Search

WHO estimates that 10.7 million women die from childbirth. About 25-50% are related to labor and puerperal problems. One of the factors that influence labor is the mother's psychology, with the active role of the family during labor can reduce the incidence of complications and achieve safe labor, namely by paying attention to aspects of the mother's affection. Study purposes: Knowing the effect of labor companion on the progress of labor in maternal at PPM in Tanjungpinang city. The design in this study is a quasi-experiment with a post-test only control group design. The study was conducted at PPM throughout Tanjungpinang City, from September to November 2021. Respondents in this study were 68 mothers who indicated normal birth at PPM in Tanjungpinang City, 34 deliveries with a labor companion role and 34 deliveries without a labor companion role. The study tool used is an observation sheet. To find out whether there is an effect of the independent variable and the dependent variable, statistical analysis of the Independent Sample T-Test is used. The results showed that there is a companion effect on labor progress. it is recommended to apply the role of labor pendampimg to each birth process

Previous studies have shown that mango has anti-inflammatory properties. Anti-inflammatory drugs are compounds or medicines used to treat diseases caused by inflammation. The most commonly used anti-inflammatory drug is a non-steroidal anti-inflammatory drug (NSAID). The drug works by inhibiting the enzyme cyclooxygenase (COX). The purpose of this study was to determine the profile metabolites present in the methanol extract of mango leaves and their interaction with the COX enzyme. This study includes an analysis of the compounds contained in the methanol extract of mango leaves using LCMS / MS and molecular docking studies of these compounds. Compounds detected by MS include C26H24O14, C45H84O14, Khellol-β-D-glucoside, Mangiferin, and Nevadensin-5-β-D-glucoside. Analysis of docking result was based on ΔG and Ki and the binding interactions that occur. Compounds that are compatible with COX1 and COX2 are Khellol βD glucoside with G and Ki values of 7.49 kcal/mol and 3.23 µM and 8.32 kcal/mol and 0.7919 µM, respectively. Through the molecular docking process, it was confirmed that khellol β-D-glucoside may be activated as an anti-inflammatory agent.

Objective: Protein-energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly., Methods and Analysis: In 2020, a 6-month double-blind randomised controlled trial in 75 predementia older people was launched to prevent muscle mass loss, in respond to the 'Joint Programming Initiative A healthy diet for a healthy life'. In the run-in phase, participants will be stabilised on a protein-rich diet (0.9-1.0 g protein/kg ideal body weight/day) and physical exercise programme (high-intensity interval training specifically developed for these subjects). Subsequently, they will be randomised into three groups (1:1:1). The study arms will have a similar isocaloric diet and follow a similar physical exercise programme. Control group (n=25) will maintain the baseline diet; intervention groups will consume either 30 g/day of dark chocolate containing 500 mg total PP (corresponding to 60 mg epicatechin) and 100 mg vitamin E (as RRR-alpha-tocopherol) (n=25); or the high polyphenol chocolate without additional vitamin E (n=25). Muscle mass will be the primary endpoint. Other outcomes are neurocognitive status and previously identified biomolecular indices of frailty in predementia patients. Muscle biopsies will be collected to assess myocyte contraction and mitochondrial metabolism. Blood and plasma samples will be analysed for laboratory endpoints including nutrition metabolism and omics., Ethics and Dissemination: All the ethical and regulatory approvals have been obtained by the ethical committees of the Azienda Ospedaliera Universitaria Integrata of Verona with respect to scientific content and compliance with applicable research and human subjects' regulation. Given the broader interest of the society toward undernutrition in the elderly, we identify four main target audiences for our research activity: national and local health systems, both internal and external to the project; targeted population (the elderly); general public; and academia. These activities include scientific workshops, public health awareness campaigns, project dedicated website and publication is scientific peer-review journals., Trial Registration Number: NCT05343611., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)

Centenarians exhibit extreme longevity and compression of morbidity and display a unique genetic signature. Centenarians' offspring seem to inherit centenarians' compression of morbidity, as measured by lower rates of age-related pathologies. We aimed to ascertain whether centenarians' offspring are less frail and whether they are endowed with a "centenarian genetic footprint" in a case-control study, matched 1:1 for gender, age ±5 years, and place of birth and residence. Cases must have a living parent aged 97 years or older, aged 65-80 years, community dwelling, not suffering from a terminal illness, or less than 6 months of life expectancy. Controls had to meet the same criteria as cases except for the age of death of their parents (not older than 89 years). Centenarians were individuals 97 years or older. Frailty phenotype was determined by Fried's criteria. We collected plasma and peripheral blood mononuclear cells from 63 centenarians, 88 centenarians' offspring, and 88 noncentenarians' offspring. miRNA expression and mRNA profiles were performed by the GeneChip miRNA 4.0 Array and GeneChip Clariom S Human Array, respectively. We found a lower incidence of frailty among centenarians' offspring when compared with their contemporaries' noncentenarians' offspring (p < .01). Both miRNA and mRNA expression patterns in centenarians' offspring were more like those of centenarians than those of noncentenarians' offspring (p < .01). In conclusion, centenarians' offspring are less frail than age-matched noncentenarians' offspring, and this may be explained by their unique genetic endowment., (© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)