20 results on '"Zayed S"'
Search Results
2. Metabolic and renal outcomes of empagliflozin in patients with type 2 diabetes mellitus attending Armed Forces Hospital in Saudi Arabia
- Author
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Alshahrani, Ali A., primary, Qahtani, Saad S. Al, additional, Qahtani, Abrar S. Al, additional, Mashhour, Saeed M., additional, Alkhtani, Zayed S., additional, and Alragea, Yahya M., additional
- Published
- 2023
- Full Text
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3. Evaluating the Oncology Research Internship (ORIoN) during the COVID-19 Pandemic: A Comparison of Virtual and In-Person Iterations
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Zayed, S., primary, Goodman, C.D., additional, Mutsaers, A., additional, Palma, D.A., additional, Velker, V., additional, Laba, J.M., additional, and Nguyen, T., additional
- Published
- 2022
- Full Text
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4. Young Patients' Satisfaction Following the Correction of Adolescent Idiopathic Scoliosis in Saudi Arabia: A Cross-Sectional Study
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Zayed S Alzayed, Ozair B Majid, Saeed A Alqahtani, Iram Saba, Mohammed A Al Rushud, and Abdullah T Eissa
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General Engineering - Abstract
Posterior spinal instrumented fusion remains the mainstay treatment for adolescent idiopathic scoliosis (AIS) with acceptable post-operative patient satisfaction. However, in Saudi Arabia, patient satisfaction after surgical management for AIS has not been thoroughly studied. The purpose of this study was to determine patient satisfaction and quality of life using the Scoliosis Research Society-22r (SRS-22r, the most recent version) questionnaire after surgical correction of AIS in Saudi Arabia.A retrospective study was conducted that included patients who underwent posterior spinal instrumented fusion for AIS from January 1995 through December 2015. We included 115 patients (both males and females) in our study. We used the Arabic version of the SRS-22r questionnaire that was completed through telephonic interviews. Data collected were then analyzed using SPSS Statistics, version 23.The mean age of our patients at the time of surgery was 15.0 ± 2.6 years and the average time from surgery to interview was 9.4 ± 4.7 years. A positive response was recorded in all domains including pain, function, mental health, and self-image. Furthermore, 76.5% of the patients were satisfied with their management outcome and 81.7% of the patients reported no complications.Surgical correction of AIS improved the quality of life of our patients that was assessed using the Arabic version of the SRS-22r questionnaire. Apart from overall patient satisfaction, positive responses were recorded in all four domains of the SRS-22r questionnaire.
- Published
- 2022
5. Young Patients’ Satisfaction Following the Correction of Adolescent Idiopathic Scoliosis in Saudi Arabia: A Cross‐Sectional Study
- Author
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Alzayed, Zayed S, primary, Majid, Ozair B, additional, Alqahtani, Saeed A, additional, Saba, Iram, additional, Al Rushud, Mohammed A, additional, and Eissa, Abdullah T, additional
- Published
- 2022
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6. Prognostic Factors for Local Failure and Overall Survival in Patients with Epidural Disease at the Cauda Equina Following Stereotactic Body Radiotherapy: A Clinical, Anatomic and Dosimetric Analysis.
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Zayed, S., Ruschin, M.E., Atenafu, E., Dinakaran, D., Chen, H., Detsky, J., Soliman, H., Myrehaug, S.D., Sahgal, A., and Tseng, C.L.
