, Crepeaux, Guillemette, Leboyer, Marion, and Tamouza, Ryad

Published
2021
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24. Impact of toll-like receptor 4 variations on nasopharyngeal carcinoma risk and survival in tunisian population

Author

Ben Chaaben, Arij, primary, Ayadi, Imen, additional, Abaza, Hejer, additional, Baroudi, Olfa, additional, Douik, Hayet, additional, Harzallah, Latifa, additional, Bouassida, Jihen, additional, Bouckouaci, Wahid, additional, Guemira, Fethi, additional, Mankai, Amani, additional, Kharrat, Maher, additional, and Tamouza, Ryad, additional

Published
2024
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26. The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control

Author

Rahmouni, Myriam, primary, De Marco, Lorenzo, additional, Spadoni, Jean-Louis, additional, Tison, Maxime, additional, Medina-Santos, Raissa, additional, Labib, Taoufik, additional, Noirel, Josselin, additional, Tamouza, Ryad, additional, Limou, Sophie, additional, Delaneau, Olivier, additional, Fellay, Jacques, additional, Bensussan, Armand, additional, Le Clerc, Sigrid, additional, McLaren, Paul J., additional, and Zagury, Jean-François, additional

Published
2023
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29. HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders

Author

Le Clerc, Sigrid, Lombardi, Laura, Baune, Bernhard T., Amare, Azmeraw T., Schubert, Klaus Oliver, Hou, Liping, Clark, Scott R., Papiol, Sergi, Cearns, Micah, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hsu, Yi-Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Brichant-Petitjean, Clara, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Dayer, Alexandre, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Jamain, Stephane, Falkai, Peter, Forstner, Andreas J., Frisen, Louise, Frye, Mark A., Fullerton, Janice M., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John R., Kittel-Schneider, Sarah, Ferensztajn-Rochowiak, Ewa, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leckband, Susan G., Tortorella, Alfonso, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan L., Colom, Francesc, Millischer, Vincent, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Ösby, Urban, Pfennig, Andrea, Potash, James B., Reif, Andreas, Reininghaus, Eva, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schweizer, Barbara W., Severino, Giovanni, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Pisanu, Claudia, Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Maj, Mario, Turecki, Gustavo, Vieta, Eduard, Veeh, Julia, Witt, Stephanie H., Wright, Adam, Zandi, Peter P., Mitchell, Philip B., Bauer, Michael, Alda, Martin, Rietschel, Marcella, McMahon, Francis J., Schulze, Thomas G., Spadoni, Jean-Louis, Boukouaci, Wahid, Richard, Jean-Romain, Le Corvoisier, Philippe, Barrau, Caroline, Zagury, Jean-François, Leboyer, Marion, and Tamouza, Ryad

Published
2021
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32. HLA peptide‐binding pocket diversity modulates immunological complications after cord blood transplant in acute leukaemia.

Author

Boukouaci, Wahid, Rivera‐Franco, Monica M., Volt, Fernanda, Lajnef, Mohamed, Wu, Ching‐Lien, Rafii, Hanadi, Cappelli, Barbara, Scigliuolo, Graziana Maria, Kenzey, Chantal, Ruggeri, Annalisa, Rocha, Vanderson, Gluckman, Eliane, and Tamouza, Ryad

Subjects
ACUTE leukemia, CORD blood, HISTOCOMPATIBILITY antigens, GRAFT versus host disease, STEM cell transplantation, HLA histocompatibility antigens, HISTOCOMPATIBILITY class I antigens
Abstract

