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Your search keyword '"Zou, Cheng-Gang"' showing total 15 results
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15 results on '"Zou, Cheng-Gang"'

5. Cellular senescence in cancer: molecular mechanisms and therapeutic targets.

Author

Jin, Ping, Duan, Xirui, Li, Lei, Zhou, Ping, Zou, Cheng‐Gang, and Xie, Ke

Subjects
CELLULAR aging, GENE targeting, DRUG target, IMMUNOSENESCENCE, AGING, BIOLOGY, CELL communication
Abstract

Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades, research into the role of cellular senescence on tumor progression has received widespread attention. While how senescence limits the course of cancer is well established, senescence has also been found to promote certain malignant phenotypes. The tumor‐promoting effect of senescence is mainly elicited by a senescence‐associated secretory phenotype, which facilitates the interaction of senescent tumor cells with their surroundings. Targeting senescent cells therefore offers a promising technique for cancer therapy. Drugs that pharmacologically restore the normal function of senescent cells or eliminate them would assist in reestablishing homeostasis of cell signaling. Here, we describe cell senescence, its occurrence, phenotype, and impact on tumor biology. A "one‐two‐punch" therapeutic strategy in which cancer cell senescence is first induced, followed by the use of senotherapeutics for eliminating the senescent cells is introduced. The advances in the application of senotherapeutics for targeting senescent cells to assist cancer treatment are outlined, with an emphasis on drug categories, and the strategies for their screening, design, and efficient targeting. This work will foster a thorough comprehension and encourage additional research within this field. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Ethanol mediates the interaction between Caenorhabditis elegans and the nematophagous fungus Purpureocillium lavendulum

Author

Zhuang, Xue-Mei, primary, Guo, Zhi-Yi, additional, Zhang, Meng, additional, Chen, Yong-Hong, additional, Qi, Feng-Na, additional, Wang, Ren-Qiao, additional, Zhang, Ling, additional, Zhao, Pei-Ji, additional, Lu, Chao-Jun, additional, Zou, Cheng-Gang, additional, Ma, Yi-Cheng, additional, Xu, Jianping, additional, Zhang, Ke-Qin, additional, Cao, Yan-Ru, additional, and Liang, Lian-Ming, additional

Published
2023
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9. Physical exercise attenuates age‐related muscle atrophy and exhibits anti‐ageing effects via the adiponectin receptor 1 signalling

Author

Chen, Yuan‐Li, primary, Ma, Yi‐Cheng, additional, Tang, Jie, additional, Zhang, Dan, additional, Zhao, Qiu, additional, Liu, Jian‐Jun, additional, Tang, Hong‐Shu, additional, Zhang, Jin‐Yu, additional, He, Guang‐Hui, additional, Zhong, Chi‐Hui, additional, Wu, Yu‐Tong, additional, Wen, Heng‐Ruo, additional, Ma, Lan‐Qing, additional, and Zou, Cheng‐Gang, additional

Published
2023
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