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Your search keyword '"Wong, Vincent Kam Wai"' showing total 185 results
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185 results on '"Wong, Vincent Kam Wai"'

6. Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis

Author

Luo, Wei-Dan, Wang, Yu-Ping, Lv, Jun, Liu, Yong, Qu, Yuan-Qing, Xu, Xiong-Fei, Yang, Li-Jun, Lin, Zi-Cong, Wang, Lin-Na, Chen, Rui-Hong, Yang, Jiu-Jie, Zeng, Ya-Ling, Zhang, Rui-Long, Huang, Bai-Xiong, Yun, Xiao-Yun, Wang, Xuan-Ying, Song, Lin-Lin, Wu, Jian-Hui, Wang, Xing-Xia, Chen, Xi, Zhang, Wei, Wang, Hui-Miao, Qu, Li-Qun, Liu, Meng-Han, Liu, Liang, Law, Betty Yuen Kwan, and Wong, Vincent Kam Wai

Published
2023
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8. Peroxide derivatives as SARS-CoV-2 entry inhibitors

Author

Zhang, Ding-qi, Ma, Qin-hai, Yang, Meng-chu, Belyakova, Yulia Yu., Yang, Zi-feng, Radulov, Peter S., Chen, Rui-hong, Yang, Li-jun, Wei, Jing-yuan, Peng, Yu-tong, Zheng, Wu-yan, Yaremenko, Ivan A., Terent'ev, Alexander O., Coghi, Paolo, and Wong, Vincent Kam Wai

Published
2024
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15. Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice

Author

Song, Lin Lin, Qu, Yuan Qing, Tang, Yong Pei, Chen, Xi, Lo, Hang Hong, Qu, Li Qun, Yun, Yun Xiao, Wong, Vincent Kam Wai, Zhang, Rui Long, Wang, Hui Miao, Liu, Meng Han, Zhang, Wei, Zhang, Hui Xia, Chan, Joyce Tsz Wai, Wang, Cai Ren, Wu, Jian Hui, and Law, Betty Yuen Kwan

Published
2023
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23. Discovery and mechanistic study of Imperatorin that inhibits HBsAg expression and cccDNA transcription.

Author

Ren, Fang, Zhao, Shiqiao, He, Xin, Lo, Hanghong, Wong, Vincent Kam Wai, Law, Betty Yuen Kwan, Wu, Anguo, and Zhang, Juan

Subjects
HEPATITIS associated antigen, CHRONIC hepatitis B, HEPATITIS B virus, PROTEOMICS, CIRCULAR DNA, CYCLIC-AMP-dependent protein kinase
Abstract

Chronic hepatitis B virus (HBV) infection remains a significant global health challenge due to its link to severe conditions like HBV‐related cirrhosis and hepatocellular carcinoma (HCC). Although current treatments effectively reduce viral levels, they have limited impact on certain HBV elements, namely hepatitis B surface antigen (HBsAg) and covalently closed circular DNA (cccDNA). This highlights the urgent need for innovative pharmaceutical and biological interventions that can disrupt HBsAg production originating from cccDNA. In this study, we identified a natural furanocoumarin compound, Imperatorin, which markedly inhibited the expression of HBsAg from cccDNA, by screening a library of natural compounds derived from Chinese herbal medicines using ELISA assay and qRT‐PCR. The pharmacodynamics study of Imperatorin was explored on HBV infected HepG2‐NTCP/PHHs and HBV‐infected humanized mouse model. Proteome analysis was performed on HBV infected HepG2‐NTCP cells following Imperatorin treatment. Molecular docking and bio‐layer interferometry (BLI) were used for finding the target of Imperatorin. Our findings demonstrated Imperatorin remarkably reduced the level of HBsAg, HBV RNAs, HBV DNA and transcriptional activity of cccDNA both in vitro and in vivo. Additionally, Imperatorin effectively restrained the actions of HBV promoters responsible for cccDNA transcription. Mechanistic study revealed that Imperatorin directly binds to ERK and subsequently interfering with the activation of CAMP response element‐binding protein (CREB), a crucial transcriptional factor for HBV and has been demonstrated to bind to the PreS2/S and X promoter regions of HBV. Importantly, the absence of ERK could nullify the antiviral impact triggered by Imperatorin. Collectively, the natural compound Imperatorin may be an effective candidate agent for inhibiting HBsAg production and cccDNA transcription by impeding the activities of HBV promoters through ERK‐CREB axis. [ABSTRACT FROM AUTHOR]

