120 results on '"Zamparini, M"'
Search Results
2. Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study
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Dalla Volta, A., Palumbo, C., Zamboni, S., Mazziotti, G., Triggiani, L., Zamparini, M., Maffezzoni, F., Rinaudo, L., Bergamini, M., Di Meo, N., Caramella, I., Valcamonico, F., Borghetti, P., Guerini, A., Farina, D., Antonelli, A., Simeone, C., and Berruti, A.
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- 2024
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3. Outcome of brain metastases from adrenocortical carcinoma: a pooled analysis
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Turla, A., Laganà, M., Cremaschi, V., Zamparini, M., De Maria, L., Consoli, F., Abate, A., Tamburello, M., Alberti, A., Sigala, S., Grisanti, S., Fontanella, M. M., Cosentini, D., and Berruti, A.
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- 2024
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4. Positivity, daily time use, mood, and functioning in patients with schizophrenia spectrum disorders: Results from the diapason multicentric study
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Martinelli, A, Moncalieri, G, Zamparini, M, Alessandri, G, Vittorio Caprara, G, Castelnuovo, G, Rocchetti, M, Starace, F, Zarbo, C, de Girolamo, G, Martinelli A., Moncalieri G., Zamparini M., Alessandri G., Vittorio Caprara G., Castelnuovo G., Rocchetti M., Starace F., Zarbo C., de Girolamo G., Martinelli, A, Moncalieri, G, Zamparini, M, Alessandri, G, Vittorio Caprara, G, Castelnuovo, G, Rocchetti, M, Starace, F, Zarbo, C, de Girolamo, G, Martinelli A., Moncalieri G., Zamparini M., Alessandri G., Vittorio Caprara G., Castelnuovo G., Rocchetti M., Starace F., Zarbo C., and de Girolamo G.
- Abstract
Background: Positivity (POS) indicates the proclivity to see life and experiences in a positive light. There is limited research on its effects on individuals with Schizophrenia Spectrum Disorders (SSD). Very little is known about the relationship between POS and daily activities in people with SSD. Aim: The study aims to compare the POS rated by patients with SSD with those obtained in an Italian normative sample matched by age and sex and to use the Ecological Momentary Assessment (EMA) to investigate the association between POS and daily time use (i.e. productive activities, leisure activities), functioning and mood in individuals with SSD. Method: 620 SSD patients were recruited from mental health services in Italy as part of the DiAPAson project. POS, symptom severity, functioning, and quality of life (QoL) were assessed. POS scores were compared to a normative sample of 5,002 Italian citizens. Additionally, a subset of 102 patients underwent 7-day assessments using mobile EMA. Results: People with SSD did not significantly differ from the Italian normative sample in POS levels (0.035, p =.190). POS showed a significant inverse association with support network (−0.586, p =.036) and symptomatology (BPRS −0.101; 95% p <.001; BNSS B = −0.113, p <.001). A significant direct association was found between POS and QoL (B = 0.310, p <.001) and functioning (B = 0.058, p <.001). In the subsample using EMA, POS ratings showed significant associations with Positive Emotions (B = 0.167, p <.001) and Negative Emotions (B = −0.201, p <.001). Conclusion: People with SSD exhibited comparable levels of POS to the normative sample. Higher POS was linked to better functioning, QoL, fewer severe symptoms, and increased positive emotions. However, it did not relate to increased productivity or engagement in leisure activities. Further research is needed to understand the relationship between POS and time use in individuals with SSD.
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- 2024
5. Conspiracy mentality and health-related behaviour during the COVID-19 pandemic: a multiwave survey in Italy
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Candini, V., Brescianini, S., Chiarotti, F., Zarbo, C., Zamparini, M., Caserotti, M., Gavaruzzi, T., Girardi, P., Lotto, L., Tasso, A., Starace, F., Calamandrei, G., and de Girolamo, G.
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- 2023
- Full Text
- View/download PDF
6. Ecological monitoring of emotional intensity, variability, and instability in individuals with schizophrenia spectrum disorders: Results of a multicentre study
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Zarbo, C, Zamparini, M, Patrono, A, Calini, C, Harvey, P, Casiraghi, L, Clerici, M, Malvezzi, M, Rocchetti, M, Starace, F, de Girolamo, G, Harvey, PD, Zarbo, C, Zamparini, M, Patrono, A, Calini, C, Harvey, P, Casiraghi, L, Clerici, M, Malvezzi, M, Rocchetti, M, Starace, F, de Girolamo, G, and Harvey, PD
- Abstract
Background: Evaluating emotional experiences in the life of people with Schizophrenia Spectrum Disorder (SSD) is fundamental for developing interventions aimed at promoting well-being in specific times and contexts. However, little is known about emotional variability in this population. In DiAPAson project, we evaluated between- and within-person differences in emotional intensity, variability, and instability between people with SSD and healthy controls, and the association with psychiatric severity and levels of functioning. Methods: 102 individuals diagnosed with SSD (57 residential patients, 46 outpatients) and 112 healthy controls were thoroughly evaluated. Daily emotions were prospectively assessed with Experience Sampling Method eight times a day for a week. Statistical analyses included ANOVA, correlations, and generalized linear models. Results: Participants with SSD, and especially residential patients, had a higher intensity of negative emotions when compared to controls. Moreover, all people with SSD reported a greater between-person-variability of both positive and negative emotions and greater intra-variability of negative emotions than healthy controls. In addition, the emotion variability in people with SSD does not follow a linear or quadratic trend but is more “chaotic” if compared to controls. Conclusions: Adequate assessments of positive and negative emotional experiences and their time course in people with SSD can assist mental health professionals with well-being assessment, implementing targeted interventions through the identification of patterns, triggers, and potential predictors of emotional states.
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- 2024
7. Epidemiology of SLE in Italy: an observational study using a primary care database
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Ferrara, P, Antonazzo, I, Zamparini, M, Fornari, C, Borrelli, C, Boarino, S, Bettiol, A, Mattioli, I, Palladino, P, Zanzottera Ferrari, E, Emmi, G, Mantovani, L, Mazzaglia, G, Ferrara, Pietro, Antonazzo, Ippazio C, Zamparini, Manuel, Fornari, Carla, Borrelli, Cristiana, Boarino, Silvia, Bettiol, Alessandra, Mattioli, Irene, Palladino, Pasquale, Zanzottera Ferrari, Elena, Emmi, Giacomo, Mantovani, Lorenzo G, Mazzaglia, Giampiero, Ferrara, P, Antonazzo, I, Zamparini, M, Fornari, C, Borrelli, C, Boarino, S, Bettiol, A, Mattioli, I, Palladino, P, Zanzottera Ferrari, E, Emmi, G, Mantovani, L, Mazzaglia, G, Ferrara, Pietro, Antonazzo, Ippazio C, Zamparini, Manuel, Fornari, Carla, Borrelli, Cristiana, Boarino, Silvia, Bettiol, Alessandra, Mattioli, Irene, Palladino, Pasquale, Zanzottera Ferrari, Elena, Emmi, Giacomo, Mantovani, Lorenzo G, and Mazzaglia, Giampiero
- Abstract
Objectives: To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE. Methods: A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompassing data from 634 753 people. SLE cases were identified over the period 2017-2022, employing three alternative definitions to provide a more detailed understanding of SLE characteristics. Incidence rates were expressed as cases per 100 000 person-years and prevalence as cases per 100 000 people. Demographic and clinical characteristics of incident SLE cases were also studied. Results: From 2017 to 2022, a total of 191 incident and 1385 prevalent cases were identified under our first definition. In 2022, the incidence rate was 6.51 cases (95% CI 6.29 to 6.74) per 100 000 person-years, and the prevalence 60.57 (95% CI 59.89 to 61.25) per 100 000 people, being the prevalence five times higher in women compared with men. Both estimates have trended upwards since 2017. A geographical variation across the country was also seen. The demographic and clinical characteristics of incident SLE cases were described, while the potential associations of SLE incidence with some pre-existing conditions were observed, such as chronic kidney disease, chronic hepatic disease, rheumatoid arthritis and Sjogren's syndrome. Conclusions: The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years. Age, sex, and area of residence strongly correlate with the epidemiology of this condition.
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- 2024
8. Positivity, daily time use, mood, and functioning in patients with schizophrenia spectrum disorders: Results from the diapason multicentric study
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Martinelli, A., Moncalieri, G., Zamparini, M., Alessandri, G., Vittorio Caprara, G., Castelnuovo, Gianluca, Rocchetti, M., Starace, F., Zarbo, C., De Girolamo, Giovanni, Castelnuovo G. (ORCID:0000-0003-2633-9822), de Girolamo G., Martinelli, A., Moncalieri, G., Zamparini, M., Alessandri, G., Vittorio Caprara, G., Castelnuovo, Gianluca, Rocchetti, M., Starace, F., Zarbo, C., De Girolamo, Giovanni, Castelnuovo G. (ORCID:0000-0003-2633-9822), and de Girolamo G.
- Abstract
Background: Positivity (POS) indicates the proclivity to see life and experiences in a positive light. There is limited research on its effects on individuals with Schizophrenia Spectrum Disorders (SSD). Very little is known about the relationship between POS and daily activities in people with SSD. Aim: The study aims to compare the POS rated by patients with SSD with those obtained in an Italian normative sample matched by age and sex and to use the Ecological Momentary Assessment (EMA) to investigate the association between POS and daily time use (i.e. productive activities, leisure activities), functioning and mood in individuals with SSD. Method: 620 SSD patients were recruited from mental health services in Italy as part of the DiAPAson project. POS, symptom severity, functioning, and quality of life (QoL) were assessed. POS scores were compared to a normative sample of 5,002 Italian citizens. Additionally, a subset of 102 patients underwent 7-day assessments using mobile EMA. Results: People with SSD did not significantly differ from the Italian normative sample in POS levels (0.035, p =.190). POS showed a significant inverse association with support network (−0.586, p =.036) and symptomatology (BPRS −0.101; 95% p <.001; BNSS B = −0.113, p <.001). A significant direct association was found between POS and QoL (B = 0.310, p <.001) and functioning (B = 0.058, p <.001). In the subsample using EMA, POS ratings showed significant associations with Positive Emotions (B = 0.167, p <.001) and Negative Emotions (B = −0.201, p <.001). Conclusion: People with SSD exhibited comparable levels of POS to the normative sample. Higher POS was linked to better functioning, QoL, fewer severe symptoms, and increased positive emotions. However, it did not relate to increased productivity or engagement in leisure activities. Further research is needed to understand the relationship between POS and time use in individuals with SSD.
