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Axial fans may be equipped with passive flow control devices to enhance rotor efficiency or minimize noise emissions. In this regard, blade designs influenced by biomimicry, such as rotors with sinusoidal leading edges (LEs), have gained popularity in recent years. However, their design is predominantly driven by a trial-and-error approach, with limited systematic studies on the influence of rotor performance. Furthermore, their effectiveness is typically evaluated under controlled conditions that may significantly differ from operations in real installation layouts. In this work, a systematic review of the design process for sinusoidal LE axial fan rotors is provided, aiming to summarize previous design experiences. Then, a modified sinusoidal LE is designed and fitted to a 7.3 m low-speed axial fan for air-cooled condensers (ACCs). These fans operate at environmental conditions, providing a quasi-zero static pressure rise, often with inflow non-uniformities. A series of RANS computations were run to simulate the performance of the baseline fan and that of the sinusoidal leading edge, considering a real installation setup at Stellenbosh University, where the ACC is constrained between buildings and has a channel running on the ground below the fan inlet. The aim is to explore the nonbalanced inflow condition effects in both rotor geometries and to test the effect of the installation layout on fan performance. The results show that the modification to the rotor allows for a more even distribution of flow in the blade-to-blade passages with respect to the baseline geometry.

Introduction: Androgenic alopecia (AGA) staging is still based on macroscopic scales, yet the introduction of trichoscopy is gradually bringing an important change, even though it remains an eye-based method. However, recently developed artificial intelligence-assisted programs can execute automated count of trichoscopic patterns. Nevertheless, to interpret data elaborated by these programs can be complex. Machine learning algorithms might represent an innovative solution. Among them, support vector machine (SVM) models are among the best methods for classification. Objectives: Our aim was to develop a SVM algorithm, based on three trichoscopic patterns, able to classify AGA patients and to calculate a severity index. Methods: We retrospectively analyzed trichoscopic images from 200 AGA patients using Trichoscale Pro® software, calculating the number of vellus hair, empty follicles and single hair follicular units. Then, we elaborated a SVM model, based on these three patterns and on sex, able to classify patients as affected by mild AGA or moderate-severe AGA, and able to calculate the probability of the classification being correct, expressed as percentage (from 50% to 100%). This probability estimate is higher in patients with more AGA trichoscopic patterns and, thus, it might serve as a severity index. Results: For training and test datasets, accuracy was 94.3% and 90.0% respectively, while the Area Under the Curve was 0.99 and 0.95 respectively. Conclusions: We believe our SVM model could be of great support for dermatologists in the management of AGA, especially in better assessing disease severity and, thus, in prescribing a more appropriate therapy.

BackgroundHematological malignancies (HMs) represent a heterogeneous group of diseases with diverse etiology, pathogenesis, and prognosis. HMs’ accurate registration by Cancer Registries (CRs) is hampered by the progressive de-hospitalization of patients and the transition to molecular rather than microscopic diagnosis.Material and methodsA dedicated software capable of automatically identifying suspected HMs cases by combining several databases was adopted by Reggio Emilia Province CR (RE-CR). Besides pathological reports, hospital discharge archives, and mortality records, RE-CR retrieved information from general and biomolecular laboratories. Incidence, mortality, and 5-year relative survival (RS) reported according to age, sex, and 4 HMs’ main categories, were noted.ResultsOverall, 7,578 HM cases were diagnosed from 1996 to 2020 by RE-CR. HMs were more common in males and older patients, except for Hodgkin Lymphoma and Follicular Lymphoma (FL). Incidence showed a significant increase for FL (annual percent change (APC)=3.0), Myeloproliferative Neoplasms (MPN) in the first period (APC=6.0) followed by a significant decrease (APC=-7.4), and Myelodysplastic Syndromes (APC=16.4) only in the first period. Over the years, a significant increase was observed in 5-year RS for Hodgkin -, Marginal Zone -, Follicular - and Diffuse Large B-cell-Lymphomas, MPN, and Acute Myeloid Leukemia. The availability of dedicated software made it possible to recover 80% of cases automatically: the remaining 20% required direct consultation of medical records.ConclusionsThe study emphasizes that HM registration needs to collect information from multiple sources. The digitalization of CRs is necessary to increase their efficiency.

