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1,053 results on '"Thabane, Lehana"'

1. How to make cardiology clinical trials more inclusive

Author

Zannad, Faiez, Berwanger, Otavio, Corda, Stefano, Cowie, Martin R., Gamra, Habib, Gibson, C. Michael, Goncalves, Alexandra, Hucko, Thomas, Khunti, Kamlesh, Kostrubiec, Maciej, Kraus, Bettina Johanna, Linde, Cecilia, Lüscher, Thomas F., Mafham, Marion, Mindham, Richard, Ortega, Rebecca F., Prescott, Eva, Thabane, Lehana, Yancy, Clyde, Ziegler, André, and Van Spall, Harriette G. C.

Published
2024
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9. Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis

Author

Dennis, Brittany, Deane, Adam, Lauzier, François, Zytaruk, Nicole, Hardie, Miranda, Hammond, Naomi, Finfer, Simon, Arabi, Yaseen, Marshall, John, Saunders, Lois, Heels-Ansdell, Diane, Myburgh, John, Knowles, Serena, Muscedere, John, Ostermann, Marlies, Rajbhandari, Dorrilyn, English, Shane, Matic, Karlo, Venkatesh, Bala, Al Fares, Abdulrahman, Guyatt, Gordon, Alhazzani, Waleed, Mumtaz, Hassan, Poole, Alexis, Xie, Feng, Thabane, Lehana, Hall, Richard, and Cook, Deborah

Published
2024
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12. Barriers and enablers for implementation of digital-linked diagnostics models at point-of-care in South Africa: stakeholder engagement

Author

Moetlhoa, Boitumelo, Nxele, Siphesihle R., Maluleke, Kuhlula, Mathebula, Evans, Marange, Musa, Chilufya, Maureen, Dzinamarira, Tafadzwa, Duah, Evans, Dzobo, Matthias, Kekana, Mable, Jaya, Ziningi, Thabane, Lehana, Dlangalala, Thobeka, Nyasulu, Peter S., Hlongwana, Khumbulani, Dlungwane, Thembelihle, Kgatle, Mankgopo, Gxekea, Nobuhle, and Mashamba-Thompson, Tivani

Published
2024
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13. Opioid reduction and enhanced recovery in orthopaedic surgery (OREOS): a protocol for a feasibility randomised controlled trial in patients undergoing total knee arthroplasty

Author

Madden, Kim, Pallapothu, Sushmitha, Young Shing, Darren, Adili, Anthony, Bhandari, Mohit, Carlesso, Lisa, Khan, Moin, Kleinlugtenbelt, Ydo V., Krsmanovic, Adrijana, Nowakowski, Matilda, Packham, Tara, Romeril, Eric, Tarride, Jean-Eric, Thabane, Lehana, Tushinski, Daniel M., Wallace, Christine, Winemaker, Mitchell, and Shanthanna, Harsha

Published
2024
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17. Development and Evaluation of a Research Methods Course in Protocol Writing for Learners in a Master of Public Health Program

Author

Anderson, Laura, Neil-Sztramko, Sarah E., Alvarez, Elizabeth, Jack, Susan M., Thabane, Lehana, Scott, Fran, and Apatu, Emma

Abstract

Training in research methods is important for improvement of healthcare delivery and population outcomes. Graduate programs of public health play a critical role in offering such education to current and future healthcare professionals as well as entry level learners with no experience in the field. A key skill across all fields of research methods and public health practice is protocol writing. It is unknown if teaching students research methods through protocol writing is a successful strategy and whether students find it to be helpful as they pursue health professions. The objective of this study was to describe the design and evaluation of a research methods course focused on protocol writing among students enrolled a Masters of Public Health Program. A case report design including description of course content, method of evaluation, and course delivery are provided. The setting was the Population and Public Health Research Methods course at a publicly funded institution in Canada. The first three cohorts of students (2016-2018) enrolled in the course were evaluated during the course period and six months after completing the course. A total of 51 students completed the survey, and the majority were students were very or extremely satisfied with the course. Overall students expressed that the course well-prepared them for their practicum or thesis work and post-graduation plans. Findings suggest that using protocol writing as a tool for teaching research methods was well-received by students and prepared them for both their potential career paths and for future research.