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- 2024
9. Time will tell: Associations between unbalanced time perspectives and symptom severity in individuals with schizophrenia spectrum disorders
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Damiani, S, Zarbo, C, Stolarski, M, Zamparini, M, Casiraghi, L, Rocchetti, M, Starace, F, Fusar-Poli, P, de Girolamo, G, Damiani S., Zarbo C., Stolarski M., Zamparini M., Casiraghi L., Rocchetti M., Starace F., Fusar-Poli P., de Girolamo G., Damiani, S, Zarbo, C, Stolarski, M, Zamparini, M, Casiraghi, L, Rocchetti, M, Starace, F, Fusar-Poli, P, de Girolamo, G, Damiani S., Zarbo C., Stolarski M., Zamparini M., Casiraghi L., Rocchetti M., Starace F., Fusar-Poli P., and de Girolamo G.
- Abstract
Patients with schizophrenia spectrum disorder (SSD) experience disrupted temporality on the immediate timescale. However, insufficient information is available for longer time frames, and the interaction of temporal perspectives with the clinical manifestations of SSD is unknown. We explored the association between unbalanced time perspectives and symptom severity. Thirty-seven Italian mental health services participating in the DiAPAson project recruited 620 patients with DSM-5 SSD (68 % males, mean age = 41.3 ± 9.5 years). Time perspective biases were measured using the Deviation from the Balanced Time Perspective-revisited (DBTP-r) indicator, based on Zimbardo Time Perspective Inventory (ZTPI) scores. Psychiatric symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS) and Brief Negative Symptoms Scale (BNSS). Preliminary analyses examined the associations between ZTPI/DBTP-r and BPRS/BNSS total scores. In secondary analyses, we first tested the associations between the ZTPI/DBTP-r and BPRS/BNSS subscales and then compared ZTPI differences between patients with and without hallucinations, delusions, and conceptual disorganisation. Statistical significance was set at Holm-Bonferroni corrected p < 0.05. Low-to-moderate positive correlations were found between the DBTP-r and BPRS/BNSS total scores (r = 0.29/0.22). The strongest associations were between DBTP-r/ZTPI_Past-Negative and anxiety/depression (r = 0.34/0.36), followed by DBTP-r/ZTPI_Present-Fatalistic with thought disturbances (r = 0.22/0.20). DBTP-r was associated with BNSS anhedonia and avolition (r = 0.21/0.24). DBTP-r was higher in patients with hallucinations (ES = 0.391) and conceptual disorganisation (ES = 0.397) than in those without these symptoms. Unbalanced time perspective was positively associated with the severity of primary and secondary SSD features. These findings provide a rationale for empirical tests focused on balancing time perspectives in patients with SSD.
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- 2023
10. Comparing Adherence to the Experience Sampling Method Among Patients With Schizophrenia Spectrum Disorder and Unaffected Individuals: Observational Study From the Multicentric DiAPAson Project
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Zarbo, C, Zamparini, M, Nielssen, O, Casiraghi, L, Rocchetti, M, Starace, F, de Girolamo, G, Collaborators, D, Zarbo C., Zamparini M., Nielssen O., Casiraghi L., Rocchetti M., Starace F., de Girolamo G., Collaborators D. A., Zarbo, C, Zamparini, M, Nielssen, O, Casiraghi, L, Rocchetti, M, Starace, F, de Girolamo, G, Collaborators, D, Zarbo C., Zamparini M., Nielssen O., Casiraghi L., Rocchetti M., Starace F., de Girolamo G., and Collaborators D. A.
- Abstract
Background: The Experience Sampling Method (ESM) is a valid method of remotely recording activities and mood, but the predictors of adherence to ESM in patients with Schizophrenia Spectrum Disorder (SSD) are not known. Studies on adherence are significant as they highlight the strengths and weaknesses of ESM-based study designs and allow the development of recommendations and practical guidelines for implementing future studies or treatment plans. Objective: The aim of this study was to compare the adherence to ESM in patients with SSD and unaffected control individuals, investigate their patterns, and report the predictors of adherence. Methods: In total, 131 patients with SSD (74 in residential facilities and 57 outpatients) and 115 unaffected control individuals were recruited at 10 different centers in Italy as part of the DiAPAson project. Demographic information, symptom severity, disability level, and level of function were recorded for the clinical sample. Participants were evaluated for daily time use and mood through a smartphone-based ESM 8 times a day for 7 consecutive days. Adherence was measured by the response rate to ESM notifications. Results were analyzed using the chi-square test, ANOVA, Kruskal-Wallis test, and Friedman test, and a logistic regression model. Results: The overall adherence rate in this study was 50% for residents, 59% for outpatients, and 78% for unaffected control individuals. Indeed, patients with SSD had a lower rate of adherence to ESM than the unaffected control group (P≤.001), independent of time slot, day of monitoring, or day of the week. No differences in adherence rates between weekdays and weekends were found among the 3 groups. The adherence rate was the lowest in the late evening time slot (8 PM to 12 AM) and days 6-7 of the study for both patients with SSD and unaffected control individuals. The adherence rate among patients with SSD was not predicted by sociodemographic characteristics, cognitive function, or other
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- 2023
11. Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study
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D'Anna, G, Zarbo, C, Cardamone, G, Zamparini, M, Calza, S, Rota, M, Correll, C, Rocchetti, M, Starace, F, de Girolamo, G, Barlati, S, Baroncelli, A, Besana, F, Boero, M, Clerici, M, Di Michele, V, Durbano, F, Foia, M, Impicci, S, Jacoponi, F, Leuci, E, Malagamba, D, Marina, M, Martinelli, A, Monzani, E, Nappi, G, Piccicacchi, B, Placenti, R, Rippa, A, Tura, G, Zizolfi, S, D'Anna G., Zarbo C., Cardamone G., Zamparini M., Calza S., Rota M., Correll C. U., Rocchetti M., Starace F., de Girolamo G., Barlati S., Baroncelli A., Besana F., Boero M. E., Clerici M., Di Michele V., Durbano F., Foia M. G., Impicci S., Jacoponi F. M., Leuci E., Malagamba D., Marina M., Martinelli A., Monzani E., Nappi G., Piccicacchi B., Placenti R., Rippa A., Tura G., Zizolfi S., D'Anna, G, Zarbo, C, Cardamone, G, Zamparini, M, Calza, S, Rota, M, Correll, C, Rocchetti, M, Starace, F, de Girolamo, G, Barlati, S, Baroncelli, A, Besana, F, Boero, M, Clerici, M, Di Michele, V, Durbano, F, Foia, M, Impicci, S, Jacoponi, F, Leuci, E, Malagamba, D, Marina, M, Martinelli, A, Monzani, E, Nappi, G, Piccicacchi, B, Placenti, R, Rippa, A, Tura, G, Zizolfi, S, D'Anna G., Zarbo C., Cardamone G., Zamparini M., Calza S., Rota M., Correll C. U., Rocchetti M., Starace F., de Girolamo G., Barlati S., Baroncelli A., Besana F., Boero M. E., Clerici M., Di Michele V., Durbano F., Foia M. G., Impicci S., Jacoponi F. M., Leuci E., Malagamba D., Marina M., Martinelli A., Monzani E., Nappi G., Piccicacchi B., Placenti R., Rippa A., Tura G., and Zizolfi S.
- Abstract
This study evaluated the relationship between negative symptoms, daily time use (productive/non-productive activities, PA/NPA), and negative emotions in schizophrenia-spectrum disorders (SSDs): 618 individuals with SSDs (311 residential care patients [RCPs], 307 outpatients) were surveyed about socio-demographic, clinical (BPRS, BNSS) and daily time use (paper-and-pencil Time Use Survey completed twice/week) characteristics. Among them 57 RCPs and 46 outpatients, matched to 112 healthy controls, also underwent ecological monitoring of emotions (8 times/day for a week) through Experience Sampling Method (ESM). RCPs spent significantly less time in PA than outpatients. Patients with more negative symptomatology spent more time in NPA and less in PA compared to patients with milder symptoms. Higher time spent in NPA was associated with negative emotions (p < 0.001 during workdays) even when correcting for BNSS total and antipsychotic polypharmacy (p = 0.002 for workdays, p = 0.006 for Sundays). Future studies are needed to explore in more detail the relationship between negative emotions, negative symptoms, time use, and functioning in individuals with SSDs, providing opportunities for more informed and personalised clinical treatment planning and research into interactions between different motivational, saliency and behavioural aspects in individuals with SSDs.
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- 2023
12. Ecological monitoring of physical activity, emotions and daily life activities in schizophrenia: The DiAPAson study
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Zarbo, C, Rota, M, Calza, S, Crouter, S, Ekelund, U, Barlati, S, Bussi, R, Clerici, M, Placenti, R, Paulillo, G, Pogliaghi, S, Rocchetti, M, Ruggeri, M, Starace, F, Zanolini, S, Zamparini, M, De Girolamo, G, Zarbo C., Rota M., Calza S., Crouter S. E., Ekelund U., Barlati S., Bussi R., Clerici M., Placenti R., Paulillo G., Pogliaghi S., Rocchetti M., Ruggeri M., Starace F., Zanolini S., Zamparini M., De Girolamo G., Zarbo, C, Rota, M, Calza, S, Crouter, S, Ekelund, U, Barlati, S, Bussi, R, Clerici, M, Placenti, R, Paulillo, G, Pogliaghi, S, Rocchetti, M, Ruggeri, M, Starace, F, Zanolini, S, Zamparini, M, De Girolamo, G, Zarbo C., Rota M., Calza S., Crouter S. E., Ekelund U., Barlati S., Bussi R., Clerici M., Placenti R., Paulillo G., Pogliaghi S., Rocchetti M., Ruggeri M., Starace F., Zanolini S., Zamparini M., and De Girolamo G.
