Search

Objective To compare the intervention effects of antidepressants combined with Yi Shu psychodrama or with general health education on depression, anxiety, self-esteem and mental resilience in depression patients with childhood trauma so as to explore a better clinical program. Methods A total of 68 patients who met the diagnostic criteria of ICD-10 unipolar depressive episode and also were positive for Childhood Trauma Questionnaire 28 item Short Form (CTQ-SF) were recruited from the psychiatric outpatients of our hospital, and then they were randomly divided into antidepressants plus Yi Shu psychodrama group and antidepressants plus general health education group. The patients were subsequently intervened for 6 months and then followed up for another 6 months. Hamilton Depression Rating Scale-17 item (HAMD-17), Beck Anxiety Inventory-21 item (BAI-21), Self-Esteem Scale (SES) and Connor-Davidson Resilience Scale (CD-RISC) were used for assessment. Repeated-measures ANOVA was adopted to compare the effects on depression and anxiety improvement, as well as the results of self-esteem and resilience development between the 2 groups at the end of intervention and during follow-up. Results ① There were 35 cases enrolled in the psychodrama group and 33 in the joint health education group. By the end of follow-up, 4 cases were lost in the former and 13 in the latter group, with statistical difference in shedding rate between the 2 groups (11.4% vs 39.4%, P < 0.01). ② At the end of intervention, the total efficacy rate of the psychodrama group was higher than that of the health education group (63.63% vs 37.04%, Chi-square=4.207, P < 0.05). ③ The results of repeated-measures ANOVA and simple effect analysis revealed that at the end of intervention, the scores of depression and anxiety were decreased in both groups, while those of self-esteem, mental resilience and its dimensions were increased, with significant differences in scores of HAMD, SES, CD-RISC and its dimensions (P < 0.05), except for BAI score. During the follow-up, the scores of self-esteem and strength dimension were higher in the psychodrama group than the health education group (P < 0.05). Conclusion In the treatment of major depressive disorder with childhood trauma, antidepressants combined with Yi Shu psychodrama has better overall efficacy and maintenance effect in improving depression, anxiety, self-esteem and mental resilience than the joint general health education program, with better treatment compliance as well.

Hydrogen production from seawater remains challenging due to the deactivation of the hydrogen evolution reaction (HER) electrode under high current density. To overcome the activity-stability trade-offs in transition-metal sulfides, we propose a strategy to engineer sulfur migration by constructing a nickel-cobalt sulfides heterostructure with nitrogen-doped carbon shell encapsulation (CN@NiCoS) electrocatalyst. State-of-the-art ex situ/in situ characterizations and density functional theory calculations reveal the restructuring of the CN@NiCoS interface, clearly identifying dynamic sulfur migration. The NiCoS heterostructure stimulates sulfur migration by creating sulfur vacancies at the Ni3S2-Co9S8 heterointerface, while the migrated sulfur atoms are subsequently captured by the CN shell via strong C-S bond, preventing sulfide dissolution into alkaline electrolyte. Remarkably, the dynamically formed sulfur-doped CN shell and sulfur vacancies pairing sites significantly enhances HER activity by altering the d-band center near Fermi level, resulting in a low overpotential of 4.6 and 8 mV at 10 mA cm−2 in alkaline freshwater and seawater media, and long-term stability up to 1000 h. This work thus provides a guidance for the design of high-performance HER electrocatalyst by engineering interfacial atomic migration. Stable and efficient hydrogen production from seawater remains challenging. Here the authors engineer sulfur migration in NiCoS electrocatalyst via N-doped carbon encapsulation, generating S vacancies and S doped CN active sites at the interface that improves electrocatalytic hydrogen evolution activity and durability in both alkaline freshwater and seawater. [ABSTRACT FROM AUTHOR]

The polarized electron source is a critical component in accelerator facilities such as the electron–ion collider, which requires a polarized electron gun with higher voltage and higher bunch charge than existing sources. One challenge we faced was the surface charge limit of the distributed Bragg reflector GaAs/GaAsP superlattice (DBR-SL-GaAs) photocathode. We suppressed this effect by optimizing the surface doping and heat cleaning procedures. We achieved up to 11.6 nC bunch charge of polarized electron beam. In this report, we discuss the performance of tests of a DBR-SL-GaAs photocathode in the high voltage direct current gun. Possible reasons for the observed peak quantum efficiency wavelength shift are analyzed, and we addressed it by using a wavelength tunable laser. In addition, the impact of the DBR layer and laser on the lifetime is investigated in this paper. The optimal DBR-SL-GaAs operating zone has been proposed, which gave us a long lifetime and high polarization at 30 μA operation. The success of this polarized gun will be key to the future of the nuclear sciences. [ABSTRACT FROM AUTHOR]