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CAUDA equina , *SPINAL canal , *MEDICAL dosimetry , *STEREOTACTIC radiotherapy , *OVERALL survival , *RADIOTHERAPY - Abstract
The relationship between spine SBRT outcomes and the extent of malignant epidural disease (MED) compression of the cauda equina has yet to be reported. Our objective was to determine clinical, anatomic and dosimetric predictive factors for local failure (LF) and overall survival (OS) in a cohort of patients with spine metastases and epidural disease at the level of the cauda equina. Consecutive patients with cauda equina MED treated with SBRT, between January 1, 2008 and July 1, 2023, were identified and retrospectively reviewed from a prospectively maintained institutional database. MED parameters including linear dimensions, surface area, and volume ratios relative to the spinal canal, lumbar stenosis grading systems, clock position and various dosimetric factors were analyzed for their predictive value for LF post-SBRT and OS. Covariates with a P value ≤ 0.20 on univariate analysis were selected for multivariable analysis (MVA), and those statistically significant (P <0.05) were included in the final model. Ninety-five individual spinal segments (79 patients) with cauda equina MED were identified, of which 69 (73%) were intact and 26 (27%) post-op. Forty-one (43.2%) received 24 Gy in 2 fractions (fr), 27 (28.4%) received 30 Gy in 4 fr, 22 (23.2%) received 28 Gy in 2 fr and 5 (5.2%) received 30 Gy in 5 fr. Median follow-up and median time to LF were 16.3 (IQR 6.7-32.0) months and 4.7 (IQR 2.2-12.1) months, respectively. The cumulative incidence of LF at 6, 12, and 24 months was 12.7%, 12.7% and 17.4% respectively. OS at 6, 12, and 24 months was 79.6%, 58.4% and 40.7% respectively. In the intact cohort only (69/95), factors predictive of a higher risk of LF on MVA were chemotherapy naive (HR = 8.197, 95% CI = 2.198-30.303, P = 0.0017), MED greater than one third of the circumference of the spinal canal (HR = 9.632, 95% CI = 1.863-49.806, P = 0.0069), and lower V50Gy Equivalent Dose in 2Gy Fractions (EQD2) to the MED volume (HR = 1.049, 95% CI = 1.018-1.081, P = 0.0014). These factors retained significance on MVA for LF when combined with the post-op (26/95) cohort (P = 0.0047, 0.0272, 0.0024, respectively). In the intact cohort only, MVA identified oligometastatic disease (HR = 0.381, 95% CI = 0.190-0.764, P = 0.0065) and MED limited to a single spinal level (HR = 0.405, 95% CI = 0.182-0.902, P = 0.0269) as prognostic for OS. Oligometastatic disease and MED limited to a single spinal level also retained significance as predictors for OS on MVA when combined with the post-op (26/95) cohort (P <0.0001, 0.0182, respectively). We identified chemotherapy naive, MED encompassing more than one third of the circumference of the spinal canal, and lower V50Gy EQD2 to the epidural disease volume, as novel predictive factors for higher LF post-SBRT for MED at the cauda equina. Consideration for more aggressive management with decompressive surgery in those with MED spanning greater than a third of the spinal canal circumference and dose escalation to the thecal sac organ-at-risk may improve outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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7. Opioid Therapy vs. Multimodal Analgesia in Head and Neck Cancer (OPTIMAL-HN): Results of a Randomized Clinical Trial.
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Zayed, S., Lang, P., Read, N.E., Correa, R.J.M., Mutsaers, A., Goodman, C.D., D'Angelo, K., Kieraszewicz, K., Vanwynsberghe, D., Kingsbury-Paul, A., Crewdson, K., Carreau, C., Winquist, E., Kuruvilla, S., Stewart, P., Moulin, D., Warner, A., and Palma, D.A.
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HEAD & neck cancer , *ACUTE kidney failure , *COMBINED modality therapy , *CLINICAL trials , *PAIN management - Abstract
Radiation-induced mucositis (RIM) pain confers substantial morbidity for head and neck cancer (HNC) patients undergoing radiotherapy (RT) or chemoradiotherapy (CRT). With no established standard treatment, OPTIMAL-HN aimed to demonstrate the non-inferiority of multimodal analgesia (MMA; analgesic medications with different mechanisms of action) to the institutional standard of opioid analgesia alone. OPTIMAL-HN (NCT04221165) was an open label, single-institution, non-inferiority, randomized clinical trial. HNC patients receiving curative-intent RT/CRT and experiencing moderate 4 of 10 RIM pain were randomized 1:1, stratified by RT vs. CRT, to opioids alone per institutional standard or MMA (Pregabalin, Acetaminophen, Naproxen, and opioids if required). The primary endpoint was mean pain score (range = 0-10) during the last week of RT. Secondary endpoints included mean weekly opioid use, duration of opioid requirement, mean daily pain score, quality of life, hospitalizations for analgesic medication-related complications, time to feeding tube insertion, weight loss, toxicity, RT interruptions, and death. Assuming a non-inferiority margin of 1 point, a standard deviation of 1.5 in both arms (80% power, 1-sided alpha 0.05, dropout rate 6%), 62 patients were required. All analyses were pre-specified, including testing for superiority if non-inferiority was demonstrated, and intention-to-treat. Forty-nine patients were enrolled, 25 in the opioid analgesia alone arm and 24 in the MMA arm. The trial was prematurely closed due to slow accrual. Baseline characteristics were well-balanced between arms; median age was 61 (IQR = 53-70) years; 36 male (73.5%) and 13 female (26.5%); baseline median pain score was 5 (IQR = 4-6) in the opioid arm and 4 (IQR = 4-6) in the MMA arm (P = 0.161). Median follow-up was 4.24 (IQR = 3.75-4.73) months. The primary endpoint, mean pain score during the last 7 days of RT, was 5.10 (95% CI = 4.11-6.09) in the opioid arm and 4.85 (95% CI = 3.81-5.90) in the MMA arm (non-inferiority P = 0.039, superiority P = 0.724). Analyzing all pain scores from enrollment to 6 weeks post-RT using linear mixed models, MMA demonstrated significantly lower pain scores compared to opioids alone (non-inferiority P = 0.002, superiority P < 0.001). Median weekly opioid use was numerically higher in the opioid arm (99.2 mg oral morphine equivalent dose [OMED], IQR = 16.3-173.1) compared to the MMA arm (50.5 mg OMED; IQR = 8.4-126.3), although nonsignificant (P = 0.435). One patient in the MMA arm was admitted with grade 3 acute kidney injury, possibly related to the analgesic regimen. There was no grade ≥ 3 toxicity in the opioid arm. Arms were similar for all other secondary endpoints. MMA demonstrates non-inferiority to opioid analgesia alone in managing RIM pain during the last week of RT and superiority when analyzing the post-RT time period. MMA is therefore an effective analgesic regimen and should be considered for use in HNC patients. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Anemia in patients with acute coronary syndrome: Epidemiological profile and impact on the prognosis
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Soula, M., primary, Azaiez, F., additional, Zayed, S., additional, Mlik, A., additional, Tlili, R., additional, and Ben Ameur, Y., additional
- Published
- 2022
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9. Management and prognosis of catheter induced aortocoronary dissection: A multicentric observational study
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Hentati, M., primary, Hammami, R., additional, Jdidi, J., additional, Boudiche, S., additional, Ben Mrad, I., additional, Gribaa, R., additional, Ben Thabet, H., additional, Ben Abdessalem, A., additional, Ben Hlima, N., additional, Jamel, A., additional, Slima, H. Ben, additional, Azaiez, F., additional, Zayed, S., additional, Charfeddine, S., additional, Bahloul, A., additional, Ellouz, T., additional, Mallek, S., additional, Abid, L., additional, Mourali, M.S., additional, and Kamoun, S., additional
- Published
- 2022
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10. Prevalence and characteristics of coronary artery anomalies in an adult population in Tunisia
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Soula, M., primary, Azaiez, F., additional, Zayed, S., additional, Mlik, A., additional, Ben Romdhane, R., additional, Tlili, R., additional, and Ben Ameur, Y., additional
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- 2022
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11. Insights of early feeding regime supplemented with glutamine and various levels of omega-3 in broiler chickens: growth performance, muscle building, antioxidant capacity, intestinal barriers health and defense against mixed Eimeria spp infection.
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Kishawy ATY, Abd El-Wahab RA, Eldemery F, Abdel Rahman MMI, Altuwaijri S, Ezz-Eldin RMM, Abd-Allah EM, Zayed S, Mulla ZS, El Sharkawy RB, Badr S, Youssef W, and Ibrahim D
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- Animals, Intestines drug effects, Intestines parasitology, Animal Nutritional Physiological Phenomena, Coccidiosis veterinary, Coccidiosis prevention & control, Chickens, Animal Feed analysis, Glutamine administration & dosage, Glutamine pharmacology, Dietary Supplements, Poultry Diseases prevention & control, Poultry Diseases parasitology, Antioxidants metabolism, Eimeria physiology, Fatty Acids, Omega-3 administration & dosage, Fatty Acids, Omega-3 pharmacology, Diet veterinary
