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5. Induced CD8[alpha] identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation

Author

Cubitt, Celia C., Wong, Pamela, Dorando, Hannah K., Foltz, Jennifer A., Tran, Jennifer, Marsala, Lynne, Marin, Nancy D., Foster, Mark, Schappe, Timothy, Fatima, Hijab, Becker-Hapak, Michelle, Zhou, Alice Y., Hwang, Kimberly, Jacobs, Miriam T., Russler-Germain, David A., Mace, Emily M., Berrien-Elliott, Melissa M., Payton, Jacqueline E., and Fehniger, Todd A.

Subjects
CD8 lymphocytes -- Influence -- Physiological aspects, Killer cells -- Identification and classification -- Growth -- Control, Company growth, Health care industry
Abstract

The surface receptor CD8[alpha] is present on 20%-80% of human (but not mouse) NK cells, yet its function on NK cells remains poorly understood. CD8[alpha] expression on donor NK cells was associated with a lack of therapeutic responses in patients with leukemia in prior studies, thus, we hypothesized that CD8[alpha] may affect critical NK cell functions. Here, we discovered that CD8[[alpha].sup.-] NK cells had improved control of leukemia in xenograft models compared with CD8[[alpha].sup.+] NK cells, likely due to an enhanced capacity for proliferation. Unexpectedly, we found that CD8[alpha] expression was induced on approximately 30% of previously CD8[[alpha].sup.- ] NK cells following IL-15 stimulation. These induced CD8[[alpha].sup.+] (iCD8[[alpha].sup.+]) NK cells had the greatest proliferation, responses to IL-15 signaling, and metabolic activity compared with those that sustained existing CD8[alpha] expression (sustained CD8[[alpha].sup.+]) or those that remained CD8[[alpha].sup.-] (persistent CD8[alpha]). These iCD8[[alpha].sup.+] cells originated from an IL- 15R[[beta].sup.hi] NK cell population, with CD8[alpha] expression dependent on the transcription factor RUNX3. Moreover, CD8A CRISPR/Cas9 deletion resulted in enhanced responses through the activating receptor NKp30, possibly by modulating KIR inhibitory function. Thus, CD8[alpha] status identified human NK cell capacity for IL-15-induced proliferation and metabolism in a time-dependent fashion, and its presence had a suppressive effect on NK cell-activating receptors., Introduction NK cells are innate lymphoid cells that protect the host from infection and malignant transformation through direct cytotoxicity and communication via cytokine and chemokine production (1-3). Human NK cells [...]

Published
2024
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17. MicroRNA‐146a deficiency enhances host protection against murine cytomegalovirus.

Author

Wong, Pamela, Leong, Jeffrey W., Sohn, Hyogon, Chang, Lily, Keppel, Catherine R., Neal, Carly C., Cubitt, Celia C., Yao, Tony, Keppel, Molly P., Tran, Jennifer, Burdi, Allison, Hwang, Kimberly, Fogel, Leslie A., Schappe, Timothy, Marsala, Lynne, Berrien‐Elliott, Melissa M., Wagner, Julia A., Schneider, Stephanie E., Sullivan, Ryan P., and Pingel, Jeanette T.

Subjects
INNATE lymphoid cells, KILLER cells, LIVER cells, T cells, BONE marrow
Abstract

Natural killer (NK) cells are innate lymphoid cells that protect a host from viral infections and malignancies. MicroRNA‐146a (miR‐146a) is an important regulator of immune function that is highly expressed in NK cells and is further upregulated during murine cytomegalovirus (MCMV) infection. Here we utilized mice with a global targeted deletion of miR‐146a to understand its impact on the innate immune responses to MCMV infection. MiR‐146a−/− mice were protected from lethal MCMV infection, which was intrinsic to the hematopoietic compartment based on bone marrow chimera experiments. NK cell depletion abrogated this protection, implicating NK cells as critical for the miR‐146a−/− protection from MCMV. Surprisingly, NK cells from miR‐146a‐deficient mice were largely similar to control NK cells with respect to development, maturation, trafficking, and effector functions. However, miR‐146a−/− mice had increased NK cell numbers and frequency of the most mature Stage IV (CD27−CD11b+) NK cells in the liver at baseline, enhanced STAT1 phosphorylation, and increased selective expansion of Ly49H+ NK cells and T cells during MCMV infection. This study demonstrates a critical role for miR‐146a in the host response to MCMV, arising from mechanisms that include increased NK cell numbers and early T‐cell expansion. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Memory-like differentiation enhances NK cell responses against colorectal cancer.