- Abstract
Background Schizophrenia spectrum disorders (SSD) compromise psychosocial functioning, including daily time use, emotional expression and physical activity (PA). Objective We performed a cohort study aimed at investigating: (1) the differences in PA, daily activities and emotions between patients with SSD and healthy controls (HC); (2) the strength of the association between these variables and clinical features among patients with SSD. Methods Ninety-nine patients with SSD (53 residential patients, 46 outpatients) and 111 matched HC were assessed for several clinical variables, and levels of functioning by means of standardised clinical measures. Self-reported daily activities and emotions were assessed with a smartphone application for ecological momentary assessment (EMA), and PA levels were assessed with a wearable accelerometer for 7 consecutive days. Findings Patients with SSD, especially those living in residential facilities, spent more time being sedentary, and self-reported more sedentary and self-care activities, experiencing higher levels of negative emotions compared with HC. Moreover, higher functioning levels among patients were associated with more time spent in moderate-to-vigorous activity. Conclusions Sedentary behaviour and negative emotions are particularly critical among patients with SSD and are associated with more impaired clinical outcomes. Clinical implications Mobile-EMA and wearable sensors are useful for monitoring the daily life of patients with SSD and the level of PA. This population needs to be targeted with specific rehabilitative programmes aimed at improving their commitment to structured daily activities.
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- 2023
13. Conspiracy mentality and health-related behaviour during the COVID-19 pandemic: a multiwave survey in Italy
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Candini, V, Brescianini, S, Chiarotti, F, Zarbo, C, Zamparini, M, Caserotti, M, Gavaruzzi, T, Girardi, P, Lotto, L, Tasso, A, Starace, F, Calamandrei, G, de Girolamo, G, Candini V., Brescianini S., Chiarotti F., Zarbo C., Zamparini M., Caserotti M., Gavaruzzi T., Girardi P., Lotto L., Tasso A., Starace F., Calamandrei G., de Girolamo G., Candini, V, Brescianini, S, Chiarotti, F, Zarbo, C, Zamparini, M, Caserotti, M, Gavaruzzi, T, Girardi, P, Lotto, L, Tasso, A, Starace, F, Calamandrei, G, de Girolamo, G, Candini V., Brescianini S., Chiarotti F., Zarbo C., Zamparini M., Caserotti M., Gavaruzzi T., Girardi P., Lotto L., Tasso A., Starace F., Calamandrei G., and de Girolamo G.
- Abstract
Objectives: This study aimed to (1) explore the changes in conspiracy mentality across the four waves of the COVID-19 pandemic; (2) assess the relationship between conspirative mentality and psychological/behavioural variables; (3) identify the predictors of conspirative mentality; and (4) explore the effect of conspirative mentality on COVID-19 protective behaviour. Study design: This was a multiwave survey. Methods: A total of 10,013 Italian individuals, aged 18–70 years, were assessed across the four waves (from January to May 2021) through online survey. We collected information about the sociodemographic characteristics of participants, personal experiences of COVID-19 infection, trust, COVID-19 protective behaviours, COVID-19 risk perception, arousal, auto-efficacy, resilience and well-being. Conspiracy mentality was assessed with the Conspiracy Mentality Questionnaire. The statistical analyses included exploratory factorial analyses, Pearson correlations and multiple linear regressions. Results: The conspiracy mentality score during the COVID-19 pandemic was medium–high (mean 59.0 on a 0–100 scale) and slightly increased from 58.2 to 59.9 across months, in parallel with a slight decrease in trust in health institutions and scientific informational sources. Individuals aged >35 years, poorly educated and particularly scared about their financial situation were at risk of showing higher levels of conspirative mentality. Higher levels of conspirative mentality were risk factors for low levels of COVID-19 protective behaviours. Conclusions: Clear and effective communication may improve trust in health institutions and informational sources, decrease conspirative theories and increase compliance with protective behaviour.
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- 2023
14. Patterns of antipsychotic prescription and accelerometer-based physical activity levels in people with schizophrenia spectrum disorders: a multicenter, prospective study
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Oliva, V, Fanelli, G, Zamparini, M, Zarbo, C, Rocchetti, M, Casiraghi, L, Starace, F, Martinelli, A, Serretti, A, de Girolamo, G, Oliva V, Fanelli G, Zamparini M, Zarbo C, Rocchetti M, Casiraghi L, Starace F, Martinelli A, Serretti A, de Girolamo G, Oliva, V, Fanelli, G, Zamparini, M, Zarbo, C, Rocchetti, M, Casiraghi, L, Starace, F, Martinelli, A, Serretti, A, de Girolamo, G, Oliva V, Fanelli G, Zamparini M, Zarbo C, Rocchetti M, Casiraghi L, Starace F, Martinelli A, Serretti A, and de Girolamo G
- Abstract
Antipsychotic polypharmacy (APP) in patients with schizophrenia spectrum disorders (SSDs) is usually not recommended, though it is very common in clinical practice. Both APP and SSDs have been linked to worse health outcomes and decreased levels of physical activity, which in turn is an important risk factor for cardiovascular diseases and premature mortality. This real-world, observational study aimed to investigate antipsychotic prescribing patterns and physical activity in residential patients and outpatients with SSDs. A total of 620 patients and 114 healthy controls were recruited in 37 centers across Italy. Each participant underwent a comprehensive sociodemographic and clinical evaluation. Physical activity was monitored for seven consecutive days through accelerometer-based biosensors. High rates of APP were found in all patients, with residential patients receiving more APP than outpatients, probably because of greater psychopathological severity. Physical activity was lower in patients compared to controls. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity than those in monopharmacy. Rehabilitation efforts in psychiatric residential treatment facilities were likely to result in improved physical activity performances in residential patients. Our findings may have important public health implications, as they indicate the importance of reducing APP and encouraging physical activity.
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- 2023
15. Openness buffers the impact of Belief in Conspiracy Theories on COVID-19 vaccine hesitancy: Evidence from a large, representative Italian sample
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Li, T, de Girolamo, G, Zamparini, M, Malvezzi, M, Candini, V, Calamandrei, G, Starace, F, Zarbo, C, Gotz, F, Li T. Y., de Girolamo G., Zamparini M., Malvezzi M., Candini V., Calamandrei G., Starace F., Zarbo C., Gotz F. M., Li, T, de Girolamo, G, Zamparini, M, Malvezzi, M, Candini, V, Calamandrei, G, Starace, F, Zarbo, C, Gotz, F, Li T. Y., de Girolamo G., Zamparini M., Malvezzi M., Candini V., Calamandrei G., Starace F., Zarbo C., and Gotz F. M.
- Abstract
As COVID-19 continues to incur enormous personal and societal costs, widespread vaccination against the virus remains the most effective strategy to end the pandemic. However, vaccine hesitancy is rampant and has been steadily rising for decades. Seeking to remedy this, personality psychologists have begun to explore psychological drivers of vaccine hesitancy, including the Big Five. Openness to Experience presents itself as a vexing case as previous attempts to study its association with vaccine hesitancy have yielded mixed findings. In this prereg-istered study, we hypothesise that the impact of Openness to Experience on Vaccine Hesitancy depends on its interplay with other factors, namely conspiracy beliefs. To test this, we apply logistic regressions, simple slopes analyses, and propensity score matching to a nationally representative sample of 2500 Italian citizens, collected in May 2021. Contrary to our original hypothesis (i.e., Openness will have a positive association with Vaccine Hesitancy at high - and a negative at low - levels of Conspiracy Beliefs) we find that high Openness diminishes the impact of Belief in Conspiracy Theories on Vaccine Hesitancy. Consistent with previous research, we propose that Openness serves as a buffer against extreme positions by allowing individuals to be exposed to a greater diversity of information.
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- 2023
16. Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients
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Mayeli, A, Lagoy, A, Smagula, S, Wilson, J, Zarbo, C, Rocchetti, M, Starace, F, Zamparini, M, Casiraghi, L, Calza, S, Rota, M, D'Agostino, A, de Girolamo, G, Martinelli, A, Nibbio, G, Pelizza, L, Pessina, R, Placenti, R, Silva, A, Ferrarelli, F, Mayeli A., LaGoy A. D., Smagula S. F., Wilson J. D., Zarbo C., Rocchetti M., Starace F., Zamparini M., Casiraghi L., Calza S., Rota M., D'Agostino A., de Girolamo G., Martinelli A., Nibbio G., Pelizza L., Pessina R., Placenti R., Silva A., Ferrarelli F., Mayeli, A, Lagoy, A, Smagula, S, Wilson, J, Zarbo, C, Rocchetti, M, Starace, F, Zamparini, M, Casiraghi, L, Calza, S, Rota, M, D'Agostino, A, de Girolamo, G, Martinelli, A, Nibbio, G, Pelizza, L, Pessina, R, Placenti, R, Silva, A, Ferrarelli, F, Mayeli A., LaGoy A. D., Smagula S. F., Wilson J. D., Zarbo C., Rocchetti M., Starace F., Zamparini M., Casiraghi L., Calza S., Rota M., D'Agostino A., de Girolamo G., Martinelli A., Nibbio G., Pelizza L., Pessina R., Placenti R., Silva A., and Ferrarelli F.
- Abstract
Sleep and rest-activity-rhythm (RAR) abnormalities are commonly reported in schizophrenia spectrum disorder (SSD) patients. However, an in-depth characterization of sleep/RAR alterations in SSD, including patients in different treatment settings, and the relationship between these alterations and SSD clinical features (e.g., negative symptoms) is lacking. SSD (N = 137 altogether, N = 79 residential and N = 58 outpatients) and healthy control (HC) subjects (N = 113) were recruited for the DiAPAson project. Participants wore an ActiGraph for seven consecutive days to monitor habitual sleep-RAR patterns. Sleep/rest duration, activity (i.e., M10, calculated on the 10 most active hours), rhythm fragmentation within days (i.e., intra-daily variability, IV; beta, steepness of rest-active changes), and rhythm regularity across days (i.e., inter-daily stability, IS) were computed in each study participant. Negative symptoms were assessed in SSD patients with the Brief Negative Symptom Scale (BNSS). Both SSD groups showed lower M10 and longer sleep/rest duration vs. HC, while only residential patients had more fragmented and irregular rhythms than HC. Compared to outpatients, residential patients had lower M10 and higher beta, IV and IS. Furthermore, residential patients had worse BNSS scores relative to outpatients, and higher IS contributed to between-group differences in BNSS score severity. Altogether, residentials and outpatients SSD had both shared and unique abnormalities in Sleep/RAR measures vs. HC and relative to one another, which also contributed to the patients' negative symptom severity. Future work will help establish whether improving some of these measures may ameliorate the quality of life and clinical symptoms of SSD patients.
