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Objectives: Ultrasound Needle, which is an improved ultrasonic horn device, has shown great potential for promoting the diffusion of thrombolytic drugs within clots and enhancing clot lysis efficiency. However, the clot lysis efficiency of different thrombolytic drugs with the synergy of Ultrasound Needle remains unknown. In this study, we aimed to compare the lysis efficiency of the non-fibrin-specific drug urokinase and fibrin-specific drug reteplase with the synergy of Ultrasound Needle. Materials and methods: Twenty-five milliliters of human blood was incubated for 1.5 h to form in vitro clots and then received the corresponding treatment protocols: control group (normal saline), US group (10 min of Ultrasound Needle treatment), UK group (30000IU of urokinase), r-PA group (2 mg of reteplase), US + UK group, and US + r-PA group. After treatment, the morphological changes of the clots were analyzed by B-mode ultrasound imaging and hematoxylin and eosin (H&E) staining. Lysis efficiency was evaluated based on the relative end weight (final weight/initial weight). The fibrin density of the different groups after treatment was assessed by immunofluorescence staining. Results: Morphological examination and relative end weight analysis showed that combination therapies induced a more thorough dissolution of clots compared with single therapies, and the US + r-PA group exhibited higher lysis efficiency than the US + UK group. In addition, immunofluorescence staining showed that the US + r-PA group had fewer remaining thrombus fibrins than the US + UK group after treatment. Conclusions: The Ultrasound Needle can significantly improve the clot lysis efficiency of both fibrinolytic drugs, and fibrin-specific reteplase exhibited superior lysis efficiency over non-fibrin-specific urokinase with the synergy of the Ultrasound Needle.

Under the background of carbon peak and carbon neutralization, it is vital to study the impact of digital economy on carbon emission reduction. Based on a provincial panel data from 2013 to 2019, this paper establishes a dynamic panel model, a dynamic spatial autoregressive model, and a dynamic threshold model to study the impact of digital economy on carbon emission intensity. Our findings show that digital economy has a significant inhibitory effect on carbon emission intensity. Results of regional heterogeneity show that the central region can transform the impact of digital economy on carbon emission reduction more efficiently. After adding the time lag term of carbon emission intensity, the impact coefficient of digital economy is still significant. Carbon emission intensity has obvious spatial effect, and the carbon emission of adjacent areas will significantly inhibit local carbon emission reduction activities. Under the threshold of innovation and environmental regulation, the emission reduction effect of digital economy is different. For regions with low technological level, digital economy is difficult to give full scope to its emission reduction advantages. At the same time, stricter environmental regulations can cooperate with digital economy to accelerate regional carbon emission reduction. Therefore, China should continue to improve the construction of digital infrastructure and promote the reform and innovation of enterprise digital technology in order to release the carbon emission reduction effect of digital economy.

A primary development plan for a country is to attain carbon neutrality and high-quality international commerce development. This study uses panel data from 30 provinces in mainland China to analyze the dynamic interplay between international trade, technological innovation, and carbon emissions. The findings show that foreign trade, technological progress, and carbon emissions all have their own “economic inertia” that can be self-motivated and self-reinforcing. Foreign commerce and carbon emissions are mutually inhibiting, but technical progress and carbon emissions are mutually reinforcing. This illustrates that achieving a positive cycle of international trade, technological improvement, and carbon emissions necessitates a significant baseline need. Overcoming carbon trade barriers is currently the most difficult challenge for Chinese enterprises involved in foreign commerce. Low-carbon technology advancements are a critical part in this process. Our research strengthens the positive connections between international trade and carbon emissions as a result of technological improvement and proposes a feasible plan for international trade to achieve carbon peaking and carbon neutrality.