Published
2022

18. The Impact of Point-of-Care Ultrasound-Guided Resuscitation on Clinical Outcomes in Patients With Shock: A Systematic Review and Meta-Analysis*

Author

Basmaji, John, Arntfield, Robert, Desai, Karishma, Lau, Vincent I., Lewis, Kim, Rochwerg, Bram, Fiorini, Kyle, Honarmand, Kimia, Slessarev, Marat, Leligdowicz, Aleks, Park, Brian, Prager, Ross, Wong, Michelle Y.S., Jones, Philip M., Ball, Ian M., Orozco, Nicolas, Meade, Maureen, Thabane, Lehana, and Guyatt, Gordon

Published
2024
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19. High continuous positive airway pressures versus non-invasive positive pressure ventilation in preterm neonates: protocol for a multicentre pilot randomised controlled trial.

Author

Mukerji, Amit, Rempel, Emily, Thabane, Lehana, Johnson, Heather, Schmolzer, Georg, Law, Brenda Hiu Yan, Jani, Pranav, Tracy, Mark, Rottkamp, Catherine, Keszler, Martin, Kirpalani, Haresh, Shah, Prakesh S, and NOVEL Trial Group

Subjects
NOVEL Trial Group, Humans, Respiratory Distress Syndrome, Newborn, Continuous Positive Airway Pressure, Intermittent Positive-Pressure Ventilation, Pilot Projects, Child, Infant, Infant, Newborn, Infant, Premature, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Noninvasive Ventilation, EPIDEMIOLOGY, NEONATOLOGY, RESPIRATORY MEDICINE, Infant Mortality, Clinical Research, Clinical Trials and Supportive Activities, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Reproductive health and childbirth, Respiratory, Good Health and Well Being, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionLow pressure nasal continuous positive airway pressure (nCPAP) has long been the mainstay of non-invasive respiratory support for preterm neonates, at a constant distending pressure of 5-8 cmH2O. When traditional nCPAP pressures are insufficient, other modes including nasal intermittent positive pressure ventilation (NIPPV) are used. In recent years, high nCPAP pressures (≥9 cmH2O) have also emerged as an alternative. However, the comparative benefits and risks of these modalities remain unknown.Methods and analysisIn this multicentre pilot randomised controlled trial, infants

Published
2023

20. Osteochondroplasty with or without labral repair is more cost-effective than arthroscopic lavage with or without labral repair for treatment of young adults with femoroacetabular impingement: A cost-utility analysis based on data from a randomized controlled trial

Author

Ayeni, Olufemi R., Bhandari, Mohit, Bedi, Asheesh, Järvinen, Teppo, Musahl, Volker, Naudie, Douglas, Seppänen, Matti, Slobogean, Gerard, Thabane, Lehana, Simunovic, Nicole, Duong, Andrew, Skelly, Matthew, Shanmugaraj, Ajay, Crouch, Sarah, Sprague, Sheila, Heels-Ansdell, Diane, Buckingham, Lisa, Ramsay, Tim, Lee, John, Kousa, Petteri, Carsen, Sasha, Choudur, Hema, Sim, Yan, Johnston, Kelly, Wong, Ivan, Murphy, Ryland, Sparavalo, Sara, Whelan, Daniel, Khan, Ryan, Wood, Gavin CA., Howells, Fiona, Grant, Heather, Zomar, Bryn, Pollock, Michael, Willits, Kevin, Firth, Andrew, Wanlin, Stacey, Remtulla, Alliya, Kaniki, Nicole, Belzile, Etienne L., Turmel, Sylvie, Jørgensen, Uffe, Gam-Pedersen, Annie, Sihvonen, Raine, Raivio, Marko, Toivonen, Pirjo, Routapohja, Mari Pirjetta, Yan, Jiajun, Humphries, Brittany, Bo, Zhenyan, Dai, Ling, and Xie, Feng

Published
2024
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21. Health service utilization, substance use treatment response, and death in patients with opioid use disorder and comorbid hepatitis C findings from prospective cohort study with administrative database linkage