Author

Marin, Nancy D., Becker-Hapak, Michelle, Song, Wilbur M., Alayo, Quazim A., Marsala, Lynne, Sonnek, Naomi, Berrien-Elliott, Melissa M., Foster, Mark, Foltz, Jennifer A., Tran, Jennifer, Wong, Pamela, Cubitt, Celia C., Pence, Patrick, Hwang, Kimberly, Zhou, Alice Y., Jacobs, Miriam T., Schappe, Timothy, Russler-Germain, David A., Fields, Ryan C., and Ciorba, Matthew A.

Subjects
INNATE lymphoid cells, KILLER cells, CELL physiology, IMMUNE checkpoint proteins, INCURABLE diseases
Abstract

Metastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade (ICB)-based immunotherapy is effective for mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) mCRC patients, but it does not benefit the majority of mCRC patients. NK cells are innate lymphoid cells with potent effector responses against a variety of tumor cells but are frequently dysfunctional in cancer patients. Memory-like (ML) NK cells differentiated after IL-12/IL-15/IL-18 activation overcome many challenges to effective NK cell anti-tumor responses, exhibiting enhanced recognition, function, and in vivo persistence. We hypothesized that ML differentiation enhances the NK cell responses to CRC. Compared to conventional (c) NK cells, ML NK cells displayed increased IFN-γ production against both CRC cell lines and primary patient-derived CRC spheroids. ML NK cells also exhibited improved killing of CRC target cells in vitro in short-term and sustained cytotoxicity assays, as well as in vivo in NSG mice. Mechanistically, enhanced ML NK cell responses were dependent on the activating receptor NKG2D as its blockade significantly decreased ML NK cell functions. Compared to cNK cells, ML NK cells exhibited greater antibody-dependent cytotoxicity when targeted against CRC by cetuximab. ML NK cells from healthy donors and mCRC patients exhibited increased anti-CRC responses. Collectively, our findings demonstrate that ML NK cells exhibit enhanced responses against CRC targets, warranting further investigation in clinical trials for mCRC patients, including those who have failed ICB. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant

Author

Bednarski, Jeffrey J., Zimmerman, Clare, Berrien-Elliott, Melissa M., Foltz, Jennifer A., Becker-Hapak, Michelle, Neal, Carly C., Foster, Mark, Schappe, Timothy, McClain, Ethan, Pence, Patrick P., Desai, Sweta, Kersting-Schadek, Samantha, Wong, Pamela, Russler-Germain, David A., Fisk, Bryan, Lie, Wen-Rong, Eisele, Jeremy, Hyde, Stephanie, Bhatt, Sima T., Griffith, Obi L., Griffith, Malachi, Petti, Allegra A., Cashen, Amanda F., and Fehniger, Todd A.

Published
2022
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21. Urban chaos memory

Author

Wong, Pamela, Yeng, Tong Tung, and Li, Catherine

Published
2023

23. T-BET and EOMES sustain mature human NK cell identity and antitumor function

Author

Wong, Pamela, Foltz, Jennifer A., Chang, Lily, Neal, Carly C., Yao, Tony, Cubit, Celia C., Tran, Jennifer, Kersting-Schadek, Samantha, Palakurty, Sathvik, Jaeger, Natalia, Russler-Germain, David A., Marin, Nancy D., Gang, Margery, Wagner, Julia A., Zhou, Alice Y., Jacobs, Miriam T., Foster, Mark, Schappe, Timothy, Marsala, Lynne, McClain, Ethan, Pence, Patrick, Becker-Hapak, Michelle, Fisk, Bryan, Petti, Allegra A., Griffith, Obi L., Griffith, Malachi, Berrien-Elliot, Melissa M., and Fehniger, Todd A.

Subjects
Immune response -- Health aspects -- Physiological aspects, Killer cells -- Genetic aspects -- Physiological aspects -- Health aspects, Transcription factors -- Physiological aspects -- Health aspects, Health care industry
Abstract

Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear. To address this, T-BET and EOMES were deleted in unexpanded primary human NK cells using CRISPR/Cas9. Deleting these TFs compromised in vivo antitumor response of human NK cells. Mechanistically, T-BET and EOMES were required for normal NK cell proliferation and persistence in vivo. NK cells lacking T-BET and EOMES also exhibited defective responses to cytokine stimulation. Singlecell RNA-Seq revealed a specific T-box transcriptional program in human NK cells, which was rapidly lost following T-BET and EOMES deletion. Further, T-BET- and EOMES-deleted [CD56.sup.bright] NK cells acquired an innate lymphoid cell precursor-like (ILCP-like) profile with increased expression of the ILC-3-associated TFs RORCand AHR, revealing a role for T-box TFs in maintaining mature NK cell phenotypes and an unexpected role of suppressing alternative ILC lineages. Our study reveals the critical importance of sustained EOMES and T-BET expression to orchestrate mature NK cell function and identity., Introduction Natural killer (NK) cells are innate lymphoid cells important for responses against pathogens and malignant cells. They direct the immune response through production of cytokines and directly kill diseased [...]

