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Your search keyword '"Zhang, Qianyuan"' showing total 14 results
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14 results on '"Zhang, Qianyuan"'

1. Spatio-Temporal Fusion Based Low-Loss Video Compression Algorithm for UAVs with Limited Processing Capability

Author

Zhang, Qianyuan, Wan, Desheng, Chen, Hao, Cheng, Lianghua, Chen, Jiayi, Xiang, Chaocan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Tari, Zahir, editor, Li, Keqiu, editor, and Wu, Hongyi, editor

Published
2024
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6. A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew.

Author

He, Huagang, Chen, Zhaozhao, Fan, Renchun, Zhang, Jie, Zhu, Shanying, Wang, Jiale, Zhang, Qianyuan, Gao, Anli, Gong, Shuangjun, Zhang, Lu, Li, Yanan, Zhao, Yitong, Krattinger, Simon G., Shen, Qian-Hua, Li, Hongjie, and Wang, Yajun

Subjects
CHIMERIC proteins, MOLECULAR cloning, CHROMOSOME abnormalities, ETHYL methanesulfonate, PROTEIN kinases, POWDERY mildew diseases, NICOTIANA benthamiana
Abstract

Many disease resistance genes have been introgressed into wheat from its wild relatives. However, reduced recombination within the introgressed segments hinders the cloning of the introgressed genes. Here, we have cloned the powdery mildew resistance gene Pm13, which is introgressed into wheat from Aegilops longissima, using a method that combines physical mapping with radiation-induced chromosomal aberrations and transcriptome sequencing analysis of ethyl methanesulfonate (EMS)-induced loss-of-function mutants. Pm13 encodes a kinase fusion protein, designated MLKL-K, with an N-terminal domain of mixed lineage kinase domain-like protein (MLKL_NTD domain) and a C-terminal serine/threonine kinase domain bridged by a brace. The resistance function of Pm13 is validated through transient and stable transgenic complementation assays. Transient over-expression analyses in Nicotiana benthamiana leaves and wheat protoplasts reveal that the fragment Brace-Kinase122-476 of MLKL-K is capable of inducing cell death, which is dependent on a functional kinase domain and the three α-helices in the brace region close to the N-terminus of the kinase domain. The powdery mildew resistance gene Pm13 was introgressed into wheat from Aegilops longissima. Here, the authors report the cloning of Pm13 and reveal that it encodes a MLKL_NTD domain-containing kinase. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Effect of anticoagulation on the incidence of venous thromboembolism, major bleeding, and mortality among hospitalized COVID-19 patients: an updated meta-analysis.

Author

Chen X, Zhang S, Liu H, Zhang Q, Chen J, Zheng Q, Guo N, Cai Y, Luo Q, Xu Q, Yang S, and Chen X

Abstract

Objective: Anticoagulation is crucial for patients hospitalized with coronavirus disease 2019 (COVID-19) due to the high risk of venous thromboembolism (VTE). However, the optimal anticoagulation regimen needs further exploration. Therefore, we evaluated the efficacy and safety of diverse anticoagulation dosage dosages for COVID-19., Methods: An updated meta-analysis was performed to assess the effect of thromboprophylaxis (standard, intermediate, and therapeutic dose) on the incidence of VTE, mortality and major bleeding among COVID-19 patients. Literature was searched via PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure (CNKI) database. The odds ratio (OR) and 95% confidence interval (CI) were calculated for effect estimates., Results: Nineteen studies involving 25,289 participants without VTE history were included. The mean age of patients was 59.3 years old. About 50.96% were admitted to the intensive care unit. In the pooled analysis, both therapeutic-dose and intermediate-dose anticoagulation did not have a significant advantage in reducing VTE risk over standard dosage (OR = 1.09, 95% CI: 0.58-2.02, and OR = 0.89, 95% CI: 0.70-1.12, respectively). Similarly, all-cause mortality was not further decreased in either therapeutic-dose group (OR = 1.12, 95% CI: 0.75-1.67) or intermediate-dose group (OR = 1.34, 95% CI: 0.83-2.17). While the major bleeding risk was significantly elevated in the therapeutic-dose group (OR = 2.59, 95%CI: 1.87-3.57) as compared with the standard-dose regimen. Compared with intermediate dosage, therapeutic anticoagulation did not reduce consequent VTE risk (OR = 0.85, 95% CI: 0.52-1.38) and all-cause mortality (OR = 0.84, 95% CI: 0.60-1.17), but significantly increased major bleeding rate (OR = 2.42, 95% CI: 1.58-3.70). In subgroup analysis of patients older than 65 years, therapeutic anticoagulation significantly lowered the incidence of VTE in comparation comparison with standard thromboprophylaxis, however, at the cost of elevated risk of major bleeding., Conclusion: Our results indicated that for most hospitalized patients with COVID-19, standard-dose prophylactic anticoagulation might be the optimal choice. For elderly patients at low risk of bleeding, therapeutic-dose anticoagulation could further reduce VTE risk and should be considered especially when there were other strong risk factors of VTE during hospital stay., Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO, identifier, CRD42023388429., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Chen, Zhang, Liu, Zhang, Chen, Zheng, Guo, Cai, Luo, Xu, Yang and Chen.)

Published
2024
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