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Your search keyword '"Warner, Harry"' showing total 12 results
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12 results on '"Warner, Harry"'

1. Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation

Author

Warner, Harry, Franciosa, Giulia, van der Borg, Guus, Coenen, Britt, Faas, Felix, Koenig, Claire, de Boer, Rinse, Classens, René, Maassen, Sjors, Baranov, Maksim V., Mahajan, Shweta, Dabral, Deepti, Bianchi, Frans, van Hilten, Niek, Risselada, Herre Jelger, Roos, Wouter H., Olsen, Jesper Velgaard, Cano, Laia Querol, and van den Bogaart, Geert

Published
2024
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2. FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

Author

Stok, Colin, Tsaridou, Stavroula, van den Tempel, Nathalie, Everts, Marieke, Wierenga, Elles, Bakker, Femke J., Kok, Yannick, Alves, Inês Teles, Jae, Lucas T., Raas, Maximilian W.D., Huis in 't Veld, Pim J., de Boer, H. Rudolf, Bhattacharya, Arkajyoti, Karanika, Eleftheria, Warner, Harry, Chen, Mengting, van de Kooij, Bert, Dessapt, Julien, ter Morsche, Lars, Perepelkina, Polina, Fradet-Turcotte, Amelie, Guryev, Victor, Tromer, Eelco C., Chan, Kok-Lung, Fehrmann, Rudolf S.N., and van Vugt, Marcel A.T.M.

Published
2023
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4. Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters

Author

Stempels, Femmy C., primary, Jiang, Muwei, additional, Warner, Harry M., additional, Moser, Magda-Lena, additional, Janssens, Maaike H., additional, Maassen, Sjors, additional, Nelen, Iris H., additional, de Boer, Rinse, additional, Jiemy, William F., additional, Knight, David, additional, Selley, Julian, additional, O’Cualain, Ronan, additional, Baranov, Maksim V., additional, Burgers, Thomas C.Q., additional, Sansevrino, Roberto, additional, Milovanovic, Dragomir, additional, Heeringa, Peter, additional, Jones, Matthew C., additional, Vlijm, Rifka, additional, ter Beest, Martin, additional, and van den Bogaart, Geert, additional

Published
2023
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6. FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

Author

Theoretical Biology and Bioinformatics, Sub Bioinformatics, Stok, Colin, Tsaridou, Stavroula, van den Tempel, Nathalie, Everts, Marieke, Wierenga, Elles, Bakker, Femke J, Kok, Yannick, Alves, Inês Teles, Jae, Lucas T, Raas, Maximilian W D, Huis In 't Veld, Pim J, de Boer, H Rudolf, Bhattacharya, Arkajyoti, Karanika, Eleftheria, Warner, Harry, Chen, Mengting, van de Kooij, Bert, Dessapt, Julien, Ter Morsche, Lars, Perepelkina, Polina, Fradet-Turcotte, Amelie, Guryev, Victor, Tromer, Eelco C, Chan, Kok-Lung, Fehrmann, Rudolf S N, van Vugt, Marcel A T M, Theoretical Biology and Bioinformatics, Sub Bioinformatics, Stok, Colin, Tsaridou, Stavroula, van den Tempel, Nathalie, Everts, Marieke, Wierenga, Elles, Bakker, Femke J, Kok, Yannick, Alves, Inês Teles, Jae, Lucas T, Raas, Maximilian W D, Huis In 't Veld, Pim J, de Boer, H Rudolf, Bhattacharya, Arkajyoti, Karanika, Eleftheria, Warner, Harry, Chen, Mengting, van de Kooij, Bert, Dessapt, Julien, Ter Morsche, Lars, Perepelkina, Polina, Fradet-Turcotte, Amelie, Guryev, Victor, Tromer, Eelco C, Chan, Kok-Lung, Fehrmann, Rudolf S N, and van Vugt, Marcel A T M

Published
2023

8. Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration Through the Extracellular Matrix

