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3. SOCIAL SKILLS INTERVENTIONS FOR ADOLESCENTS WITH LEVEL 1 AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.

Author

Narzisi, Antonio, Sesso, Gianluca, Fabbri-Destro, Maddalena, Berloffa, Stefano, Fantozzi, Pamela, Muccio, Rosy, Bruzzi, Gianina, Scatigna, Stefano, Valente, Elena, Viglione, Valentina, Milone, Annarita, Cortese, Samuele, and Masi, Gabriele

Subjects
SOCIAL skills education, AUTISM spectrum disorders, RANDOMIZED controlled trials, SOCIAL skills, INVESTIGATIONAL therapies
Abstract

Objective: Evidence on the efficacy of social skills training for adolescents with Level 1 Autism Spectrum Disorder (ASD) is unclear. Method: We searched Pubmed, Scopus, and Web of Science until July 27th, 2023, for randomized controlled trials (RCTs) of social skills training for pre-adolescents and adolescents (aged 9-18) with Level 1 ASD. We then pooled data on efficacy from individual RCTs by conducting multivariate mixed-effects meta-analyses in R. We estimated possible bias in the retained RCTs using the RoB2 tool. Results: We retained 36 RCTs (encompassing 2796 participants), including 18 RCTs comparing an experimental treatment to a waiting list, and 18 RCTs comparing it to standard care/control treatment. Meta-analyses showed that experimental treatments were significantly more efficacious than waiting list or standard care/ control treatments in improving social skills (SMD = 0.3745; 95%CI = [0.2396; 0.5093]), as well as reducing behavioral symptoms (0.3154;0.1783, 0.4525) and anxious/depressive symptoms (0.2780; 0.0432, 0.5128). However, for some outcomes there was significant heterogeneity across studies and evidence of publication bias. Subgroup analyses and meta-regressions did not identify any specific clinical or demographic factors as significant predictors of outcome. The most common risk of bias across studies was related to deviations from intended interventions and measurement of the outcomes. Conclusions: At the group level, social skills training for adolescents with Level 1 ASD is efficacious, with small-to-moderate effect size. Future research should focus on personalized medicine approaches, aimed at tailoring interventions to specific characteristics of adolescents with Level 1 ASD. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author