- Abstract
Early nutritional management approach greatly impacts broilers' performance and resistance against coccidiosis. The current study explored the impact of post-hatch feeding with a combination of glutamine (Glut) and different levels of omega-3 on broiler chickens' growth performance, muscle building, intestinal barrier, antioxidant ability and protection against avian coccidiosis. A total of six hundred Cobb 500 was divided into six groups: first group (fed basal diet and unchallenged (control) and challenged (negative control, NC) groups were fed a basal diet without additives, and the other groups were infected with Eimeria spp and supplemented with 1.5% Glut alone or with three different levels of omega-3 (0.25, 0.5 and 1%) during the starter period. Notable improvement in body weight gain was observed in the group which fed basal diet supplemented with glut and 1% omega 3 even after coccidia infection (increased by 25% compared challenged group) while feed conversion ratio was restored to control. Myogeneis was enhanced in the group supplemented with Glut and omega-3 (upregulation of myogenin, MyoD, mechanistic target of rapamycin kinase and insulin like growth factor-1 and downregulating of myostatin genes). Groups supplemented with Glut and higher levels of omega-3 highly expressed occluding, mucin-2, junctional Adhesion Molecule 2, b-defensin-1 and cathelicidins-2 genes. Group fed 1% Glut + omega-3 showed an increased total antioxidant capacity and glutathione peroxidase and super oxide dismutase enzymes activities with reduced levels of malondialdehyde, reactive oxygen species and H
2 O2 . Post-infection, dietary Glut and 1% omega-3 increased intestinal interleukin-10 (IL) and secretory immunoglobulin-A and serum lysozyme, while decreased the elevated inflammatory mediators comprising interleukin IL-6, tumor necrosis factor-alpha, nitric oxide (NO) and inducible NO synthase. Fecal oocyst excretion and lesions score severity were lowered in the group fed 1% Glut and omega 3. Based on these findings, dietary Glut and omega-3 supplementation augmented restored overall broilers' performance after coccidial challenge.- Published
- 2024
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12. Simultaneous determination of selected ionophoric coccidiostats and amino acids in feed premixes using high-performance liquid chromatography-ultraviolet detection method.
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Zayed S, Belal F, Barghash S, and Fouad F
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- Chromatography, High Pressure Liquid, Ionophores analysis, Amino Acids, Monensin analysis, Coccidiostats analysis
- Abstract
The combination of ionophoric coccidiostats and amino acids (AAs) is important in poultry feeding to enhance immunity and improve the growth and feed efficiency of birds suffering from coccidiosis. A simple, rapid, and economical high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method for the simultaneous determination of three ionophoric coccidiostats, namely salinomycin (SAL), maduramicin (MAD), and monensin (MON) in addition to three AAs; L-tryptophan (L-TRP), alpha-ketoleucin (KLEU), and L-valine (L-VAL) in feed premixes was developed and validated. Chromatographic separation was achieved in less than 12 min using a phenyl hexyl column with a mobile phase consisting of acetonitrile/methanol/water (25:20:55, v/v/v) adjusted to pH 3 using phosphoric acid. Isocratic elution was performed at a flow rate of 1 mL/min with UV detection at 210 nm. The method showed good linearity in the ranges 0.50-5.0 mg/mL for MON, 0.20-2.0 mg/mL for MAD and SAL, 10.0-100.0 μg/mL for L-TRP and KLEU, and 50.0-500.0 μg/mL for VAL. The developed method was successfully applied to determine the studied analytes in feed premixes with good recoveries and precision. The good validation criteria of the proposed method allow its utilization in quality control laboratories., (© 2024 Wiley-VCH GmbH.)
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- 2024
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13. Chlorella vulgaris extract conjugated magnetic iron nanoparticles in nile tilapia (Oreochromis niloticus): Growth promoting, immunostimulant and antioxidant role and combating against the synergistic infection with Ichthyophthirius multifiliis and Aeromonashydrophila.
