The discharge of wastewater containing phenol and Its derivatives causes serious position to water re¬sources. In order to solve the problem, SiO2-Cu2 and SiO2-CuO catalysts were prepared by impregnation, calcination and other treatment methods, using the laboratory-made SiO2 particles as the catalyst career to support the five center Cu (II). And the prepared catalysts were applied to the CWPO of phenol. Based on the conversion of phenol after degraded in aqueous solution and the COD removal rate of the sample, the effects of reaction conditions such as reaction temperature, reaction time, oxidant concentration, catalyst concentration and initial pH value of the medium on the catalytic performance of the two catalysts were systematically studied. The experimental results show that the SiO2-Cu2 and SiO2-CuO catalysts have excipient catalytic activity in a wide pH range, and the 100% phenol conversion rate and about 90% COD removal rate can be achieved under the conditions of phenol concentration of 1.0 g/L, catalyst concentration of 0.23 g/L, reaction temperature of 70 °C, reaction time of 20 h, and hydrogen peroxide concentration of 5,0 g/L. [ABSTRACT FROM AUTHOR]