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Your search keyword '"Zhang, Ruili"' showing total 284 results
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284 results on '"Zhang, Ruili"'

1. Canonical Hamiltonian Guiding Center Dynamics and Its Intrinsic Magnetic Moment

Author

Zhang, Ruili, Liu, Jian, Liu, Tong, Li, Wenxiang, Wang, Xiaogang, and Tang, Yifa

Subjects
Physics - Plasma Physics
Abstract

The concept of guiding center is potent in astrophysics, space plasmas, fusion researches, and arc plasmas to solve the multi-scale dynamics of magnetized plasmas. In this letter, we rigorously prove that the guiding center dynamics can generally be described as a constrained canonical Hamiltonian system with two constraints in six dimensional phase space, and that the solution flow of the guiding center lies on a canonical symplectic sub-manifold. The guiding center can thus be modeled as a pseudo-particle with an intrinsic magnetic moment, which properly replaces the charged particle dynamics on time scales larger than the gyro-period. The complete dynamical behaviors, such as the velocity and force, of the guiding center pseudo-particle can be clearly deduced from the model. Furthermore, a series of related theories, such as symplectic numerical methods, the canonical gyro-kinetic theory, and canonical particle-in-cell algorithms can be systematically developed based on the canonical guiding center system. The canonical guiding center theory also provides an enlightenment for the origin of the intrinsic magnetic moment., Comment: 14pages, 4 figures

Published
2024

29. Smart Education F5G All-Optical Network Solution

Author

Zhang, Jun, Zhang, Ruili, Zhang, Xiang, Luo, Peng, Jia, Lin, Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, Zeng, Haijun, editor, Li, Zhisheng, editor, Guo, Jiong, editor, and Zhang, Zhuo, editor

Published
2023
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40. Proton nanomodulators for enhanced Mn2+-mediated chemodynamic therapy of tumors via HCO3− regulation.

Author

Yang, Peng, Liu, Shaojie, Chen, Zhuang, Liu, Weijing, Duan, Deshang, Yang, Zuo, Yan, Haohao, Rao, Zhiping, Zhang, Xianghan, Zhang, Ruili, and Wang, Zhongliang

Subjects
IONIC equilibrium, REACTIVE oxygen species, TUMOR microenvironment, LABORATORY mice, TREATMENT effectiveness
Abstract

Background: Mn2+-mediated chemodynamic therapy (CDT) has been emerged as a promising cancer therapeutic modality that relies heavily on HCO3− level in the system. Although the physiological buffers (H2CO3/HCO3−) provide certain amounts of HCO3−, the acidity of the tumor microenvironment (TME) would seriously affect the HCO3− ionic equilibrium (H2CO3 ⇌ H+ + HCO3−). As a result, HCO3− level in the tumor region is actually insufficient to support effective Mn2+-mediated CDT. Results: In this study, a robust nanomodulator MnFe2O4@ZIF-8 (PrSMZ) with the capability of in situ self-regulation HCO3− is presented to enhance therapeutic efficacy of Mn2+-mediated CDT. Under an acidic tumor microenvironment, PrSMZ could act as a proton sponge to shift the HCO3− ionic equilibrium to the positive direction, significantly boosting the generation of the HCO3−. Most importantly, such HCO3− supply capacity of PrSMZ could be finely modulated by its ZIF-8 shell thickness, resulting in a 1000-fold increase in reactive oxygen species (ROS) generation. Enhanced ROS-dependent CDT efficacy is further amplified by a glutathione (GSH)-depletion ability and the photothermal effect inherited from the inner core MnFe2O4 of PrSMZ to exert the remarkable antitumor effect on mouse models. Conclusions: This work addresses the challenge of insufficient HCO3− in the TME for Mn2+-mediated Fenton catalysts and could provide a promising strategy for designing high-performance Mn2+-mediated CDT agents to treat cancer effectively. [ABSTRACT FROM AUTHOR]

Published
2024
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