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3 results on '"Wishy, Andrew"'

1. In-situ bypass is associated with superior infection-free survival compared with extra-anatomic bypass for the management of secondary aortic graft infections without enteric involvement

Author

Janko, Matthew R., primary, Hubbard, Grant, additional, Back, Martin, additional, Shah, Samir K., additional, Pomozi, Eniko, additional, Szeberin, Zoltan, additional, DeMartino, Randall, additional, Wang, Linda J., additional, Crofts, Sarah, additional, Belkin, Michael, additional, Davila, Victor J., additional, Lemmon, Gary W., additional, Wang, Shihuan K., additional, Czerny, Martin, additional, Kreibich, Maximilian, additional, Humphries, Misty D., additional, Shutze, William, additional, Joh, Jin Hyun, additional, Cho, Sungsin, additional, Behrendt, Christian-Alexander, additional, Setacci, Carlo, additional, Hacker, Robert I., additional, Sobreira, Marcone Lima, additional, Yoshida, Winston Bonetti, additional, D’Oria, Mario, additional, Lepidi, Sandro, additional, Chiesa, Roberto, additional, Kahlberg, Andrea, additional, Go, Michael R., additional, Rizzo, Anthony N., additional, Black, James H., additional, Magee, Gregory A., additional, Elsayed, Ramsey, additional, Baril, Donald T., additional, Beck, Adam W., additional, McFarland, Graeme E., additional, Gavali, Hamid, additional, Wanhainen, Anders, additional, Kashyap, Vikram S., additional, Stoecker, Jordan B., additional, Wang, Grace J., additional, Zhou, Wei, additional, Fujimura, Naoki, additional, Obara, Hideaki, additional, Wishy, Andrew M., additional, Bose, Saideep, additional, Smeds, Matthew, additional, Liang, Patric, additional, Schermerhorn, Marc, additional, Conrad, Mark F., additional, Hsu, Jeffrey H., additional, Patel, Rhusheet, additional, Lee, Jason T., additional, Liapis, Christos D., additional, Moulakakis, Konstantinos G., additional, Farber, Mark A., additional, Motta, Fernando, additional, Ricco, Jean-Baptiste, additional, Bath, Jonathan, additional, Coselli, Joseph S., additional, Aziz, Faisal, additional, Coleman, Dawn M., additional, Davis, Frank M., additional, Fatima, Javairiah, additional, Irshad, Ali, additional, Shalhub, Sherene, additional, Kakkos, Stavros, additional, Zhang, Qianzi, additional, Lawrence, Peter F., additional, Woo, Karen, additional, and Chung, Jayer, additional

Published
2022
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2. In-situ bypass is associated with superior infection-free survival compared with extra-anatomic bypass for the management of secondary aortic graft infections without enteric involvement

Author

Janko, Matthew R., Hubbard, Grant, Back, Martin, Shah, Samir K., Pomozi, Eniko, Szeberin, Zoltan, DeMartino, Randall, Wang, Linda J., Crofts, Sarah, Belkin, Michael, Davila, Victor J., Lemmon, Gary W., Wang, Shihuan K., Czerny, Martin, Kreibich, Maximilian, Humphries, Misty D., Shutze, William, Joh, Jin Hyun, Cho, Sungsin, Behrendt, Christian-Alexander, Setacci, Carlo, Hacker, Robert, I, Sobreira, Marcone Lima, Yoshida, Winston Bonetti, D'Oria, Mario, Lepidi, Sandro, Chiesa, Roberto, Kahlberg, Andrea, Go, Michael R., Rizzo, Anthony N., Black, James H., Magee, Gregory A., Elsayed, Ramsey, Baril, Donald T., Beck, Adam W., McFarland, Graeme E., Gavali, Hamid, Wanhainen, Anders, Kashyap, Vikram S., Stoecker, Jordan B., Wang, Grace J., Zhou, Wei, Fujimura, Naoki, Obara, Hideaki, Wishy, Andrew M., Bose, Saideep, Smeds, Matthew, Liang, Patric, Schermerhorn, Marc, Conrad, Mark F., Hsu, Jeffrey H., Patel, Rhusheet, Lee, Jason T., Liapis, Christos D., Moulakakis, Konstantinos G., Farber, Mark A., Motta, Fernando, Ricco, Jean-Baptiste, Bath, Jonathan, Coselli, Joseph S., Aziz, Faisal, Coleman, Dawn M., Davis, Frank M., Fatima, Javairiah, Irshad, Ali, Shalhub, Sherene, Kakkos, Stavros, Zhang, Qianzi, Lawrence, Peter F., Woo, Karen, Chung, Jayer, Janko, Matthew R., Hubbard, Grant, Back, Martin, Shah, Samir K., Pomozi, Eniko, Szeberin, Zoltan, DeMartino, Randall, Wang, Linda J., Crofts, Sarah, Belkin, Michael, Davila, Victor J., Lemmon, Gary W., Wang, Shihuan K., Czerny, Martin, Kreibich, Maximilian, Humphries, Misty D., Shutze, William, Joh, Jin Hyun, Cho, Sungsin, Behrendt, Christian-Alexander, Setacci, Carlo, Hacker, Robert, I, Sobreira, Marcone Lima, Yoshida, Winston Bonetti, D'Oria, Mario, Lepidi, Sandro, Chiesa, Roberto, Kahlberg, Andrea, Go, Michael R., Rizzo, Anthony N., Black, James H., Magee, Gregory A., Elsayed, Ramsey, Baril, Donald T., Beck, Adam W., McFarland, Graeme E., Gavali, Hamid, Wanhainen, Anders, Kashyap, Vikram S., Stoecker, Jordan B., Wang, Grace J., Zhou, Wei, Fujimura, Naoki, Obara, Hideaki, Wishy, Andrew M., Bose, Saideep, Smeds, Matthew, Liang, Patric, Schermerhorn, Marc, Conrad, Mark F., Hsu, Jeffrey H., Patel, Rhusheet, Lee, Jason T., Liapis, Christos D., Moulakakis, Konstantinos G., Farber, Mark A., Motta, Fernando, Ricco, Jean-Baptiste, Bath, Jonathan, Coselli, Joseph S., Aziz, Faisal, Coleman, Dawn M., Davis, Frank M., Fatima, Javairiah, Irshad, Ali, Shalhub, Sherene, Kakkos, Stavros, Zhang, Qianzi, Lawrence, Peter F., Woo, Karen, and Chung, Jayer