Published
2023
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25. Enhanced mucosal B- and T-cell responses against SARS-CoV-2 after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant.

Author

Laghlali, Gabriel, primary, Wiest, Matthew J, additional, Karada, Dilara, additional, Warang, Prajakta, additional, O'Konek, Jessica J, additional, Chang, Lauren A, additional, Park, Seokchan, additional, Farazuddin, Mohammad, additional, Landers, Jeffrey J, additional, Janczak, Katarzyna W, additional, Garcia-Sastre, Adolfo, additional, Baker, James R, additional, Wong, Pamela Tinmoi, additional, and Schotsaert, Michael, additional

Published
2024
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26. Donor-Derived Memory-like NK Cells for the Treatment of Children and Young Adults with Relapsed AML Following Allo-HCT

Author

Pfeiffer, Thomas, primary, Zimmerman, Clare, additional, Berrien-Elliott, Melissa M, additional, Foltz, Jennifer, additional, Becker-Hapak, Michelle, additional, Neal, Carly, additional, Foster, Mark, additional, Schappe, Timothy, additional, McClain, Ethan, additional, Pence, Patrick, additional, Desai, Sweta, additional, Wong, Pamela, additional, Russler-Germain, David, additional, Fisk, Bryan, additional, Wen-Rong, Lie, additional, Eisele, Jeremy, additional, Hyde, Stephanie, additional, Bhatt, Sima, additional, Griffith, Obi, additional, Griffith, Malachi, additional, Rueve, Joseph, additional, Pureti, Sushanth, additional, Cashen, Amanda, additional, Bednarski, Jeffrey J, additional, and Fehniger, Todd A, additional

Published
2024
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27. Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation.

Author

Foltz, Jennifer A., Tran, Jennifer, Wong, Pamela, Fan, Changxu, Schmidt, Evelyn, Fisk, Bryan, Becker-Hapak, Michelle, Russler-Germain, David A., Johnson, Jeanette, Marin, Nancy D., Cubitt, Celia C., Pence, Patrick, Rueve, Joseph, Pureti, Sushanth, Hwang, Kimberly, Gao, Feng, Zhou, Alice Y., Foster, Mark, Schappe, Timothy, and Marsala, Lynne

Subjects
KILLER cells, GENETIC transcription regulation, EPIGENETICS, CYTOKINES, INTERLEUKIN-12
Abstract

Activation of natural killer (NK) cells with the cytokines interleukin-12 (IL-12), IL-15, and IL-18 induces their differentiation into memory-like (ML) NK cells; however, the underlying epigenetic and transcriptional mechanisms are unclear. By combining ATAC-seq, CITE-seq, and functional analyses, we discovered that IL-12/15/18 activation results in two main human NK fates: reprogramming into enriched memory-like (eML) NK cells or priming into effector conventional NK (effcNK) cells. eML NK cells had distinct transcriptional and epigenetic profiles and enhanced function, whereas effcNK cells resembled cytokine-primed cNK cells. Two transcriptionally discrete subsets of eML NK cells were also identified, eML-1 and eML-2, primarily arising from CD56bright or CD56dim mature NK cell subsets, respectively. Furthermore, these eML subsets were evident weeks after transfer of IL-12/15/18–activated NK cells into patients with cancer. Our findings demonstrate that NK cell activation with IL-12/15/18 results in previously unappreciated diverse cellular fates and identifies new strategies to enhance NK therapies. Editor's summary: Cytokine-induced memory-like (ML) natural killer (NK) cells are an attractive candidate for NK-based immunotherapies. To determine how cytokine stimulation epigenetically and transcriptionally regulates ML NK differentiation, Foltz et al. used multiomics to study interleukin-12/15/18–activated human NK cells. They identified a subset of enriched memory-like (eML) NK cells with unique epigenetic and transcriptional profiles and enhanced function. eML NK cells were composed of two transcriptionally distinct subsets, eML-1 and eML-2, that had unique features and origins. Furthermore, eML-1 and eML-2 populations were detected in patients with leukemia receiving ML NK cell therapy. These findings shed light on the molecular mechanisms governing cytokine-induced NK memory and may help to inform NK-based immunotherapies. —Hannah Isles [ABSTRACT FROM AUTHOR]

Published
2024
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28. Supplementary Figure S7 from Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer

Author

Jacobs, Miriam T., primary, Wong, Pamela, primary, Zhou, Alice Y., primary, Becker-Hapak, Michelle, primary, Marin, Nancy D., primary, Marsala, Lynne, primary, Foster, Mark, primary, Foltz, Jennifer A., primary, Cubitt, Celia C., primary, Tran, Jennifer, primary, Russler-Germain, David A., primary, Neal, Carly, primary, Kersting-Schadek, Samantha, primary, Chang, Lily, primary, Schappe, Timothy, primary, Pence, Patrick, primary, McClain, Ethan, primary, Zevallos, Jose P., primary, Rich, Jason T., primary, Paniello, Randal C., primary, Jackson, Ryan S., primary, Pipkorn, Patrik, primary, Adkins, Douglas R., primary, DeSelm, Carl J., primary, Berrien-Elliott, Melissa M., primary, Puram, Sidharth V., primary, and Fehniger, Todd A., primary

Published
2023
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29. Data from Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer

Author

Jacobs, Miriam T., primary, Wong, Pamela, primary, Zhou, Alice Y., primary, Becker-Hapak, Michelle, primary, Marin, Nancy D., primary, Marsala, Lynne, primary, Foster, Mark, primary, Foltz, Jennifer A., primary, Cubitt, Celia C., primary, Tran, Jennifer, primary, Russler-Germain, David A., primary, Neal, Carly, primary, Kersting-Schadek, Samantha, primary, Chang, Lily, primary, Schappe, Timothy, primary, Pence, Patrick, primary, McClain, Ethan, primary, Zevallos, Jose P., primary, Rich, Jason T., primary, Paniello, Randal C., primary, Jackson, Ryan S., primary, Pipkorn, Patrik, primary, Adkins, Douglas R., primary, DeSelm, Carl J., primary, Berrien-Elliott, Melissa M., primary, Puram, Sidharth V., primary, and Fehniger, Todd A., primary

Published
2023
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30. Supplementary Table S1 from Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer

Author

Jacobs, Miriam T., primary, Wong, Pamela, primary, Zhou, Alice Y., primary, Becker-Hapak, Michelle, primary, Marin, Nancy D., primary, Marsala, Lynne, primary, Foster, Mark, primary, Foltz, Jennifer A., primary, Cubitt, Celia C., primary, Tran, Jennifer, primary, Russler-Germain, David A., primary, Neal, Carly, primary, Kersting-Schadek, Samantha, primary, Chang, Lily, primary, Schappe, Timothy, primary, Pence, Patrick, primary, McClain, Ethan, primary, Zevallos, Jose P., primary, Rich, Jason T., primary, Paniello, Randal C., primary, Jackson, Ryan S., primary, Pipkorn, Patrik, primary, Adkins, Douglas R., primary, DeSelm, Carl J., primary, Berrien-Elliott, Melissa M., primary, Puram, Sidharth V., primary, and Fehniger, Todd A., primary

Published
2023
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31. Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer

Author

Jacobs, Miriam T., primary, Wong, Pamela, additional, Zhou, Alice Y., additional, Becker-Hapak, Michelle, additional, Marin, Nancy D., additional, Marsala, Lynne, additional, Foster, Mark, additional, Foltz, Jennifer A., additional, Cubitt, Celia C., additional, Tran, Jennifer, additional, Russler-Germain, David A., additional, Neal, Carly, additional, Kersting-Schadek, Samantha, additional, Chang, Lily, additional, Schappe, Timothy, additional, Pence, Patrick, additional, McClain, Ethan, additional, Zevallos, Jose P., additional, Rich, Jason T., additional, Paniello, Randal C., additional, Jackson, Ryan S., additional, Pipkorn, Patrik, additional, Adkins, Douglas R., additional, DeSelm, Carl J., additional, Berrien-Elliott, Melissa M., additional, Puram, Sidharth V., additional, and Fehniger, Todd A., additional

Published
2023
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32. Gender Affirming Hormones Do Not Affect the Exposure and Efficacy of F/TDF or F/TAF for HIV Preexposure Prophylaxis: A Subgroup Analysis from the DISCOVER Trial.

Author

Cespedes, Michelle S., Das, Moupali, Yager, Jenna, Prins, Maria, Krznaric, Ivanka, de Jong, Jan, Xiao, Deqing, Shao, Yongwu, Wong, Pamela, Kintu, Alexander, Carter, Christoph, Hoornenborg, Elske, Ruane, Peter, Phoenix, John, Younis, Islam, and Halperin, Jason

Subjects
HIV infections, STATISTICS, RESEARCH, GENDER affirming care, HORMONE therapy, MONONUCLEAR leukocytes, TRANS women, BLACK people, HISPANIC Americans, PRE-exposure prophylaxis, TREATMENT effectiveness, COMPARATIVE studies, EMTRICITABINE-tenofovir, DRUG interactions, MEN who have sex with men, DATA analysis, WHITE people, NUCLEOSIDE reverse transcriptase inhibitors, CISGENDER people, METABOLITES, EVALUATION
Abstract