- Published
- 2023
17. Time perspective affects daily time use and daily functioning in individuals with Schizophrenia Spectrum Disorders: Results from the multicentric DiAPAson study
- Author
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Zarbo, C, Stolarski, M, Zamparini, M, Damiani, S, Casiraghi, L, Rocchetti, M, Starace, F, de Girolamo, G, Zarbo C., Stolarski M., Zamparini M., Damiani S., Casiraghi L., Rocchetti M., Starace F., de Girolamo G., Zarbo, C, Stolarski, M, Zamparini, M, Damiani, S, Casiraghi, L, Rocchetti, M, Starace, F, de Girolamo, G, Zarbo C., Stolarski M., Zamparini M., Damiani S., Casiraghi L., Rocchetti M., Starace F., and de Girolamo G.
- Abstract
Time perspective (TP) influences various aspects of human life. We aimed to explore the associations between TP, daily time use, and levels of functioning among 620 patients (313 residential patients and 307 outpatients) with a diagnosis of Schizophrenia Spectrum Disorders (SSD) recruited from 37 different centres in Italy. The Brief Psychiatric Rating Scale and the Specific Levels of Functioning (SLOF) were used to assess psychiatric symptoms severity and levels of functioning. Daily time use was assessed using an ad hoc paper and pencil Time Use Survey. The Zimbardo Time Perspective Inventory (ZTPI) was used to assess TP. Deviation from Balanced Time Perspective (DBTP-r) was used as an indicator of temporal imbalance. Results showed that the amount of time spent on non-productive activities (NPA) was positively predicted by DBTP-r (Exp(0): 1.36; p .003), and negatively predicted by the Past-Positive (Exp(0): 0.80; p .022), Present-Hedonistic (Exp(0): 0.77; p .008), and Future (Exp(0): 0.78; p .012) subscales. DBTP-r significantly negatively predicted SLOF outcomes (p .002), and daily time use, in particular the amount of time spent in NPA and Productive Activities (PA), mediated their association. Results suggested that rehabilitative programs for individuals with SSD should consider fostering a balanced time perspective to reduce inactivity, increase physical activity, and promote healthy daily functioning and autonomy.
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- 2023
18. Needs for care of residents with schizophrenia spectrum disorders and association with daily activities and mood monitored with experience sampling method: the DIAPASON study
- Author
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Martinelli, A, D'Addazio, M, Zamparini, M, Thornicroft, G, Torino, G, Zarbo, C, Rocchetti, M, Starace, F, Casiraghi, L, Ruggeri, M, De Girolamo, G, Boero, M, Cardamone, G, Clerici, M, Dal Corso, E, Durbano, F, Foia, M, Latorre, V, Impicci, S, Malagamba, D, Marina, M, Monzani, E, Necchini, N, Orticola, J, Paolone, F, Paulillo, G, Piccicacchi, B, Placenti, R, Politi, P, Rippa, A, Tranquilli, L, Zizolfi, S, Martinelli A., D'Addazio M., Zamparini M., Thornicroft G., Torino G., Zarbo C., Rocchetti M., Starace F., Casiraghi L., Ruggeri M., De Girolamo G., Boero M. E., Cardamone G., Clerici M., Dal Corso E., Durbano F., Foia M. G., Latorre V., Impicci S., Malagamba D., Marina M., Monzani E., Necchini N., Orticola J., Paolone F., Paulillo G., Piccicacchi B., Placenti R., Politi P., Rippa A., Tranquilli L., Zizolfi S., Martinelli, A, D'Addazio, M, Zamparini, M, Thornicroft, G, Torino, G, Zarbo, C, Rocchetti, M, Starace, F, Casiraghi, L, Ruggeri, M, De Girolamo, G, Boero, M, Cardamone, G, Clerici, M, Dal Corso, E, Durbano, F, Foia, M, Latorre, V, Impicci, S, Malagamba, D, Marina, M, Monzani, E, Necchini, N, Orticola, J, Paolone, F, Paulillo, G, Piccicacchi, B, Placenti, R, Politi, P, Rippa, A, Tranquilli, L, Zizolfi, S, Martinelli A., D'Addazio M., Zamparini M., Thornicroft G., Torino G., Zarbo C., Rocchetti M., Starace F., Casiraghi L., Ruggeri M., De Girolamo G., Boero M. E., Cardamone G., Clerici M., Dal Corso E., Durbano F., Foia M. G., Latorre V., Impicci S., Malagamba D., Marina M., Monzani E., Necchini N., Orticola J., Paolone F., Paulillo G., Piccicacchi B., Placenti R., Politi P., Rippa A., Tranquilli L., and Zizolfi S.
- Abstract
Aims. Care needs represent an essential paradigm in planning residential facility (RF) interventions. However, possible disagreements between users and staff are critical issues in service delivery. The Experience Sampling Method (ESM) tracks experiences in the real world and real time. This study aimed to evaluate the care needs of patients with schizophrenia spectrum disorder (SSD) in RFs and its association with daily activities and mood monitored using the ESM.Methods. As part of the DIAPASON project, 313 residents with SSD were recruited from 99 Italian RFs. Sociodemographic and clinical characteristics were recorded. Care needs, the severity of symptomatology and negative symptoms were assessed. Fifty-six residents were also assessed for 7 consecutive days using the mobile ESM. Descriptive, agreement, predictor and moderator analyses were conducted.Results. The staff rated a higher number of total and met needs than service users (p < 0.001). Only a slight agreement between users and staff on unmet needs was found in self-care (k = 0.106) and information (k = 0.100) needs, while a moderate agreement was found in accommodation (k = 0.484), food (k = 0.406), childcare (k = 0.530), physical health (k = 0.470), telephone (k = 0.458) and transport (k = 0.425) needs. Older age (-0.15; p < 0.01), longer SSD diagnosis (-0.16; p < 0.01), higher collaboration (-0.16; p < 0.01) and lower symptomatology (-0.16; p < 0.01) decreased the number of unmet needs, while being a female (0.27; p < 0.05) and a shorter length of stay in an RF (0.54; p < 0.001) increased the number of unmet needs. A higher number of unmet needs was associated with a lower amount of time spent in leisure activities or reporting a positive mood: on the contrary, more unmet needs were associated with a greater amount of time spent in religious or non-productive activities. The associations between unmet needs rated by staff and users and momentary mood as assessed using the ESM were
- Published
- 2023
19. Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study
- Author
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Dalla Volta, A., primary, Palumbo, C., additional, Zamboni, S., additional, Mazziotti, G., additional, Triggiani, L., additional, Zamparini, M., additional, Maffezzoni, F., additional, Rinaudo, L., additional, Bergamini, M., additional, Di Meo, N., additional, Caramella, I., additional, Valcamonico, F., additional, Borghetti, P., additional, Guerini, A., additional, Farina, D., additional, Antonelli, A., additional, Simeone, C., additional, and Berruti, A., additional
- Published
- 2023
- Full Text
- View/download PDF
20. Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients
- Author
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Mayeli A., LaGoy A. D., Smagula S. F., Wilson J. D., Zarbo C., Rocchetti M., Starace F., Zamparini M., Casiraghi L., Calza S., Rota M., D'Agostino A., de Girolamo G., Martinelli A., Nibbio G., Pelizza L., Pessina R., Placenti R., Silva A., Ferrarelli F., Mayeli, A, Lagoy, A, Smagula, S, Wilson, J, Zarbo, C, Rocchetti, M, Starace, F, Zamparini, M, Casiraghi, L, Calza, S, Rota, M, D'Agostino, A, de Girolamo, G, Martinelli, A, Nibbio, G, Pelizza, L, Pessina, R, Placenti, R, Silva, A, and Ferrarelli, F
- Subjects
symptoms of Schizophrenia - Abstract
Sleep and rest-activity-rhythm (RAR) abnormalities are commonly reported in schizophrenia spectrum disorder (SSD) patients. However, an in-depth characterization of sleep/RAR alterations in SSD, including patients in different treatment settings, and the relationship between these alterations and SSD clinical features (e.g., negative symptoms) is lacking. SSD (N = 137 altogether, N = 79 residential and N = 58 outpatients) and healthy control (HC) subjects (N = 113) were recruited for the DiAPAson project. Participants wore an ActiGraph for seven consecutive days to monitor habitual sleep-RAR patterns. Sleep/rest duration, activity (i.e., M10, calculated on the 10 most active hours), rhythm fragmentation within days (i.e., intra-daily variability, IV; beta, steepness of rest-active changes), and rhythm regularity across days (i.e., inter-daily stability, IS) were computed in each study participant. Negative symptoms were assessed in SSD patients with the Brief Negative Symptom Scale (BNSS). Both SSD groups showed lower M10 and longer sleep/rest duration vs. HC, while only residential patients had more fragmented and irregular rhythms than HC. Compared to outpatients, residential patients had lower M10 and higher beta, IV and IS. Furthermore, residential patients had worse BNSS scores relative to outpatients, and higher IS contributed to between-group differences in BNSS score severity. Altogether, residentials and outpatients SSD had both shared and unique abnormalities in Sleep/RAR measures vs. HC and relative to one another, which also contributed to the patients' negative symptom severity. Future work will help establish whether improving some of these measures may ameliorate the quality of life and clinical symptoms of SSD patients.
