1. Clinical relevance of circulating angiogenic cells in patients with ischemic stroke
- Author
-
Francisco Rodríguez-Esparragón, Laura B. Torres-Mata, Juan Carlos López-Fernández, Laura Cappiello, Jesús M. González-Martín, Bernardino Clavo, Jaime A. Serna-Gómez, Lidia Estupiñán-Quintana, Cristina Torres-Ascensión, and Jesús Villar
- Subjects
Ischemic stroke ,Endothelial progenitor cells ,Circulating angiogenic cells ,Colony forming cells ,Late outgrowth endothelial cells ,Biomarkers ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) patients and predictors of their variance evaluated. Methods This is a single-center observational study evaluating 187 consecutively hospitalized patients with IS. EPCs were isolated from blood samples. The number of circulating angiogenic cells (CACs), colony-forming units (CFU-ECs) and the emergence of late outgrowths endothelial cells (LOECs) were counted. We collected clinical variables and measured the stromal cell-derived factor 1 alpha (SDF1α) serum levels. We also examined the relative telomere length and the expression of osteogenic gene markers in CACs. Results CACs counts and CFU-ECs colony numbers were positively correlated (rho = 0.41, p
- Published
- 2022
- Full Text
- View/download PDF