Purpose: Transgender women are disproportionately affected by HIV and are underutilizing preexposure prophylaxis (PrEP). The lower uptake of PrEP by transgender women may be, in part, owing to the perception that taking PrEP may lower the efficacy of gender-affirming hormone therapy (GAHT) or to provider concerns that GAHT may lower the efficacy of PrEP. Methods: DISCOVER was a randomized, double-blind, noninferiority trial comparing emtricitabine (FTC, F) and tenofovir alafenamide (F/TAF) versus emtricitabine and tenofovir disoproxil fumarate (F/TDF) as PrEP among transgender women and cisgender men who have sex with men (MSM). This nested substudy of the DISCOVER trial compared the exposure of the active intracellular metabolites of FTC and tenofovir (TFV), FTC triphosphate (FTC-TP) and TFV diphosphate (TFV-DP), in peripheral blood mononuclear cells (PBMC) among transgender women receiving GAHT versus MSM within the F/TAF and F/TDF groups. Results: Our results demonstrate that TFV-DP and FTC-TP levels in PBMC were comparable between transgender women on GAHT and MSM receiving F/TAF, and between transgender women on GAHT and MSM receiving F/TDF. TFV-DP concentrations remained above the EC90 of 40 fmol/106 cells across all groups. No clinically significant drug–drug interactions of GAHT were observed with either F/TAF or F/TDF in this subanalysis. Conclusions: These findings are consistent with the clinical pharmacology of GAHT, FTC, TDF, and TAF reported in previous studies, and support the continued use of F/TAF and F/TDF for PrEP in transgender women. Clinicaltrials.gov registration number: NCT02842086. [ABSTRACT FROM AUTHOR]

Published
2024
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33. A rationally designed combined intranasal adjuvant drives robust and broad humoral, cellular, and mucosal immune responses to SARS-CoV-2

Author

Wong, Pamela T, primary, Jangra, Sonia, additional, Landers, Jeffrey J, additional, Laghlali, Gabriel, additional, Rathnasinghe, Raveen, additional, O’Konek, Jessica J, additional, Janczak, Katarzyna W, additional, Garcia-Sastre, Adolfo, additional, Baker, James R, additional, and Schotsaert, Michael, additional

Published
2023
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34. Brief IL-12, IL-15, IL-18 activation drives the acquisition of two distinct memory-like NK cell states

Author

Foltz, Jennifer Ann, primary, Tran, Jennifer, additional, Fisk, Bryan, additional, Wong, Pamela, additional, Khan, Saad M., additional, Berrien-Elliott, Melissa M., additional, Becker-Hapak, Michelle, additional, Russler-Germain, David A., additional, Marsala, Lynne, additional, Bednarski, Jeffrey J., additional, Zimmerman, Clare, additional, Cubitt, Celia C., additional, Marin, Nancy D., additional, Zhou, Alice Y., additional, Jacobs, Miriam T., additional, Foster, Mark, additional, Schappe, Timothy, additional, Pence, Patrick, additional, Cashen, Amanda, additional, Griffith, Obi L., additional, Griffith, Malachi, additional, Petti, Allegra A., additional, and Fehniger, Todd A, additional

Published
2023
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35. Combined IL-12, IL-15 and IL-18 activation induces epigenetic changes in human NK cells during the memory-like state transition

Author

Tran, Jennifer, primary, Wong, Pamela, additional, Fan, Changxu, additional, Russler-Germain, David, additional, Cubitt, Celia C, additional, Marin, Nancy D, additional, Schappe, Timothy, additional, Berrien-Elliott, Melissa, additional, Wang, Ting, additional, Foltz, Jennifer A, additional, and Fehniger, Todd A, additional

Published
2023
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38. Supplementary Table 5 from A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Author

Becker-Hapak, Michelle K., primary, Shrestha, Niraj, primary, McClain, Ethan, primary, Dee, Michael J., primary, Chaturvedi, Pallavi, primary, Leclerc, Gilles M., primary, Marsala, Lynne I., primary, Foster, Mark, primary, Schappe, Timothy, primary, Tran, Jennifer, primary, Desai, Sweta, primary, Neal, Carly C., primary, Pence, Patrick, primary, Wong, Pamela, primary, Wagner, Julia A., primary, Russler-Germain, David A., primary, Zhu, Xiaoyun, primary, Spanoudis, Catherine M., primary, Gallo, Victor L., primary, Echeverri, Christian A., primary, Ramirez, Laritza L., primary, You, Lijing, primary, Egan, Jack O., primary, Rhode, Peter R., primary, Jiao, Jin-an, primary, Muniz, Gabriela J., primary, Jeng, Emily K., primary, Prendes, Caitlin A., primary, Sullivan, Ryan P., primary, Berrien-Elliott, Melissa M., primary, Wong, Hing C., primary, and Fehniger, Todd A., primary

