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Your search keyword '"Zhong, Nanbert"' showing total 19 results
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19 results on '"Zhong, Nanbert"'

1. Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies

Author

Chen, Xinlin, Zhao, Sheng, Dong, Xiaoyan, Liu, Juntao, Guo, Yulin, Ju, Weina, Chen, Peiwen, Gao, Yanduo, Feng, Qian, Zhu, Xia, Huang, Hui, Lu, Xiaojun, Yang, Xiaohong, Yang, Fan, Cheng, Chen, Luo, Xishun, Cheng, Longxian, and Zhong, Nanbert

Published
2023
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8. CAG Repeat Expansion inTHAP11Is Associated with a Novel Spinocerebellar Ataxia

Author

Tan, Dandan, primary, Wei, Cuijie, additional, Chen, Zhao, additional, Huang, Yu, additional, Deng, Jianwen, additional, Li, Jingjing, additional, Liu, Yidan, additional, Bao, Xinhua, additional, Xu, Jin, additional, Hu, Zhengmao, additional, Wang, Suxia, additional, Fan, Yanbin, additional, Jiang, Yizheng, additional, Wu, Ye, additional, Wu, Yuan, additional, Wang, Shuang, additional, Liu, Panyan, additional, Zhang, Yuehua, additional, Yang, Zhixian, additional, Jiang, Yuwu, additional, Zhang, Hong, additional, Hong, Daojun, additional, Zhong, Nanbert, additional, Jiang, Hong, additional, and Xiong, Hui, additional

Published
2023
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10. Epigenetic impact of long non-coding RNA lnc-ADAM9 on extracellular matrix pathway in preterm syndrome through down-regulation of mRNA-ADAM9

Author

Wang, Xiaohua, primary, Liu, Aiju, additional, Hou, Dongxia, additional, Dong, Xiaoyang, additional, Chu, Chu, additional, Ju, Weina, additional, Zhang, Junhui, additional, Jia, Yueqi, additional, Yang, Xiaoyan, additional, Ji, Yunpeng, additional, Wang, Tingting, additional, Bonney, Elizabeth A., additional, Wang, Guixiang, additional, and Zhong, Nanbert, additional

Published
2023
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16. Additional file 1 of Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing

Author

Zheng, Yuhua, Pan, Jing, Xia, Chenglai, Chen, Haiying, Zhou, Huadong, Ju, Weina, Wegiel, Jerzy, Myatt, Leslie, Roberts, James M., Guo, Xiaoling, and Zhong, Nanbert

Abstract

Additional file 1: Figure S1. Heatmap of marker genes in cell clusters of early pregnancy loss. Heatmap of marker genes in cell clusters of different groups of early pregnancy loss. The numbers of clusters in groups A, B, C, and D were 16, 15, 16, and 18, respectively. Figure S2. Dot plot of top-10 marker genes (X axis) in trophoblast cell clusters VCT1 (upper), STB1 (middle), and EVT3 (lower), respectively, among early groups A_SM, B_SM, C_RM, and D_ET. Figure S3. Gene set variation analysis (GSVA) analysis. Figure S4. Cell cycle

Published
2022
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17. Additional file 1 of Developmental deficits and staging of dynamics of age associated Alzheimer���s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Author

Wegiel, Jerzy, Flory, Michael, Kuchna, Izabela, Nowicki, Krzysztof, Wegiel, Jarek, Ma, Shuang Yong, Zhong, Nanbert, Bobrowicz, Teresa Wierzba, de Leon, Mony, Lai, Florence, Silverman, Wayne P., and Wisniewski, Thomas

Abstract

Additional file 1. Stereological parameters and procedures applied for examination of DS brains.

Published
2022
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19. CAG Repeat Expansion in THAP11 Is Associated with a Novel Spinocerebellar Ataxia.

Author

Tan D, Wei C, Chen Z, Huang Y, Deng J, Li J, Liu Y, Bao X, Xu J, Hu Z, Wang S, Fan Y, Jiang Y, Wu Y, Wu Y, Wang S, Liu P, Zhang Y, Yang Z, Jiang Y, Zhang H, Hong D, Zhong N, Jiang H, and Xiong H

Subjects
Humans, Proteins genetics, Pedigree, Repressor Proteins genetics, Trinucleotide Repeat Expansion genetics, Spinocerebellar Ataxias genetics
Abstract

Background: More than 50 loci are associated with spinocerebellar ataxia (SCA), and the most frequent subtypes share nucleotide repeats expansion, especially CAG expansion., Objective: The objective of this study was to confirm a novel SCA subtype caused by CAG expansion., Methods: We performed long-read whole-genome sequencing combined with linkage analysis in a five-generation Chinese family, and the finding was validated in another pedigree. The three-dimensional structure and function of THAP11 mutant protein were predicted. Polyglutamine (polyQ) toxicity of THAP11 gene with CAG expansion was assessed in skin fibroblasts of patients, human embryonic kidney 293 and Neuro-2a cells., Results: We identified THAP11 as the novel causative SCA gene with CAG repeats ranging from 45 to 100 in patients with ataxia and from 20 to 38 in healthy control subjects. Among the patients, the number of CAA interruptions within CAG repeats was decreased to 3 (up to 5-6 in controls), whereas the number of 3' pure CAG repeats was up to 32 to 87 (4-16 in controls), suggesting that the toxicity of polyQ protein was length dependent on the pure CAG repeats. Intracellular aggregates were observed in cultured skin fibroblasts from patients. THAP11 polyQ protein was more intensely distributed in the cytoplasm of cultured skin fibroblasts from patients, which was replicated with in vitro cultured neuro-2a transfected with 54 or 100 CAG repeats., Conclusions: This study identified a novel SCA subtype caused by intragenic CAG repeat expansion in THAP11 with intracellular aggregation of THAP11 polyQ protein. Our findings extended the spectrum of polyQ diseases and offered a new perspective in understanding polyQ-mediated toxic aggregation. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society., (© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)

Published
2023
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