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This study aimed to evaluate the survival outcomes of neoadjuvant radiochemotherapy (NARCT) for early breast cancer. Female patients ≤ 80 years old with unilateral T1-T4 invasive ductal breast cancer treated with neoadjuvant chemotherapy (NAC) and radiation therapy (RT) between 2006 and 2015 were enrolled from SEER database. Baseline differences in clinical and pathological characteristics were evaluated using chi-square test. The survival outcomes were estimated by Kaplan–Meier analysis and compared using Cox hazards models. The effects of baseline differences on survival outcome in patients treated with neoadjuvant radiation therapy (NART) and post-operation radiation therapy (PORT) were circumvented by propensity score matching (PSM). Altogether 14,151 patients receiving NAC and RT were enrolled, among whom 386 underwent NART. Based on a 1:4 PSM cohort, NART was an independent unfavorable prognostic factor for breast cancer-specific survival (BCSS) and overall survival (OS) for the whole cohort. However, among patients receiving breast conserving surgery (BCS) (HR 1.029, P = 0.915 for BCSS; HR 1.003, P = 0.990 for OS) or implant-based immediate breast reconstruction (IBR) (HR 1.039, P = 0.921 for BCSS; HR 1.153, P = 0.697 for OS), those treated with NART had similar survival outcomes compared with patients treated with PORT. In conclusion, NARCT was a safe and feasible approach for patients undergoing BCS and IBR. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the significance of chemotherapy (CT) among metaplastic breast cancer (MpBC), and to compare the survival outcomes between triple negative MpBC (MpBC-TNBC) and triple negative invasive ductal carcinoma (IDC-TNBC). SEER database was indexed to identify female unilateral primary MpBC diagnosed from 2010 to 2017. Patients were classified into neoadjuvant chemotherapy (NAC) with response (NAC-response), NAC-no response, adjuvant chemotherapy, and no CT. Breast cancer-specific survival (BCSS) and overall survival (OS) was estimated using the Kaplan–Meier method and compared by log-rank test. Cox regression was used to evaluate the independent prognostic factors. A 1:4 propensity score matching method was adopted to balance baseline differences. Altogether 1186 MpBC patients were enrolled, among them 181 received NAC, 647 received adjuvant CT and 358 did not receive any CT. Chemotherapy was an independent favorable prognostic factor. NAC-response and adjuvant CT had a significant or an obvious trend of survival improvement compared with NAC-no response or no CT. MpBC-TNBC was an independent unfavorable prognostic factor compared with IDC-TNBC. Among them, there was significant or trend of survival improvement among all TNBCs receiving NAC or adjuvant CT compared with no CT. Chemotherapy was of important significance to MpBC prognosis and should be integrated in comprehensive treatment for MpBC. [ABSTRACT FROM AUTHOR]

Achieving the desired color temperature and color rendering index in light sources is challenging because of the deficiency of certain color components, notably cyan in the illumination spectra. In this investigation, we successfully synthesized orthogonal Ca5Ga6O14: Bi3+ (CGO: Bi3+) phosphors with space group Cmc21, featuring two distinct Ca(1) and Ca(2) sites. Under the excitation of 335 nm, a broad cyan emission with a 495 nm peak was observed. Gaussian peak fitting revealed two sub-peaks at 445 and 500 nm, originating from the emission of Bi3+ occupying Ca(1) and Ca(2) sites, respectively. As Bi3+ doping concentration increased, the luminescence experienced a red shift, attributed to the cooperative impact of crystal field splitting and electron cloud rearrangement. Through the substitution of Sr2+ ions, we achieved a 2.15 times enhancement in emission intensity and an increase in lifetime from 0.451 to 0.551 μs. This substitution also led to a consistent increase in the relative emission percentage of Bi(1) from 46.5% to 73.1%, while that of Bi(2) decreased from 70.5% to 44.9%. It is likely a result of some Bi3+ ions originally situated in the Ca(2) site migrating to the Ca(1) site. Finally, the introduction of Na+ ions for charge compensation resulted in a 20.18% increase in the luminescence intensity and an enhanced quantum efficiency of 84.21%. This CGO: Bi3+ phosphor holds promise as a potential cyan phosphor for white light sources. [ABSTRACT FROM AUTHOR]