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Ibrahim D, I Abdel Rahman MM, M Abd El-Ghany A, A A Hassanen E, A Al-Jabr O, A Abd El-Wahab R, Zayed S, Abd El Khalek Salem M, Nabil El Tahawy S, Youssef W, A Tolba H, E Dawod R, Taha R, H Arisha A, and T Y Kishawy A
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- Animals, Antioxidants metabolism, Adjuvants, Immunologic metabolism, Dietary Supplements, Diet, Aeromonas hydrophila physiology, Magnetic Iron Oxide Nanoparticles, Immunoglobulin M metabolism, Iron metabolism, Animal Feed analysis, Disease Resistance, Cichlids, Chlorella vulgaris, Fish Diseases
- Abstract
Nile tilapia reared under intensive conditions was more susceptible for Ichthyophthirius multifilii (I. multifiliis) infection eliciting higher mortality, lower productive rate and further bacterial coinfection with Aeromonas hydrophila (A. hydrophila). The higher potency of magnetic field of iron oxide nanoparticles (NPs) can kill pathogens through inhibiting their viability. Herein, coating of Chlorella vulgaris extract (ChVE) with magnetic iron oxide NPs (Mag iron NPs) can create an external magnetic field that facilitates their release inside the targeted tissues. Thus, the current study is focused on application of new functionalized properties of Mag iron NPs in combination with ChVE and their efficacy to alleviate I. multifiliis and subsequent infection with A. hydrophila in Nile tilapia. Four hundred fingerlings were divided into: control group (with no additives), three groups fed control diet supplemented with ChVE, Mag iron NPs and ChVE@Mag iron NPs for 90 days. At the end of feeding trial fish were challenged with I. multifiliis and at 9 days post challenge was coinfected by A. hydrophila. A remarkable higher growth rate and an improved feed conversion ratio were detected in group fed ChVE@Mag iron-NPs. The maximum expression of antioxidant enzymes in skin and gills tissues (GSH-Px, CAT, and SOD) which came in parallel with higher serum activities of these enzymes was identified in groups received ChVE@Mag iron-NPs. Furthermore, group fed a combination of ChVE and Mag iron-NPs showed a boosted immune response (higher lysozyme, IgM, ACH
50 , and MPO) prior to challenge with I. multifiliis. In contrast, fish fed ChVE@Mag iron-NPs supplemented diet had lower infection (decreased by 62%) and mortality rates (decreased by 84%), as well as less visible white spots (decreased by 92 % at 12 dpi) on the body surfaces and mucous score. Interestingly, post I. multifiliis the excessive inflammatory response in gill and skin tissues was subsided by feeding on ChVE@Mag iron-NPs as proved by down regulation of IL-1β, TNFα, COX-2 and iNOS and upregulation of IL-10, and IgM, IgT and Muc-2 genes. Notably, group exposed to I. multifiliis-showed higher mortality when exposed to Aeromonas hydrophilia (increased by 43 %) while group fed ChVE@Mag iron-NPs exhibited lower morality (2%). Moreover, the bacterial loads of A. hydrophilia in fish infected by I. multifiliis and fed control diet were higher than those received dietary supplement of ChVE, Mag iron-NPs and the most reduced load was obtained in group fed ChVE@Mag iron-NPs at 7 dpi. In conclusion, ChVE@Mag iron-NPs fed fish had stronger immune barrier and antioxidant functions of skin and gills, and better survival following I. multifiliis and A. hydrophilia infection., (Copyright © 2023. Published by Elsevier Ltd.)- Published
- 2024
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14. Unusual presentation and histopathology of bilateral nasal polypi; cavernous hemangioma (right) and inverted papilloma (left).
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Hasan A, Mairaj MY, Elbadawy A, Zayed S, Alghamdi AS, Alrashdi SA, and Nafie K
- Abstract
Hemangiomas are common lesions in medical practice, but those arising in the nasal cavity and/or paranasal sinuses are rare. Inverted papilloma is a rare benign tumor with a high incidence rate in both the nasal cavity and sinuses. The presence of both lesions in the same patient is even rarer. Here we present a case of a male patient with an unusual presentation and dual pathologies of cavernous hemangioma and inverted papilloma of the sinonasal tract that underwent endoscopic surgery and showed no recurrence of disease after a 2-year follow-up. The association of nasal cavernous hemangioma at one side and inverted papilloma at the other side is a very rare occasion that requires further studies and histopathology is the only diagnostic tool., Competing Interests: The authors declare no conflict of interest., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
- Published
- 2023
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15. Determination of ticagrelol in rat plasma and tablets by micellar electrokinetic chromatography coupled with large volume sample stacking: Application to a pharmacokinetic study.
- Author
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Zayed S and Belal F
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- Rats, Animals, Micelles, Reproducibility of Results, Tablets, Sodium, Chromatography, Micellar Electrokinetic Capillary methods
- Abstract
A method using micellar electrokinetic chromatography coupled with large-volume sample stacking for the determination of ticagrelol was developed and validated. The analysis was performed in a fused silica capillary (41.5 cm effective length, 50 μm diameter) with ultraviolet detection at 195 nm. The background electrolytes were 30 mM phosphate buffer of pH 3.0 with 120 mM sodium dodecylsulfate and 10 % (v/v) acetonitrile (120 s X 50 mbar; 20°C; -18 kV) and 30 mM borate buffer of pH 8.5 with 75 mM sodium dodecylsulfate (120 s X 50 mbar; 20°C; 25 kV); under acidic and alkaline conditions, respectively. The method was found to be reliable with respect to specificity, linearity of the calibration line (R
2 > 0.99), repeatability (relative standard deviation 2.56%-3.34%), and accuracy (recovery in the range 101.21%-102.67%). The limits of detection and quantitation were 0.032, 0.071, and 0.087, 0.188 μg/mL, respectively. The method was successfully applied for the determination of ticagrelol concentrations in rat plasma and tablets with good recoveries and reproducibility. The presented method proved to be suitable for monitoring ticagrelor in rat plasma., (© 2023 Wiley-VCH GmbH.)- Published
- 2023
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16. Popular Diets and Kidney Stones.