Summary: Pocket motifs and their amino acid positions of HLA molecules are known to govern antigen presentation to effector cells. Our objective was to analyse their influence on the risk of graft‐versus‐host disease (GVHD) and relapse after umbilical cord blood transplant (UCBT). The transplant characteristics of 849 patients with acute leukaemia were obtained from the Eurocord/EBMT database. Higher acute (a) GVHD was associated with homozygosity of UCB HLA‐C amino acid positions 77 and 80 (NN/KK) (p = 0.008). Severe aGVHD was associated with HLA‐A pocket B YSAVMENVHY motif (p = 0.002) and NN and RR genotypes of the HLA‐C amino acid positions 77 and 156 (p = 0.006 and p = 0.002). Such risk was also increased in case of recipient and UCB mismatches in P4 (p < 0.0001) and P9 (p = 0.003) pockets of HLA‐DQB1 alleles. For chronic GVHD, the pocket B YYAVMEISNY motif of the HLA‐B*15:01 allele and the absence of mismatch between recipient and UCB in the P6 pocket of HLA‐DRB1 were associated with a lower risk (p = 0.0007 and p = 0.0004). In relapse, both UCB pocket B YFAVMENVHY belonging to HLA‐A*32:01 and recipient pocket B YDSVGENYQY motif of the HLA‐C*07:01 allele were associated with higher risk (p = 0.0026 and p = 0.015). We provide clues on HLA‐mediated cellular interactions and their role in the development of GVHD and relapse. [ABSTRACT FROM AUTHOR]

Published
2024
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35. A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

Author

Onderwijscentrum, Brain, Ontwikkelingsstoornissen Ond., Lombardi, Laura, Le Clerc, Sigrid, Wu, Ching-Lien, Bouassida, Jihène, Boukouaci, Wahid, Sugusabesan, Sobika, Richard, Jean-Romain, Lajnef, Mohamed, Tison, Maxime, Le Corvoisier, Philippe, Barau, Caroline, Banaschewski, Tobias, Holt, Rosemary, Durston, Sarah, Persico, Antonio M, Oakley, Bethany, Loth, Eva, Buitelaar, Jan, Murphy, Declan, Leboyer, Marion, Zagury, Jean-François, Tamouza, Ryad, Onderwijscentrum, Brain, Ontwikkelingsstoornissen Ond., Lombardi, Laura, Le Clerc, Sigrid, Wu, Ching-Lien, Bouassida, Jihène, Boukouaci, Wahid, Sugusabesan, Sobika, Richard, Jean-Romain, Lajnef, Mohamed, Tison, Maxime, Le Corvoisier, Philippe, Barau, Caroline, Banaschewski, Tobias, Holt, Rosemary, Durston, Sarah, Persico, Antonio M, Oakley, Bethany, Loth, Eva, Buitelaar, Jan, Murphy, Declan, Leboyer, Marion, Zagury, Jean-François, and Tamouza, Ryad

Published
2023

36. Patients with psychosis spectrum disorders hospitalized during the COVID-19 pandemic unravel overlooked SARS-CoV-2 past infection clustering with HERV-W ENV expression and chronic inflammation

Author

Tamouza, Ryad; https://orcid.org/0000-0003-3992-9565, Meyer, Urs; https://orcid.org/0000-0001-7244-0345, Lucas, Alexandre, Richard, Jean Romain, Nkam, Irène; https://orcid.org/0000-0001-7515-3704, Pinot, Armand, Djonouma, Ndilyam, Boukouaci, Wahid, Charvet, Benjamin, Pierquin, Justine, Brunel, Joanna, Fourati, Slim, Rodriguez, Christophe, Barau, Caroline, Le Corvoisier, Philippe, El Abdellati, Kawtar, De Picker, Livia, Perron, Hervé, Leboyer, Marion; https://orcid.org/0000-0001-5473-3697, Tamouza, Ryad; https://orcid.org/0000-0003-3992-9565, Meyer, Urs; https://orcid.org/0000-0001-7244-0345, Lucas, Alexandre, Richard, Jean Romain, Nkam, Irène; https://orcid.org/0000-0001-7515-3704, Pinot, Armand, Djonouma, Ndilyam, Boukouaci, Wahid, Charvet, Benjamin, Pierquin, Justine, Brunel, Joanna, Fourati, Slim, Rodriguez, Christophe, Barau, Caroline, Le Corvoisier, Philippe, El Abdellati, Kawtar, De Picker, Livia, Perron, Hervé, and Leboyer, Marion; https://orcid.org/0000-0001-5473-3697