Recent flood disasters caused by extreme meteorological events highlight the need of fast and reliable tools for flooding forecast. For our purposes, the danger associated with floods is embodied in a single risk-level flag which considers both local water depth and velocity. The methodology here derived is applied and validated for the case study of the St. Lucia island in the eastern Caribbean Sea that experiences flash flooding as a result of combined intense rainfall and steep slopes, difficult to predict with traditional early-warning systems. A multi-layer perceptron neural network is trained on a high-fidelity dataset generated through full two-dimensional shallow water simulations of real and synthetic events. The dataset is validated against social markers obtained from real events. The predictive capabilities of the neural network model are tested on the out-of-box case of the Dean and Tomas hurricanes and compared with the solutions of the shallow water solver. The surrogate solver allows a significant speed-up in the prediction time with respect to traditional CFD (seconds vs hours), showing a high precision and accuracy, with accuracy, precision and F1-score above 0.99. [ABSTRACT FROM AUTHOR]

Wind turbines play a major role in the European Green Deal for clean energy transition. Noise is a critical aspect among open technological issues, as it determines the possibility of onshore installations near inhabited places and the possible detrimental effects on wildlife when offshore. This paper assesses the accuracy of different approaches to predicting the sound pressure level (SPL) of a wind turbine. The 2.75 MW Neg Micon NM80 horizontal axis wind turbine (HWAT) was simulated in OpenFOAM, modeling the turbine with the actuator line method (ALM) implemented in the turbinesFoam library. Two different inflow conditions were considered: a stationary inflow with a typical atmospheric boundary layer profile and a time-dependent inflow derived from a precursor channel with fully turbulent conditions. The surrogate model for noise prediction used for this work is based on the synthetic/surrogate acoustics models (SAMs) of Amiet and Brooks-Pope-Marcolini (BPM). This approach allows for blade motion modeling and the prediction of the SPL of the URANS postprocessing results. The SPL spectrum obtained was then compared to the results from the other aeroacoustic solvers of IEA Task 39 participants, showing the best performance in the fully turbulent case. The results demonstrate that coupling between the ALM and surrogate acoustics provides more accurate results than the blade element momentum (BEM) approach.

Most patients with myelofibrosis (MF) discontinue ruxolitinib (JAK1/JAK2 inhibitor) in the first 5 years of therapy due to therapy failure. As the therapeutic possibilities of MF are expanding, it is critical to identify patients predisposed to early ruxolitinib monotherapy failure and worse outcomes. We investigated predictors of early ruxolitinib discontinuation and death on therapy in 889 patients included in the “RUX-MF” retrospective study. Overall, 172 patients were alive on ruxolitinib after ≥5 years (long-term ruxolitinib, LTR), 115 patients were alive but off ruxolitinib after ≥5 yrs (short-term RUX, STR), and 123 patients died while on ruxolitinib after p = 0.08). Overall survival (OS) was significantly longer in LTR pts (p = 0.002). In multivariate analysis, PLT < 100 × 109/L, Hb < 10 g/dL, primary MF, absence of spleen response at 3 months and ruxolitinib starting dose

Introdução: O uso dos implantes osseointegrados para reabilitação de pacientes com dificuldade de adaptação de próteses convencionais mostra-se mais frequente a cada dia. Um grande grupo candidato à reabilitação com essa modalidade são os pacientes tratados para as neoplasias de cabeça e pescoço (CP). A irradiação na região de CP pode ser limitante para a instalação de implantes, porém a literatura apresenta evidências de técnicas e planejamentos favoráveis ao procedimento nesse grupo de pacientes. As técnicas menos traumáticas para intervenções na cavidade oral devem ser avaliadas, e os guias cirúrgicos para colocação de implantes podem ser aliados nesses procedimentos. Relato do caso: Paciente do sexo feminino, 64 anos, tratada com cirurgia, quimioterapia e radioterapia em cavidade oral para um carcinoma espinocelular (CEC) em língua e, em um segundo momento, diagnosticada e tratada com cirurgia para CEC em região de rebordo alveolar maxilar esquerdo por meio de hemipalatecmia, necessitava de reabilitação com implantes osseointegrados na região onde havia sido tratada com radiação primariamente. Realizou-se a cirurgia de colocação dos implantes com a tecnologia guiada para acarretar o mínimo trauma às estruturas bucais. Conclusão: O procedimento cirúrgico foi executado com sucesso. Atualmente, aguarda-se o período de osseointegração para a posterior reabilitação protética.

