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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide. Significantly activated uridine nucleotide and fatty acid metabolism in HCC cells promote malignant proliferation and immune evasion. Herein, it is demonstrated that the tripartite motif 65 (TRIM65) E3 ubiquitin‐protein ligase, O‐GlcNAcylated via O‐GlcNAcylation transferase, is highly expressed in HCC and facilitated metabolic remodeling to promote the accumulation of products related to uracil metabolism and palmitic acid, driving the progression of HCC. Mechanistically, it is showed that TRIM65 mediates ubiquitylation at the K44 residue of neurofibromatosis type 2 (NF2), the key protein upstream of classical Hippo signaling. Accelerated NF2 degradation inhibits yes‐associated protein 1 phosphorylation, inducing aberrant activation of related metabolic enzyme transcription, and orchestrating metabolic and immune advantages. In conclusion, these results reveal a critical role for the TRIM family molecule TRIM65 in supporting HCC cell survival and highlight the therapeutic potential of targeting its E3 ligase activity to alter the regulation of proteasomal degradation. [ABSTRACT FROM AUTHOR]

To maintain a reasonable sediment regulation system in the Loess Plateau, it is critical to determine the effects of check dam construction on sediment production and topographic changes. An indoor simulation experiment was conducted to investigate sediment production at the outlet section of the gully and micro‐topographic changes within the channel before and after dam construction. The results showed that check dam significantly affected the run‐off and sediment transport processes in the watershed. Specifically, the cross‐sectional morphology index (η) and the width‐depth ratio increased by 10.23% and 40.44%, respectively, while sediment content and particle size decreased by 39.29% and 18.58%, respectively. Additionally, the relative importance of section parameters and micro‐topographic parameters that affect sediment production rate and particle size was ranked using the random forest algorithm. The roughness after check dam construction was identified as a relatively important topographic factor affecting sediment production and particle selection by erosion. These findings provide valuable information for future check dam construction and development in the Loess Plateau region. [ABSTRACT FROM AUTHOR]