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Ethiopia's Tigray in 2020. This war has had a detrimental impact on the mental health and overall wellbeing of Tigrayans living in other countries and abroad. The present study investigated the state of mental health and wellbeing among Tigrayan diaspora living in Australia, many of whom are migrants, but most are refugees., Methods: We employed a cross-sectional survey gathered through Qualtrics-designed hybrid data collection techniques. We assessed vicarious trauma using the secondary traumatic stress scale (STSS), depression, anxiety, and stress using the Depression Anxiety and Stress Scale-21 (DASS-21), PTSD using PTSD Checklist- Civilian Version (PCLC), and resilience using the Connor-Davidson Resilience Scale (CD-RISC-10). We calculated the psychometric properties of these tools among the population. We employed binary logistic regression analysis to identify factors associated with the outcomes of interest., Findings: 241 people participated in the survey. Intrusion symptoms of vicarious trauma were prevalent among 85.6 % (172/201) of participants, avoidance symptoms of vicarious trauma among 87.6 % (176/201) of participants, and arousal vicarious trauma among 83.6 % (168/201) of participants. Extremely severe depression was prevalent among 38.2 % (81/212) of participants, extremely severe anxiety among 47.6 % (101/212) of participants, and extremely severe stress among (26.9 % (57/212) of participants. PTSD symptoms were prevalent among 75 % (151/204) of participants. Resilience was reduced among 67.5 % (135/200) of participants., Interpretation: The study implies that conflict occurring in one's home country can have a profound impact on the mental wellbeing of individuals residing abroad., Competing Interests: Declaration of competing interest The authors have no competing interest to declare., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Aim: To determine the efficacy and safety of pharmacogenomics (PGx)-guided antidepressant prescribing in patients with depression through an umbrella review and updated meta-analysis., Methods: A comprehensive systematic search was conducted on PsycINFO, PubMed, Embase and the Cochrane databases. The pooled effect sizes of randomized controlled trials (RCTs) were expressed as mean differences for continuous data and risk ratios for noncontinuous data., Results: Patients who received PGx-guided medications were 41% to 78% more likely to achieve remission and 20% to 49% more likely to respond to antidepressants than patients receiving treatment-as-usual (TAU)., Conclusion: PGx-guided antidepressant prescribing improves the treatment of depression. However, the significance and magnitude of the benefit varies widely between studies and different PGx testing panels., Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42022321324., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Tesfamicael, Zhao, Fernández-Rodríguez, Adelson, Musker, Polasek and Lewis.)