Published
2023
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39. Abstract 893: Memory like differentiation enhances in vitro and in vivo NK cell responses against colorectal cancer

Author

Marin, Nancy D., primary, Becker-Hapak, Michelle, additional, Alayo, Quazim A., additional, Berrien-Elliot, Melissa, additional, Marsala, Lynne, additional, Sonnek, Naomi, additional, Jacobs, Miriam T., additional, Foltz, Jennifer A., additional, Zhou, Alice, additional, Tran, Jennifer, additional, Wong, Pamela, additional, Cubit, Celia, additional, Hwang, Kimberly, additional, Schappe, Timothy, additional, Fields, Ryan C., additional, Ciorba, Matthew A., additional, and Fehniger, Todd A., additional

Published
2023
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40. Data from A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Author

Becker-Hapak, Michelle K., primary, Shrestha, Niraj, primary, McClain, Ethan, primary, Dee, Michael J., primary, Chaturvedi, Pallavi, primary, Leclerc, Gilles M., primary, Marsala, Lynne I., primary, Foster, Mark, primary, Schappe, Timothy, primary, Tran, Jennifer, primary, Desai, Sweta, primary, Neal, Carly C., primary, Pence, Patrick, primary, Wong, Pamela, primary, Wagner, Julia A., primary, Russler-Germain, David A., primary, Zhu, Xiaoyun, primary, Spanoudis, Catherine M., primary, Gallo, Victor L., primary, Echeverri, Christian A., primary, Ramirez, Laritza L., primary, You, Lijing, primary, Egan, Jack O., primary, Rhode, Peter R., primary, Jiao, Jin-an, primary, Muniz, Gabriela J., primary, Jeng, Emily K., primary, Prendes, Caitlin A., primary, Sullivan, Ryan P., primary, Berrien-Elliott, Melissa M., primary, Wong, Hing C., primary, and Fehniger, Todd A., primary

Published
2023
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41. Supplementary Figure Legends from A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Author

Becker-Hapak, Michelle K., primary, Shrestha, Niraj, primary, McClain, Ethan, primary, Dee, Michael J., primary, Chaturvedi, Pallavi, primary, Leclerc, Gilles M., primary, Marsala, Lynne I., primary, Foster, Mark, primary, Schappe, Timothy, primary, Tran, Jennifer, primary, Desai, Sweta, primary, Neal, Carly C., primary, Pence, Patrick, primary, Wong, Pamela, primary, Wagner, Julia A., primary, Russler-Germain, David A., primary, Zhu, Xiaoyun, primary, Spanoudis, Catherine M., primary, Gallo, Victor L., primary, Echeverri, Christian A., primary, Ramirez, Laritza L., primary, You, Lijing, primary, Egan, Jack O., primary, Rhode, Peter R., primary, Jiao, Jin-an, primary, Muniz, Gabriela J., primary, Jeng, Emily K., primary, Prendes, Caitlin A., primary, Sullivan, Ryan P., primary, Berrien-Elliott, Melissa M., primary, Wong, Hing C., primary, and Fehniger, Todd A., primary

Published
2023
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42. Supplementary Table 4 from A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Author

Becker-Hapak, Michelle K., primary, Shrestha, Niraj, primary, McClain, Ethan, primary, Dee, Michael J., primary, Chaturvedi, Pallavi, primary, Leclerc, Gilles M., primary, Marsala, Lynne I., primary, Foster, Mark, primary, Schappe, Timothy, primary, Tran, Jennifer, primary, Desai, Sweta, primary, Neal, Carly C., primary, Pence, Patrick, primary, Wong, Pamela, primary, Wagner, Julia A., primary, Russler-Germain, David A., primary, Zhu, Xiaoyun, primary, Spanoudis, Catherine M., primary, Gallo, Victor L., primary, Echeverri, Christian A., primary, Ramirez, Laritza L., primary, You, Lijing, primary, Egan, Jack O., primary, Rhode, Peter R., primary, Jiao, Jin-an, primary, Muniz, Gabriela J., primary, Jeng, Emily K., primary, Prendes, Caitlin A., primary, Sullivan, Ryan P., primary, Berrien-Elliott, Melissa M., primary, Wong, Hing C., primary, and Fehniger, Todd A., primary

Published
2023
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43. Supplementary Figures 1-8 and Tables 1-3 from A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Author