La Maida, Nunzia, primary, Di Giorgi, Alessandro, additional, Pellegrini, Manuela, additional, Ceccanti, Mauro, additional, Caruso, Salvatore, additional, Ricci, Giuseppe, additional, Neri, Isabella, additional, Lana, Sheherazade, additional, Minutillo, Adele, additional, Berretta, Paolo, additional, Busardò, Francesco Paolo, additional, Pichini, Simona, additional, Camandona, Franco, additional, Vaccari, Lucia, additional, Travan, Laura, additional, Maso, Giampaolo, additional, Stampalija, Tamara, additional, Zanazzo, Lucia, additional, Pisana, Paola, additional, Driul, Lorenza, additional, Barbui, Elisa, additional, Caissutti, Claudia, additional, Valente, Elena, additional, Ricchi, Alba, additional, Bettiga, Elisa, additional, Piccolo, Elisa, additional, Pati, Mariangela, additional, Pedori, Simona, additional, Antonazzo, Patrizio, additional, Sottile, Gilda, additional, Faro, Fabrizio Lo, additional, Tini, Anastasio, additional, Massacesi, Mario, additional, Rapisarda, Carmen, additional, Vivirito, Gabriella, additional, Pinna, Giampiero, additional, D'anna, Mariarosa, additional, Klein, Lili, additional, Bucolo, Antonino, additional, D'Anna, Rosario, additional, Monaco, Caterina, additional, La Ferrera, Giuseppe, additional, Capobianco, Giampiero, additional, Olzai, Mauro Giorgio, additional, Angioni, Stefano, additional, D'Alterio, Maurizio Nicola, additional, Serravalle, Paolo, additional, Vicquéry, Christine, additional, Scalchi, Sabrina, additional, Morando, Carla, additional, Meneghin, Margherita, additional, Scapolan, Cinzia, additional, Maggino, Tiziano, additional, Guarinoni, Barbara, additional, Napolitano, Giovanna M. Cristina, additional, De Vita, Maria Grazia, additional, Carlo, Costantino Di, additional, Interlandi, Fabiana, additional, Bisceglia, Massimo, additional, Barbaglia, Michelangelo, additional, Arnulfo, Alberto, additional, Finale, Enrico, additional, Marozio, Luca, additional, Natali, Ilaria, additional, Grazia, Signoretti Maria, additional, Staffler, Alex, additional, Tarani, Luigi, additional, Coriale, Giovanna, additional, Messina, Marisa Patrizia, additional, D'Angelo, Alessio, additional, Bonito, Marco, additional, Haass, Cristina, additional, Capasso, Letizia, additional, Raimondi, Francesco, additional, De Bernardo, Giuseppe, additional, Iacobelli, Pietro, additional, Spadarella, Simona, additional, Mastantuoni, Enrica, additional, Rabuano, Raffaello, additional, Calzatini, Francesco, additional, Bossi, Anna, additional, Aversa, Salvatore, additional, Prefumo, Federico, additional, Bellan, Cristina, additional, Leone, Giovanna, additional, Ciammella, Massimo, additional, Von-Wunster, Silvia, additional, Liguori, Antonella, additional, Ornaghi, Sara, additional, Fumagalli, Simona, additional, Sanguineti, Fabio, additional, Gianola, Gaia, additional, Cagnacci, Angelo, additional, Amidani, Arianna, additional, Sisto, Antonio, additional, Marcello, Francesca Di, additional, Santillo, Vincenzo, additional, Bartolomeo, Cristina Di, additional, Gerli, Sandro, additional, Cagnoli, Giacomo, additional, Petrisano, Mirella, additional, Pesce, Simona, additional, Lascio, Nicola Di, additional, Falvino, Sonia, additional, Appio, Petronilla, additional, Targiani, Vincenza, additional, Cavaliere, Anna Franca, additional, Turrini, Irene, additional, Belli, Gilda, additional, Gambi, Beatrice, additional, Florio, Pasquale, additional, Innocenti, Elena Degli, additional, Magi, Letizia, additional, Civitelli, Flavio, additional, Nappi, Luigi, additional, Sorrentino, Felice, additional, Silvestris, Teresa, additional, Indrio, Flavia, additional, Laforgia, Nicola, additional, Rizzo, Valentina, additional, La Rocca, Maria, additional, Pradal, Ugo, additional, Memo, Luigi, additional, Diaz, Claudio, additional, Riscica, Patrizia, additional, and Bazz, Stefania, additional

Published
2023
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6. Persistent Non-Suicidal Self-Injury and Suicidality in Referred Adolescents: A Longitudinal Study Exploring the Role of Cyclothymic Temperament

Author

Masi, Gabriele, primary, Pisano, Simone, additional, Sesso, Gianluca, additional, Mazzullo, Cristina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Narzisi, Antonio, additional, Placini, Francesca, additional, Valente, Elena, additional, Viglione, Valentina, additional, and Milone, Annarita, additional

Published
2023
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7. Micromolar Dihydroartemisinin Concentrations Elicit Lipoperoxidation in Plasmodium falciparum -Infected Erythrocytes.

Author

Skorokhod, Oleksii, Valente, Elena, Mandili, Giorgia, Ulliers, Daniela, and Schwarzer, Evelin

Subjects
PLASMODIUM falciparum, ERYTHROCYTES, PARASITIC diseases, LIPIDS, REACTIVE oxygen species, ARTEMISININ
Abstract

Malaria is still the most important parasitic infectious disease. Numerous substances are known to have antimalarial activity; among them, artemisinin is the most widely used one, and artemisinin-based combination therapy (ACT) is recommended for the treatment of Plasmodium falciparum (P.f.) malaria. Antitumor, immunomodulatory, and other therapeutic applications of artemisinin are under extensive study. Several different mechanisms of action were proposed for dihydroartemisinin (DHA), the active metabolite of artemisinin, such as eliciting oxidative stress in target cells. The goal of this study is to monitor the generation of reactive oxygen species (ROS) and lipid peroxidation product 4-hydroxynonenal (4-HNE) by DHA in P.f.-infected human erythrocytes. Checking ROS and 4-HNE-protein adducts kinetics along the maturation of the parasite, we detected the highest level of 4-HNE in ring forms of P.f. due to DHA treatment. Low micromolar concentrations of DHA quickly induced levels of 4-HNE-adducts which are supposed to be damaging. Mass spectrometry identified the P.f. protein cysteine proteinase falcipain-1 as being heavily modified by 4-HNE, and plausibly, 4-HNE conjugation with vital P.f. proteins might contribute to DHA-elicited parasite death. In conclusion, significant 4-HNE accumulation was detectable after DHA treatment, though, at concentrations well above pharmacologically effective ranges in malaria treatment, but at concentrations described for antitumor activity. Thus, lipid peroxidation with consequent 4-HNE conjugation of functionally relevant proteins might be considered as a uniform mechanism for how DHA potentiates antimalarials' action in ACT and controls the progression of tumors. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author