Author

Warner, Harry Marcus, primary, Franciosa, Giulia, additional, van der Borg, Guus, additional, Faas, Felix, additional, Koenig, Claire, additional, de Boer, Rinse, additional, Classens, Rene, additional, Maassen, Sjors, additional, Baranov, Maksim, additional, Mahajan, Shweta, additional, Dabral, Deepti, additional, Coenen, Britt, additional, Bianchi, Frans, additional, van Hilten, Niek, additional, Risselada, Herre Jelger, additional, Roos, Wouter, additional, Olsen, Jesper Velgaard, additional, Querol Cano, Laia, additional, and van den Bogaart, Geert, additional

Published
2023
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9. Activated Dendritic Cells Round their Nuclei through Adhesion Loss and Atypical Cofilin Signaling

Author

Warner, Harry, Franciosa, Giulia, Van Der Borg, Guus, Faas, Felix, Koenig, Claire, De Boer, Rinse, Classens, René, Maasen, Sjors, Baranov, Maksim, Mahajan, Shweta, Dabral, Deepti, Bianchi, Frans, Van Hilten, Niek, Herre Jelger Risselada, Roos, Wouter, Olsen, Jesper, Cano, Laia Querol, and Van Den Bogaart, Geert

Abstract

To mount a secondary immune response, dendritic cells must process antigens, migrate to lymph nodes and form synapses with T cells. Critical to 3D migration and mechano-sensing is the nucleus, which is the size-limiting barrier for navigation through gaps in the extracellular matrix. Here, we show that spherical deformations of the dendritic cell nuclear membrane occur following inflammatory activation, as a partial result of reduced cell adhesion. By re-programming the nucleus, dendritic cells are less confined by complex 3D environments and can overcome the typical 2 – 3-micron pore limit for migration. Nuclear deformation is concomitant with the redistribution and bundling of perinuclear actin away from the nucleus, reducing force across Nesprin-2G based linker of nucleoskeleton and cytoskeleton (LINC) complexes. Furthermore, through phosphoproteomics, we connect this nuclear deformation to cofilin-1 serine 41 phosphorylation. This phosphorylation further drives nuclear deformation and bundles cofilin-1 with F-actin into a peri-nuclear halo-shaped micro-domain. In summary, these data describe novel signaling events through which dendritic cells deform their nucleus to enhance their migratory capacity; a molecular event that may be re-capitulated in other contexts such as wound healing and cancer.

Published
2022
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12. Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages

Author

European Commission, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Wellcome Trust, Royal Society (UK), Maassen, Sjors, Warner, Harry, Ioannidis, Melina, Jansma, Jack, Markus, Hugo, El Aidy, Sahar, Chiara, María-Dolores, Chiara, José Luis, Maierhofer, Larissa, Weavers, Helen, Van Den Boogart, Geert, European Commission, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Wellcome Trust, Royal Society (UK), Maassen, Sjors, Warner, Harry, Ioannidis, Melina, Jansma, Jack, Markus, Hugo, El Aidy, Sahar, Chiara, María-Dolores, Chiara, José Luis, Maierhofer, Larissa, Weavers, Helen, and Van Den Boogart, Geert

Abstract

5-methoxy tryptophan (5-MTP) is an anti-fibrotic metabolite made by fibroblasts and epithelial cells, present in a micromolar concentrations in human blood, and is associated with the progression of fibrotic kidney disease, but the mechanism is unclear. Here, we show by microscopy and functional assays that 5-MTP influences mitochondria in human peripheral blood monocyte-derived macrophages. As a result, the mitochondrial membranes are more rigid, more branched, and are protected against oxidation. The macrophages also change their metabolism by reducing mitochondrial import of acyl-carnitines, intermediates of fatty acid metabolism, driving glucose import. Moreover, 5-MTP increases the endocytosis of collagen by macrophages, and experiments with inhibition of glucose uptake showed that this is a direct result of their altered metabolism. However, 5-MTP does not affect the macrophages following pathogenic stimulation, due to 5-MTP degradation by induced expression of indole-amine oxygenase-1 (IDO-1). Thus, 5-MTP is a fibrosis-protective metabolite that, in absence of pathogenic stimulation, promotes collagen uptake by anti-inflammatory macrophages by altering the physicochemical properties of their mitochondrial membranes.

Published
2022

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