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Your search keyword '"Yvonne Yee Siang Tee"' showing total 3 results
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3 results on '"Yvonne Yee Siang Tee"'

1. Early pregnancy body mass index and gestational weight gain: A mediating or moderating factor for short stature and risk of gestational diabetes mellitus?

Author

Heng Yaw Yong, Zalilah Mohd Shariff, Barakatun Nisak Mohd Yusof, Zulida Rejali, Yvonne Yee Siang Tee, Jacques Bindels, and Eline M. van der Beek

Subjects
Medicine, Science
Abstract

This study examined the association between height and the risk of Gestational Diabetes Mellitus (GDM), and whether this association was mediated or moderated by early pregnancy body mass index (BMI) and gestational weight gain (GWG) that are known independent risk factors for GDM. Data of a retrospective cohort of pregnant women (N = 1,945) were extracted from antenatal clinic cards. The cut-off values of height in relation to risk of GDM were identified using receiver operating characteristic analysis and four categories of height were derived: < 150 cm, 150–155 cm, 156–160 cm, and > 160cm. Mediation analysis was performed using the Preacher and Hayes bootstrapping method while the moderation effect was tested with multiple regression analysis with interaction terms. Although there was no mediation effect of BMI and GWG on the association between height and risk of GDM, both factors moderated this association with a significant association between shorter height and risk of GDM was observed in overweight / obese women (height < 150 cm: AOR = 1.41, 95% CI = 1.03–2.44; height 156–160 cm: AOR = 1.48, 95% CI = 1.03–2.14). Overweight / obese women with height < 150 cm and excessive GWG at the end of the second trimester (AOR = 2.25, 95% CI = 1.45–4.17) had significantly higher risk of GDM than those without these factors. Short stature (< 150 cm) was significantly associated with GDM risk among OW/OB women with excessive gestational weight gain at the end of second trimester. This finding underscores the importance of maintaining a healthy BMI during reproductive age and gaining weight in recommended range during pregnancy.

Published
2022

2. Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus

Author

Heng Yaw, Yong, Zalilah, Mohd Shariff, Barakatun Nisak, Mohd Yusof, Zulida, Rejali, Yvonne Yee Siang, Tee, Jacques, Bindels, Eline M, van der Beek, Center for Liver, Digestive and Metabolic Diseases (CLDM), and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
Adult, MATERNAL HEMOGLOBIN, Adolescent, Medicine (miscellaneous), Hb change, Gestational diabetes mellitus, TRIMESTER, Young Adult, Hemoglobins, AGE, Risk Factors, Pregnancy, Humans, Obesity, ANEMIA, Retrospective Studies, Nutrition and Dietetics, WOMEN, OVERLOAD, DIETARY IRON INTAKE, Middle Aged, Overweight, Hg, PREVALENCE, Diabetes, Gestational, Female
Abstract

This study aimed to determine the association between hemoglobin (Hb) concentration and Hb change, during early to mid-pregnancy with the risk of gestational diabetes mellitus (GDM). This was a clinic-based retrospective cohort study of 1951 healthy pregnant women (18-45 years old) with a singleton gestation attending antenatal care at government health clinics. Hb concentration at first prenatal visit and each trimester was extracted from the antenatal cards. Hb changes from first prenatal visit to first and second trimester as well as from second to third trimester were calculated. Multivariate logistic regression was used with adjustment for covariates. Women with GDM had significantly higher Hb concentrations (Hb 1) at first prenatal visit (< 12 weeks) compared with non-GDM women (11 center dot 91 g/dl v.11 center dot 74 g/dl). Hb 1 and Hb changes (Hb change 2) from first prenatal visit to the second trimester (23-27th weeks) were significantly associated with GDM risk, with an adjusted OR of 1 center dot 14 (95 % CI 1 center dot 01, 1 center dot 29) and 1 center dot 25 (95 % CI 1 center dot 05, 1 center dot 49), respectively. The significant associations between Hb 1 and Hb change 2 with the risk of GDM were found among non-Malays, overweight/obese and women aged 35 years and above. Women with higher Hb concentrations in early pregnancy were at higher risk of GDM, and such association was significant among women aged 35 years and above, non-Malays and overweight/obese. This raises a potential concern for elevated Fe status in early pregnancy as a risk factor of GDM among Fe-replete women.

Published
2022

3. High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus

Author

Heng Yaw Yong, Zalilah Mohd Shariff, Lalitha Palaniveloo, Su Peng Loh, Barakatun Nisak Mohd Yusof, Zulida Rejali, Jacques Bindels, Yvonne Yee Siang Tee, Eline M. van der Beek, Reproductive Origins of Adult Health and Disease (ROAHD), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
Nutrition and Dietetics, Vitamin D deficiency, endocrine system diseases, nutritional and metabolic diseases, Vitamin D, Gestational diabetes mellitus, Body mass index, Food Science, Original Research
Abstract

BACKGROUND/OBJECTIVES: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possible influencers on this association.SUBJECTS/METHODS: This study included 259 pregnant women within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 24 to 32 weeks of gestation using a standard procedure. Association between serum vitamin D and GDM was tested using binary logistic regression.RESULTS: Nearly all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy serum vitamin D levels had a greater risk of GDM. However, this significant association was only identified among those with a family history of type 2 diabetes mellitus (T2DM) and in women with a body mass index indicating overweight or obese status.CONCLUSIONS: The high prevalence of VDD in this sample of pregnant women underscores the need for effective preventive public health strategies. Further investigation of this unexpected association between serum vitamin D level and GDM risk in predominantly VDD pregnant women and the potential effects of adiposity and family history of T2DM on that association is warranted.

Published
2022

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