Published
2024
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24. The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

Author

Qiu, Congling, primary, Chan, Joyce Tsz Wai, additional, Zhang, David Wei, additional, Wong, Io Nam, additional, Zeng, Yaling, additional, Law, Betty Yuen Kwan, additional, Mok, Simon Wing Fai, additional, De Seabra Rodrigues Dias, Ivo Ricardo, additional, Liu, Wenfeng, additional, Liu, Liang, additional, and Wong, Vincent Kam Wai, additional

Published
2023
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28. Naproxen-Derived New Compound Inhibits the NF-κB, MAPK and PI3K/Akt Signaling Pathways Synergistically with Resveratrol in RAW264.7 Cells

Author

Ou, Yi, primary, You, Zonglin, additional, Yao, Min, additional, Cao, Yingfan, additional, Xue, Xiu, additional, Chen, Min, additional, Wu, Rihui, additional, Gan, Lishe, additional, Li, Dongli, additional, Wu, Panpan, additional, Xu, Xuetao, additional, Wong, Wingleung, additional, Wong, Vincent Kam Wai, additional, Liu, Wenfeng, additional, Ye, Jiming, additional, and Jin, Jingwei, additional

Published
2023
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30. Exploring SARS-CoV-2 Delta variant spike protein receptor-binding domain (RBD) as a target for tanshinones and antimalarials

Author

Coghi, Paolo, Yun, Xiao Yun, Ng, Jerome P. L., Law, Betty Yuan Kwan, Memo, Maurizio, Gianoncelli, Alessandra, Wong, Vincent Kam Wai, and Ribaudo, Giovanni

Subjects
Delta variant, Binding Sites, SARS-CoV-2, Bio-layer interferometry, RBD, spike protein, tanshinones, Organic Chemistry, Plant Science, Peptidyl-Dipeptidase A, Biochemistry, COVID-19 Drug Treatment, Analytical Chemistry, Methylene Blue, Antimalarials, Spike Glycoprotein, Coronavirus, Humans
Abstract

The interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) of spike protein with angiotensin-converting enzyme 2 (ACE2) mediates cell invasion. While this interaction mechanism is conserved, the RBD is affected by amino acid mutations in variants such as Delta and Omicron, resulting in enhanced transmissibility and altered ligand binding. Tanshinones are currently investigated as multi-target antiviral agents, but the studies were limited to the original SARS-CoV-2. This study aims at investigating the interaction of tanshinones with the Delta RBD. Chloroquine, methylene blue and pyronaridine, antimalarials previously identified as SARS-CoV-2 RBD binders, were studied for reference. Docking indicated the best scores for tanshinones, while bio-layer interferometry and molecular dynamics highlighted methylene blue as the best Delta RBD binder, although with decreased affinity with respect to the original strain.

Published
2022

31. Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity.

Author

Sharma, Richa, Yadav, Lalit, Nasim, Ali Adnan, Yadav, Ravi Kant, Chen, Rui Hong, Kumari, Neha, Ruiqi, Fan, Sharon, Ashoke, Sahu, Nawal Kishore, Ippagunta, Sirish Kumar, Coghi, Paolo, Wong, Vincent Kam Wai, and Chaudhary, Sandeep

Subjects
ANTINEOPLASTIC agents, CELL lines, MICROWAVES, CANCER cells, IRRADIATION
Abstract

A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen) reaction under microwave irradiation conditions. The structure elucidation of all the synthesized spirooxindoles were done using 1H and 13C NMR and HRMS spectral analysis. The single crystal X-ray crystallographic study of compound 4l was used to assign the stereochemical arrangements of the groups around the pyrrolidine ring in spiro[pyrrolidine-2,3′-oxindoles] skeleton. The in vitro anticancer activity of spiro[pyrrolidine-2,3′-oxindoles] analogs 4a–w against human lung (A549) and liver (HepG2) cancer cell lines along with immortalized normal lung (BEAS-2B) and liver (LO2) cell lines shows promising results. Out of the 23 synthesized spiro[pyrrolidine-2,3′-oxindoles], while five compounds (4c, 4f, 4m, 4q, 4t) (IC50 = 34.99–47.92 µM; SI = 0.96–2.43) displayed significant in vitro anticancer activity against human lung (A549) cancer cell lines, six compounds (4c, 4f, 4k, 4m, 4q, 4t) (IC50 = 41.56–86.53 µM; SI = 0.49–0.99) displayed promising in vitro anticancer activity against human liver (HepG2) cancer cell lines. In the case of lung (A549) cancer cell lines, these compounds were recognized to be more efficient and selective than standard reference artemisinin (IC50 = 100 µM) and chloroquine (IC50 = 100 µM; SI: 0.03). However, none of them were found to be active as compared to artesunic acid [IC50 = 9.85 µM; SI = 0.76 against lung (A549) cancer cell line and IC50 = 4.09 µM; SI = 2.01 against liver (HepG2) cancer cell line]. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy

Author

Fang, Ren, primary, Ming, Tan, additional, Ng, Jerome P.L., additional, An Guo, Wu, additional, Si Yu, Yuan, additional, Hui, Zhang, additional, Ji Hua, Ren, additional, Sheng Tao, Cheng, additional, Juan, Zhang, additional, Hang Hong, Lo, additional, Wong, Vincent Kam Wai, additional, Law, Betty Yuen Kwan, additional, and Juan, Chen, additional

Published
2023
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34. Therapeutic potential of Polygala saponins in neurological diseases

Author

Zhang, Li, primary, Yong, Yuan-Yuan, additional, Deng, Lan, additional, Wang, Jing, additional, Law, Betty Yuen-Kwan, additional, Hu, Meng-Ling, additional, Wu, Jian-Ming, additional, Yu, Lu, additional, Wong, Vincent Kam-Wai, additional, Yu, Chong-Lin, additional, Qin, Da-Lian, additional, Zhou, Xiao-Gang, additional, and Wu, An-Guo, additional

Published
2023
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35. Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases

Author

He, Chang-Long, primary, Tang, Yong, additional, Chen, Xue, additional, Long, Tao, additional, He, Yan-Ni, additional, Wei, Jing, additional, Wu, Jian-Ming, additional, Lan, Cai, additional, Yu, Lu, additional, Huang, Fei-Hong, additional, Gu, Cong-Wei, additional, Liu, Jian, additional, Yu, Chong-Lin, additional, Wong, Vincent Kam-Wai, additional, Law, Betty Yuen-Kwan, additional, Qin, Da-Lian, additional, Wu, An-Guo, additional, and Zhou, Xiao-Gang, additional

Published
2023
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36. N-Acetylcysteine overcomes epalrestat-mediated increase of toxic 4-hydroxy-2-nonenal and potentiates the anti-arthritic effect of epalrestat in AIA model

Author

Wang, Linna, primary, Huang, Baixiong, additional, Zeng, Yaling, additional, Yang, Jiujie, additional, Li, Zhi, additional, Ng, Jerome P. L., additional, Xu, Xiongfei, additional, Su, Lu, additional, Yun, Xiaoyun, additional, Qu, Liqun, additional, Chen, Ruihong, additional, Luo, Weidan, additional, Wang, Yuping, additional, Chen, Chang, additional, Yang, Lijun, additional, Qu, Yuanqing, additional, Zhang, Wei, additional, Chan, Joyce Tsz Wai, additional, Wang, Xingxia, additional, Law, Betty Yuen Kwan, additional, Mok, Simon Wing Fai, additional, Chung, Sookja Kim, additional, and Wong, Vincent Kam Wai, additional

Published
2023
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38. Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV ‐2: A repurposing study

Author

Ribaudo, Giovanni, primary, Yun, Xiaoyun, additional, Ongaro, Alberto, additional, Oselladore, Erika, additional, Ng, Jerome P. L., additional, Haynes, Richard K., additional, Law, Betty Yuen Kwan, additional, Memo, Maurizio, additional, Wong, Vincent Kam Wai, additional, Coghi, Paolo, additional, and Gianoncelli, Alessandra, additional

Published
2022
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41. Combining Computational and Experimental Evidence on the Activity of Antimalarial Drugs on Papain-Like Protease of SARS-CoV-2: A Repurposing Study

Author

Ribaudo, Giovanni, Yun, Xiaoyun, Ongaro, Alberto, Oselladore, Erika, Jerome P L, Ng, Haynes, Richard K, Law, Betty Yuen Kwan, Memo, Maurizio, Wong, Vincent Kam Wai, Coghi, Paolo, and Gianoncelli, Alessandra

Subjects
Pharmacology, PL-pro, SARS-CoV-2, antimalarial drugs, drug repurposing, papain-like protease, Drug Discovery, Organic Chemistry, Molecular Medicine, Biochemistry
Abstract

