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Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Conventional treatment options for TNBC often have limited efficacy and significant side effects. In recent years, traditional Chinese medicine (TCM) has shown promising results in the treatment of TNBC. TCMs include herb combinations that have synergistic effects to regulate homeostasis in the body, reduce tumor resistance, and improve patient quality of life. At present, three main TCM methods are used to treat TNBC in the clinic: strengthening the body's resistance, dispelling phlegm, and removing cancer toxins. This paper reviews the theories and mechanisms of each in TNBC treatment. The method of strengthening the body's resistance emphasizes enhancing the body's original Qi to fight against pathogenic factors; the method of dispelling phlegm seeks to eliminate phlegm stagnation and alleviate the burden on affected organs; the method of removing cancer toxins focuses on detoxification and detumescence to remove the toxic elements associated with TNBC. Although these methods treat TNBC from different etiologies, they have achieved good therapeutic effects and represent an important academic approach: That is, to cure the disease with a comprehensive view of the body and restore the balance of Yin and Yang. This knowledge lays a foundation for the future development and reasonable application of TCM in the clinic. [ABSTRACT FROM AUTHOR]

Rail transportation is regarded as a reliable, quick, and secure mode of transportation. The wheel-rail contact interaction is crucial to the railway operation since it is responsible for supporting, traction, braking, and steering of railway vehicles. Improper wheel-rail interactions may produce or exacerbate wheel-rail interface issues such as rolling contact fatigue (RCF) and wear, which can threaten the vehicle's running safety and stability. A review of the evolution and recent literature on wheel-rail contact mechanics and tribology is presented here. Topics covered include the basics of wheel-rail contact problem and methodologies for modeling both the normal contact (Hertzian and non-Hertzian) and tangential contact (Kalker's theories including CONTACT and FASTSIM algorithms, Polach's theory, USETAB program, etc.). The paper also reviewed various effects of contaminants and environmental conditions (water, leaves, sand, temperature, humidity, etc.) in wheel-rail contact. Various wheel-rail empirical adhesion models like the Water-induced low adhesion creep force model (WILAC) model and adhesion models based on elastohydrodynamic lubrication (EHL) theory (Greenwood-Tripp [GT] and Greenwood-Williamson [GW] models) are also reviewed. Lastly, the paper discusses the need and challenges for developing and integrating the wheel-rail non-Hertz contact model and adhesion model, as well as open areas for further research. [ABSTRACT FROM AUTHOR]

AbstractAs a crucial load-bearing component, coupler’s safety is pivotal for sustainable railway industry development and is extensively scrutinized due to its complex loading environment. However, current research predominantly concentrates on the longitudinal dynamic behavior of couplers, neglecting factors such as nodding and shaking during traversals along curves and ramps. This study proposes an innovative method aimed at identifying multiple loads on couplers, which includes longitudinal tension and compression, lateral shaking, and vertical nodding forces. A theoretical load identification method based on strain sum and difference on coupler shank faces under various loading scenarios is established by finite element analysis. To facilitate accurate measurement, Wheatstone bridges are employed for three-dimensional force measurement, facilitating strain calculation and temperature compensation. The validity of the proposed approach is confirmed through comprehensive validation, encompassing finite element simulation, laboratory experimentation, and vehicle tests. Results demonstrate the robustness of the method, with maximum load deviations of 2.32% longitudinally, 22.52% horizontally, and 19.86% vertically observed during laboratory tests. Results indicate the proposed method’s accuracy and efficiency in heavy haul train coupler load assessment. [ABSTRACT FROM AUTHOR]