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Lysophosphatidylcholine acyltransferase 1(LPCAT1), a key metabolic enzyme in the phosphatidyl-choline metabolism pathway, mediates phosphatidylcholine synthesis through deacylation-reacylation, which leads to alterations in the phospholipids composition of cell membranes and the remodelling of the cellular cytoskeleton. Lysophosphatidylcholine acyltransferase 1 has been shown to be highly expressed in gastric, breast and colorectal cancer, and can accelerate the alteration of the phospholipids composition of tumor cell membranes or interact with tumor driver genes, such as epidermal growth factor receptor and cell cycle-related genes. It might promote tumor development by affecting tumor cell proliferation, migration, invasion and resistance to chemotherapy.

Rail breakage can cause train derailment that leads to catastrophic consequences, prevention of which is worthy of a significant amount of investment in finance and time. Non-destructive evaluation can provide qualitative and quantitative inspection of rail tracks in-situ to detect dangerous faults, even though these defects are primarily invisible or hardly noticed from the surface of the rail. To make it efficient and convenient, infrared thermography technique offers a remote operation without interfering with rail transportation. The image processing for edge detection can further quantify the defect deterioration by depicting the contour of the defect. Moreover, the optimal parameters for various edge operators provide reliable detection for natural fracture defects. [ABSTRACT FROM AUTHOR]

Raspberry ketone accounts for the characteristic aroma of the raspberry fruit. In order to explore the genes involved in raspberry ketone synthesis, the transcriptome in fruit tissues of two red raspberry varieties "Polka" and "Orange legend", were sequenced and 24213 single genes were obtained. As the red raspberry fruit ripening, genes involved in flavonoid and anthocyanin synthesis were up-regulated, while those associated with lignin synthesis were down-regulated. A gene (RinPKS4) highly related to raspberry ketone synthesis was identified by transcriptome analysis, and RinPKS4 gene was over-expressed in raspberry in order to further understand the function of RinPKS4 gene in raspberry ketone synthesis. The results showed that the gene expression level of RinPKS4 in the leaf tissues of a transgenic lines increased by about 4-fold and the content of raspberry ketone increased by 42.64% compared with the wide type. This study lays a theoretical foundation for further study on the synthesis and regulation of raspberry ketone in red raspberry. [ABSTRACT FROM AUTHOR]

Elimination of antibiotics such as tetracycline hydrochloride (TC) from wastewater is of great significance, but still faces challenges. In this regard, Cu2O decorated CuZnAl-layered double hydroxide (Cu2O/CuZnAl-LDHs) heterostructure photocatalysts were designed via a facile coprecipitation method and subsequent in situ reduction approach. The XRD, XPS, UV-vis DRS, PL, Mott–Schottky plots, and VB-XPS results together revealed that the construction of a heterostructure inhibits the recombination of relatively useful electrons and holes, providing a strong driving force for the photocatalytic degradation of TC. Additionally, the synergistic effects increased visible light absorption and the population of adsorption sites, which also played pivotal roles in the removal of TC. As a result, the degradation efficiency of TC catalyzed by Cu2O/CuZnAl-LDHs under visible light reached 94.1% within 120 min. The capture experiments of active species and ESR analysis confirm that the superoxide radical (˙O2−), holes (h+) and hydroxyl radicals (˙OH) were responsible for the decomposition of TC. This study provides a rational design strategy and performance assessment of LDH-based heterostructured photocatalysts for the treatment of antibiotic-contaminated water. [ABSTRACT FROM AUTHOR]