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369 results on '"Wang, Lingyan"'

8. Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process

Author

Wang, Lingyan, Song, Kaiyuan, Yu, Jin, and Da, Lin-Tai

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, 1.1 Normal biological development and functioning, Generic health relevance, DNA, DNA Repair, Nucleotides, Sugars, Thymine DNA Glycosylase, DNA repair, DNA glycosylase, Markov state model, molecular dynamics simulation, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways. Efficient corrections of these DNA lesions are critical for maintaining genome integrity and preventing premature aging and cancers. The target-site searching/recognition mechanisms and the subsequent conformational dynamics of DNA glycosylase, however, remain challenging to be characterized using experimental techniques. In this review, we summarize our recent studies of sequential structural changes of thymine DNA glycosylase (TDG) during the DNA repair process, achieved mostly by molecular dynamics (MD) simulations. Computational simulations allow us to reveal atomic-level structural dynamics of TDG as it approaches the target-site, and pinpoint the key structural elements responsible for regulating the translocation of TDG along DNA. Subsequently, upon locating the lesions, TDG adopts a base-flipping mechanism to extrude the mispaired nucleobase into the enzyme active-site. The constructed kinetic network model elucidates six metastable states during the base-extrusion process and suggests an active role of TDG in flipping the intrahelical nucleobase. Finally, the molecular mechanism of product release dynamics after catalysis is also summarized. Taken together, we highlight to what extent the computational simulations advance our knowledge and understanding of the molecular mechanism underlying the conformational dynamics of TDG, as well as the limitations of current theoretical work.

Published
2022

26. A pref-1-controlled non-inflammatory mechanism of insulin resistance

Author

Huang, Yiheng, Cui, Donghong, Chen, Liujun, Tong, Haibin, Wu, Hong, Muller, Grace K., Qi, Yadan, Wang, Shuxia, Xu, Jinjie, Gao, Xiang, Fifield, Kathleen E., Wang, Lingyan, Xia, Zhengyuan, Vanderluit, Jacqueline L., Liu, Suixin, Leng, Lin, Sun, Guang, McGuire, John, Young, Lawrence H., Bucala, Richard, and Qi, Dake

Published
2023
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30. Natural Wetland Evolution in China: A Review

Author

Wang, Lingyan, Ma, Liang, Sheng, Lianxi, Zang, Shuying, Wang, Hanxi, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, He, Bao-Jie, editor, Prasad, Deo, editor, and Jupesta, Joni, editor

Published
2022
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31. Research on a Space Anti-irradiation Magnetic Feedback DCDC Conversion Technology

Author

Li, Chunyu, Wang, Lingyan, Hu, Cong, Li, Xuyang, Yue, Changlu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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32. Research on Anti-saturation Control Strategy of High-Power and High-Dynamic Servo Power Supply

Author

Wang, Lingyan, Li, Xuyang, Yang, Lei, Hu, Cong, Yue, Changlu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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44. Remote epitaxy of K0.5Na0.5NbO3 films on SrTiO3.

Author

Yang, Jun, Wang, Yankun, Dai, Liyan, Wu, Heping, Ren, Xin, An, Ruihua, Li, Sijin, Wang, Lingyan, Huang, Linya, Zhao, Libo, Jiang, Zhuangde, Ren, Wei, Schroeder, Thomas, Schwarzkopf, Jutta, and Niu, Gang

Abstract

Remote epitaxy represents a novel method for the preparation of high-quality epitaxial single crystalline films capable of being transferred onto arbitrary substrates for electronic and flexible functional devices. It was initially applied for semiconductors and later for functional complex perovskite oxides. However, the understanding of the impact of substrate orientation, growth mode, crystallinity and strain relaxation on oxide remote epitaxial systems is still lacking. Lead-free potassium sodium niobate (KNN) thin films have attracted intense interests owing to their superior piezoelectric properties and environment-friendly features. However, the remote epitaxy of KNN has rarely been reported. Therefore, in this study, we present the remote epitaxy of KNN on single-layer graphene-covered SrTiO3 (STO) substrates with different orientations. All STO substrates with three orientations, i.e. (001), (011) and (111), permitted the remote epitaxy of KNN, with STO (001) leading to superior crystallinity. The growth mode of KNN on graphene/STO (G-STO) was found to be Volmer–Weber, with initial island nucleation on the wrinkles of graphene and a subsequent coalescence to complete the growth and obtain flat films. Furthermore, remote epitaxial KNN on G-STO (001) displayed an abrupt interface without pinholes in graphene or layer interdiffusion. The strain relaxation of remote epitaxial KNN films was explored as a function of film thickness, which already underwent partial relaxation due to the weaker substrate clamping effect through graphene but experienced a slight strain increase after island coalescence. These results not only show that the applied material systems for remote epitaxy can be expanded to more complex oxides, but also enrich the understanding of the oxide heteroepitaxy mechanism involving a graphene monolayer, particularly nucleation and strain relaxation. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Ultrahigh Electrostrictive Effect in Lead-Free Sodium Bismuth Titanate-Based Relaxor Ferroelectric Thick Film.

Author

Li, Yizhuo, Zhao, Jinyan, Wang, Zhe, Zheng, Kun, Zhang, Jie, Chen, Chuying, Wang, Lingyan, Wang, Genshui, Li, Xin, Zhao, Yulong, Niu, Gang, and Ren, Wei

Subjects
MICROELECTROMECHANICAL systems, THICK films, BISMUTH titanate, ELECTRONIC equipment, SUBSTRATES (Materials science), ALKALINE earth metals, BISMUTH, ELECTROMECHANICAL effects
Abstract

In recent years, the development of environmentally friendly, lead-free ferroelectric films with prominent electrostrictive effects have been a key area of focus due to their potential applications in micro-actuators, sensors, and transducers for advanced microelectromechanical systems (MEMS). This work investigated the enhanced electrostrictive effect in lead-free sodium bismuth titanate-based relaxor ferroelectric films. The films, composed of (Bi0.5Na0.5)0.8−xBaxSr0.2TiO3 (BNBST, x = 0.02, 0.06, and 0.11), with thickness around 1 μm, were prepared using a sol-gel method on Pt/TiO2/SiO2/Si substrates. By varying the Ba2+ content, the crystal structure, morphology, and electrical properties, including dielectric, ferroelectric, strain, and electromechanical performance, were investigated. The films exhibited a single pseudocubic structure without preferred orientation. A remarkable strain response (S > 0.24%) was obtained in the films (x = 0.02, 0.06) with the coexistence of nonergodic and ergodic relaxor phases. Further, in the x = 0.11 thick films with an ergodic relaxor state, an ultrahigh electrostrictive coefficient Q of 0.32 m4/C2 was achieved. These findings highlight the potential of BNBST films as high-performance, environmentally friendly electrostrictive films for advanced microelectromechanical systems (MEMS) and electronic devices. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Mn-inlaid antiphase boundaries in perovskite structure

Author

Wang, Lingyan, primary, Li, Chao, additional, Xu, Liqiang, additional, Ren, Xuerong, additional, Yao, Fangzhou, additional, Lu, Jiangbo, additional, Wang, Dong, additional, Liang, zhongshuai, additional, Huang, Ping, additional, Wu, Shengqiang, additional, Jing, Hongmei, additional, Zhang, Yijun, additional, Dong, Guohua, additional, Liu, Haixia, additional, Ma, Chuansheng, additional, Lyu, Yinong, additional, Wei, Xiaoyong, additional, Ren, Wei, additional, Wang, Ke, additional, Ye, Zuo-Guang, additional, and Chen, Feng, additional

Published
2024
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