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Your search keyword '"Yuan, Yi-Yuan"' showing total 11 results
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11 results on '"Yuan, Yi-Yuan"'

3. Author Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Author

Qiao, Ya-Nan, primary, Li, Lei, additional, Hu, Song-Hua, additional, Yang, Yuan-Xin, additional, Ma, Zhen-Zhen, additional, Huang, Lin, additional, An, Yan-Peng, additional, Yuan, Yi-Yuan, additional, Lin, Yan, additional, Xu, Wei, additional, Li, Yao, additional, Lin, Peng-Cheng, additional, Cao, Jing, additional, Zhao, Jian-Yuan, additional, and Zhao, Shi-Min, additional

Published
2024
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5. Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation.

Author

Zhang, Kai-Hui, Zhang, Fei-Fei, Zhang, Zhi-Ling, Fang, Ke-Fei, Sun, Wen-Xing, Kong, Na, Wu, Min, Liu, Hai-Ou, Liu, Yan, Li, Zhi, Cai, Qing-Qing, Wang, Yang, Wei, Quan-Wei, Lin, Peng-Cheng, Lin, Yan, Xu, Wei, Xu, Cong-Jian, Yuan, Yi-Yuan, and Zhao, Shi-Min

Abstract

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. Inadequate understanding of the ovulation drivers hinders PCOS intervention. Herein, we report that follicle stimulating hormone (FSH) controls follicular fluid (FF) glutamine levels to determine ovulation. Murine ovulation starts from FF-exposing granulosa cell (GC) apoptosis. FF glutamine, which decreases in pre-ovulation porcine FF, elevates in PCOS patients FF. High-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal, metabolic, and morphologic PCOS traits. Mechanistically, follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine, which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic pathway. FSH and glutamine inhibit the rapture of cultured murine follicles. Glutamine removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or EsR1 -KO. These suggest that glutamine, FSH, and ASK1-JNK pathway are targetable to alleviate PCOS. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Author

Qiao, Ya-Nan, primary, Li, Lei, additional, Hu, Song-Hua, additional, Yang, Yuan-Xin, additional, Ma, Zhen-Zhen, additional, Huang, Lin, additional, An, Yan-Peng, additional, Yuan, Yi-Yuan, additional, Lin, Yan, additional, Xu, Wei, additional, Li, Yao, additional, Lin, Peng-Cheng, additional, Cao, Jing, additional, Zhao, Jian-Yuan, additional, and Zhao, Shi-Min, additional

Published
2024
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9. IL-27 promotes decidualization via the STAT3-ESR/PGR regulatory axis

Author

Zhang, Xin-Yan, primary, Shen, Hui-Hui, additional, Qin, Xue-Yun, additional, Wang, Cheng-Jie, additional, Hu, Wen-Ting, additional, Liu, Song-Ping, additional, Wu, Jiang-Nan, additional, Xie, Feng, additional, Xu, Feng-Yuan, additional, Zhao, Shi-Min, additional, Yuan, Yi-Yuan, additional, and Li, Ming-Qing, additional

Published
2022
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10. Gestational Leucylation Suppresses Embryonic T‐Box Transcription Factor 5 Signal and Causes Congenital Heart Disease

Author

Zhang, Xuan, primary, Liu, Lian, additional, Chen, Wei‐Cheng, additional, Wang, Feng, additional, Cheng, Yi‐Rong, additional, Liu, Yi‐Meng, additional, Lai, Yang‐Fan, additional, Zhang, Rui‐Jia, additional, Qiao, Ya‐Nan, additional, Yuan, Yi‐Yuan, additional, Lin, Yan, additional, Xu, Wei, additional, Cao, Jing, additional, Gui, Yong‐Hao, additional, and Zhao, Jian‐Yuan, additional

Published
2022
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11. Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

Author

Hu, Song-Hua, primary, He, Xia-Di, additional, Nie, Ji, additional, Hou, Jun-Li, additional, Wu, Jiang, additional, Liu, Xiao-Yan, additional, Wei, Yun, additional, Tang, Hui-Ru, additional, Sun, Wen-Xing, additional, Zhou, Shu-Xian, additional, Yuan, Yi-Yuan, additional, An, Yan-Peng, additional, Yan, Guo-Quan, additional, Lin, Yan, additional, Lin, Peng-Cheng, additional, Zhao, Jean J., additional, Ye, Ming-Liang, additional, Zhao, Jian-Yuan, additional, Xu, Wei, additional, and Zhao, Shi-Min, additional

Published
2022
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