- Published
- 2023
21. Needs for care of residents with schizophrenia spectrum disorders and association with daily activities and mood monitored with experience sampling method: the DIAPASON study
- Author
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Martinelli A., D'Addazio M., Zamparini M., Thornicroft G., Torino G., Zarbo C., Rocchetti M., Starace F., Casiraghi L., Ruggeri M., De Girolamo G., Boero M. E., Cardamone G., Clerici M., Dal Corso E., Durbano F., Foia M. G., Latorre V., Impicci S., Malagamba D., Marina M., Monzani E., Necchini N., Orticola J., Paolone F., Paulillo G., Piccicacchi B., Placenti R., Politi P., Rippa A., Tranquilli L., Zizolfi S., Martinelli, A, D'Addazio, M, Zamparini, M, Thornicroft, G, Torino, G, Zarbo, C, Rocchetti, M, Starace, F, Casiraghi, L, Ruggeri, M, De Girolamo, G, Boero, M, Cardamone, G, Clerici, M, Dal Corso, E, Durbano, F, Foia, M, Latorre, V, Impicci, S, Malagamba, D, Marina, M, Monzani, E, Necchini, N, Orticola, J, Paolone, F, Paulillo, G, Piccicacchi, B, Placenti, R, Politi, P, Rippa, A, Tranquilli, L, and Zizolfi, S
- Subjects
schizophrenia ,Community mental health ,epidemiology ,psychiatric service - Abstract
Aims. Care needs represent an essential paradigm in planning residential facility (RF) interventions. However, possible disagreements between users and staff are critical issues in service delivery. The Experience Sampling Method (ESM) tracks experiences in the real world and real time. This study aimed to evaluate the care needs of patients with schizophrenia spectrum disorder (SSD) in RFs and its association with daily activities and mood monitored using the ESM.Methods. As part of the DIAPASON project, 313 residents with SSD were recruited from 99 Italian RFs. Sociodemographic and clinical characteristics were recorded. Care needs, the severity of symptomatology and negative symptoms were assessed. Fifty-six residents were also assessed for 7 consecutive days using the mobile ESM. Descriptive, agreement, predictor and moderator analyses were conducted.Results. The staff rated a higher number of total and met needs than service users (p < 0.001). Only a slight agreement between users and staff on unmet needs was found in self-care (k = 0.106) and information (k = 0.100) needs, while a moderate agreement was found in accommodation (k = 0.484), food (k = 0.406), childcare (k = 0.530), physical health (k = 0.470), telephone (k = 0.458) and transport (k = 0.425) needs. Older age (-0.15; p < 0.01), longer SSD diagnosis (-0.16; p < 0.01), higher collaboration (-0.16; p < 0.01) and lower symptomatology (-0.16; p < 0.01) decreased the number of unmet needs, while being a female (0.27; p < 0.05) and a shorter length of stay in an RF (0.54; p < 0.001) increased the number of unmet needs. A higher number of unmet needs was associated with a lower amount of time spent in leisure activities or reporting a positive mood: on the contrary, more unmet needs were associated with a greater amount of time spent in religious or non-productive activities. The associations between unmet needs rated by staff and users and momentary mood as assessed using the ESM were not moderated by the severity of symptomatology.Conclusions. Although care needs are fundamental in planning residential activities aimed at recovery-oriented rehabilitation, RF interventions did not fully meet users' needs, and some disagreements on unmet needs between users and staff were reported. Further efforts are necessary to overcome Italian RF limits in delivering rehabilitative interventions defined by real users' needs to facilitate users' productivity and progress towards personal recovery.
- Published
- 2023
22. Assessing adherence to and usability of Experience Sampling Method (ESM) and actigraph in patients with Schizophrenia Spectrum Disorder: A mixed-method study
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Zarbo, C, Agosta, S, Casiraghi, L, De Novellis, A, Leuci, E, Paulillo, G, Rocchetti, M, Starace, F, Zamparini, M, de Girolamo, G, Zarbo C, Agosta S, Casiraghi L, De Novellis A, Leuci E, Paulillo G, Rocchetti M, Starace F, Zamparini M, de Girolamo G, Zarbo, C, Agosta, S, Casiraghi, L, De Novellis, A, Leuci, E, Paulillo, G, Rocchetti, M, Starace, F, Zamparini, M, de Girolamo, G, Zarbo C, Agosta S, Casiraghi L, De Novellis A, Leuci E, Paulillo G, Rocchetti M, Starace F, Zamparini M, and de Girolamo G
- Abstract
The application of innovative technologies in psychiatry is promising, but the debate about its feasibility is not settled. Our aim was to investigate and compare adherence to and usability of 7-day monitoring with an Experience Sampling Method (ESM) and Actigraphy among a sample of individuals with a diagnosis of Schizophrenia Spectrum Disorders (SSD) and paired healthy controls. Twenty-two patients living in residential facilities (RFs), 20 outpatients and 26 controls were enrolled in this study as part of the DiAPAson project. Participants wore an actigraph and were evaluated for daily time use and mood with a smartphone-based ESM. Then, they completed questionnaires to assess the usability of the devices and were interviewed. Adherence was assessed as the percentage of time spent wearing actigraph and answering ESM notifications. Residential patients, compared to controls, showed significantly higher usability of the actigraph and lower adherence to both the actigraph and ESM. From the qualitative interviews, four high-order themes emerged: effects of monitoring, adherence and usability, emotions and mental states, and advice. Findings are promising for the application of these methodologies in such populations. The role of multidisciplinary staff in RFs is crucial for guaranteeing the realization of such projects.
- Published
- 2022
23. COVID-19 Vaccine Hesitancy in Italy: Predictors of Acceptance, Fence Sitting and Refusal of the COVID-19 Vaccination
- Author
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Zarbo, C, Candini, V, Ferrari, C, D'Addazio, M, Calamandrei, G, Starace, F, Caserotti, M, Gavaruzzi, T, Lotto, L, Tasso, A, Zamparini, M, de Girolamo, G, Zarbo C., Candini V., Ferrari C., d'Addazio M., Calamandrei G., Starace F., Caserotti M., Gavaruzzi T., Lotto L., Tasso A., Zamparini M., de Girolamo G., Zarbo, C, Candini, V, Ferrari, C, D'Addazio, M, Calamandrei, G, Starace, F, Caserotti, M, Gavaruzzi, T, Lotto, L, Tasso, A, Zamparini, M, de Girolamo, G, Zarbo C., Candini V., Ferrari C., d'Addazio M., Calamandrei G., Starace F., Caserotti M., Gavaruzzi T., Lotto L., Tasso A., Zamparini M., and de Girolamo G.
- Abstract
BackgroundThe hesitancy in taking the COVID-19 vaccine is a global challenge. The need to identify predictors of COVID-19 vaccine reluctance is critical. Our objectives were to evaluate sociodemographic, psychological, and behavioral factors, as well as attitudes and beliefs that influence COVID-19 vaccination hesitancy in the general population of Italy. MethodsA total of 2,015 people were assessed in two waves (March, April and May, 2021). Participants were divided into three groups: (1) individuals who accepted the vaccination ("accepters"); (2) individuals who refused the vaccination ("rejecters"); and (3) individuals who were uncertain about their attitudes toward the vaccination ("fence sitters"). Group comparisons were performed using ANOVA, the Kruskal-Wallis test and chi-square tests. The strength of the association between the groups and the participants' characteristics was analyzed using a series of multinomial logistic regression models with bootstrap internal validation (one for each factor). ResultsThe "fence sitters" group, when compared to the others, included individuals of younger age, lower educational level, and worsening economic situation in the previous 3 months. After controlling for sociodemographic factors, the following features emerged as the main risk factors for being "fence sitters" (compared with vaccine "accepters"): reporting lower levels of protective behaviors, trust in institutions and informational sources, frequency of use of informational sources, agreement with restrictions and higher conspirative mentality. Higher levels of COVID-19 perceived risk, trust in institutions and informational sources, frequency of use of informational sources, agreement with restrictions and protective behaviors were associated with a higher likelihood of becoming "fence sitters" rather than vaccine "rejecters." ConclusionsThe "fence sitters" profile revealed by this study is intriguing and should be the focus of public programmes aimed at impro
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- 2022
24. Psychological well-being during the COVID-19 pandemic in Italy assessed in a four-waves survey
- Author
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de Girolamo, G, Ferrari, C, Candini, V, Buizza, C, Calamandrei, G, Caserotti, M, Gavaruzzi, T, Girardi, P, Habersaat, K, Lotto, L, Scherzer, M, Starace, F, Tasso, A, Zamparini, M, Zarbo, C, de Girolamo G, Ferrari C, Candini V, Buizza C, Calamandrei G, Caserotti M, Gavaruzzi T, Girardi P, Habersaat KB, Lotto L, Scherzer M, Starace F, Tasso A, Zamparini M, Zarbo C, de Girolamo, G, Ferrari, C, Candini, V, Buizza, C, Calamandrei, G, Caserotti, M, Gavaruzzi, T, Girardi, P, Habersaat, K, Lotto, L, Scherzer, M, Starace, F, Tasso, A, Zamparini, M, Zarbo, C, de Girolamo G, Ferrari C, Candini V, Buizza C, Calamandrei G, Caserotti M, Gavaruzzi T, Girardi P, Habersaat KB, Lotto L, Scherzer M, Starace F, Tasso A, Zamparini M, and Zarbo C
- Abstract
COVID-19 pandemic had a negative impact on the mental health and well-being (WB) of citizens. This cross-sectional study included 4 waves of data collection aimed at identifying profiles of individuals with different levels of WB. The study included a representative stratified sample of 10,013 respondents in Italy. The WHO 5-item well-being scale (WHO-5) was used for the assessment of WB. Different supervised machine learning approaches (multinomial logistic regression, partial least-square discriminant analysis—PLS-DA—, classification tree—CT—) were applied to identify individual characteristics with different WB scores, first in waves 1–2 and, subsequently, in waves 3 and 4. Forty-one percent of participants reported “Good WB”, 30% “Poor WB”, and 28% “Depression”. Findings carried out using multinomial logistic regression show that Resilience was the most important variable able for discriminating the WB across all waves. Through the PLS-DA, Increased Unhealthy Behaviours proved to be the more important feature in the first two waves, while Financial Situation gained most relevance in the last two. COVID-19 Perceived Risk was relevant, but less than the other variables, across all waves. Interestingly, using the CT we were able to establish a cut-off for Resilience (equal to 4.5) that discriminated good WB with a probability of 65% in wave 4. Concluding, we found that COVID-19 had negative implications for WB. Governments should support evidence-based strategies considering factors that influence WB (i.e., Resilience, Perceived Risk, Healthy Behaviours, and Financial Situation).