Abstract

Epidemiology has repeatedly associated certain infections with a risk of further developing psychiatric diseases. Such infections can activate retro-transposable genetic elements (HERV) known to trigger immune receptors and impair synaptic plasticity of neuroreceptors. Since the HERV-W ENV protein was recently shown to co-cluster with pro-inflammatory cytokines in a subgroup of patients with schizophrenia or bipolar disorder, we questioned the influence of the COVID-19 pandemic on patients with psychosis spectrum disorders (PSD). Present results revealed that (i) SARS-CoV-2 serology shows high prevalence and titers of antibodies in PSD, (ii) HERV-W ENV is detected in seropositive individuals only and (iii) SARS-CoV-2 and HERV-W ENV positivity co-clustered with high serum levels of pro-inflammatory cytokines in psychotic patients. These results thus suggest that SARS-CoV-2 infection in many patients with psychotic disorders now admitted in the psychiatry department did not cause severe COVID-19. They also confirm the previously reported association of elevated serum pro-inflammatory cytokines and HERV-W ENV in a subgroup of psychotic patients. In the context of the COVID-19 pandemic, this cluster is only found in SARS-CoV-2 seropositive PSD cases, suggesting a dominant influence of this virus on HERV-W ENV and cytokine expression, and/or patients’ greater susceptibility to SARS-CoV-2 infection. Further investigation on an interplay between this viral infection and the clinical evolution of such PSD patients is needed. However, this repeatedly defined subgroup of psychotic patients with a pro-inflammatory phenotype and HERV expression calls for a differential therapeutic approach in psychoses, therefore for further precision medicine development.

Published
2023

37. Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder

Author

Skorobogatov, Katrien, primary, Autier, Valérie, additional, Foiselle, Marianne, additional, Richard, Jean-Romain, additional, Boukouaci, Wahid, additional, Wu, Ching-Lien, additional, Raynal, Sophie, additional, Carbonne, Christel, additional, Laukens, Kris, additional, Meysman, Pieter, additional, Coppens, Violette, additional, le Corvoisier, Philippe, additional, Barau, Caroline, additional, De Picker, Livia, additional, Morrens, Manuel, additional, Tamouza, Ryad, additional, and Leboyer, Marion, additional

Published
2023
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38. Comparative analysis of the variability of the human leukocyte antigen peptide‐binding pockets in patients with acute leukaemia

Author

Boukouaci, Wahid, primary, Rivera‐Franco, Monica M., additional, Volt, Fernanda, additional, Wu, Ching‐Lien, additional, Rafii, Hanadi, additional, Cappelli, Barbara, additional, Scigliuolo, Graziana Maria, additional, Kenzey, Chantal, additional, Ruggeri, Annalisa, additional, Rocha, Vanderson, additional, Gluckman, Eliane, additional, and Tamouza, Ryad, additional

Published
2022
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39. Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Author

Tamouza, Ryad, primary, Volt, Fernanda, additional, Richard, Jean-Romain, additional, Wu, Ching-Lien, additional, Bouassida, Jihène, additional, Boukouaci, Wahid, additional, Lansiaux, Pauline, additional, Cappelli, Barbara, additional, Scigliuolo, Graziana Maria, additional, Rafii, Hanadi, additional, Kenzey, Chantal, additional, Mezouad, Esma, additional, Naamoune, Soumia, additional, Chami, Leila, additional, Lejuste, Florian, additional, Farge, Dominique, additional, and Gluckman, Eliane, additional

Published
2022
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40. Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort

Author

Foiselle, Marianne, primary, Barbosa, Susana, additional, Godin, Ophélia, additional, Wu, Ching-Lien, additional, Boukouaci, Wahid, additional, Andre, Myrtille, additional, Aouizerate, Bruno, additional, Berna, Fabrice, additional, Barau, Caroline, additional, Capdevielle, Delphine, additional, Vidailhet, Pierre, additional, Chereau, Isabelle, additional, Davidovic, Laetitia, additional, Dorey, Jean-Michel, additional, Dubertret, Caroline, additional, Dubreucq, Julien, additional, Faget, Catherine, additional, Fond, Guillaume, additional, Leigner, Sylvain, additional, Llorca, Pierre-Michel, additional, Mallet, Jasmina, additional, Misdrahi, David, additional, Martinuzzi, Emanuela, additional, Passerieux, Christine, additional, Rey, Romain, additional, Pignon, Baptiste, additional, Urbach, Mathieu, additional, Schürhoff, Franck, additional, Glaichenhaus, Nicolas, additional, Leboyer, Marion, additional, Tamouza, Ryad, additional, Berna, F., additional, Haffen, E., additional, Leboyer, M., additional, Llorca, P.M., additional, Schürhoff, F., additional, Barteau, V., additional, Bensalem, S., additional, Godin, O., additional, Laouamri, H., additional, Souryis, K., additional, Offerlin-Meyer, I., additional, Pignon, B., additional, Szöke, A., additional, Aouizerate, B., additional, Deloge, A., additional, Misdrahi, D., additional, Vilà, E., additional, Blanc, O., additional, Chéreau, I., additional, Denizot, H., additional, Honciuc, R.M., additional, Lacelle, D., additional, Pires, S., additional, Dubertret, C., additional, Mallet, J., additional, Portalier, C., additional, Dubreucq, J., additional, Fluttaz, C., additional, Gabayet, F., additional, Roman, C., additional, Chesnoy-Servanin, G., additional, D'Amato, T., additional, Dorey, J.M., additional, Rey, R., additional, Vehier, A., additional, Lançon, C., additional, Faget, C., additional, Metairie, E., additional, Peri, P., additional, Vaillant, F., additional, Boyer, L., additional, Fond, G., additional, Vidailhet, P., additional, Zinetti-Bertschy, A., additional, Capdevielle, D., additional, Yazbek, H., additional, Esselin, S., additional, Jarroir, M., additional, Passerieux, C., additional, and Urbach, M., additional

Published
2022
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42. TLR2 genetic diversity and the risk of Schizophrenia

Author

Ayari, fayza, primary, Chaaben, Arij Ben, additional, Abbaza, Hajer, additional, Mihoub, Ons, additional, Ouni, Nesrine, additional, Mankai, Amani, additional, Boukouaci, Wahid, additional, kharat, Maher, additional, Leboyer, Marion, additional, and Tamouza, Ryad, additional

Published
2022
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44. Comparative analysis of the variability of the human leukocyte antigen peptide‐binding pockets in patients with acute leukaemia.

Author

Boukouaci, Wahid, Rivera‐Franco, Monica M., Volt, Fernanda, Wu, Ching‐Lien, Rafii, Hanadi, Cappelli, Barbara, Scigliuolo, Graziana Maria, Kenzey, Chantal, Ruggeri, Annalisa, Rocha, Vanderson, Gluckman, Eliane, and Tamouza, Ryad

Subjects
HLA histocompatibility antigens, ACUTE leukemia, HISTOCOMPATIBILITY antigens, ACUTE myeloid leukemia, LYMPHOBLASTIC leukemia, AMINO acids
Abstract

Summary: The association between acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) and the human leukocyte antigens (HLA) has rarely been studied in terms of diversity of peptide‐binding pockets. The objective of this study was to analyse whether motifs of HLA class I and class II peptide‐binding pockets and/or their amino acid positions were differentially associated with ALL and AML. We included 849 patients from the Eurocord/European Blood and Marrow Transplant registry. The HLA peptide‐binding pockets whose amino acid variability was analysed were B and F for HLA class I, P4, P6, and P9 for HLA‐DRB1, and P4 and P9 for HLA‐DQB1. The motif RFDRAY in P4 of HLA‐DRB1*16:01/02/03/05 alleles and the motif YYVSY in P9 of HLA‐DQB1*05:02/04/05 alleles, were statistically associated with ALL (corrected p value [pc] = 0.001 and pc = 0.035 respectively). The frequency of serine 57 in the P9 of HLA‐DQB1 was higher in ALL (odds ratio 2.09, 95% confidence interval: 1.27–3.44; pc = 0.037). Our analysis suggests that specific motifs in terms of HLA class II pockets and amino acids might be unique to ALL. The associations identified in this study encourage further investigation oF the role of HLA peptide‐binding pockets and their amino acids in immune processes underpinning acute leukaemia and ultimately in immunotherapy settings. [ABSTRACT FROM AUTHOR]