In polycythemia vera (PV), the prognostic relevance of an ELN-defined complete response (CR) to hydroxyurea (HU), the predictors of response, and patients’ triggers for switching to ruxolitinib are uncertain. In a real-world analysis, we evaluated the predictors of response, their impact on the clinical outcomes of CR to HU, and the correlations between partial or no response (PR/NR) and a patient switching to ruxolitinib. Among 563 PV patients receiving HU for ≥12 months, 166 (29.5%) achieved CR, 264 achieved PR, and 133 achieved NR. In a multivariate analysis, the absence of splenomegaly (p = 0.03), pruritus (p = 0.002), and a median HU dose of ≥1 g/day (p < 0.001) remained associated with CR. Adverse events were more frequent with a median HU dose of ≥1 g/day. Overall, 283 PR/NR patients (71.3%) continued HU, and 114 switched to ruxolitinib. In the 449 patients receiving only HU, rates of thrombosis, hemorrhages, progression, and overall survival were comparable among the CR, PR, and NR groups. Many PV patients received underdosed HU, leading to lower CR and toxicity rates. In addition, many patients continued HU despite a PR/NR; however, splenomegaly and other symptoms were the main drivers of an early switch. Better HU management, standardization of the criteria for and timing of responses to HU, and adequate intervention in poor responders should be advised.

In this retrospective comparative study, we evaluated the effectiveness of remdesivir (RDSV) in patients with SARS-CoV-2 pneumonia. Individuals hospitalized between March 2020 and August 2022 at S.M. Goretti Hospital, Latina, with a positive test for SARS-CoV-2 and, concomitantly, pneumonia, were included. The overall survival was the primary endpoint. The composite secondary endpoint included death or progression in severe ARDS at 40 days. The study population was stratified according to treatment into two groups: the RDSV group (patients treated with RDSV-based regimens) and the no-RDSV group (patients treated with any other, not RDSV-based, regimens). Factors associated with death and progression to severe ARDS or death were assessed by multivariable analysis. A total of 1153 patients (632 belonging to the RDSV group and 521 to the no-RDSV group) were studied. The groups were comparable in terms of sex, PaO2/FiO2 at admission, and duration of symptoms before hospitalization. Further, 54 patients (8.5%) in the RDSV group and 113 (21.7%) in the no-RDSV group (p < 0.001) died. RDSV was associated with a significantly reduced hazard ratio (HR) of death (HR, 0.69 [95% CI, 0.49–0.97]; p = 0.03), compared to the no-RDSV group, as well as a significantly reduced OR of progression in severe ARDS or death (OR, 0.70 [95% CI 0.49–0.98]; p = 0.04). An overall significantly higher survival rate was observed in the RDSV group (p < 0.001, by log-rank test). These findings reinforce the survival benefit of RDSV and support its routine clinical use for the treatment of COVID-19 patients.

In 2022, three antiviral drugs—molnupiravir, remdesivir and nirmatrelvir/ritonavir—were introduced for treatment of mild-to-moderate COVID-19 in high-risk patients. The aim of this study is the evaluation of their effectiveness and tolerability in a real-life setting. A single-center observational study was set up, with the involvement of 1118 patients, with complete follow-up data, treated between the 5th of January and the 3rd of October 2022 at Santa Maria Goretti’s hospital in Latina, Central Italy. A univariable and a multivariable analysis were performed on clinical and demographic data and composite outcome, the persistence of symptoms at 30 days and time to negativization, respectively. The three antivirals showed a similar effectiveness in containing the progression of the infection to severe COVID-19 and a good tolerability in the absence of serious adverse effects. Persistence of symptoms after 30 days was more common in females than males and less common in patients treated with molnupiravir and nirmatrelvir/r. The availability of different antiviral molecules is a strong tool and, if correctly prescribed, they can have a significant role in changing the natural history of infection for frail persons, in which vaccination could be not sufficient for the prevention of severe COVID-19.

