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PurposeIn this article, a practical design methodology is proposed for discrete sizing optimization of high-rise concrete buildings with a focus on large-scale and real-life structures.Design/methodology/approachThis framework relies on a computationally efficient approximation of the constraint and objective functions using a radial basis function model with a linear tail, also called the combined response surface methodology (RSM) in this article. Considering both the code-stipulated constraints and other construction requirements, three sub-optimization problems were constructed based on the relaxation model of the original problem, and then the structural weight could be automatically minimized under multiple constraints and loading scenarios. After modulization, the obtained results could meet the discretization requirements. By integrating the commercially available ETABS, a dedicated optimization software program with an independent interface was developed and details for practical software development were also presented in this paper.FindingsThe proposed framework was used to optimize different high-rise concrete buildings, and case studies showed that material usage could be saved by up to 12.8% compared to the conventional design, and the over-limit constraints could be adjusted, which proved the feasibility and effectiveness.Originality/valueThis methodology can therefore be applied by engineers to explore the optimal distribution of dimensions for high-rise buildings and to reduce material usage for a more sustainable design.