Becker-Hapak, Michelle K., primary, Shrestha, Niraj, primary, McClain, Ethan, primary, Dee, Michael J., primary, Chaturvedi, Pallavi, primary, Leclerc, Gilles M., primary, Marsala, Lynne I., primary, Foster, Mark, primary, Schappe, Timothy, primary, Tran, Jennifer, primary, Desai, Sweta, primary, Neal, Carly C., primary, Pence, Patrick, primary, Wong, Pamela, primary, Wagner, Julia A., primary, Russler-Germain, David A., primary, Zhu, Xiaoyun, primary, Spanoudis, Catherine M., primary, Gallo, Victor L., primary, Echeverri, Christian A., primary, Ramirez, Laritza L., primary, You, Lijing, primary, Egan, Jack O., primary, Rhode, Peter R., primary, Jiao, Jin-an, primary, Muniz, Gabriela J., primary, Jeng, Emily K., primary, Prendes, Caitlin A., primary, Sullivan, Ryan P., primary, Berrien-Elliott, Melissa M., primary, Wong, Hing C., primary, and Fehniger, Todd A., primary

Published
2023
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44. Data from Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

Author

Berrien-Elliott, Melissa M., primary, Cashen, Amanda F., primary, Cubitt, Celia C., primary, Neal, Carly C., primary, Wong, Pamela, primary, Wagner, Julia A., primary, Foster, Mark, primary, Schappe, Timothy, primary, Desai, Sweta, primary, McClain, Ethan, primary, Becker-Hapak, Michelle, primary, Foltz, Jennifer A., primary, Cooper, Matthew L., primary, Jaeger, Natalia, primary, Srivatsan, Sridhar Nonavinkere, primary, Gao, Feng, primary, Romee, Rizwan, primary, Abboud, Camille N., primary, Uy, Geoffrey L., primary, Westervelt, Peter, primary, Jacoby, Meagan A., primary, Pusic, Iskra, primary, Stockerl-Goldstein, Keith E., primary, Schroeder, Mark A., primary, DiPersio, John, primary, and Fehniger, Todd A., primary

Published
2023
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45. Supplementary Tables from Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

Author

Berrien-Elliott, Melissa M., primary, Cashen, Amanda F., primary, Cubitt, Celia C., primary, Neal, Carly C., primary, Wong, Pamela, primary, Wagner, Julia A., primary, Foster, Mark, primary, Schappe, Timothy, primary, Desai, Sweta, primary, McClain, Ethan, primary, Becker-Hapak, Michelle, primary, Foltz, Jennifer A., primary, Cooper, Matthew L., primary, Jaeger, Natalia, primary, Srivatsan, Sridhar Nonavinkere, primary, Gao, Feng, primary, Romee, Rizwan, primary, Abboud, Camille N., primary, Uy, Geoffrey L., primary, Westervelt, Peter, primary, Jacoby, Meagan A., primary, Pusic, Iskra, primary, Stockerl-Goldstein, Keith E., primary, Schroeder, Mark A., primary, DiPersio, John, primary, and Fehniger, Todd A., primary

Published
2023
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46. Supplementary Methods from Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

Author

Berrien-Elliott, Melissa M., primary, Cashen, Amanda F., primary, Cubitt, Celia C., primary, Neal, Carly C., primary, Wong, Pamela, primary, Wagner, Julia A., primary, Foster, Mark, primary, Schappe, Timothy, primary, Desai, Sweta, primary, McClain, Ethan, primary, Becker-Hapak, Michelle, primary, Foltz, Jennifer A., primary, Cooper, Matthew L., primary, Jaeger, Natalia, primary, Srivatsan, Sridhar Nonavinkere, primary, Gao, Feng, primary, Romee, Rizwan, primary, Abboud, Camille N., primary, Uy, Geoffrey L., primary, Westervelt, Peter, primary, Jacoby, Meagan A., primary, Pusic, Iskra, primary, Stockerl-Goldstein, Keith E., primary, Schroeder, Mark A., primary, DiPersio, John, primary, and Fehniger, Todd A., primary

Published
2023
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47. Supplementary Figures from Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

Author

Berrien-Elliott, Melissa M., primary, Cashen, Amanda F., primary, Cubitt, Celia C., primary, Neal, Carly C., primary, Wong, Pamela, primary, Wagner, Julia A., primary, Foster, Mark, primary, Schappe, Timothy, primary, Desai, Sweta, primary, McClain, Ethan, primary, Becker-Hapak, Michelle, primary, Foltz, Jennifer A., primary, Cooper, Matthew L., primary, Jaeger, Natalia, primary, Srivatsan, Sridhar Nonavinkere, primary, Gao, Feng, primary, Romee, Rizwan, primary, Abboud, Camille N., primary, Uy, Geoffrey L., primary, Westervelt, Peter, primary, Jacoby, Meagan A., primary, Pusic, Iskra, primary, Stockerl-Goldstein, Keith E., primary, Schroeder, Mark A., primary, DiPersio, John, primary, and Fehniger, Todd A., primary

