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Your search keyword '"Wei-Wei Zuo"' showing total 4 results
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4 results on '"Wei-Wei Zuo"'

2. High Expression of PARP1 in Tumor and Stroma Cells Predicts Different Prognosis and Platinum Resistance in Patients With Advanced Epithelial Ovarian Cancer

Author

Wei-Wei Zuo, Chun-Fang Zhao, Yan Li, Hai-Yan Sun, Guo-Ming Ma, Yue-Ping Liu, and Shan Kang

Subjects
advanced epithelial ovarian cancer, PARP1, cytokeratin, platinum resistance, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

ObjectiveThis study aimed to explore the roles of PARP1 mRNA and protein expression in platinum resistance and prognosis of EOC patients, and reveal the different roles of PARP1 protein in epithelial tumor and stroma cells.MethodsThe PARP1 mRNA expression of the EOC tissues was examined by RT-qPCR. The impacts of PARP1 expression on prognosis were measured by Kaplan-Meier and Cox regression. Receiver operating characteristic (ROC) curve analysis was employed for calculating the diagnostic value of PARP1 on platinum resistance. The microarray of formalin-fixed, paraffin-embedded (FFPE) tissues was processed for multiplex immunofluorescence to detect the protein levels of PARP1 and cytokeratin (CK).ResultsThe PARP1mRNA expression of EOC patients was higher in the platinum-resistant group compared with the sensitive group (P

Published
2022
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4. High Expression of

Author

Wei-Wei, Zuo, Chun-Fang, Zhao, Yan, Li, Hai-Yan, Sun, Guo-Ming, Ma, Yue-Ping, Liu, and Shan, Kang

Abstract

This study aimed to explore the roles of PARP1 mRNA and protein expression in platinum resistance and prognosis of EOC patients, and reveal the different roles of PARP1 protein in epithelial tumor and stroma cells.TheThe

Published
2022

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