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Zayed S, Goldfarb DS, and Joshi S
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- Animals, Humans, Diet, Vegetarian, Calcium, Dietary urine, Oxalates, Vegetables, Diet adverse effects, Kidney Calculi etiology
- Abstract
Popular diets often influence dietary patterns, which have different implications for kidney stone risk. Despite the wide variety of popular diets, some general principles can be gleaned from investigating their potential impact on nephrolithiasis. Plant-based diets, including Dietary Approaches to Stop Hypertension, Mediterranean, flexitarian, and vegetarian diets, may protect against nephrolithiasis when they consist largely of unprocessed plant foods, while carbohydrate-restricted diets (including high-protein diets and the ketogenic diet) may raise kidney stone risk. Patients should be advised to consume a diet rich in whole plants, particularly fruits and vegetables, and minimize their consumption of animal proteins. Accompanying fruits and vegetables that are higher in oxalate content with more water and some dairy intake may also be useful. (We address the oxalate content of fruits and vegetables further below). Calcium consumption is an important component of decreasing the risk of kidney stones, as higher dietary calcium from dairy or nondairy sources is independently associated with lower kidney stone risk. Patients should also be advised to be conscious of fat intake, as fat in the intestinal lumen may complex with calcium and therefore increase urinary oxalate excretion. Finally, patients should avoid consumption of processed foods, which often contain added fructose and high sodium content, two factors that increase kidney stone risk., (Copyright © 2023 National Kidney Foundation, Inc. All rights reserved.)
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- 2023
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17. Radiation and immune checkpoint inhibitors in the treatment of oligometastatic non-small-cell lung cancer: a practical review of rationale, recent data, and research questions.
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Zayed S, Louie AV, Breadner DA, Palma DA, and Correa RJM
- Abstract
The combined use of stereotactic ablative radiotherapy (SABR) and immune checkpoint inhibitors (ICIs) is an emerging treatment paradigm for oligometastatic non-small-cell lung cancer (NSCLC). Recent phase I and II trial data suggest that SABR to multiple metastases in addition to ICI use is safe and effective with promising progression-free survival and overall survival signals. There is great interest in capitalizing on combined immunomodulation from these two modalities for the treatment of oligometastatic NSCLC. Ongoing trials seek to validate the safety, efficacy, and preferred sequencing of SABR and ICI. This narrative review of the role of SABR when combined with ICI in oligometastatic NSCLC discusses the rationale for this bimodality treatment, summarizes recent clinical trial evidence, and proposes key principles of management based on the available evidence., Competing Interests: Dr. Louie has received honoraria from AstraZeneca, unrelated to this review. Dr. Breadner has honoraria from Astra Zeneca, Bristol Myers Squibb, Takeda, Merck, and Amgen, unrelated to this review., (© The Author(s), 2023.)
- Published
- 2023
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18. Radiation management of a late thoracic metastasis from an intracranial solitary fibrous tumour.
