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Your search keyword '"Yue, Yale"' showing total 18 results
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18 results on '"Yue, Yale"'

7. Self‐Oxygenated Biomimetic Nanozyme for Tumor Catalytic Immunotherapy.

Author

Zhang, Baohua, Yuan, Ye, Xin, Qi, Wang, Shuyu, Feng, Yiming, Yan, Xiyun, Fan, Tianli, Jiang, Bing, and Yue, Yale

Subjects
GLUCOSE oxidase, BIOMIMETICS, BACTERIAL cell walls, SYNTHETIC enzymes, TUMOR growth
Abstract

The treatment of solid tumors remains a significant challenge due to the complex, immunosuppressive tumor microenvironment (TME). This manuscript introduces the self‐oxygenated biomimetic nanozyme system, SS‐MSN@Au‐BOM, which innovatively combines catalytic therapy with immunotherapy to modulate the TME for enhanced therapeutic efficacy. Employing mesoporous silicon nanoparticles doped with disulfide bonds, the system integrates gold nanozymes that exhibit glucose oxidase (GOx)‐like and peroxidase (POD)‐like activities, along with a catalase (CAT) function derived from bacterial outer membrane (BOM) coatings. SS‐MSN@Au‐BOM significantly disrupted tumor growth by catalyzing endogenous hydrogen peroxide to generate cytotoxic ROS and essential oxygen, enhancing intratumoral ROS levels while alleviating hypoxia. This catalytic action facilitates immunogenic cell death, enhances dendritic cell maturation, and T‐cell activation. Notably, the system shows excellent biocompatibility, effective tumor targeting, and prolonged systemic circulation. SS‐MSN@Au‐BOM offers a dual‐functional approach that effectively disrupts the TME and promotes robust antitumor immunity. This study paves the way for further clinical investigation and the development of enzyme‐based therapeutics, potentially transforming the landscape of cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2025
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9. Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity

Author

Liu, Guangna, primary, Ma, Nana, additional, Cheng, Keman, additional, Feng, Qingqing, additional, Ma, Xiaotu, additional, Yue, Yale, additional, Li, Yao, additional, Zhang, Tianjiao, additional, Gao, Xiaoyu, additional, Liang, Jie, additional, Zhang, Lizhuo, additional, Wang, Xinwei, additional, Ren, Zhenhua, additional, Fu, Yang-Xin, additional, Zhao, Xiao, additional, and Nie, Guangjun, additional

Published
2023
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11. Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis (Adv. Mater. 17/2023)

Author

Li, Fenfen, primary, Zhao, Ying, additional, Cheng, Zhaoxia, additional, Wang, Yazhou, additional, Yue, Yale, additional, Cheng, Xiaoyu, additional, Sun, Jingyi, additional, Atabakhshi‐Kashi, Mona, additional, Yao, Jundong, additional, Dou, Jianping, additional, Yu, Jie, additional, Zhang, Xiuping, additional, Qi, Yingqiu, additional, Li, Xiaotian, additional, Qi, Xiaolong, additional, and Nie, Guangjun, additional

Published
2023
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12. Normalizing the Immune Macroenvironment via Debulking Surgery to Strengthen Tumor Nanovaccine Efficacy and Eliminate Metastasis

Author

Ma, Nana, primary, Chen, Zhiqiang, additional, Liu, Guangna, additional, Yue, Yale, additional, Li, Yao, additional, Cheng, Keman, additional, Ma, Xiaotu, additional, Feng, Qingqing, additional, Liang, Jie, additional, Zhang, Tianjiao, additional, Gao, Xiaoyu, additional, Wang, Xinwei, additional, Guo, Xinjing, additional, Zhu, Fei, additional, Nie, Guangjun, additional, and Zhao, Xiao, additional

Published
2022
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13. Engineered Bacterial Outer Membrane Vesicles as Controllable Two‐Way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy

Author

Feng, Qingqing, primary, Ma, Xiaotu, additional, Cheng, Keman, additional, Liu, Guangna, additional, Li, Yao, additional, Yue, Yale, additional, Liang, Jie, additional, Zhang, Lizhuo, additional, Zhang, Tianjiao, additional, Wang, Xinwei, additional, Gao, Xiaoyu, additional, Nie, Guangjun, additional, and Zhao, Xiao, additional

Published
2022
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15. Rapid Surface Display of mRNA Antigens by Bacteria‐Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine

Author

Li, Yao, primary, Ma, Xiaotu, additional, Yue, Yale, additional, Zhang, Kaiyue, additional, Cheng, Keman, additional, Feng, Qingqing, additional, Ma, Nana, additional, Liang, Jie, additional, Zhang, Tianjiao, additional, Zhang, Lizhuo, additional, Chen, Zhiqiang, additional, Wang, Xinwei, additional, Ren, Lei, additional, Zhao, Xiao, additional, and Nie, Guangjun, additional

Published
2022
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