Camandona, Franco, Vaccari, Lucia, Travan, Laura, Maso, Giampaolo, Stampalija, Tamara, Zanazzo, Lucia, Pisana, Paola, Driul, Lorenza, Barbui, Elisa, Caissutti, Claudia, Valente, Elena, Ricchi, Alba, Bettiga, Elisa, Piccolo, Elisa, Pati, Mariangela, Pedori, Simona, Antonazzo, Patrizio, Sottile, Gilda, Faro, Fabrizio Lo, Tini, Anastasio, Massacesi, Mario, Rapisarda, Carmen, Vivirito, Gabriella, Pinna, Giampiero, D'anna, Mariarosa, Klein, Lili, Bucolo, Antonino, D'Anna, Rosario, Monaco, Caterina, La Ferrera, Giuseppe, Capobianco, Giampiero, Olzai, Mauro Giorgio, Angioni, Stefano, D'Alterio, Maurizio Nicola, Serravalle, Paolo, Vicquéry, Christine, Scalchi, Sabrina, Morando, Carla, Meneghin, Margherita, Scapolan, Cinzia, Maggino, Tiziano, Guarinoni, Barbara, Napolitano, Giovanna M. Cristina, De Vita, Maria Grazia, Carlo, Costantino Di, Interlandi, Fabiana, Bisceglia, Massimo, Barbaglia, Michelangelo, Arnulfo, Alberto, Finale, Enrico, Marozio, Luca, Natali, Ilaria, Grazia, Signoretti Maria, Staffler, Alex, Tarani, Luigi, Coriale, Giovanna, Messina, Marisa Patrizia, D'Angelo, Alessio, Bonito, Marco, Haass, Cristina, Capasso, Letizia, Raimondi, Francesco, De Bernardo, Giuseppe, Iacobelli, Pietro, Spadarella, Simona, Mastantuoni, Enrica, Rabuano, Raffaello, Calzatini, Francesco, Bossi, Anna, Aversa, Salvatore, Prefumo, Federico, Bellan, Cristina, Leone, Giovanna, Ciammella, Massimo, Von-Wunster, Silvia, Liguori, Antonella, Ornaghi, Sara, Fumagalli, Simona, Sanguineti, Fabio, Gianola, Gaia, Cagnacci, Angelo, Amidani, Arianna, Sisto, Antonio, Marcello, Francesca Di, Santillo, Vincenzo, Bartolomeo, Cristina Di, Gerli, Sandro, Cagnoli, Giacomo, Petrisano, Mirella, Pesce, Simona, Lascio, Nicola Di, Falvino, Sonia, Appio, Petronilla, Targiani, Vincenza, Cavaliere, Anna Franca, Turrini, Irene, Belli, Gilda, Gambi, Beatrice, Florio, Pasquale, Innocenti, Elena Degli, Magi, Letizia, Civitelli, Flavio, Nappi, Luigi, Sorrentino, Felice, Silvestris, Teresa, Indrio, Flavia, Laforgia, Nicola, Rizzo, Valentina, La Rocca, Maria, Pradal, Ugo, Memo, Luigi, Diaz, Claudio, Riscica, Patrizia, Bazz, Stefania, La Maida, Nunzia, Di Giorgi, Alessandro, Pellegrini, Manuela, Ceccanti, Mauro, Caruso, Salvatore, Ricci, Giuseppe, Neri, Isabella, Lana, Sheherazade, Minutillo, Adele, Berretta, Paolo, Busardò, Francesco Paolo, and Pichini, Simona

Published
2023
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10. Early Sensory Profile in Autism Spectrum Disorders Predicts Emotional and Behavioral Issues