- Published
- 2022
25. 35P Feasibility and activity of megestrol acetate in addition to EDP-M as first-line therapy in patients with metastatic/unresectable adrenocortical carcinoma
- Author
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Turla, A., primary, Laganà, M., additional, Cosentini, D., additional, Zamparini, M., additional, Ambrosini, R., additional, Cremaschi, V., additional, Tiberio, G., additional, Abate, A., additional, Tamburello, M., additional, Sigala, S., additional, Grisanti, S., additional, and Berruti, A., additional
- Published
- 2023
- Full Text
- View/download PDF
26. Openness buffers the impact of Belief in Conspiracy Theories on COVID-19 vaccine hesitancy: Evidence from a large, representative Italian sample
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Li T. Y., de Girolamo G., Zamparini M., Malvezzi M., Candini V., Calamandrei G., Starace F., Zarbo C., Gotz F. M., Li, T, de Girolamo, G, Zamparini, M, Malvezzi, M, Candini, V, Calamandrei, G, Starace, F, Zarbo, C, and Gotz, F
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Conspiracy theorie ,Italy ,Pandemic ,Openness to Experience ,Vaccination ,COVID-19 ,M-PSI/07 - PSICOLOGIA DINAMICA ,Vaccine hesitancy ,General Psychology ,Personality - Abstract
As COVID-19 continues to incur enormous personal and societal costs, widespread vaccination against the virus remains the most effective strategy to end the pandemic. However, vaccine hesitancy is rampant and has been steadily rising for decades. Seeking to remedy this, personality psychologists have begun to explore psychological drivers of vaccine hesitancy, including the Big Five. Openness to Experience presents itself as a vexing case as previous attempts to study its association with vaccine hesitancy have yielded mixed findings. In this prereg-istered study, we hypothesise that the impact of Openness to Experience on Vaccine Hesitancy depends on its interplay with other factors, namely conspiracy beliefs. To test this, we apply logistic regressions, simple slopes analyses, and propensity score matching to a nationally representative sample of 2500 Italian citizens, collected in May 2021. Contrary to our original hypothesis (i.e., Openness will have a positive association with Vaccine Hesitancy at high - and a negative at low - levels of Conspiracy Beliefs) we find that high Openness diminishes the impact of Belief in Conspiracy Theories on Vaccine Hesitancy. Consistent with previous research, we propose that Openness serves as a buffer against extreme positions by allowing individuals to be exposed to a greater diversity of information.
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- 2023
27. Conspiracy Mentality and Health-Related Behaviour During the Covid-19 Pandemic: An Italian Multi-Wave Survey
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Candini, V., Brescianini, S., Chiarotti, F., Zarbo, C., Zamparini, M., Caserotti, M., Gavaruzzi, T., Girardi, P., Lotto, L., Tasso, A., Starace, F., Calamandrei, G., Girolamo, De, and G
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ConspiracyCOVID-19TrustBeliefsHealth behaviour - Published
- 2023
28. EP08.02-172 Effect of EGFR Inhibition on Bone Health in NSCLC Patients without Skeletal Metastasis
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Mandruzzato, M., primary, Cortinovis, D.L., additional, Fassi, E., additional, Ammoni, L., additional, Zamparini, M., additional, Colonese, F., additional, Bianchi, S., additional, Baggi, A., additional, Berruti, A., additional, Grisanti, S., additional, and Frigerio, M., additional
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- 2022
- Full Text
- View/download PDF
29. 833P Longer follow up of a real-world study of cemiplimab in advanced cutaneous squamous cell carcinoma: Focus on late toxicities and long term benefit
- Author
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Quaglino, P., primary, Baggi, A., additional, Depenni, R., additional, Guida, M., additional, Ascierto, P.A., additional, Queirolo, P., additional, Peris, K., additional, Spagnolo, F., additional, Bianchi, L., additional, De Galitiis, F., additional, Zamparini, M., additional, Proietti, I., additional, Marconcini, R., additional, Botticelli, A., additional, Barbieri, V., additional, Alfieri, S., additional, Fargnoli, M.C., additional, Occelli, M., additional, and Bossi, P., additional
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- 2022
- Full Text
- View/download PDF
30. 664P A multicentre retrospective analysis of recurrent/metastatic (RM) nasopharyngeal cancer (NPC) from non-endemic areas: Results in the pre-immunotherapy era
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Bossi, P., primary, Alberti, A., additional, Zamparini, M., additional, Orlandi, E., additional, Grisanti, S., additional, Trama, A., additional, Resteghini, C., additional, Mesia Nin, R., additional, Mohamad, I., additional, Ozyar, E., additional, Buglione, M., additional, Airoldi, M., additional, Vecchio, S., additional, Livi, L., additional, Cirauqui Cirauqui, B., additional, El-Sherify, M., additional, Ursino, S., additional, Argiris, A., additional, Linares Galiana, I., additional, and Licitra, L.F., additional
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- 2022
- Full Text
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31. 1624P Total and regional changes in body composition in metastatic hormone-sensitive prostate cancer (mHSPC) patients randomized to receive androgen deprivation + enzalutamide +/- zoledronic acid: The BonEnza study
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Buffoni, M., Dalla Volta, A., Valcamonico, F., Apollo, D.D., Zivi, A., Procopio, G., Sepe, P., Del Conte, G., Di Meo, N., Foti, S., Zamboni, S., Messina, C., Lucchini, E., Rizzi, A., Ravanelli, M., Zamparini, M., Zacchi, F., Suardi, N., Farina, D., and Berruti, A.
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- 2024
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- View/download PDF
32. 891P Pembrolizumab and olaparib in recurrent/metastatic, platinum resistant nasopharyngeal cancer: The POINT study
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Gurizzan, C., Farinatti, S., Alberti, A., Bonomo, P., Resteghini, C., Alfieri, S., Bergamini, C., Perri, F., Moretti, G., Galizia, D., Cossu Rocca, M., Sponghini, A.P., Secondino, S., Zamparini, M., Lorini, L., and Bossi, P.
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- 2024
- Full Text
- View/download PDF
33. Assessment of DXA derived bone quality indexes and bone geometry parameters in early breast cancer patients: A single center cross-sectional study
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Pedersini, R., Cosentini, D., Rinaudo, L., Zamparini, M., Ulivieri, F. M., di Mauro, P., Maffezzoni, F., Monteverdi, S., Vena, W., Laini, L., Amoroso, V., Simoncini, E. L., Farina, D., Mazziotti, G., and Berruti, A.
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History ,Aromatase inhibitors ,Bone strain index ,Dual-energy X-ray absorptiometry ,Vertebral fractures ,Polymers and Plastics ,Endocrinology, Diabetes and Metabolism ,Orthopedics and Sports Medicine ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2023
34. Clinical presentation and outcome of patients with enteric-type adenocarcinoma of the lung: A pooled analysis of published cases
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Fassi, E., Mandruzzato, M., Zamparini, M., Bianchi, S., Petrelli, F., Baggi, A., Alberti, A., Grisanti, S., and Berruti, A.
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Pulmonary and Respiratory Medicine ,Cancer Research ,Pulmonary adenocarcinoma with enteric differentiation (PEAD) ,Oncology ,NSCLC ,Prognosis ,Prognostic factors ,Pulmonary enteric adenocarcinoma (PEAC) ,Systematic review - Published
- 2023
35. Corrigendum: “Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma” (European Journal of Cancer (2021) 157 (250–258), (S0959804921005360), (10.1016/j.ejca.2021.08.018))
- Author
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Baggi, A., Quaglino, P., Rubatto, M., Depenni, R., Guida, M., Ascierto, P. A., Trojaniello, C., Queirolo, P., Saponara, M., Peris, Ketty, Spagnolo, F., Bianchi, L., De Galitiis, F., Potenza, M. C., Proietti, I., Marconcini, R., Botticelli, A., Barbieri, Pietro Vittorio, Licitra, L., Alfieri, S., Ficorella, C., Cortellini, A., Fargnoli, Maria Concetta, Troiani, T., Tondulli, L., Zamparini, M., Bossi, P., Peris K. (ORCID:0000-0002-5237-0463), Barbieri V., Fargnoli M. C., Baggi, A., Quaglino, P., Rubatto, M., Depenni, R., Guida, M., Ascierto, P. A., Trojaniello, C., Queirolo, P., Saponara, M., Peris, Ketty, Spagnolo, F., Bianchi, L., De Galitiis, F., Potenza, M. C., Proietti, I., Marconcini, R., Botticelli, A., Barbieri, Pietro Vittorio, Licitra, L., Alfieri, S., Ficorella, C., Cortellini, A., Fargnoli, Maria Concetta, Troiani, T., Tondulli, L., Zamparini, M., Bossi, P., Peris K. (ORCID:0000-0002-5237-0463), Barbieri V., and Fargnoli M. C.
- Abstract
The authors regret that some Author information was incorrectly given in the published article. Author Manuel Zamparini was missed in the Author list, and the listed affiliation for Paola Queirolo was incorrect. The full and correct details for the Authors are: Paola Queirolo Division of Melanoma, Sarcomas and Rare Tumors, IEO, European Institute of Oncology, IRCCS, Milan, Italy Manuel Zamparini University of Brescia, Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, ASST-Spedali Civili, Brescia, Lombardia, ItalyThe Authors also note that values in the first column of Table 4 were mistakenly reversed for ‘Antibiotic intake (within 1 month before therapy)’ and ‘Haemoglobin’. The correct table in full is given here.
