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386 results on '"Zou, Huachun"'

2. Incidence and Clearance of Anal Human Papillomavirus Infection in 16 164 Individuals, According to Human Immunodeficiency Virus Status, Sex, and Male Sexuality: An International Pooled Analysis of 34 Longitudinal Studies.

Author

Wei, Feixue, Goodman, Marc T, Xia, Ningshao, Zhang, Jun, Giuliano, Anna R, D'Souza, Gypsyamber, Hessol, Nancy A, Schim van der Loeff, Maarten F, Dai, Jianghong, Neukam, Karin, de Pokomandy, Alexandra, Poynten, I Mary, Geskus, Ronald B, Burgos, Joaquin, Etienney, Isabelle, Moscicki, Anna-Barbara, Donà, Maria Gabriella, Gillison, Maura L, Nyitray, Alan G, Nowak, Rebecca G, Yunihastuti, Evy, Zou, Huachun, Hidalgo-Tenorio, Carmen, Phanuphak, Nittaya, Molina, Jean-Michel, Schofield, Alice M, Kerr, Stephen, Fan, Song, Lu, Yong, Ong, Jason J, Chikandiwa, Admire T, Teeraananchai, Sirinya, Squillace, Nicola, Wiley, Dorothy J, Palefsky, Joel M, Georges, Damien, Alberts, Catharina J, and Clifford, Gary M

Subjects
Cancer, Infectious Diseases, Behavioral and Social Science, Sexually Transmitted Infections, Clinical Research, Sexual and Gender Minorities (SGM/LGBT*), Prevention, HIV/AIDS, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Male, Humans, Female, Homosexuality, Male, Human Papillomavirus Viruses, Papillomavirus Infections, HIV Infections, Incidence, Sexual and Gender Minorities, Sexual Behavior, Anal Canal, Anus Diseases, Longitudinal Studies, Anus Neoplasms, Human papillomavirus 16, HIV, Papillomaviridae, HPV, anus, incidence, clearance, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundUnderstanding the natural history of anal high-risk human papillomavirus (hrHPV) infection is key for designing anal cancer prevention programs but has not been systematically characterized.MethodsWe reanalyzed data from 34 studies including 16 164 individuals in 6 risk groups defined by human immunodeficiency virus (HIV) status, sex, and male sexuality: men who have sex with men (MSM) and people with HIV (MSMWH), HIV-negative MSM, women with HIV (WWH), HIV-negative women, men who have sex with women (MSW) with HIV (MSWWH), and HIV-negative MSW. We used Markov models to estimate incidence and clearance of 13 hrHPV types and their determinants.ResultsHuman papillomavirus (HPV) 16 had the highest incidence-clearance ratio of the hrHPV types. MSMWH had the highest hrHPV incidence (eg, 15.5% newly HPV-16 infected within 2 years), followed by HIV-negative MSM (7.5%), WWH (6.6%), HIV-negative women (2.9%), MSWWH (1.7%), and HIV-negative MSW (0.7%). Determinants of HPV-16 incidence included HIV status and number of sexual partners for MSM, women, and MSW, and anal sex behavior for MSM only. HPV-16 clearance was lower for people with HIV (PWH) and lower for prevalent than incident infection. Among MSM, increasing age was associated with lower clearance of prevalent, but not incident, HPV-16 infection.ConclusionsThis robust and unifying analysis of anal hrHPV natural history is essential to designing and predicting the impact of HPV vaccination and HPV-based screening programs on anal cancer prevention, particularly in MSM and PWH. Importantly, it demonstrates the higher carcinogenic potential of longstanding anal prevalent hrHPV infection than more recent incident infection.

Published
2023

8. Immediate and long-term outcomes after treat-all among people living with HIV in China: an interrupted time series analysis

Author

Wu, Xinsheng, Wu, Guohui, Ma, Ping, Wang, Rugang, Li, Linghua, Sun, Yinghui, Xu, Junjie, Li, Yuwei, Zhang, Tong, Li, Quanmin, Yang, Yuecheng, Wang, Lijing, Xin, Xiaoli, Qiao, Ying, Fang, Bingxue, Lu, Zhen, Zhou, Xinyi, Chen, Yuanyi, Liu, Qi, Fu, Gengfeng, Wei, Hongxia, Huang, Xiaojie, Su, Bin, Wang, Hui, and Zou, Huachun

Published
2023
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12. Increasing awareness of HIV pre‐exposure prophylaxis (PrEP) and willingness to use HIV PrEP among men who have sex with men: a systematic review and meta‐analysis of global data

Author

Sun, Zhishan, Gu, Qianfei, Dai, Yifan, Zou, Huachun, Agins, Bruce, Chen, Qiaosen, Li, Peiyang, Shen, Junchun, Yang, Yi, and Jiang, Hongbo