Abstract

Objective: The optimal revascularization modality following complete resection of aortic graft infection (AGI) without enteric involvement remains unclear. The purpose of this investigation is to determine the revascularization approach associated with the lowest morbidity and mortality using real-world data in patients undergoing complete excision of AGI. Methods: A retrospective, multi-institutional study of AGI from 2002 to 2014 was performed using a standardized database. Baseline demographics, comorbidities, and perioperative variables were recorded. The primary outcome was infection-free survival. Descriptive statistics, Kaplan-Meier survival analysis, and univariate and multivariable analyses were performed. Results: A total of 241 patients at 34 institutions from seven countries presented with AGI during the study period (median age, 68 years; 75% male). The initial aortic procedures that resulted in AGI were 172 surgical grafts (71%), 66 endografts (27%), and three unknown (2%). Of the patients, 172 (71%) underwent complete excision of infected aortic graft material followed by in situ (in-line) bypass (ISB), including antibiotic-treated prosthetic graft (35%), autogenous femoral vein (neo-aortoiliac surgery) (24%), and cryopreserved allograft (41%). Sixty-nine patients (29%) underwent extra-anatomic bypass (EAB). Overall median Kaplan-Meier estimated survival was 5.8 years. Perioperative mortality was 16%. When stratified by ISB vs EAB, there was a significant difference in Kaplan-Meier estimated infection-free survival (2910 days; interquartile range, 391-3771 days vs 180 days; interquartile range, 27-3750 days; P <.001). There were otherwise no significant differences in presentation, comorbidities, or perioperative variables. Multivariable Cox regression showed lower infection-free survival among patients with EAB (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.6-3.6; P <.001), polymicrobial infection (HR, 2.2; 95% CI, 1.4-3.5; P = .001)

Published
2022
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3. Improvised Field Expedient Method for Renal Replacement Therapy in a Porcine Model of Acute Kidney Injury.

Author

Hoareau, Guillaume L., Beyer, Carl A., Kashtan, Harris W., Walker, Lauren E., Wilson, Christopher, Wishy, Andrew, Grayson, J. Kevin, and Stewart, Ian J.

Subjects
RENAL replacement therapy, ACUTE kidney failure, DISASTER medicine
Abstract

Objective: Dialysis patients may not have access to conventional renal replacement therapy (RRT) following disasters. We hypothesized that improvised renal replacement therapy (ImpRRT) would be comparable to continuous renal replacement therapy (CRRT) in a porcine acute kidney injury model. Methods: Following bilateral nephrectomies and 2 hours of caudal aortic occlusion, 12 pigs were randomized to 4 hours of ImpRRT or CRRT. In the ImpRRT group, blood was circulated through a dialysis filter using a rapid infuser to collect the ultrafiltrate. Improvised replacement fluid, made with stock solutions, was infused pre-pump. In the CRRT group, commercial replacement fluid was used. During RRT, animals received isotonic crystalloids and norepinephrine. Results: There were no differences in serum creatinine, calcium, magnesium, or phosphorus concentrations. While there was a difference between groups in serum potassium concentration over time (P < 0.001), significance was lost in pairwise comparison at specific time points. Replacement fluids or ultrafiltrate flows did not differ between groups. There were no differences in lactate concentration, isotonic crystalloid requirement, or norepinephrine doses. No difference was found in electrolyte concentrations between the commercial and improvised replacement solutions. Conclusion: The ImpRRT system achieved similar performance to CRRT and may represent a potential option for temporary RRT following disasters. [ABSTRACT FROM AUTHOR]

Published
2021
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