Published
2023
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46. A replication study of sHLA-E influence on schizophrenia and bipolar disorder

Author

Mihoub, Ons, Chaaben, Arij Ben, Boukouaci, Wahid, Lajnef, Mohamed, Wu, Ching-Lien, Bouassida, Jihène, Saitoh, Kaori, Sugunasabesan, Sobika, Naamoune, Soumia, Richard, Jean-Romain, Kefi, Hamdi El, Ammar, Hanen Ben, Hechmi, Zouhair El, Guemira, Fathi, Kharrat, Maher, Leboyer, Marion, and Tamouza, Ryad

Abstract

Objectives: Schizophrenia (SZ) and bipolar disorders (BP) are chronic and severe neuropsychiatric diseases. These disorders are tightly related to immune deregulations. In the current study, we intended to replicate the previously reported involvement of the soluble HLA-E isoforms (sHLA-E) in the risk of developing the two conditions along with disease severity in a Tunisian population-group.

Published
2024
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47. Association between genetic variants of TLR2, TLR4, TLR9and schizophrenia

Author

Ayari, Fayza, Chaaben, Arij Ben, Abaza, Hajer, Mihoub, Ons, Ouni, Nesrine, Boukouaci, Wahid, Kharrat, Maher, Leboyer, Marion, Guemira, Fethi, Tamouza, Ryad, and Mankai, Amani

Abstract

Schizophrenia (SZ) is a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction plays a key etiopathogenic role. In order to explore the control of innate immune responses in SZ, we aimed to investigate the potential association between twelve TLR2, TLR4and TLR9variants (TLR2: rs4696480T>A, rs3804099T>C, rs3804100T>C; TLR4: rs1927914G>A, rs10759932T>C, rs4986790A>G, rs4986791T>C, rs11536889G>C, rs11536891T>C; TLR9: rs187084A>G, rs352139T>C and rs352140C>T) and SZ susceptibility in a Tunisian population.

Published
2023
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48. Diet quality and associations with lactate and metabolic syndrome in bipolar disorder.

Author

Zachos KA, Godin O, Choi J, Jung JH, Aouizerate B, Aubin V, Bellivier F, Belzeaux-R R, Courtet P, Dubertret C, Etain B, Haffen E, Lefrere A A, Llorca PM, Olié E, Polosan M, Samalin L, Schwan R, Roux P, Barau C, Richard JR, Tamouza R, Leboyer M, and Andreazza AC

Subjects
Humans, Female, Male, Adult, Retrospective Studies, Middle Aged, Diet, Schizophrenia epidemiology, Seafood, France epidemiology, Dietary Fiber, Body Mass Index, Meat, Affect, Bipolar Disorder epidemiology, Metabolic Syndrome epidemiology, Lactic Acid blood
Abstract

Background: Nutrition is largely affected in bipolar disorder (BD), however, there is a lack of understanding on the relationship between dietary categories, BD, and the prevalence of metabolic syndrome. The objective of this study is to examine dietary trends in BD and it is hypothesized that diets with increased consumption of seafood and high-fiber carbohydrates will be correlated to improved patient outcomes, and a lower frequency of metabolic syndrome., Methods: This retrospective cohort study includes two French cohorts. The primary cohort, FACE-BD, includes 268 stable BD patients. The second cohort, I-GIVE, includes healthy controls, both stable and acute BD and schizophrenia patients. Four dietary categories were assessed: meat, seafood, low-fiber and high-fiber carbohydrates. Dietary data from two food frequency questionnaires were normalized using min-max scaling and assessed using various statistical analyses., Results: In our primary cohort, the increased high-fiber carbohydrate consumption was correlated to lower prevalence of metabolic syndrome and improved mood. Low-fiber carbohydrate consumption is associated with higher BMI, while higher seafood consumption was correlated to improved mood and delayed age of onset. Results were not replicated in our secondary cohort., Limitations: Our populations were small and two different dietary questionnaires were used; thus, results were used to examine similarities in trends., Conclusions: Overall, various dietary trends were associated with metabolic syndrome, BMI, lactate, mood and age of onset. Improving our understanding of nutrition in BD can provide mechanistic insight, clinically relevant nutritional guidelines for precision medicine and ultimately improve the quality of lives for those with BD., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2024
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49. Mitochondria at the crossroad of dysregulated inflammatory and metabolic processes in bipolar disorders.