Author

Dennis, Brittany B., Babe, Glenda, Gayowsky, Anastasia, Rosic, Tea, Rodrigues, Myanca, Bach, Paxton, Perez, Richard, de Oliveira, Claire, Samet, Jeffrey, Weaver, Victoria, Young, Samantha, Dionne, Joanna, Ahmed, Aijaz, Kim, Donghee, Thabane, Lehana, and Samaan, Zainab

Published
2024
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27. Effect of spirulina on risk of hospitalization among patients with COVID-19: the TOGETHER randomized trial

Author

Reis, Gilmar, Augusto dos Santos Moreira Silva, Eduardo, Carla Medeiros Silva, Daniela, Thabane, Lehana, Santiago Ferreira, Thiago, Vitor Quirino dos Santos, Castilho, Paula Figueiredo Guimaraes Almeida, Ana, Cançado Monteiro Savassi, Leonardo, Dias de Figueiredo Neto, Adhemar, Lanna França Reis, Luiza, Helena de Souza Campos, Vitoria, Bitarães, Carina, Diniz Callegari, Eduardo, Izabel Campos Simplicio, Maria, Barra Ribeiro, Luciene, Oliveira, Rosemary, Harari, Ofir, Forrest, Jamie I, Lat, Prince Kumar, Dron, Louis, Thorlund, Kristian, and Mills, Edward J

Published
2024
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28. Time from injury to hip-fracture surgery in low-income and middle-income regions: a secondary analysis of data from the International Orthopaedic Multicentre Study in Fracture Care (INORMUS)

Author

Guyatt, Gordon, Petrisor, Brad, Thabane, Lehana, Boniface, Respicious, Browner, Bruce, Pollak, Andrew, Slobogean, Gerard, Schemitsch, Emil, McKay, Paula, Tai, Kerry, Heels-Ansdell, Diane, Buckingham, Lisa, Norton, Robyn, Zhang, Jing, Parveen, Samina, Bhaumik, Soumyadeep, Morshed, Saam, Mackechnie, Madeline C., Zhang, Zhentao, Ma, Yinghua, Qin, Yanguo, Hu, Sanbao, Qi, Baochang, Dai, Wenjie, Cai, Xinyu, Rui, Gang, Chen, Hua, Shetty, Vijay, Dumbre Patil, Sampat, Patil, Sanjay, Shrivastava, Sandeep, Mittal, Ravi, Jepegnanam, Thilak Samuel, Mahajan, Anupam, Chhabra, Harvinder Singh, N, Rajagopalan, Amaravathi, Rajkumar S., Dhillon, Mandeep S., Chase, Asolie, Bhavsar, Neel M., Saadat, Soheil, Byanjankar, Subin, Qadir, Raja Irfan, Tabu, Irewin Alagar, Ponggsamakthai, Wanjak, Sa-ngasoongsong, Paphon, Subramanian, Panchu, Ndeleva, Benjamin Muluku, Lutomia, Mark, Otseyeno, Fred Mathew Toboso, Mwangi, Geoffrey Chege, Ndasi, Henry Tanyi, Konadu-Yeboah, Dominic, Firth, Gregory, Marealle, Paul, Temu, Rogers, Mutanda, Tony, Rio, Marcelo, Quintero, Jose Eduardo, Zuluaga, Mauricio, Minueza, Tomás, Madrigal, Ricardo, Ylizaliturri, Manuel, Garuz, Mario, Segovia Altieri, Julio, Escalante Elguezabal, Igor A., Armstrong, Elizabeth, Rogers, Kris, Li, Chuan Silvia, Jagnoor, Jagnoor, Moroz, Paul, Oguzie, Gerald Chukwuemeka, Hailu, Samuel, Miclau, Theodore, III, de la Huerta, Fernando, Martinez-Ruiz, Jose de Jesus, Bidolegui, Fernando, Zhou, Junlin, Ma, Xinlong, Wu, Bo, Sancheti, Parag, Quang, La Ngoc, Baigi, Vali, Haddadi, Mashyaneh, Tian, Maoyi, Sprague, Sheila, Devereaux, P J, Bhandari, Mohit, and Ivers, Rebecca