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- 2022
36. Shared and Unique Abnormalities in Sleep and Rest-Activity Rhythms in Residential and Outpatient Schizophrenia Spectrum Disorder Patients
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Mayeli, A, Lagoy, A, Smagula, S, Wilson, J, Zarbo, C, Rocchetti, M, Starace, F, Zamparini, M, Casiraghi, L, Calza, S, Rota, M, de Girolamo, G, Ferrarelli, F, Mayeli, A, Lagoy, A, Smagula, S, Wilson, J, Zarbo, C, Rocchetti, M, Starace, F, Zamparini, M, Casiraghi, L, Calza, S, Rota, M, de Girolamo, G, and Ferrarelli, F
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- 2022
37. Phase II study of cabazitaxel as second-third line treatment in patients with metastatic adrenocortical carcinoma
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Laganà, M., primary, Grisanti, S., additional, Ambrosini, R., additional, Cosentini, D., additional, Abate, A., additional, Zamparini, M., additional, Ferrari, V.D., additional, Gianoncelli, A., additional, Turla, A., additional, Canu, L., additional, Terzolo, M., additional, Tiberio, G.A.M., additional, Sigala, S., additional, and Berruti, A., additional
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- 2022
- Full Text
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38. A multicentre retrospective analysis of recurrent/metastatic (RM) nasopharyngeal cancer (NPC) from non-endemic areas: Results in the pre-immunotherapy era
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Bossi, P., Alberti, A., Zamparini, M., Orlandi, E., Grisanti, S., Trama, A., Resteghini, C., Nin, R. Mesia, Mohamad, I., Ozyar, E., Buglione, M., Airoldi, M., Vecchio, S., Livi, L., Cirauqui, B. Cirauqui, El-Sherify, M., Ursino, S., Argiris, A., Galiana, I. Linares, Licitra, L. F., and Acibadem University Dspace
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- 2022
39. Corrigendum to 'Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma' [Eur J Canc 157 (2021) 250-258]
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Baggi, A, Quaglino, P, Rubatto, M, Depenni, R, Guida, M, Ascierto, Pa, Trojaniello, C, Queirolo, P, Saponara, M, Peris, K, Spagnolo, F, Bianchi, L, De Galitiis, F, Potenza, Mc, Proietti, I, Marconcini, R, Botticelli, A, Barbieri, V, Licitra, L, Alfieri, S, Ficorella, C, Cortellini, A, Fargnoli, Mc, Troiani, T, Tondulli, L, Zamparini, M, and Bossi, P
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Cancer Research ,Settore MED/35 ,Oncology - Published
- 2022
40. Psychological Well-Being During the Covid-19 Pandemic in Italy: Results from a Four-Wave Survey
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Girolamo, De, Ferrari, G., Candini, V., Buizza, C., Calamandrei, G., Caserotti, M., Gavaruzzi, T., Girardi, P., Habersaat, K. B., Lotto, L., Scherzer, M., Starace, F., Tasso, A., Zamparini, M., and Zarbo, C.
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- 2022
41. Shared and Unique Abnormalities in Sleep and Rest- Activity Rhythms in Residential and Outpatient Schizophrenia Spectrum Disorder Patients
- Author
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Mayeli, A., Lagoy, A., Smagula, S., Wilson, J., Zarbo, C., Rocchetti, M., Starace, F., Zamparini, M., Casiraghi, L., Calza, S., Rota, M., De Girolamo, G., and Ferrarelli, F.
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Actigraphy, Schizophrenia (SCZ), Circadian Rhythm, Brief Negative Symptom Scale (BNSS) ,Actigraphy ,Schizophrenia (SCZ) ,Circadian Rhythm ,Brief Negative Symptom Scale (BNSS) - Published
- 2022
42. 277P Fat body mass independently predicts incident vertebral fractures in breast cancer patients given adjuvant aromatase inhibitor therapy and denosumab
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Schivardi, G., Pedersini, R., Cosentini, D., di Mauro, P., Zamparini, M., Rinaudo, L., Di Meo, N., Delbarba, A., Cappelli, C., Laganà, M., Alberti, A., Baronchelli, M., Guerci, G., Laini, L., Simoncini, E.L., Farina, D., Mazziotti, G., and Berruti, A.
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- 2023
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- View/download PDF
43. 470P Increased risk of vertebral fractures in healthy bone in metastatic breast cancer patients treated with CDK4/6 inhibitors combined with endocrine therapy
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Bergamini, M., Pedersini, R., Brentegani, C., Baluta, V., Schivardi, G., Cosentini, D., di Mauro, P., Zamparini, M., Laganà, M., Amoroso, V., Vassalli, L., Alberti, A., Laini, L., Simoncini, E.L., and Berruti, A.
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- 2023
- Full Text
- View/download PDF
44. 1785P Changes in bone mineral density, trabecular bone score and body composition in metastatic hormone-sensitive prostate cancer (mHSPC) patients randomized to receive androgen deprivation + enzalutamide plus/minus zoledronic acid: The BonEnza study
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Dalla Volta, A., Valcamonico, F., Zivi, A., Procopio, G., Sepe, P., Del Conte, G., Di Meo, N., Foti, S., Zamboni, S., Messina, C., Lucchini, E., Rizzi, A., Ravanelli, M., Caramella, I., Zamparini, M., Milella, M., Suardi, N., Maroldi, R., Farina, D., and Berruti, A.
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- 2023
- Full Text
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45. A pilot Randomized Controlled Trial (RCT) study protocol for assessing physical activity in individuals diagnosed with Borderline Personality Disorder (PABORD).
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Martinelli, A., D'Addazio, M., Leone, S., Rossi, R., Pogliaghi, S., Marchitelli, G., Zamparini, M., Moncalieri, G., Toffol, E., and de Girolamo, G.
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MENTAL health services ,PSYCHOTHERAPY ,CAREGIVERS ,BORDERLINE personality disorder ,SLEEP - Abstract
Introduction: Most treatments for severe mental disorders involve either pharmacotherapy or psychological interventions, which show mild to moderate effectiveness and may not lead to complete remission. Physical activity (PA), effective in enhancing physical health among the general population, emerges as a potential adjunctive treatment option that can address the existing gaps. Borderline Personality Disorder (BPD) is a severe condition associated with profound psychosocial impairment, a heightened risk of suicide, and considerable burden on informal caregivers and mental health service providers. While there is a lack of approved medications for individuals with BPD, psychosocial interventions demonstrated good efficacy. However, the implementation of these treatments is limited by the demanded extensive training for staff. No studies have investigated the effectiveness of structured PA as an adjunctive treatment for individuals with BPD. Objectives: The primary objective of this study is to assess whether the intervention group outperforms the control group in terms of improvement on a standardized assessment scale evaluating BPD psychopathology, the Zanarini Rating Scale for Borderline Disorder. Secondary objective is to assess whether the intervention group can increase and sustain higher levels of PA. We hypothesise that a structured PA program will demonstrate superior results compared to the psychoeducation control group concerning PA levels upon completion of the intervention. Additionally, we hypothesise that the intervention group will exhibit enhanced outcomes in psychopathology, functioning, and sleep. Methods: The PABORD Randomized Controlled Trial is designed for female outpatient individuals diagnosed with BPD aged 18-40 years. This trial will involve two distinct groups: (i) an intervention group (25 participants) that will engage in a 12-week structured PA program under the supervision of a sports medicine physician; (ii) a control group (25 individuals) that will undergo a 12-week psychoeducation program focused on PA and diet. Patients are assessed at three different time points. Standardized assessments include psychopathology, psychosocial functioning, sleep, menstrual cycle and nutrition data. Measurements are taken on the amount and intensity of PA and sleep patterns using a biosensor device (Actigraph GT9X), dynamometric measures and BMI. Biomarkers and hormonal cycles are examined through the collection of plasma and saliva samples. The trial is financially supported through donations (5x1000 fund), and has been submitted to the local Ethics Committee for approval. The trial registration process is also currently in progress. Results: Not yet available. Conclusions: The study will provide new knowledge which may enhance our treatment options with patients suffering from BPD. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
46. COVID-19 Vaccine Hesitancy in Italy: Predictors of Acceptance, Fence Sitting and Refusal of the COVID-19 Vaccination
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Cristina Zarbo, Valentina Candini, Clarissa Ferrari, Miriam d'Addazio, Gemma Calamandrei, Fabrizio Starace, Marta Caserotti, Teresa Gavaruzzi, Lorella Lotto, Alessandra Tasso, Manuel Zamparini, Giovanni de Girolamo, Zarbo C., Candini V., Ferrari C., d'Addazio M., Calamandrei G., Starace F., Caserotti M., Gavaruzzi T., Lotto L., Tasso A., Zamparini M., de Girolamo G., Zarbo, C, Candini, V, Ferrari, C, D'Addazio, M, Calamandrei, G, Starace, F, Caserotti, M, Gavaruzzi, T, Lotto, L, Tasso, A, Zamparini, M, and de Girolamo, G
- Subjects
Cross-Sectional Studie ,conspiracy ,COVID-19 Vaccines ,SARS-CoV-2 ,COVID-19 Vaccine ,Public Health, Environmental and Occupational Health ,COVID-19 ,restriction ,trust ,protective behaviors ,SH4_4 ,vaccination ,perceived risk ,NO ,restrictions ,Cross-Sectional Studies ,protective behavior ,Humans ,Vaccination Hesitancy ,Human - Abstract
BackgroundThe hesitancy in taking the COVID-19 vaccine is a global challenge. The need to identify predictors of COVID-19 vaccine reluctance is critical. Our objectives were to evaluate sociodemographic, psychological, and behavioral factors, as well as attitudes and beliefs that influence COVID-19 vaccination hesitancy in the general population of Italy.MethodsA total of 2,015 people were assessed in two waves (March, April and May, 2021). Participants were divided into three groups: (1) individuals who accepted the vaccination (“accepters”); (2) individuals who refused the vaccination (“rejecters”); and (3) individuals who were uncertain about their attitudes toward the vaccination (“fence sitters”). Group comparisons were performed using ANOVA, the Kruskal-Wallis test and chi-square tests. The strength of the association between the groups and the participants' characteristics was analyzed using a series of multinomial logistic regression models with bootstrap internal validation (one for each factor).ResultsThe “fence sitters” group, when compared to the others, included individuals of younger age, lower educational level, and worsening economic situation in the previous 3 months. After controlling for sociodemographic factors, the following features emerged as the main risk factors for being “fence sitters” (compared with vaccine “accepters”): reporting lower levels of protective behaviors, trust in institutions and informational sources, frequency of use of informational sources, agreement with restrictions and higher conspirative mentality. Higher levels of COVID-19 perceived risk, trust in institutions and informational sources, frequency of use of informational sources, agreement with restrictions and protective behaviors were associated with a higher likelihood of becoming “fence sitters” rather than vaccine “rejecters.”ConclusionsThe “fence sitters” profile revealed by this study is intriguing and should be the focus of public programmes aimed at improving adherence to the COVID-19 vaccination campaign.