Subjects
Public Health, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, HIV/AIDS, Sexual and Gender Minorities (SGM/LGBT*), Behavioral and Social Science, Prevention, Infectious Diseases, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Infection, Female, HIV Infections, Health Knowledge, Attitudes, Practice, Homosexuality, Male, Humans, Male, Patient Acceptance of Health Care, Pre-Exposure Prophylaxis, Sexual Partners, Sexual and Gender Minorities, men who have sex with men, pre-exposure prophylaxis, awareness, willingness, trend, meta-analysis, Public Health and Health Services, Other Medical and Health Sciences, Clinical sciences, Epidemiology, Public health
Abstract

IntroductionIntegrated knowledge regarding pre-exposure prophylaxis (PrEP) awareness and willingness to use PrEP can be useful for HIV prevention in high incidence groups. This review summarizes the awareness of PrEP and willingness to use PrEP among men who have sex with men (MSM).MethodsOnline electronic databases were searched before 31 August 2021. A meta-analysis was conducted to pool studies analysing PrEP awareness and willingness to use PrEP. LOESS regression and linear regression were applied to fit the trends over time for the proportion of MSM aware of PrEP and willing to use PrEP. Dose-response meta-analysis (DRMA) was conducted by a restricted cubic spline model to explore the relationship between willingness to use PrEP and selected factors.Results and discussionA total of 156 articles involving 228,403 MSM were included. The pooled proportions of MSM aware of PrEP and willing to use PrEP were 50.0 (95% CI: 44.8-55.2) and 58.6% (95% CI: 54.8-62.4), respectively. PrEP awareness varied among countries with different economic status and different WHO regions, among different publication and research years, PrEP types and support policies. PrEP willingness differed among countries with different economic status and groups with different risks of HIV. The awareness of PrEP increased from 2007 to 2019 with a slope of 0.040260 (p

Published
2022

27. Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men

Author

Gao, Yanxiao, primary, Zhan, Yuewei, additional, Sun, Yinghui, additional, Zheng, Weiran, additional, Zhang, Weijie, additional, Fu, Leiwen, additional, Guo, Zhihui, additional, Lin, Yi-Fan, additional, Li, Yuwei, additional, Zheng, Lingling, additional, Zhan, Yiqiang, additional, Zhu, Zhiqiang, additional, Duan, Junyi, additional, Zhang, Guanghui, additional, Huang, Tao, additional, Su, Bin, additional, Yu, Maohe, additional, Wu, Guohui, additional, Ouyang, Lin, additional, Zhao, Jin, additional, Wang, Guanghui, additional, Zhou, Yepeng, additional, Qian, Han-Zhu, additional, Fitzpatrick, Thomas, additional, Vermund, Sten H., additional, and Zou, Huachun, additional

Published
2024
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28. The impact of COVID-19 non-pharmaceutical interventions on HIV care continuum in China: An interrupted time series analysis

Author

Wu, Xinsheng, Wu, Guohui, Ma, Yanmin, Huang, Xiaojie, Yang, Yuecheng, Cai, Yanshan, Luo, Ganfeng, Ma, Ping, Qiao, Ying, Chen, Yuanyi, Lin, Yi-Fan, Gao, Yanxiao, Zhan, Yuewei, Song, Wei, Wang, Yingying, Wang, Rugang, Yang, Xuejuan, Sun, Lijun, Wei, Hongxia, Li, Quanmin, Xin, Xiaoli, Wang, Lijing, Wang, Xicheng, Xie, Ronghui, Yang, Lijuan, Meng, Xiaojun, Zhao, Jin, Li, Linghua, Zhang, Tong, Xu, Junjie, Fu, Gengfeng, and Zou, Huachun

Published
2022
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34. Associations between COVID-19 related stigma and sleep quality among COVID-19 survivors six months after hospital discharge

Author

Fu, Leiwen, Wang, Bingyi, Chan, Paul Shing Fong, Luo, Dan, Zheng, Weiran, Ju, Niu, Hu, Yuqing, Xiao, Xin, Xu, Hui, Yang, Xue, Fang, Yuan, Xu, Zhijie, Chen, Ping, He, Jiaoling, Zhu, Hongqiong, Tang, Huiwen, Huang, Dixi, Hong, Zhongsi, Ma, Xiaojun, Hao, Yanrong, Cai, Lianying, Yang, Jianrong, Yuan, Jianhui, Chen, Yao-Qing, Xiao, Fei, Wang, Zixin, Ye, Shupei, and Zou, Huachun

Published
2022
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35. Sexual function and correlates among adults aged 50+ years in China: Findings from the sexual well‐being (SWELL) study