- Author
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Patel A, Palma D, Sangle N, and Zayed S
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- Male, Humans, Neoplasm Recurrence, Local radiotherapy, Severe Fever with Thrombocytopenia Syndrome, Solitary Fibrous Tumors diagnosis, Soft Tissue Neoplasms pathology
- Abstract
Solitary fibrous tumours (SFTs) are a rare soft tissue sarcoma. We present a case of a male patient with an SFT of the right posterior fossa, with a late metastasis to the right lung and chest wall identified 18 years later.A small number of late metastases of SFTs have previously been reported. Metastases are typically managed surgically, although there is limited evidence suggesting that radiotherapy may be effective for primary SFTs.In this case, the patient declined treatment for his metastasised cancer for 5 years. He then only agreed to radiation treatment without surgery, which uniquely resulted in excellent symptom relief and durable local control. This case illustrates the importance of further research on the role of radiation in managing SFTs, the value of long-term follow-up and the necessity of exploring barriers to care.This case also highlights issues regarding barriers to care related to late diagnoses of recurrence in rare tumours. In this case, at the time of recurrence the original tissue blocks were not available for review. The patient had moved to a different province where his former records were not easily accessible, and the original tissue blocks had been discarded. In that jurisdiction, laboratories must keep cytology slides for 5 years, histopathology slides for 10 years and paraffin blocks for 2 years. This contributed to a misdiagnosis of the recurrence as an Ewing sarcoma, resulting in the patient initially declining treatment at the time of disease recurrence, and leading to a long-standing mistrust of his physicians which impacted his decision-making., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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19. Design and Rationale of the National Tunisian Registry of Percutaneous Coronary Intervention: Protocol for a Prospective Multicenter Observational Study.
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Hammami R, Boudiche S, Rami T, Ben Halima N, Jamel A, Rekik B, Gribaa R, Imtinene BM, Charfeddine S, Ellouze T, Bahloul A, Hédi BS, Langar J, Ben Ahmed H, Ibn Elhadj Z, Hmam M, Ben Abdessalem MA, Maaoui S, Fennira S, Lobna L, Hassine M, Ouanes S, Mohamed Faouzi D, Mallek S, Mahdhaoui A, Meriem D, Jomaa W, Zayed S, Kateb T, Bouchahda N, Azaiez F, Ben Salem H, Marouen M, Noamen A, Abdesselem S, Hichem D, Ibn Hadj Amor H, Abdeljelil F, Amara A, Bejar K, Khaldoun BH, Hamza C, Ben Jamaa M, Fourati S, Elleuch F, Grati Z, Chtourou S, Marouene S, Sahnoun M, Hadrich M, Mohamed Abdelkader M, Bouraoui H, Kamoun K, Hadrich M, Ben Chedli T, Drissa MA, Charfeddine H, Saadaoui N, Achraf G, Ahmed S, Ayari M, Nabil M, Mnif S, Sahnoun M, Kammoun H, Ben Jemaa K, Mostari G, Hamrouni N, Yamen M, Ellouz Y, Smiri Z, Hdiji A, Bassem J, Ayadi W, Zouari A, Abbassi C, Fatma BM, Battikh K, Kharrat E, Gtif I, Sami M, Bezdah L, Kachboura S, Maatouk MF, Kraiem S, Jeridi G, Neffati E, Kammoun S, Ben Ameur Y, Fehri W, Gamra H, Zakhama L, Addad F, Mohamed Sami M, and Abid L
- Abstract
Background: Coronary artery diseases remain the leading cause of death in the world. The management of this condition has improved remarkably in the recent years owing to the development of new technical tools and multicentric registries., Objective: The aim of this study is to investigate the in-hospital and 1-year clinical outcomes of patients treated with percutaneous coronary intervention (PCI) in Tunisia., Methods: We will conduct a prospective multicentric observational study with patients older than 18 years who underwent PCI between January 31, 2020 and June 30, 2020. The primary end point is the occurrence of a major adverse cardiovascular event, defined as cardiovascular death, myocardial infarction, cerebrovascular accident, or target vessel revascularization with either repeat PCI or coronary artery bypass grafting (CABG). The secondary end points are procedural success rate, stent thrombosis, and the rate of redo PCI/CABG for in-stent restenosis., Results: In this study, the demographic profile and the general risk profile of Tunisian patients who underwent PCI and their end points will be analyzed. The complexity level of the procedures and the left main occlusion, bifurcation occlusion, and chronic total occlusion PCI will be analyzed, and immediate as well as long-term results