Air-cooled condensers (ACCs) are commonly found in power plants working with concentrated solar power or in steam power plants operated in regions with limited water availability. In ACCs, the flow of air is driven toward the heat exchangers by axial fans that are characterized by large diameters and operate at very high mass flow rates with a near-zero static pressure rise. Given the overall requirements in steam plants, these fans are subjected to inflow distortions, unstable operations, and are characterized by high noise emissions. Previous studies show that leading edge bumps in the tip region of axial fans can effectively reduce the sound pressure levels without affecting the static efficiency. Nevertheless, the effects of this treatment in terms of flow patterns and heat exchange in the whole ACC system were not investigated. In this work, the effect of leading edge bumps on the flow patterns is analyzed. Two RANS simulations were carried out using OpenFOAM on a simplified model of the air-cooled condenser. The fans are simulated using a frozen rotor approach. Turbulence modeling relies on the RNG k-epsilon model. The fan is characterized by a diameter of 7.3 m and a 333 m3/s volumetric flow rate at the design point. The presence of the heat exchanger is modeled using a porous medium. The comparison between the flow fields clearly exerts that the modified blade is responsible for the redistribution of radial velocities in the rotor region. This drastically reduces the losses related to the installation of the fan in a real configuration.

Reduction of gas turbine (GT) carbon emissions relies on a strategy for fueling the engines with pure or blended hydrogen. The major technical challenges to solve are (i) the adjustments to the engine and in particular the combustion chamber and (ii) a series of issues to solve to guarantee safe operations. In fact, compared to natural gas, hydrogen fueling implies higher risks of explosion in case of leak in the turbine enclosure and a more careful design of the ventilation system. Thus, a deeper comprehension of hydrogen leak scenarios is needed to adjust the safe design strategy of the enclosure. To this aim, a series of numerical investigations was carried out to understand how different methane-hydrogen blends (from pure methane to pure hydrogen) behave when leaking from a pipeline with fuel pressure that span from 1.5 to 4.5 MPa. The different fuel blends' leaks in form of underexpanded jets were studied under different cross-flow ventilation conditions, with ventilation velocity spanning from 0 m/s to 5 m/s. When compared to pure methane, the outcome is a three times longer penetration distance for pure hydrogen axisymmetric flammable clouds, whereas in cross-flow conditions a more complex three-dimensional behavior was found, potentially opening a safety-related concerns discussed in the paper. [ABSTRACT FROM AUTHOR]

Monkeypox infection is an emerging problem and a new challenge for modern medicine. With an increasing number of new cases worldwide, new data regarding the clinical manifestations, characteristics of the patients, risk factors and treatment options are coming to light. Knowing more about the disease will allow to elaborate new helpful methods to facilitate its diagnosis. Special attention should be paid to the careful dermatologic and dermoscopic examination of the patient. The analysis of available data also suggests possible strategies for the prevention of Monkeypox virus spread; the vaccine against Smallpox seems to be an effective solution. This case report describes the diagnostic approach and management of a non-vaccinated adult patient with several risk factors and a history of sexually transmitted disease. The patient had no history of travel abroad. Even though a clinical diagnose of Monkeypox can be challenging due to its similarities with skin rashes caused by other Orthopoxviral infections, there are fine differences between the rashes which can be helpful in their differentiation, although laboratory analysis is required for a definitive identification. A careful study of the characteristics of the rash, such as diameter, its presence on palms and soles and its evolution in time, provided important clues for the diagnosis of Monkeypox infection. The lack of vaccinations in the history of the patient was another crucial finding in the diagnostic process.

In the direct-acting antiviral (DAA) era, it is important to understand the immunological changes after HCV eradication in HCV monoinfected (mHCV) and in HIV/HCV coinfected (HIV/HCV) patients. In this study, we analyzed sub-populations of monocytes, dendritic cells (DCs), T-lymphocytes and inflammatory biomarkers following initiation of DAA in 15 mHCV and 16 HIV/HCV patients on effective antiretroviral therapy at baseline and after sustained virological response at 12 weeks (SVR12). Fifteen age- and sex-matched healthy donors (HD) were enrolled as a control group. Activated CD4+ and CD8+ T-lymphocytes, mDCs, pDCs, MDC8 and classical, non-classical and intermediate monocytes were detected using flow cytometry. IP-10, sCD163 and sCD14 were assessed by ELISA while matrix metalloproteinase-2 (MMP-2) was measured by zymography. At baseline, increased levels of IP-10, sCD163 and MMP-2 were found in both HIV/HCV and mHCV patients compared to HD, whereas sCD14 increased only in HIV/HCV patients. After therapy, IP-10, sCD163 and sCD14 decreased, whereas MMP-2 persistently elevated. At baseline, activated CD8+ T-cells were high in HIV/HCV and mHCV patients compared to HD, with a decrease at SVR12 only in HIV/HCV patients. Activated CD4+ T-cells were higher in HIV/HCV patients without modification after DAAs therapy. These results suggest complex interactions between both viruses and the immune system, which are only partially reversed by DAA treatment.