Author

Wang, Bingyi, primary, Peng, Xin, additional, Fu, Leiwen, additional, Lu, Zhen, additional, Li, Xinyi, additional, Tian, Tian, additional, Xiao, Xin, additional, Zhang, Weijie, additional, Guo, Zhihui, additional, Ouyang, Lin, additional, Wang, Ying, additional, Yu, Maohe, additional, Wu, Guohui, additional, Wu, Dan, additional, Tang, Weiming, additional, Tucker, Joseph D., additional, Cai, Yong, additional, and Zou, Huachun, additional

Published
2024
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37. Acceptance and Factors Associated With Participation in Functional Cure–Related Trials Among People Living With HIV: A Cross-sectional Study in Southern China

Author

Deng, Zhaomin, primary, Shi, Minjuan, additional, Yuan, Yue, additional, Cao, Guangjin, additional, Wen, Chunyan, additional, Chen, Lijuan, additional, Fan, Xueying, additional, Wu, Linan, additional, Yuan, Jianhui, additional, Zou, Huachun, additional, Li, Linghua, additional, and Sun, Caijun, additional

Published
2024
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41. Stakeholder efforts to mitigate antiretroviral therapy interruption among people living with HIV during the COVID-19 pandemic in China: a qualitative study

Author

Sun, Yinghui, Zhan, Yuewei, Li, Hui, Yuan, Tanwei, Gao, Yanxiao, Liang, Bowen, Feng, Anping, Li, Peiyang, Zheng, Weiran, Fitzpatrick, Thomas, Wu, Dan, Zhai, Xinyi, and Zou, Huachun

Subjects
Health
Abstract

Introduction: The COVID-19 pandemic has affected antiretroviral therapy (ART) continuity among people living with HIV (PLHIV) worldwide. We conducted a qualitative study to explore barriers to ART maintenance and solutions to ART interruption when stringent COVID-19 control measures were implemented in China, from the perspective of PLHIV and relevant key stakeholders. Methods: Between 11 February and 15 February 2020, we interviewed PLHIV, community-based organization (CBO) workers, staff from centres for disease control and prevention (CDC) at various levels whose work is relevant to HIV care (CDC staff), HIV doctors and nurses and drug vendors from various regions in China. Semi-structured interviews were conducted using a messaging and social media app. Challenges and responses relevant to ART continuity during the COVID-19 pandemic were discussed. Themes were identified by transcript coding and mindmaps. Results: Sixty-four stakeholders were recruited, including 16 PLHIV, 17 CBO workers, 15 CDC staff, 14 HIV doctors and nurses and two drug vendors. Many CDC staff, HIV doctors and nurses responsible for ART delivery and HIV care were shifted to COVID-19 response efforts. Barriers to ART maintenance were (a) travel restrictions, (b) inadequate communication and bureaucratic obstacles, (c) shortage in personnel, (d) privacy concerns, and (e) insufficient ART reserve. CBO helped PLHIV maintain access to ART through five solutions identified from thematic analysis: (a) coordination to refill ART from local CDC clinics or hospitals, (b) delivery of ART by mail, (c) privacy protection measures, (d) mental health counselling, and (e) providing connections to alternative sources of ART. Drug vendors contributed to ART maintenance by selling out-of-pocket ART. Conclusions: Social and institutional disruption from COVID-19 contributed to increased risk of ART interruption among PLHIV in China. Collaboration among key stakeholders was needed to maintain access to ART, with CBO playing an important role. Other countries facing ART interruption during current or future public health emergencies may learn from the solutions employed in China. Keywords: antiretroviral therapy; antiretroviral therapy maintenance; community-based organization; COVID-19; HIV; people living with HIV, 1 INTRODUCTION Access and adherence to antiretroviral therapy (ART) is needed for people living with HIV (PLHIV) to achieve viral suppression, reduce HIV-associated morbidity and mortality, and prevent HIV transmission [...]

Published
2021
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42. Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies

Author

Wei, Feixue, Gaisa, Michael M, D'Souza, Gypsyamber, Xia, Ningshao, Giuliano, Anna R, Hawes, Stephen E, Gao, Lei, Cheng, Shu-Hsing, Donà, Maria Gabriella, Goldstone, Stephen E, Schim van der Loeff, Maarten F, Neukam, Karin, Meites, Elissa, Poynten, I Mary, Dai, Jianghong, Combes, Jean-Damien, Wieland, Ulrike, Burgos, Joaquin, Wilkin, Timothy J, Hernandez, Alexandra L, Iribarren Díaz, Mauricio, Hidalgo-Tenorio, Carmen, Valencia Arredondo, Marleny, Nyitray, Alan G, Wentzensen, Nicolas, Chow, Eric PF, Smelov, Vitaly, Nowak, Rebecca G, Phanuphak, Nittaya, Woo, Yin Ling, Choi, Yoojin, Hu, Yifei, Schofield, Alice M, Woestenberg, Petra J, Chikandiwa, Admire T, Hickey, Andrew C, de Pokomandy, Alexandra, Murenzi, Gad, Péré, Hélène, del Pino, Marta, Ortiz, Ana P, Charnot-Katsikas, Angella, Liu, Xing, Chariyalertsak, Suwat, Strong, Carol, Ong, Jason J, Yunihastuti, Evy, Etienney, Isabelle, Ferré, Valentine M, Zou, Huachun, Segondy, Michel, Chinyowa, Simbarashe, Alberts, Catharina J, and Clifford, Gary M