will be determined. The National Tunisian Registry of PCI (NATURE-PCI) will be the first national multicentric registry of angioplasty in Africa. For this study, the institutional ethical committee approval was obtained (0223/2020). This trial consists of 97 cardiologists and 2498 patients who have undergone PCI with a 1-year follow-up period. Twenty-eight catheterization laboratories from both public (15 laboratories) and private (13 laboratories) sectors will enroll patients after receiving informed consent. Of the 2498 patients, 1897 (75.9%) are managed in the public sector and 601 (24.1%) are managed in the private sector. The COVID-19 pandemic started in Tunisia in March 2020; 719 patients (31.9%) were included before the COVID-19 pandemic and 1779 (60.1%) during the pandemic. The inclusion of patients has been finished, and we expect to publish the results by the end of 2022., Conclusions: This study would add data and provide a valuable opportunity for real-world clinical epidemiology and practice in the field of interventional cardiology in Tunisia with insights into the uptake of PCI in this limited-income region., Trial Registration: Clinicaltrials.gov NCT04219761; https://clinicaltrials.gov/ct2/show/NCT04219761., International Registered Report Identifier (irrid): RR1-10.2196/24595., (©Rania Hammami, Selim Boudiche, Tlili Rami, Nejeh Ben Halima, Ahmed Jamel, Bassem Rekik, Rym Gribaa, Ben Mrad Imtinene, Salma Charfeddine, Tarek Ellouze, Amine Bahloul, Ben Slima Hédi, Jamel Langar, Habib Ben Ahmed, Zied Ibn Elhadj, Mohamed Hmam, Mohamed Aymen Ben Abdessalem, Sabri Maaoui, Sana Fennira, Laroussi Lobna, Majed Hassine, Sami Ouanes, Drissi Mohamed Faouzi, Souad Mallek, Abdallah Mahdhaoui, Dghim Meriem, Walid Jomaa, Sofien Zayed, Tawfik Kateb, Nidhal Bouchahda, Fares Azaiez, Helmi Ben Salem, Morched Marouen, Aymen Noamen, Salem Abdesselem, Denguir Hichem, Hassen Ibn Hadj Amor, Farhati Abdeljelil, Amine Amara, Karim Bejar, Ben Hamda Khaldoun, Chiheb Hamza, Mohsen Ben Jamaa, Sami Fourati, Faycal Elleuch, Zeineb Grati, Slim Chtourou, Sami Marouene, Mohamed Sahnoun, Morched Hadrich, Maalej Mohamed Abdelkader, Hatem Bouraoui, Kamel Kamoun, Moufid Hadrich, Tarek Ben Chedli, Mohamed Akrem Drissa, Hanene Charfeddine, Nizar Saadaoui, Gargouri Achraf, Siala Ahmed, Mokdad Ayari, Marsit Nabil, Sabeur Mnif, Maher Sahnoun, Helmi Kammoun, Khaled Ben Jemaa, Gharbi Mostari, Nebil Hamrouni, Maazoun Yamen, Yassine Ellouz, Zahreddine Smiri, Amine Hdiji, Jerbi Bassem, Wacef Ayadi, Amir Zouari, Chedly Abbassi, Boujelben Masmoudi Fatma, Kais Battikh, Elyes Kharrat, Imen Gtif, Milouchi Sami, Leila Bezdah, Salem Kachboura, Mohamed Faouzi Maatouk, Sondes Kraiem, Gouider Jeridi, Elyes Neffati, Samir Kammoun, Youssef Ben Ameur, Wafa Fehri, Habib Gamra, Lilia Zakhama, Faouzi Addad, Mourali Mohamed Sami, Leila Abid. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 05.08.2022.)
- Published
- 2022
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20. Determination of the Monoclonal Antibody Tocilizumab by a Validated Micellar Electrokinetic Chromatography Method.
- Author
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Zayed S and Belal F
- Abstract
Tocilizumab is a monoclonal antibody used in the treatment of several inflammatory and autoimmune diseases as well as cancers. Tocilizumab improves clinical outcomes and reduce mortality rates in patients with COVID-19 disease. A novel, simple and reliable method was developed to determine tocilizumab using micellar electrokinetic chromatography (MEKC). Separation of tocilizumab and the internal standard, methotrexate, was achieved with a background electrolyte consisting of phosphoric acid buffer and sodium dodecyl sulfate (SDS) with UV detection at 195 nm. The method was linear in the concentration range from 10 to 250 µg/mL with correlation coefficient greater than 0.995. The method was successfully applied to the analysis of human and rat plasma samples with good recoveries. Sample preparation involved protein precipitation followed by dilution of the supernatant. The intra- and inter-day precisions were less than 5%, the accuracy varied from - 2.71 to 3.84%. The proposed method has acceptable analytical performance and could be applied in future clinical and pharmacokinetic studies including anticancer therapy., Supplementary Information: The online version contains supplementary material available at 10.1007/s10337-022-04148-w., Competing Interests: Conflict of InterestThere are no conflicts of interest to declare., (© The Author(s) 2022.)
- Published
- 2022
- Full Text
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