Published
2024
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32. Findings from a pragmatic cluster randomised controlled feasibility trial of a music and dance programme for community dwelling older adults

Author

Clifford, Amanda M., Cheung, Pui-Sze, Malley, Nicola O’, Byrne, Steven, Whiston, Aoife, Kennelly, Brendan, Mphepo, Tumeliwa, Eshghimanesh, Zohreh, Thabane, Lehana, Louw, Quinette, Moss, Hilary, Gowran, Rosemary Joan, Neill, Desmond O’, Glynn, Liam, Woods, Catherine B., Maher, Catherine, Sheikhi, Ali, Salsberg, Jon, and Bhriain, Orfhlaith Ni

Published
2024
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33. What makes a good survey?

Author

Chang, Yaping, Wang, Li, Phillips, Mark R., Wykoff, Charles C., Garg, Sunir J., Thabane, Lehana, Bhandari, Mohit, and Chaudhary, Varun

Published
2023
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34. Actualisation 2023 des lignes directrices de pratique clinique pour la prise en charge de l'osteoporose et la prevention des fractures au Canada

Author

Morin, Suzanne N., Feldman, Sidney, Funnell, Larry, Giangregorio, Lora, Kim, Sandra, McDonald-Blumer, Heather, Santesso, Nancy, Ridout, Rowena, Ward, Wendy, Ashe, Maureen C., Bardai, Zahra, Bartley, Joan, Binkley, Neil, Burrell, Steven, Butt, Debra, Cadarette, Suzanne M., Cheung, Angela M., Chilibeck, Phil, Dunn, Sheila, Falk, Jamie, Frame, Heather, Gittings, William, Hayes, Kaleen, Holmes, Carol, Ioannidis, George, Jaglal, Susan B., Josse, Robert, Khan, Aliya A., McIntyre, Virginia, Nash, Lynn, Negm, Ahmed, Papaioannou, Alexandra, Ponzano, Matteo, Rodrigues, Isabel B., Thabane, Lehana, Thomas, Christine A., Tile, Lianne, and Wark, John D.

Subjects
Amgen Inc., Denosumab, Biotechnology industry, Restaurants, Health
Abstract

Contexte: Au Canada, plus de 2 millions de personnes vivent avec l'osteoporose, une maladie qui accroTt le risque de fracture, ce qui fait augmenter la morbidite et la mortalite, et entraTne une perte de qualite de vie et d'autonomie. La presente actualisation des lignes directrices vise a accompagner les professionnelles et professionnels de la sante au Canada dans la prestation de soins visant a optimiser la sante osseuse et a prevenir les fractures chez les femmes menopausees et les hommes de 50 ans et plus. Methodes: Le present document fournit une actualisation des lignes directrices de pratique clinique de 2010 d'Osteoporose Canada sur le diagnostic et la prise en charge de l'osteoporose au pays. Nous avons utilise l'approche GRADE (Grading of Recommendations Assessment, Development and Evaluation) et effectue l'assurance de la qualite conformement aux normes de qualite et de presentation des rapports de la grille AGREE II (Appraisal of Guidelines for Research & Evaluation). Les medecins de premier recours et les patientes et patients partenaires ont ete representes a tous les niveaux des comites et des groupes ayant participe a l'elaboration des lignes directrices, et ont participe a toutes les etapes du processus pour garantir la pertinence des informations pour les futurs utilisateurs et utilisatrices. Le processus de gestion des interets concurrents a ete entame avant l'elaboration des lignes directrices et s'est poursuivi sur toute sa duree, selon les principes du Reseau international en matiere de lignes directrices. Dans la formulation des recommandations, nous avons tenu compte des avantages et des risques, des valeurs et preferences de la patientele, des ressources, de l'equite, de l'acceptabilite et de la faisabilite; la force de chacune des recommandations a ete determinee en fonction du cadre GRADE. Recommandations: Les 25 recommandations et les 10 enonces de bonne pratique sont repartis en sections: activite physique, alimentation, evaluation du risque de fracture, instauration du traitement, interventions pharmacologiques, duree et sequence du traitement, et monitorage. La prise en charge de l'osteoporose devrait se fonder sur le risque de fracture, etabli au moyen d'une evaluation clinique realisee avec un outil d'evaluation du risque de fracture valide. L'activite physique, l'alimentation et la pharmacotherapie sont des elements essentiels a la strategie de prevention des fractures, qui devraient etre personnalises. Interpretation: Les presentes lignes directrices ont pour but d'outiller les professionnelles et professionnels de la sante et la patientele afin qu'ensemble ils puissent parler de l'importance de la sante osseuse et du risque de fracture tout au long de la vie adulte avancee. La detection et la prise en charge efficace de la fragilite osseuse peuvent contribuer a reduire les fractures et a preserver la mobilite, l'autonomie et la qualite de vie., Le risque de fracture augmente avec l'age, en raison du declin de la robustesse squelettique et de l'augmentation du risque de chute. Au Canada, plus de 2 millions de personnes [...]