The development of inhibitors that target the papain-like protease (PLpro) has the potential to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent causing coronavirus disease 2019 (COVID-19). Based on a consideration of its several downstream effects, interfering with PLpro would both revert immune suppression exerted by the virus and inhibit viral replication. By following a repurposing strategy, the current study evaluates the potential of antimalarial drugs as PLpro inhibitors, and thereby the possibility of their use for treatment of SARS-CoV-2 infection. Computational tools were employed for structural analysis, molecular docking and molecular dynamics simulations to screen antimalarial drugs against PLpro, and in silico data were validated by in vitro experiments. Virtual screening highlighted amodiaquine and methylene blue as the best candidates, and these findings were complemented by the in vitro results that indicated amodiaquine as a μM PLpro deubiquitinase inhibitor. The results of this study demonstrate that the computational workflow adopted here can correctly identify active compounds. Thus, the highlighted antimalarial drugs represent a starting point for the development of new PLpro inhibitors through structural optimization.

Published
2022

42. Self-DNA accumulation as a risk factor for accelerating the pathogenesis of rheumatoid arthritis in elderly individuals

Author

Luo, Wei Dan, primary, Yang, Li Jun, additional, Qu, Yuanqing, additional, Lin, Zicong, additional, Lv, Jun, additional, Xu, Xiongfei, additional, Wang, Linna, additional, Chen, Ruihong, additional, Yang, Jiujie, additional, Zeng, Yaling, additional, Zhang, Ruilong, additional, Huang, Baixiong, additional, Song, Linlin, additional, Chen, Xi, additional, Yun, Xiaoyun, additional, Zhang, Wei, additional, Zhang, Kaixin, additional, Wang, Hui Miao, additional, Wang, Xingxia, additional, Qu, Li Qun, additional, Liu, Menghan, additional, Wang, Yuping, additional, Liu, Liang, additional, Law, Betty Yuen-Kwan, additional, and Wong, Vincent Kam Wai, additional

Published
2022
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43. Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes

Author

Coghi, Paolo, primary, Yaremenko, Ivan A., additional, Prommana, Parichat, additional, Wu, Jia Ning, additional, Zhang, Rui Long, additional, Ng, Jerome P. L., additional, Belyakova, Yulia Yu., additional, Law, Betty Yuen Kwan, additional, Radulov, Peter S., additional, Uthaipibull, Chairat, additional, Wong, Vincent Kam Wai, additional, and Terent'ev, Alexander O., additional

Published
2022
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46. Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity

Author

Yuan, Si-Yu, primary, Yu, Hai-Bo, additional, Yang, Zhen, additional, Qin, Yi-Ping, additional, Ren, Ji-Hua, additional, Cheng, Sheng-Tao, additional, Ren, Fang, additional, Law, Betty Yuen Kwan, additional, Wong, Vincent Kam Wai, additional, Ng, Jerome P. L., additional, Zhou, Yu-Jiao, additional, He, Xin, additional, Tan, Ming, additional, Zhang, Zhen-Zhen, additional, and Chen, Juan, additional

Published
2022
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47. Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV‐2: A repurposing study.

Author

Ribaudo, Giovanni, Yun, Xiaoyun, Ongaro, Alberto, Oselladore, Erika, Ng, Jerome P. L., Haynes, Richard K., Law, Betty Yuen Kwan, Memo, Maurizio, Wong, Vincent Kam Wai, Coghi, Paolo, and Gianoncelli, Alessandra

Subjects
SARS-CoV-2, COMPUTATIONAL neuroscience, COVID-19
Abstract

The development of inhibitors that target the papain‐like protease (PLpro) has the potential to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the agent causing coronavirus disease 2019 (COVID‐19). Based on a consideration of its several downstream effects, interfering with PLpro would both revert immune suppression exerted by the virus and inhibit viral replication. By following a repurposing strategy, the current study evaluates the potential of antimalarial drugs as PLpro inhibitors, and thereby the possibility of their use for treatment of SARS‐CoV‐2 infection. Computational tools were employed for structural analysis, molecular docking, and molecular dynamics simulations to screen antimalarial drugs against PLpro, and in silico data were validated by in vitro experiments. Virtual screening highlighted amodiaquine and methylene blue as the best candidates, and these findings were complemented by the in vitro results that indicated amodiaquine as a μM PLpro deubiquitinase inhibitor. The results of this study demonstrate that the computational workflow adopted here can correctly identify active compounds. Thus, the highlighted antimalarial drugs represent a starting point for the development of new PLpro inhibitors through structural optimization. [ABSTRACT FROM AUTHOR]

Published
2023
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