Background: Anemia is frequently present in patients with myelofibrosis (MF), and it may be exacerbated by treatment with the JAK2‐inhibitor ruxolitinib (RUX). Recently, a relevant blast phase (BP) incidence has been reported in anemic MF patients unexposed to RUX. Methods: The authors investigated the incidence of BP in 886 RUX‐treated MF patients, included in the "RUX‐MF" retrospective study. Results: The BP incidence rate ratio (IRR) was 3.74 per 100 patient‐years (3.74 %p‐y). At therapy start, Common Terminology Criteria for Adverse Events grade 3‐4 anemia (hemoglobin [Hb] <8 g/dL) and severe sex/severity‐adjusted anemia (Hb <8/<9 g/dL in women/men) were present in 22.5% and 25% patients, respectively. IRR of BP was 2.34 in patients with no baseline anemia and reached respectively 4.22, 4.89, and 4.93 %p‐y in patients with grade 1, 2, and 3–4 anemia. Considering the sex/severity‐adjusted Hb thresholds, IRR of BP was 2.85, 4.97, and 4.89 %p‐y in patients with mild/no anemia, moderate, and severe anemia. Transfusion‐dependent patients had the highest IRR (5.03 %p‐y). Progression‐free survival at 5 years was 70%, 52%, 43%, and 27% in patients with no, grade 1, 2, and 3–4 anemia, respectively (p <.001). At 6 months, 260 of 289 patients with no baseline anemia were receiving ruxolitinib, and 9.2% had developed a grade 3–4 anemia. By 6‐month landmark analysis, BP‐free survival was significantly worse in patients acquiring grade 3–4 anemia (69.3% vs. 88.1% at 5 years, p <.001). Conclusions: This study highlights that anemia correlates with an increased risk of evolution into BP, both when present at baseline and when acquired during RUX monotherapy. Innovative anemia therapies and disease‐modifying agents are warranted in these patients. Anemia correlates with an increased risk of evolution into blast phase, both when present at baseline and when acquired during ruxolitinib monotherapy. Innovative anemia therapies and disease‐modifying agents are warranted in these patients. [ABSTRACT FROM AUTHOR]

Low-speed axial fans must comply with a wide number of standards and normative restrictions, often related to the maximum noise emission levels. Among the noise control techniques in axial fans, skewed fan blades and leading edge serrations have been found to be effective in leading edge noise control, which represents one of the dominant phenomena in axial fan broadband emissions. However, these solutions are usually applied separately, and literature is scarce on systematic studies on the coupling of the two modifications. In this work, a campaign of experimental measurements was conducted on unskewed and forward-skewed axial fan blades with and without leading-edge serrations. The tests were performed in undisturbed inflow conditions. The flow field and the turbulence characteristics were measured using three-dimensional hot-wire anemometry. The suction-side sound radiation of the fans was measured with microphones in an anechoic chamber. In addition, the rotating beamforming method was used to localize the sound sources at the axial fans. It was found that, regardless of the blade skew, the leading edge serrations lead to a reduction of the sound pressure level, whereby the aerodynamic properties of the fan decrease. At the same operating points, which were achieved by adjusting the rotational speed, the sound radiation through the leading edge serrations could be reduced at high-volume flows. This effect was more pronounced with the unskewed rotor, which indicates that the positive effect of the serrations is reduced by the already optimized shape of the forward skewed fan blade. Based on the experimental results, the four geometries were further considered for numerical investigations to understand how the serrations affect the fan operations and the overall aerodynamics of the rotor. All four geometries were simulated with RANS approach at the duty point to derive a flow survey and better understand the dynamics driven by serrations and blade skewing. [ABSTRACT FROM AUTHOR]