Author

Fabbri-Destro, Maddalena, primary, Maugeri, Federica, additional, Ianni, Carolina, additional, Corsini, Sofia, additional, Di Stefano, Erica, additional, Scatigna, Stefano, additional, Crifaci, Giulia, additional, Bruzzi, Gianina, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Pelagatti, Susanna, additional, Pecchini, Edoardo, additional, Zulli, Filippo, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Viglione, Valentina, additional, Barone, Rita, additional, Masi, Gabriele, additional, and Narzisi, Antonio, additional

Published
2022
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11. An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

Author

Berneburg, Isabell, primary, Peddibhotla, Satyamaheshwar, additional, Heimsch, Kim C., additional, Haeussler, Kristina, additional, Maloney, Patrick, additional, Gosalia, Palak, additional, Preuss, Janina, additional, Rahbari, Mahsa, additional, Skorokhod, Oleksii, additional, Valente, Elena, additional, Ulliers, Daniela, additional, Simula, Luigi Felice, additional, Buchholz, Kathrin, additional, Hedrick, Michael P., additional, Hershberger, Paul, additional, Chung, Thomas D. Y., additional, Jackson, Michael R., additional, Schwarzer, Evelin, additional, Rahlfs, Stefan, additional, Bode, Lars, additional, Becker, Katja, additional, and Pinkerton, Anthony B., additional

Published
2022
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12. Sensory Profiles in School-Aged Children with Autism Spectrum Disorder: A Descriptive Study Using the Sensory Processing Measure-2 (SPM-2)

Author

Narzisi, Antonio, primary, Fabbri-Destro, Maddalena, additional, Crifaci, Giulia, additional, Scatigna, Stefano, additional, Maugeri, Federica, additional, Berloffa, Stefano, additional, Fantozzi, Pamela, additional, Prato, Adriana, additional, Muccio, Rosy, additional, Valente, Elena, additional, Viglione, Valentina, additional, Pecchini, Edoardo, additional, Pelagatti, Susanna, additional, Rizzo, Renata, additional, Milone, Annarita, additional, Barone, Rita, additional, and Masi, Gabriele, additional

Published
2022
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14. Neuropsychological Characterization of Aggressive Behavior in Children and Adolescents with CD/ODD and Effects of Single Doses of Medications: The Protocol of the Matrics_WP6-1 Study.

Author

Balia, Carla, Carucci, Sara, Milone, Annarita, Romaniello, Roberta, Valente, Elena, Donno, Federica, Montesanto, Annarita, Brovedani, Paola, Masi, Gabriele, Glennon, Jeffrey C., Coghill, David, and Zuddas, Alessandro

Subjects
CHILD psychology, AGGRESSION (Psychology), MENTAL health services, DYSAUTONOMIA, CONDUCT disorders in children, HEART beat, DRUGS, CONDUCT disorders in adolescence
Abstract

Aggressive behaviors and disruptive/conduct disorders are some of the commonest reasons for referral to youth mental health services; nevertheless, the efficacy of therapeutic interventions in real-world clinical practice remains unclear. In order to define more appropriate targets for innovative pharmacological therapies for disruptive/conduct disorders, the European Commission within the Seventh Framework Programme (FP7) funded the MATRICS project (Multidisciplinary Approaches to Translational Research in Conduct Syndromes) to identify neural, genetic, and molecular factors underpinning the pathogenesis of aggression/antisocial behavior in preclinical models and clinical samples. Within the program, a multicentre case-control study, followed by a single-blind, placebo-controlled, cross-over, randomized acute single-dose medication challenge, was conducted at two Italian sites. Aggressive children and adolescents with conduct disorder (CD) or oppositional defiant disorder (ODD) were compared to the same age (10–17 y) typically developing controls (TDC) on a neuropsychological tasks battery that included both "cold" (e.g., inhibitory control, decision making) and "hot" executive functions (e.g., moral judgment, emotion processing, risk assessment). Selected autonomic measures (heart rate variability, skin conductance, salivary cortisol) were recorded before/during/after neuropsychological testing sessions. The acute response to different drugs (methylphenidate/atomoxetine, risperidone/aripiprazole, or placebo) was also examined in the ODD/CD cohort in order to identify potential neuropsychological/physiological mechanisms underlying aggression. The paper describes the protocol of the clinical MATRICS WP6-1 study, its rationale, the specific outcome measures, and their implications for a precision medicine approach. [ABSTRACT FROM AUTHOR]

Published
2021
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