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Your search keyword '"Zhang, Gengshen"' showing total 7 results
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7 results on '"Zhang, Gengshen"'

4. Angiotensin II type 1 receptor deficiency protects against the impairment of blood–brain barrier in a mouse model of traumatic brain injury.

Author

Yang, Lijun, Chen, Zeshang, Wan, Xiangdong, Liu, Minghao, Wu, Jianliang, Chen, Yan, Zhang, Gengshen, and Fan, Zhenzeng

Subjects
BRAIN injuries, ANGIOTENSIN II, BLOOD-brain barrier, AMYLOID beta-protein precursor, AQUAPORINS
Abstract

Aquaporin 4 (AQP4), usually expressed at astrocytes end-feet, is a main component of the lymph-lymphatic system and promotes paravascular cerebrospinal fluid-interstitial fluid exchange. Moreover, angiotensin II type 1 (AT1) receptor affects amyloid β (Aβ) levels. This study aimed to detect the effect of AT1 receptor deficiency on the blood-brain barrier (BBB) of traumatic brain injury (TBI) mice and the effect on Aβ level and glial lymphatic circulation. TBI model was built using AT1 receptor knockout mice (AT1-KO) and C57BL/6 mice (wild type, WT). BBB integrity was detected by Evans blue extravasation. The expression of the astrocytic water channel AQP4 and astrocyte activation were evaluated with immunofluorescence. The expressions of amyloid precursor protein (APP), junction protein zonula occludens protein-1 (ZO-1) and occludin in mice brain were detected by Western blot (WB). Aβ levels were assayed by enzyme-linked immunosorbent assay (ELISA). AT1 receptor deficiency defended BBB integrity and rescued occludin and ZO-1 decrease in mice brain induced by TBI. AT1-KO mice had less increase of APP expression and Aβ 1–42, Aβ 1–40 levels compared to WT mice under TBI. Moreover, AT1 receptor deficiency was found to significantly inhibit AQP4 depolarization after TBI. T1 receptor deficiency attenuated TBI-induced impairments of BBB by rescuing tight junction proteins and inhibited AQP4 polarization, thus improving the function of glymphatic system to enhance interstitial Aβ clearance in TBI mice brain. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Evaluation of theTherapeutic Effect of the Hybrid Operation on Patients with Aneurysms Associated with Cerebral Arteriovenous Malformations with different Redekop Classifications

Author

Zhang Chao, Li Peng, Liu Ling, Liu Xiaosong, Zhang Gengshen, Zhao Lei, null Tangkai, Liu Xiaomeng, Wang Xiaoliang, and Wu Jianliang

Subjects
Intracranial Arteriovenous Malformations, Treatment Outcome, Rehabilitation, Humans, Surgery, Intracranial Aneurysm, Neurology (clinical), Cardiology and Cardiovascular Medicine, Embolization, Therapeutic, Intracranial Hemorrhages, Retrospective Studies
Abstract

Intracranial aneurysms associated with cerebral arteriovenous malformations (AVMs) are a rare condition in the clinic, and treatment is very difficult due to their particular anatomical features. We present our experience in the treatment of intracranial aneurysms with AVMs and evaluate the effectiveness and safety of endovascular treatment combined with microsurgical resection (the hybrid operation).This was a single-center retrospective study in our neurosurgical department from January 2015 to January 2021. We collected clinical data from 48 patients with intracranial aneurysms associated with AVMs and categorized them according to Redekop classifications according to the results of cerebral imaging examination to compare the therapeutic effects of endovascular embolization and the hybrid operation.Compared to nonaneurysmal AVMs, intracranial aneurysms with AVMs more often presented with intracranial hemorrhage (P0.05). Massive hematoma and severe neurological impairment were more often found in patients with intracranial aneurysms with AVMs (P0.05). For flow-related aneurysms, the hybrid surgery had a higher one-stage cure rate than endovascular embolization alone (P0.05). Both treatment methods had similar effects on intranidal aneurysms (P0.05). There were no significant differences in prognostic indicators between the two treatments. However, the recurrence rate of AVMs with proximal flow-related aneurysms was lower in patients who underwent the hybrid operation (P0.05).The hybrid operation was safe and effective for patients with intracranial aneurysms associated with AVMs. For flow-related aneurysms, the one-stage cure rate was higher and the recurrence rate was lower with the hybrid operation than with endovascular embolization alone.

Published
2021

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