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Background Hypertrophic scarring is a disease of abnormal skin fibrosis caused by excessive fibroblast proliferation. Existing drugs have not achieved satisfactory therapeutic effects. Objectives To explore the molecular pathogenesis of hypertrophic scars and screen effective drugs for their treatment. Methods Existing human hypertrophic scar RNA sequencing data were utilized to search for hypertrophic scar-related gene modules and key genes through weighted gene co-expression network analysis (WGCNA). Candidate compounds were screened in a compound library. Potential drugs were screened by molecular docking and verified in human hypertrophic scar fibroblasts and a mouse mechanical force hypertrophic scar model. Results WGCNA showed that hypertrophic scar-associated gene modules influence focal adhesion, the transforming growth factor (TGF)-β signalling pathway and other biologic pathways. Integrin β1 (ITGB1) is the hub protein. Among the candidate compounds obtained by computer virtual screening and molecular docking, crizotinib, sorafenib and SU11274 can inhibit the proliferation and migration of human hypertrophic scar fibroblasts and profibrotic gene expression. Crizotinib had the best effect on hypertrophic scar attenuation in mouse models. At the same time, mouse ITGB1 small interfering RNA can also inhibit mouse scar hyperplasia. Conclusions ITGB1 and TGF-β signalling pathways are important for hypertrophic scar formation. Crizotinib could be a potential treatment drug for hypertrophic scars. [ABSTRACT FROM AUTHOR]

Background: The high recurrence rate after nonsurgical treatment of keloid is a major challenge for clinicians. Although there are many existing treatment options, how to optimize and upgrade the existing options and make a reasonable combination of utilization is our concern. The aim of this study is to provide a comprehensive non‐surgical treatment for keloid—cocktail therapy. Methods: According to the different changes of keloid with treatment, the treatment was divided into four stages, and different treatment schemes were adopted for each stage. The incidence of side effects of keloid at each stage and the effective rate and cure rate 16 months after the end of treatment were analyzed. Results: All patients completed this study on time, and were followed up 16 months after the end of treatment, the treatment effective rate was 100%, and the cure rate was up to 92.8%. Conclusion: Cocktail therapy can achieve a higher cure rate of keloid, and is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Background: Auricular keloids are difficult to treat, and recurrent keloids are more aggressive and more likely to develop aural deformities. Surgical excision, injections, or radiotherapy alone have high recurrence rates. An algorithmic approach of auricular keloid remains to be explored. Aims: To investigate the sequential treatment protocol for the treatment of auricle keloids to maintain auricle morphology and reduce the postoperative recurrence rate. Patients/Methods: A retrospective analysis of 42 patients who attended the scar minimally invasive treatment center of the Hospital of Plastic Surgery, Chinese Academy of Medical Sciences for serial treatment from January 2019 to June 2021. According to the size and involvement of the keloid, the core excision of the scar was excised under the condition of ensuring the priority of the auricular contour, and the scar flap was repaired to reconstruct the auricular appearance, and electron beam treatment was performed within 24 h after the operation, ray energy: 6–7 MeV, dose: Dt18Gy/2f; regular trimethoprim combined with 5‐Fu injection treatment and the application of silicone ear clips for local compression treatment were performed 1 month after the operation. Results: Thirty‐five patients were followed up from 12 to 40 months after surgery, and three of them showed a tendency of recurrence, and early local treatment with trimethoprim and 5‐Fu injection achieved favorable results. Conclusion: A standardized and sequential treatment plan for keloids with different morphology and anatomical locations can achieve remodeling of the auricular morphology and maintain long‐term results. [ABSTRACT FROM AUTHOR]

Background: The nose is located in the middle of the face; therefore, nasal scarring will bring a significant psychological impact on patients. Although there are many treatment methods for depressed scars, these methods have varying degrees of efficacy and all carry certain adverse effects. A better treatment method is urgent to be found. In this study, the effect of micro‐plasma radiofrequency technology combined with subcision to treat nasal depressed scars is evaluated. Methods: 18 Chinese patients with nasal depressed scars participated in this study. All patients received one session of micro‐plasma radiofrequency treatment first. 2 months later, subcision combined with micro‐plasma radiofrequency technology was performed on them at 6‐month intervals, and a total of 2 sessions of combined treatment were performed. Goodman and Baron Scale was used to evaluate nasal scars before treatment and 6 months after the final session. Results: All 18 patients in this study had Grade 4 nasal scars before treatment. 6 months after the end of treatment, 13 patients (72.2%) showed excellent or near total improvement, and 5 patients (27.8%) showed marked improvement. No adverse side effects were observed during treatment. Patient self‐evaluation indicated that all patients were satisfied with the cosmetic outcomes. Conclusions: In this study, we explored a new treatment method for nasal depressed scars. We used micro‐plasma radiofrequency technology combined with subcision to treat nasal depressed scars and obtained relatively satisfactory results with no adverse effects. [ABSTRACT FROM AUTHOR]

80% of the patients underwent 5 maintenance injections, the keloid in the laser treated area showed a white, soft healing state. Treating cysts in keloids with Ultrapulse mode-fractionated carbon dioxide lasers can effectively cure the cysts, thereby inhibiting the growth of keloids and reducing the recurrence rate of keloids. Treatment of sebaceous cysts in keloids: Ultrapulse mode-fractionated carbon dioxide lasers combined with injection of low-concentration triamcinolone acetonide and 5-fluorouracil. [Extracted from the article]

Much existing literature indicates that the efficacy of 5-FU combined with glucocorticoid injection therapy is much higher than that of hormone injection therapy alone, and the recurrence rate is much lower than it. 300 (95.5%) cases were completely cured after one treatment session,10 (3.18%) cases were completely cured after two treatment sessions, and 4 (1.3%) cases were completely cured after three treatment sessions. Keywords: 5-Fluorouracil; acne; keloid; treatment EN 5-Fluorouracil acne keloid treatment 3606 3607 2 08/09/22 20220801 NES 220801 Acknowledgment We are grateful that this work was supported by Key Projects of Medical School Development of Shijingshan District. [Extracted from the article]