Author

Bernard J, Tamouza R, Godin O, Berk M, Andreazza AC, and Leboyer M

Abstract

In last few decades, considerable evidence has emphasized the significant involvement of mitochondria, often referred to as the "powerhouse of the cell," in the pathophysiology of bipolar disorder (BD). Given crucial mitochondrial functions in cellular metabolism and inflammation, both of which are compromised in BD, this perspective review examines the central role of mitochondria in inflammation and metabolism within the context of this disorder. We first describe the significance of mitochondria in metabolism before presenting the dysregulated inflammatory and metabolic processes. Then, we present a synthetic and hypothetical model of the importance of mitochondria in those dysfunctional pathways. The article also reviews different techniques for assessing mitochondrial function and discuss diagnostic and therapeutic implications. This review aims to improve the understanding of the inflammatory and metabolic comorbidities associated with bipolar disorders along with mitochondrial alterations within this context., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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50. Low-dose interleukin-2 in patients with bipolar depression: A phase 2 randomised double-blind placebo-controlled trial.

Author

Leboyer M, Foiselle M, Tchitchek N, Tamouza R, Lorenzon R, Richard JR, Arrouasse R, Le Corvoisier P, Le Dudal K, Vicaut E, Ellul P, Rosenzwajg M, and Klatzmann D

Abstract

Immune abnormalities including an insufficiency of regulatory T cells (Treg) and increased blood-based inflammatory markers have been observed in bipolar disorders (BD), particularly during depression. As Tregs are pivotal to control inflammation, Treg stimulation by low-dose IL-2 (IL-2 LD ) could have a therapeutic impact on bipolar depression. We performed a randomized, double-blind, placebo-controlled (2 active: 1 placebo) proof-of-concept trial of add-on IL-2 LD in patients with bipolar depression. Patients received a placebo or IL-2 LD (1MIU) once a day for 5 days, and then once a week for 4 weeks starting on week 2. The primary objective was to demonstrate a biological Treg response to IL-2 LD assessed by fold increase in Treg percentage of CD4 + cells from baseline to day 5. Secondary objectives included safety assessment and mood improvement throughout the study period. This trial is registered with ClinicalTrials.gov, number NCT04133233. Fourteen patients with bipolar depression were included, with 4 receiving placebo and 10 IL-2 LD . Baseline clinical and biological characteristics were balanced between groups. The primary evaluation criterion was met, with IL-2 LD expanding 1.17 [95 % CI 1.01-1.34] vs 1.01 [95 % CI 0.90-1.12] (p = 0.0421) and activating Tregs. Secondary evaluation criteria were also met with significant improvements of depressive symptoms and global functioning from day-15 onwards in the IL-2 LD treated patients. The treatment was well-tolerated, with no serious adverse events related to treatment. This proof-of-concept trial shows that stimulating Tregs in patients with bipolar depression is safe and associated with clinical improvements. This supports a pathophysiological role of inflammation in BD and warrants pursuing the evaluation of IL-2 LD as an adjunct treatment of major mood disorders., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: MR, RL and DK are inventors for patent applications related to the therapeutic use of IL-2(LD), which belongs to their academic institutions and has been licensed to ILTOO Pharma. MR and DK hold shares in ILTOO Pharma. No other potential conflicts of interest relevant to this article were reported., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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