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Objective This study aimed to evaluate the expression levels of Shh, Gli1, and Cyr61 proteins in gastric cancer tissues and analyze the relationship between these three proteins and the clinicopathological factors and prognosis of patients. Methods This was a retrospective study. Four hundred gastric cancer tissue specimens from patients who underwent radical gastrectomy in Zhangye People’s Hospital affiliated to Hexi University between February 2013 and February 2021 underwent immunohistochemical analysis. Results The positive expression rates of Shh, Gli1, and Cyr61 in gastric cancer tissues were 55.5%, 56.5%, and 64.5%, respectively. The expressions of Shh, Gli1, and Cyr61 in gastric cancer tissues were significantly correlated with tumor size, depth of invasion, and degree of differentiation (P < .05). The expression of Shh protein was positively correlated with the expression of Gli1 protein (P < .01), and the expression of Gli1 protein was positively correlated with the expression of Cyr61 protein (P < .01). Univariate and multivariate analyses showed that the expression of Shh, Gli1, and Cyr61 could predict the prognosis of patients (P < .05). Receiver operating characteristic curve analysis combined with TNM staging could better predict the three-year overall survival of patients (P < .05). Conclusion Shh, Gli1, and Cyr61 proteins are significantly expressed in gastric cancer tissues and are risk factors for the prognosis of patients with gastric cancer.

Chinese satellite carrying synthetic aperture radar (SAR) with spatial resolution up to 1 m, denoted as 1mC-SAR, is the successor of Gaofen-3 (GF-3). The main purpose of this study is to conduct the preliminary analysis of wind and wave retrieval from more than 400 1mC-SAR images acquired in quad-polarization stripmap (QPS), which are located at China coastal waters on April 2023. The co-polarized (vertical−vertical [VV] and horizontal−horizontal [HH]) geophysical model function (GMF), denoted as CSARMOD-GF, is employed for wind speed retrieval from those images taking prior information on wind directions from European Centre for Medium-Range Weather Forecasts (ECMWF). Validation against the wind products from Haiyang-2 (HY-2) (2B/2C/2D) scatterometers yields a 1.78/1.91 m/s root mean squared error (RMSE) with a 0.22/0.23 scatter index (SI) for SAR retrievals at VV/HH polarization channels. Moreover, the accuracy of SAR-derived winds at spatial resolution of 2 km for QPS-I and 6 km for QPS-II is relatively higher than that achieved from the retrievals at spatial resolution of 4 km for QPS-I and 12 km. The wave slop spectrum is inverted from co-polarized image by polarimetric technique, in which the term of wind speed is included in the model transfer function (MTF) of tilt modulation. Significant wave height (SWH) retrievals are compared with the simulations by the third-generation numeric wave model, denoted as WAVEWATCH-III (WW3), showing a 0.53 m RMSE with a 0.36 SI. This behavior is also confirmed as comparing with SAR-derived wave spectra and WW3-simulated wave spectra, i.e. a 0.79 correlation coefficient (Cor) and a 0.92 squared error (Err). The variation of bias in wind speed and SWH indicates an increasing tendency with the growth of sea state, meaning that calibration is a heedful issue for 1mC-SAR.

Presently, there is limited data on the potential survival benefits of transurethral resection of the prostate (TURP) in patients with metastatic hormone-sensitive prostate cancer (mHSPCa). In this study, we aimed to assess the effects of TURP on the survival of mHSPCa patients. Of the 59 patients diagnosed with mHSPCa included, 28 received androgen deprivation therapy (ADT) alone, and the remaining received TURP plus ADT. Their time to biochemical progression (TBCP) and progression-free survival (PFS) were analyzed. Our results showed that for a median follow-up time of 15 (range, 3–40) months and 21 (range, 6–39) months for the ADT group and the TURP group, respectively, the TURP group exhibited significantly longer TBCP than the ADT group (p = 0.020). In addition, patients in the TURP group had numerically longer PFS, although the difference between the two groups was not significantly different (p = 0.110). Cox multivariate analysis indicated that longer TBCP was independently associated with TURP (p = 0.032) and lower Gleason scores (p = 0.001). Altogether this study showed that TURP could prolong TBCP and potentially improve the PFS of mHSPCa patients. However, further studies with a larger sample size are needed to confirm these findings.

Chinese satellite carrying synthetic aperture radar (SAR) with spatial resolution up to 1 m, denoted as 1mC-SAR, is the successor of Gaofen-3 (GF-3). The main purpose of this study is to conduct the preliminary analysis of wind and wave retrieval from more than 400 1mC-SAR images acquired in quad-polarization stripmap (QPS), which are located at China coastal waters on April 2023. The co-polarized (vertical−vertical [VV] and horizontal−horizontal [HH]) geophysical model function (GMF), denoted as CSARMOD-GF, is employed for wind speed retrieval from those images taking prior information on wind directions from European Centre for Medium-Range Weather Forecasts (ECMWF). Validation against the wind products from Haiyang-2 (HY-2) (2B/2C/2D) scatterometers yields a 1.78/1.91 m/s root mean squared error (RMSE) with a 0.22/0.23 scatter index (SI) for SAR retrievals at VV/HH polarization channels. Moreover, the accuracy of SAR-derived winds at spatial resolution of 2 km for QPS-I and 6 km for QPS-II is relatively higher than that achieved from the retrievals at spatial resolution of 4 km for QPS-I and 12 km. The wave slop spectrum is inverted from co-polarized image by polarimetric technique, in which the term of wind speed is included in the model transfer function (MTF) of tilt modulation. Significant wave height (SWH) retrievals are compared with the simulations by the third-generation numeric wave model, denoted as WAVEWATCH-III (WW3), showing a 0.53 m RMSE with a 0.36 SI. This behavior is also confirmed as comparing with SAR-derived wave spectra and WW3-simulated wave spectra, i.e. a 0.79 correlation coefficient (Cor) and a 0.92 squared error (Err). The variation of bias in wind speed and SWH indicates an increasing tendency with the growth of sea state, meaning that calibration is a heedful issue for 1mC-SAR. [ABSTRACT FROM AUTHOR]