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- 2022
47. Psychological well-being during the COVID-19 pandemic in Italy assessed in a four-waves survey
- Author
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Giovanni de Girolamo, Clarissa Ferrari, Valentina Candini, Chiara Buizza, Gemma Calamandrei, Marta Caserotti, Teresa Gavaruzzi, Paolo Girardi, Katrine Bach Habersaat, Lorella Lotto, Martha Scherzer, Fabrizio Starace, Alessandra Tasso, Manuel Zamparini, Cristina Zarbo, de Girolamo, G, Ferrari, C, Candini, V, Buizza, C, Calamandrei, G, Caserotti, M, Gavaruzzi, T, Girardi, P, Habersaat, K, Lotto, L, Scherzer, M, Starace, F, Tasso, A, Zamparini, M, Zarbo, C, de Girolamo G., Ferrari C., Candini V., Buizza C., Calamandrei G., Caserotti M., Gavaruzzi T., Girardi P., Habersaat K.B., Lotto L., Scherzer M., Starace F., Tasso A., Zamparini M., and Zarbo C.
- Subjects
Cross-Sectional Studie ,Cross-Sectional Studies ,Multidisciplinary ,Mental Health ,Italy ,Pandemic ,Surveys and Questionnaires ,Humans ,Surveys and Questionnaire ,COVID-19 ,Pandemics ,Human - Abstract
COVID-19 pandemic had a negative impact on the mental health and well-being (WB) of citizens. This cross-sectional study included 4 waves of data collection aimed at identifying profiles of individuals with different levels of WB. The study included a representative stratified sample of 10,013 respondents in Italy. The WHO 5-item well-being scale (WHO-5) was used for the assessment of WB. Different supervised machine learning approaches (multinomial logistic regression, partial least-square discriminant analysis—PLS-DA—, classification tree—CT—) were applied to identify individual characteristics with different WB scores, first in waves 1–2 and, subsequently, in waves 3 and 4. Forty-one percent of participants reported “Good WB”, 30% “Poor WB”, and 28% “Depression”. Findings carried out using multinomial logistic regression show that Resilience was the most important variable able for discriminating the WB across all waves. Through the PLS-DA, Increased Unhealthy Behaviours proved to be the more important feature in the first two waves, while Financial Situation gained most relevance in the last two. COVID-19 Perceived Risk was relevant, but less than the other variables, across all waves. Interestingly, using the CT we were able to establish a cut-off for Resilience (equal to 4.5) that discriminated good WB with a probability of 65% in wave 4. Concluding, we found that COVID-19 had negative implications for WB. Governments should support evidence-based strategies considering factors that influence WB (i.e., Resilience, Perceived Risk, Healthy Behaviours, and Financial Situation).
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- 2022
48. Time perspective affects daily time use and daily functioning in individuals with Schizophrenia Spectrum Disorders: Results from the multicentric DiAPAson study
- Author
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Cristina Zarbo, Maciej Stolarski, Manuel Zamparini, Stefano Damiani, Letizia Casiraghi, Matteo Rocchetti, Fabrizio Starace, Giovanni de Girolamo, Zarbo, C, Stolarski, M, Zamparini, M, Damiani, S, Casiraghi, L, Rocchetti, M, Starace, F, and de Girolamo, G
- Subjects
Psychiatry and Mental health ,Italy ,Time Perception ,Schizophrenia ,Brief Psychiatric Rating Scale ,M-PSI/07 - PSICOLOGIA DINAMICA ,Biological Psychiatry ,Human - Abstract
Time perspective (TP) influences various aspects of human life. We aimed to explore the associations between TP, daily time use, and levels of functioning among 620 patients (313 residential patients and 307 outpatients) with a diagnosis of Schizophrenia Spectrum Disorders (SSD) recruited from 37 different centres in Italy. The Brief Psychiatric Rating Scale and the Specific Levels of Functioning (SLOF) were used to assess psychiatric symptoms severity and levels of functioning. Daily time use was assessed using an ad hoc paper and pencil Time Use Survey. The Zimbardo Time Perspective Inventory (ZTPI) was used to assess TP. Deviation from Balanced Time Perspective (DBTP-r) was used as an indicator of temporal imbalance. Results showed that the amount of time spent on non-productive activities (NPA) was positively predicted by DBTP-r (Exp(0): 1.36; p .003), and negatively predicted by the Past-Positive (Exp(0): 0.80; p .022), Present-Hedonistic (Exp(0): 0.77; p .008), and Future (Exp(0): 0.78; p .012) subscales. DBTP-r significantly negatively predicted SLOF outcomes (p .002), and daily time use, in particular the amount of time spent in NPA and Productive Activities (PA), mediated their association. Results suggested that rehabilitative programs for individuals with SSD should consider fostering a balanced time perspective to reduce inactivity, increase physical activity, and promote healthy daily functioning and autonomy.
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- 2023
49. Patterns of antipsychotic prescription and accelerometer-based physical activity levels in people with schizophrenia spectrum disorders: a multicenter, prospective study
- Author
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Oliva, Vincenzo, Fanelli, Giuseppe, Zamparini, Manuel, Zarbo, Cristina, Rocchetti, Matteo, Casiraghi, Letizia, Starace, Fabrizio, Martinelli, Alessandra, Serretti, Alessandro, de Girolamo, Giovanni, Pelizza, Lorenzo, the Diapason Consortium, Oliva, V, Fanelli, G, Zamparini, M, Zarbo, C, Rocchetti, M, Casiraghi, L, Starace, F, Martinelli, A, Serretti, A, de Girolamo, G, Oliva, Vincenzo, Fanelli, Giuseppe, Zamparini, Manuel, Zarbo, Cristina, Rocchetti, Matteo, Casiraghi, Letizia, Starace, Fabrizio, Martinelli, Alessandra, Serretti, Alessandro, de Girolamo, Giovanni, Pelizza, Lorenzo, and the Diapason Consortium
- Subjects
wearable accelerometer-based biosensor ,psychosi ,rehabilitation ,All institutes and research themes of the Radboud University Medical Center ,Humans ,Pharmacology (medical) ,psychosis ,Prospective Studies ,polypharmacy ,Exercise ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,actigraph, antipsychotics, monopharmacy, physical fitness, polypharmacy, psychiatric residential treatment facilities, psychosis, psychotropic drugs, rehabilitation, wearable accelerometer-based biosensor ,psychiatric residential treatment facilities ,psychotropic drugs ,antipsychotic ,Psychiatry and Mental health ,antipsychotics ,Prescriptions ,physical fitne ,physical fitness ,Schizophrenia ,actigraph ,monopharmacy ,psychiatric residential treatment facilitie ,psychotropic drug ,Antipsychotic Agents - Abstract
Antipsychotic polypharmacy (APP) in patients with schizophrenia spectrum disorders (SSDs) is usually not recommended, though it is very common in clinical practice. Both APP and SSDs have been linked to worse health outcomes and decreased levels of physical activity, which in turn is an important risk factor for cardiovascular diseases and premature mortality. This real-world, observational study aimed to investigate antipsychotic prescribing patterns and physical activity in residential patients and outpatients with SSDs. A total of 620 patients and 114 healthy controls were recruited in 37 centers across Italy. Each participant underwent a comprehensive sociodemographic and clinical evaluation. Physical activity was monitored for seven consecutive days through accelerometer-based biosensors. High rates of APP were found in all patients, with residential patients receiving more APP than outpatients, probably because of greater psychopathological severity. Physical activity was lower in patients compared to controls. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity than those in monopharmacy. Rehabilitation efforts in psychiatric residential treatment facilities were likely to result in improved physical activity performances in residential patients. Our findings may have important public health implications, as they indicate the importance of reducing APP and encouraging physical activity.
- Published
- 2023
50. Conspiracy mentality and health-related behaviour during the COVID-19 pandemic: a multiwave survey in Italy
- Author
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V. Candini, S. Brescianini, F. Chiarotti, C. Zarbo, M. Zamparini, M. Caserotti, T. Gavaruzzi, P. Girardi, L. Lotto, A. Tasso, F. Starace, G. Calamandrei, G. de Girolamo, Candini, V, Brescianini, S, Chiarotti, F, Zarbo, C, Zamparini, M, Caserotti, M, Gavaruzzi, T, Girardi, P, Lotto, L, Tasso, A, Starace, F, Calamandrei, G, and de Girolamo, G
- Subjects
Settore M-PSI/01 - Psicologia Generale ,Conspiracy ,Belief ,Beliefs ,Settore M-PSI/03 - Psicometria ,Public Health, Environmental and Occupational Health ,COVID-19 ,Health behaviour ,General Medicine ,Trust ,Settore MED/01 - Statistica Medica - Abstract
Objectives: This study aimed to (1) explore the changes in conspiracy mentality across the four waves of the COVID-19 pandemic; (2) assess the relationship between conspirative mentality and psychological/behavioural variables; (3) identify the predictors of conspirative mentality; and (4) explore the effect of conspirative mentality on COVID-19 protective behaviour. Study design: This was a multiwave survey. Methods: A total of 10,013 Italian individuals, aged 18–70 years, were assessed across the four waves (from January to May 2021) through online survey. We collected information about the sociodemographic characteristics of participants, personal experiences of COVID-19 infection, trust, COVID-19 protective behaviours, COVID-19 risk perception, arousal, auto-efficacy, resilience and well-being. Conspiracy mentality was assessed with the Conspiracy Mentality Questionnaire. The statistical analyses included exploratory factorial analyses, Pearson correlations and multiple linear regressions. Results: The conspiracy mentality score during the COVID-19 pandemic was medium–high (mean 59.0 on a 0–100 scale) and slightly increased from 58.2 to 59.9 across months, in parallel with a slight decrease in trust in health institutions and scientific informational sources. Individuals aged >35 years, poorly educated and particularly scared about their financial situation were at risk of showing higher levels of conspirative mentality. Higher levels of conspirative mentality were risk factors for low levels of COVID-19 protective behaviours. Conclusions: Clear and effective communication may improve trust in health institutions and informational sources, decrease conspirative theories and increase compliance with protective behaviour.
- Published
- 2022
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