Published
2023
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35. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update

Author

Morin, Suzanne N., Feldman, Sidney, Funnell, Larry, Giangregorio, Lora, Kim, Sandra, McDonald-Blumer, Heather, Santesso, Nancy, Ridout, Rowena, Ward, Wendy, Ashe, Maureen C., Bardai, Zahra, Bartley, Joan, Binkley, Neil, Burrell, Steven, Butt, Debra, Cadarette, Suzanne M., Cheung, Angela M., Chilibeck, Phil, Dunn, Sheila, Falk, Jamie, Frame, Heather, Gittings, William, Hayes, Kaleen, Holmes, Carol, Ioannidis, George, Jaglal, Susan B., Josse, Robert, Khan, Aliya A., McIntyre, Virginia, Nash, Lynn, Negm, Ahmed, Papaioannou, Alexandra, Ponzano, Matteo, Rodrigues, Isabel B., Thabane, Lehana, Thomas, Christine A., Tile, Lianne, and Wark, John D.

Subjects
Amgen Inc. -- Management, Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Osteoporosis -- Care and treatment, Strategic planning (Business) -- Health aspects, Postmenopausal women -- Care and treatment, Mortality -- United States -- Canada, Biotechnology industry -- Health aspects, Medical personnel -- Health aspects, Company business management, Health, McMaster University -- Management
Abstract

Background: In Canada, more than 2 million people live with osteoporosis, a disease that increases the risk for fractures, which result in excess mortality and morbidity, decreased quality of life and loss of autonomy. This guideline update is intended to assist Canadian health care professionals in the delivery of care to optimize skeletal health and prevent fractures in postmenopausal females and in males aged 50 years and older. Methods: This guideline is an update of the 2010 Osteoporosis Canada clinical practice guideline on the diagnosis and management of osteoporosis in Canada. We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework and quality assurance as per Appraisal of Guidelines for Research and Evaluation (AGREE II) quality and reporting standards. Primary care physicians and patient partners were represented at all levels of the guideline committees and groups, and participated throughout the entire process to ensure relevance to target users. The process for managing competing interests was developed before and continued throughout the guideline development, informed by the Guideline International Network principles. We considered benefits and harms, patient values and preferences, resources, equity, acceptability and feasibility when developing recommendations; the strength of each recommendation was assigned according to the GRADE framework. Recommendations: The 25 recommendations and 10 good practice statements are grouped under the sections of exercise, nutrition, fracture risk assessment and treatment initiation, pharmacologic interventions, duration and sequence of therapy, and monitoring. The management of osteoporosis should be guided by the patient's risk of fracture, based on clinical assessment and using a validated fracture risk assessment tool. Exercise, nutrition and pharmacotherapy are key elements of the management strategy for fracture prevention and should be individualized. Interpretation: The aim of this guideline is to empower health care professionals and patients to have meaningful discussions on the importance of skeletal health and fracture risk throughout older adulthood. Identification and appropriate management of skeletal fragility can reduce fractures, and preserve mobility, autonomy and quality of life., Fracture risk increases with advancing age, as a result of declining skeletal strength and increased risk of falling. In Canada, more than 2 million people live with osteoporosis. (1) Every [...]

