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Your search keyword '"Yu Zhi Zhang"' showing total 10 results
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10 results on '"Yu Zhi Zhang"'

1. Author Correction: Integrated genomics point to immune vulnerabilities in pleural mesothelioma

Author

Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris‑Rosendahl, Yu Zhi Zhang, Xiao‑Ming Sun, Spyridon Gennatas, Robert C. Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G. Nicholson, Sanjay Popat, Anne E. Willis, Marion MacFarlane, Mark Lathrop, Anne M. Bowcock, Miriam F. Moffatt, and William O. C. M. Cookson

Subjects
Medicine, Science
Published
2022
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2. Pulmonary sclerosing pneumocytoma - rare diagnosis in a Caucasian woman: case report and review of the literature.

Author

Gorman, William, Shehata, Monica, Bashir, Mohamed Ryan, Yu Zhi Zhang, Wassilew, Katharina, AlShammari, Abdullah, Buderi, Silviu, and Jordan, Simon

Subjects
LITERATURE reviews, DIAGNOSIS, BENIGN tumors, THORACIC surgery
Abstract

Pulmonary sclerosing pneumocytoma (PSP) is a rare benign pulmonary tumour, most reported cases of PSP are from Eastern Asia, with a female to male ratio of 5:1, and average age at diagnosis in the 5th decade. We present the case of a 63-year-old Caucasian woman diagnosed with PSP who underwent a left lower lobe basal segmentectomy with systematic nodal dissection, performed via video assisted thoracic surgery (VATS). [ABSTRACT FROM AUTHOR]

Published
2024
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3. Prediction of next generation sequencing test failure in lung adenocarcinoma in a genomic laboratory hub setting

Author

Yu Zhi Zhang, Stuart Sherlock, Suzanne MacMahon, Cecilia Brambilla, Alexandra Rice, Jan Lukas Robertus, Katharina Wassilew, Eric Lim, Sofina Begum, Silviu Buderi, Simon Jordan, Vladimir Anikin, Jonathan Finch, Nizar Asadi, Emma Beddow, Justin L Garner, Jaymin Morjaria, Richard Lee, Fiona McDonald, Georgios Antoniou, Carole Ridge, Simon Padley, Paras Dalal, Deborah Morris-Rosendahl, Mikel Valganon-Petrizan, Pallav L Shah, Anand Devaraj, Sanjay Popat, and Andrew G Nicholson

Subjects
Pulmonary and Respiratory Medicine, Cancer Research, Oncology
Published
2023
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4. Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal Melanoma

Author

Yasemin C. Cole, Yu-Zhi Zhang, Beatrice Gallo, Adam P. Januszewski, Anca Nastase, David J. Essex, Caroline M. H. Thaung, Victoria M. L. Cohen, Mandeep S. Sagoo, and Anne M. Bowcock

Subjects
Cancer Research, Oncology, uveal melanoma, biomarkers, survival, metastasis, BAP1, SF3B1, EIF1AX, monosomy 3, immunohistochemistry, nonsense-mediated decay
Abstract

Uveal melanoma (UM) is an uncommon but highly aggressive ocular malignancy. Poor overall survival is associated with deleterious BAP1 alterations, which frequently occur with monosomy 3 (LOH3) and a characteristic gene expression profile. Tumor DNA from a cohort of 100 UM patients from Moorfields Biobank (UK) that had undergone enucleation were sequenced for known UM driver genes (BAP1, SF3B1, EIF1AX, GNAQ, and GNA11). Immunohistochemical staining of BAP1 and interphase FISH for chromosomes 3 and 8 was performed, and cellular localization of BAP1 was correlated with BAP1 mutations. Wildtype (WT) BAP1 staining was characterized by nBAP1 expression with 10% cBAP1.

Published
2022
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6. A Study on the Train-Induced Vibration Responses of Heavy Haul Railway Subgrade in Seasonally Frozen Regions Using Field Experiments

Author

Yu-Zhi Zhang, Ya-Qian Dong, Xiu-Xiu Cao, and Pei Li

Subjects
Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, Building and Construction, Management, Monitoring, Policy and Law, seasonally frozen region, heavy haul railway subgrade, dynamic response, vibration acceleration, on-site monitoring
Abstract

The dynamic response resulting from heavy haul train leads to the deterioration of the railway subgrade, especially those built in seasonally frozen regions. In this work, a typical heavy haul railway section in a seasonally frozen region is monitored on-site. The time domain and the frequency domain analysis of the subgrade vertical vibration acceleration, dynamic speed, and displacement during the non-frozen period and the frozen period are investigated. The results show that the vibration response of the subgrade is affected by various factors, including the train type, locomotive, traveling speed, train formation, heavy load, and the prevalent season. Further, it is observed that the maximum and average vertical acceleration of the subgrade, the vibration speed, and the dynamic displacement increase during the frozen period. However, the main frequency of the natural vibration remains significantly higher than that before freezing. Moreover, the frozen soil has a significant amplification effect both on the acceleration and the attenuation rate. Similarly, the subgrade’s vibration mode has a low frequency and high amplitude during the freezing period, and the dynamic response characteristics become increasingly apparent as the axle load increases.

Published
2022
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10. Evaluation indices of the temperature difference of subgrade and the optimization of mitigation measures in cold regions

Author

Yu-zhi Zhang, Xiao-jie Liang, Ya-qian Dong, Cheng-yan Li, and Zhi-rong Zhao

Subjects
Transverse ground temperature difference, Homogeneity index, Symmetry index, Mitigation measure, Insulation material, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

With the construction and operation of railways in cold regions, the asymmetric deformation of subgrades due to the difference in the transverse ground temperature has become a prominent issue. A comprehensive evaluation of the transverse ground temperature difference and investigation of the corresponding mitigation measures should be conducted to avoid or minimize the damage resulting from this difference, thereby improving subgrade stability and reducing deformation. In this study, the time history variations in the homogeneity and symmetry indices of the ground temperature at typical instances that reflect the spatial and temporal changes in the temperature difference of the subgrade were proposed as evaluation indices. The feasibility of these evaluation indices was verified through numerical models with different types of anti-frost berms. Subsequently, the numerical models were used to analyze the ground temperature evaluation indices of a subgrade with expanded polystyrene (EPS) insulation board and polyurethane (PU) insulation board at different locations. Additionally, the performances of each mitigation measure in eliminating or reducing the ground temperature difference were assessed and compared. The results show that all the mitigation measures could improve the homogeneity and symmetry of the ground temperature distribution. The maximum mitigation rates for the homogeneity and symmetry are 97.87% and 45.90%, respectively. This study provides a comprehensive evaluation method for the temperature difference of subgrades constructed in cold regions and a theoretical reference for the selection of anti-frost measures in the design, operation, and maintenance of subgrades in cold regions.

Published
2023
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