Published
2021
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44. Safety Assessment of Concurrent Vaccination with the HPV Vaccine and the COVID-19 Vaccine in Fujian Province, China: A Retrospective Study.

Author

Zhang, Yan, Zhang, Yuhang, Dong, Binhua, Lin, Wenyu, Huang, Yuxuan, Osafo, Kelvin Stefan, Lin, Xite, Jiang, Tingting, Zhang, Yu, Zou, Huachun, and Sun, Pengming

Subjects
HUMAN papillomavirus vaccines, COVID-19 vaccines, COVID-19, FISHER exact test, HUMAN papillomavirus
Abstract

During acute respiratory infections, women may concurrently receive human papillomavirus (HPV) and respiratory vaccines, as observed during the coronavirus disease 2019 (COVID-19) pandemic in China. However, few studies have assessed the safety of such concurrent administration, which could impact HPV vaccination schedules. This study analyzes the safety and optimal sequence of concurrent HPV and COVID-19 vaccinations. For this purpose, we surveyed women with both vaccines from January to October 2023 in Fujian Province, China. During this process, we collected vaccination history and adverse event (AE) data via telephone or interviews. Participants were grouped as Before, Concurrent, or After based on their vaccination sequence. A Chi-squared test, exact Fisher tests, and logistic regression were used to analyze the incidence of AEs and factors influencing vaccine safety. Overall, 1416 eligible participants were included. Although overall AE risk with the HPV vaccine was unaffected by vaccination sequence, individual AEs varied statistically between groups, including pain at the vaccination site (p < 0.001) and prolonged menstruation duration (p = 0.003). Based on the results, the optimal sequence would be to receive the HPV vaccine after the COVID-19 vaccine (After group). This insight may guide future emergency vaccination sequences for HPV and other respiratory infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Human papillomavirus and p16INK4a in oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis.

Author

Lu, Yong, Clifford, Gary M., Fairley, Christopher K., Grulich, Andrew E., Garland, Suzanne M., Xiao, Fei, Wang, Yuan, and Zou, Huachun

Subjects
HUMAN papillomavirus, SQUAMOUS cell carcinoma, HUMAN papillomavirus vaccines, ELECTRONIC publications, GENITAL warts
Abstract

We intended to update human papillomavirus (HPV) prevalence and p16INK4a positivity in oropharyngeal squamous cell carcinomars (SCC), and calculate HPV attributable fraction (AF) for oropharyngeal SCC by geographic region. We searched Medline, Embase, and the Cochrane Library to identify published studies of HPV prevalence and p16INK4a positivity alone or together in oropharyngeal SCC before December 28, 2021. Studies that reported type‐specific HPV DNA prevalence using broad‐spectrum PCR‐based testing methods were included. We estimated pooled HPV prevalence, type‐specific HPV prevalence, and p16INK4a positivity. AF of HPV was calculated by geographic region. One hundred and thirty‐four studies including 12 139 cases were included in our analysis. The pooled HPV prevalence estimate for oropharyngeal SCC was 48.1% (95% confidence interval [CI] 43.2‐53.0). HPV prevalence varied significantly by geographic region, and the highest HPV prevalence in oropharyngeal SCC was noted in North America (72.6%, 95% CI 63.8‐80.6). Among HPV positive cases, HPV 16 was the most common type with a prevalence of 40.2% (95% CI 35.7‐44.7). The pooled p16INK4a positivity in HPV positive and HPV16 positive oropharyngeal SCC cases was 87.2% (95% CI 81.6‐91.2) and 91.7% (84.3‐97.2). The highest AFs of HPV and HPV16 were noted in North America at 69.6% (95% CI 53.0‐91.5) and 63.0% (48.0‐82.7). [Correction added on 31 October 2023, after first online publication: the percentage symbol (%) was missing and has been added to 63.0% (48.0‐82.7) in the Abstract and Conclusion.] A significant proportion of oropharyngeal SCC was attributable to HPV. HPV16 accounts for the majority of HPV positive oropharyngeal SCC cases. These findings highlight the importance of HPV vaccination in the prevention of a substantial proportion of oropharyngeal SCC cases. [ABSTRACT FROM AUTHOR]

Published
2024
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