Published
2023
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48. Supplementary Figure S4 from Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood–Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies

Author

Kerbauy, Lucila N., primary, Marin, Nancy D., primary, Kaplan, Mecit, primary, Banerjee, Pinaki P., primary, Berrien-Elliott, Melissa M., primary, Becker-Hapak, Michelle, primary, Basar, Rafet, primary, Foster, Mark, primary, Garcia Melo, Luciana, primary, Neal, Carly C., primary, McClain, Ethan, primary, Daher, May, primary, Nunez Cortes, Ana Karen, primary, Desai, Sweta, primary, Inng Lim, Francesca Wei, primary, Mendt, Mayela Carolina, primary, Schappe, Timothy, primary, Li, Li, primary, Shaim, Hila, primary, Shanley, Mayra, primary, Ensley, Emily L., primary, Uprety, Nadima, primary, Wong, Pamela, primary, Liu, Enli, primary, Ang, Sonny O., primary, Cai, Rong, primary, Nandivada, Vandana, primary, Mohanty, Vakul, primary, Miao, Qi, primary, Shen, Yifei, primary, Baran, Natalia, primary, Fowlkes, Natalie W., primary, Chen, Ken, primary, Muniz-Feliciano, Luis, primary, Champlin, Richard E., primary, Nieto, Yago L., primary, Koch, Joachim, primary, Treder, Martin, primary, Fischer, Wolfgang, primary, Okamoto, Oswaldo Keith, primary, Shpall, Elizabeth J., primary, Fehniger, Todd A., primary, and Rezvani, Katayoun, primary

Published
2023
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49. Supplementary Table S2 from Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood–Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies

Author

Kerbauy, Lucila N., primary, Marin, Nancy D., primary, Kaplan, Mecit, primary, Banerjee, Pinaki P., primary, Berrien-Elliott, Melissa M., primary, Becker-Hapak, Michelle, primary, Basar, Rafet, primary, Foster, Mark, primary, Garcia Melo, Luciana, primary, Neal, Carly C., primary, McClain, Ethan, primary, Daher, May, primary, Nunez Cortes, Ana Karen, primary, Desai, Sweta, primary, Inng Lim, Francesca Wei, primary, Mendt, Mayela Carolina, primary, Schappe, Timothy, primary, Li, Li, primary, Shaim, Hila, primary, Shanley, Mayra, primary, Ensley, Emily L., primary, Uprety, Nadima, primary, Wong, Pamela, primary, Liu, Enli, primary, Ang, Sonny O., primary, Cai, Rong, primary, Nandivada, Vandana, primary, Mohanty, Vakul, primary, Miao, Qi, primary, Shen, Yifei, primary, Baran, Natalia, primary, Fowlkes, Natalie W., primary, Chen, Ken, primary, Muniz-Feliciano, Luis, primary, Champlin, Richard E., primary, Nieto, Yago L., primary, Koch, Joachim, primary, Treder, Martin, primary, Fischer, Wolfgang, primary, Okamoto, Oswaldo Keith, primary, Shpall, Elizabeth J., primary, Fehniger, Todd A., primary, and Rezvani, Katayoun, primary

Published
2023
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50. Supplementary Materials and Methods from Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood–Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies

Author

Kerbauy, Lucila N., primary, Marin, Nancy D., primary, Kaplan, Mecit, primary, Banerjee, Pinaki P., primary, Berrien-Elliott, Melissa M., primary, Becker-Hapak, Michelle, primary, Basar, Rafet, primary, Foster, Mark, primary, Garcia Melo, Luciana, primary, Neal, Carly C., primary, McClain, Ethan, primary, Daher, May, primary, Nunez Cortes, Ana Karen, primary, Desai, Sweta, primary, Inng Lim, Francesca Wei, primary, Mendt, Mayela Carolina, primary, Schappe, Timothy, primary, Li, Li, primary, Shaim, Hila, primary, Shanley, Mayra, primary, Ensley, Emily L., primary, Uprety, Nadima, primary, Wong, Pamela, primary, Liu, Enli, primary, Ang, Sonny O., primary, Cai, Rong, primary, Nandivada, Vandana, primary, Mohanty, Vakul, primary, Miao, Qi, primary, Shen, Yifei, primary, Baran, Natalia, primary, Fowlkes, Natalie W., primary, Chen, Ken, primary, Muniz-Feliciano, Luis, primary, Champlin, Richard E., primary, Nieto, Yago L., primary, Koch, Joachim, primary, Treder, Martin, primary, Fischer, Wolfgang, primary, Okamoto, Oswaldo Keith, primary, Shpall, Elizabeth J., primary, Fehniger, Todd A., primary, and Rezvani, Katayoun, primary

Published
2023
Full Text
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