Published
2023
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36. Finding the Optimal Resistance Training Intensity for Your Bones: Protocol for a Randomized Controlled Trial

Author

Giangregorio, Lora M., Bleakney, Robert R., Brien, Sheila, Butcher, Scotty J., Chan, Brian C.F., Chilibeck, Philip D., Devries, Michaela C., Funnell, Larry, Jain, Ravi, Keller, Heather H., Milligan, James, Mourtzakis, Marina, S. O'Hare, Bonny, Thabane, Lehana, and Cheung, Angela M.

Subjects
Osteoporosis -- Care and treatment, Exercise therapy -- Testing, Middle aged persons -- Care and treatment
Abstract

Objective. The purpose of this trial is to evaluate the effect of twice-weekly, moderate-to-high intensity progressive resistance training (PRT) for 1 year on lumbar spine bone mineral density (BMD) in individuals with low BMD, compared to attention control. Secondary analyses will examine if resistance training improves other health outcomes; if high intensity is more effective than moderate intensity resistance training for all outcomes; the cost of intervention versus benefit; the willingness to pay; and harms. Methods. For this study, 324 men or postmenopausal women aged >50 years with a femoral neck, total hip, or lumbar spine BMD T-score of [less than or equal to] -1, or a Fracture Risk Assessment Tool probability of >20% for major osteoporotic fracture or [greater than or equal to]3% for hip fracture are being recruited to participate in a randomized controlled trial with 1:1:1 randomization. Participants will be stratified by site (3 centers) to twice-weekly, supervised PRT at moderate intensity (about 10 repetitions maximum), to high intensity PRT ([less than or equal to]6 repetitions maximum), or to a home posture and balance exercise program (attention control) for 1 year (resistance training to comparator allocation ratio of 2:1). The primary outcome is lumbar spine BMD via dual-energy X-ray absorptiometry. Secondary outcomes include trabecular bone score, proximal femur and total hip BMD and structure, bone-free and appendicular lean mass, physical functioning, falls, fractures, glucose metabolism, cost per life-year gained, adverse events, and quality of life. Between-group differences will be tested in intention-to-treat and per-protocol analyses using analysis of covariance, chi-square tests, or negative binomial or logistic regression, adjusting for site and baseline values. Impact. The Finding the Optimal Resistance Training Intensity For Your Bones trial will support decision making on resistance training for people at risk of fracture. Keywords: Bone Mineral Density, Fracture, Intensity, Moderate, Osteoporosis, Progressive Resistance Training, Introduction Exercise is recommended for fall and fracture prevention. (1,2) Progressive resistance training (PRT) has the potential to be osteogenic, but concerns about safety in people with osteoporosis limit its [...]

Published
2023
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38. Role of anti-vascular endothelial growth factor in the management of non-proliferative diabetic retinopathy without centre-involving diabetic macular oedema: a meta-analysis of trials

Author

Chaudhary, Varun, Sarohia, Gurkaran S., Phillips, Mark R., Park, Daniel, Xie, Jim, Zeraatkar, Dena, Fung, Matthew, Thabane, Lehana, Loewenstein, Anat, Holz, Frank G., Garg, Sunir J., Kaiser, Peter K., Bhandari, Mohit, Guymer, Robyn H., Fraser-Bell, Samantha, Sivaprasad, Sobha, and Wykoff, Charles C.

Published
2023
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50. REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial

Author

Heels-Ansdell, Diane, Billot, Laurent, Thabane, Lehana, Alhazzani, Waleed, Deane, Adam, Guyatt, Gordon, Finfer, Simon, Lauzier, François, Myburgh, John, Young, Paul, Arabi, Yaseen, Marshall, John, English, Shane, Muscedere, John, Ostermann, Marlies, Venkatesh, Bala, Zytaruk, Nicole, Hardie, Miranda, Hammond, Naomi, Knowles, Serena, Saunders, Lois, Poole, Alexis, Al-Fares, Abdulrahman, Xie, Feng, Hall, Richard, and Cook, Deborah

Published
2023
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