13 results on '"de Hoog, Joeri"'
Search Results
2. The enigma of sclera-specific autoimmunity in scleritis
- Author
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Vergouwen, Daphne P.C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Ten Berge, Josianne C., and Schreurs, Marco W.J.
- Published
- 2024
- Full Text
- View/download PDF
3. Potential Biomarkers for Noninfectious Scleritis Identified by Serum and Tear Fluid Proteomics
- Author
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Vergouwen, Daphne P.C., Kolijn, P. Martijn, de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., de Jong, Pascal H.P., Rothova, Aniki, Ten Berge, Josianne C., and Schreurs, Marco W.J.
- Published
- 2024
- Full Text
- View/download PDF
4. Posterior vitreous membrane findings on OCT related to collagen type IV abnormalities.
- Author
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de Hoog, Joeri, Marlies Govers, Birgit, Christien Burggraaff, Marloes, and Keijser, Sander
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- 2023
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5. Potential Biomarkers for Noninfectious Scleritis Identified by Serum and Tear Fluid Proteomics
- Author
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Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Vergouwen, Daphne P.C., Kolijn, P. Martijn, de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., de Jong, Pascal H.P., Rothova, Aniki, Ten Berge, Josianne C., Schreurs, Marco W.J., Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Vergouwen, Daphne P.C., Kolijn, P. Martijn, de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., de Jong, Pascal H.P., Rothova, Aniki, Ten Berge, Josianne C., and Schreurs, Marco W.J.
- Published
- 2024
6. The enigma of sclera-specific autoimmunity in scleritis
- Author
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Vergouwen, Daphne P. C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Berge, Josianne C. Ten, Schreurs, Marco W. J., Vergouwen, Daphne P. C., van Beek, Adriaan A., de Hoog, Joeri, de Boer, Joke H., Los, Leonoor I., Gijs, Marlies, Erckens, Roel J., Verdijk, Rob M., Haasnoot, Geert W., Roelen, Dave L., Rothova, Aniki, Rönnelid, Johan, Berge, Josianne C. Ten, and Schreurs, Marco W. J.
- Abstract
Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
- Published
- 2024
- Full Text
- View/download PDF
7. Bilateral diffuse uveal melanocytic proliferation mistaken for nivolumab-induced VKH-like syndrome
- Author
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Dallinga, Marchien Geesje, primary, Bolhuis, Karen, additional, Bins, Adriaan, additional, and de Hoog, Joeri, additional
- Published
- 2023
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8. A CASE OF MIGRATING AND RESOLVING SUBRETINAL PERFLUOROCARBON LIQUID FOLLOWING RETINAL DETACHMENT SURGERY
- Author
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de Vries, Ewout W, primary and de Hoog, Joeri, additional
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- 2022
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9. Vitreous proteomics, a gateway to improved understanding and stratification of diverse uveitis aetiologies
- Author
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Schrijver, Benjamin, Kolijn, P. Martijn, ten Berge, Josianne C.E.M., Nagtzaam, Nicole M.A., van Rijswijk, Angelique L.C.T., Swagemakers, Sigrid M.A., van der Spek, Peter J., Missotten, Tom O.A.R., van Velthoven, Mirjam E.J., de Hoog, Joeri, van Hagen, P. Martin, Langerak, Anton W., Dik, Willem A., Schrijver, Benjamin, Kolijn, P. Martijn, ten Berge, Josianne C.E.M., Nagtzaam, Nicole M.A., van Rijswijk, Angelique L.C.T., Swagemakers, Sigrid M.A., van der Spek, Peter J., Missotten, Tom O.A.R., van Velthoven, Mirjam E.J., de Hoog, Joeri, van Hagen, P. Martin, Langerak, Anton W., and Dik, Willem A.
- Abstract
Purpose: The vitreous proteome might provide an attractive gateway to discriminate between various uveitis aetiologies and gain novel insights into the underlying pathophysiological processes. Here, we investigated 180 vitreous proteins to discover novel biomarkers and broaden disease insights by comparing (1). primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies, (2). sarcoid uveitis versus tuberculosis (TB)-associated uveitis and (3). granulomatous (sarcoid and TB) uveitis versus other aetiologies. Methods: Vitreous protein levels were determined by proximity extension assay in 47 patients with intraocular inflammation and a prestudy diagnosis (cohort 1; training) and 22 patients with a blinded diagnosis (cohort 2; validation). Differentially expressed proteins identified by t-tests on cohort 1 were used to calculate Youden’s indices. Pathway and network analysis was performed by ingenuity pathway analysis. A random forest classifier was trained to predict the diagnosis of blinded patients. Results: For (P)VRL stratification, the previously reported combined diagnostic value of IL-10 and IL-6 was confirmed. Additionally, CD70 was identified as potential novel marker for (P)VRL. However, the classifier trained on the entire cohort (cohort 1 and 2) relied primarily on the interleukin score for intraocular lymphoma diagnosis (ISOLD) or IL-10/IL-6 ratio and only showed a supportive role for CD70. Furthermore, sarcoid uveitis displayed increased levels of vitreous CCL17 as compared to TB-associated uveitis. Conclusion: We underline the previously reported value of the ISOLD and the IL-10/IL-6 ratio for (P)VRL identification and present CD70 as a potentially valuable target for (P)VRL stratification. Finally, we also show that increased CCL17 levels might help to distinguish sarcoid uveitis from TB-associated uveitis.
- Published
- 2022
10. BILATERAL SEROUS RETINAL DETACHMENT AND UVEITIS ASSOCIATED WITH PEMBROLIZUMAB TREATMENT IN METASTATIC MELANOMA.
- Author
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de Vries, Ewout W., Schauwvlieghe, Ann-Sofie, Haanen, John B., and de Hoog, Joeri
- Abstract
A case report regarding a patient with metastatic melanoma who exhibited bilateral serous retinal detachment and uveitis after administration of pembrolizumab. The symptoms resolved after cessation of the pembrolizumab treatment cycles and initiation of oral and topical prednisone. Purpose: To describe the pathological features, treatment, and resolution of pembrolizumab-associated retinal detachment. Methods: A case report with a brief review of the literature and details of patient presentation, physical examination, systemic workup, fluorescein angiography, and indocyanine angiography. Results: A 25-year-old white woman was diagnosed with unresectable metastatic melanoma of the skin with a BRAF V600E mutation. The patient was treated with pembrolizumab injections every 3 weeks, upon which quick remission was seen of the metastases. After five injections, visual acuity of the patient deteriorated to 20/32 in the right eye. Ocular examination revealed bilateral panuveitis, papillitis, and serous retinal detachments. Treatment consisted of an oral prednisone taper schedule, topical prednisolone drops, and cessation of the pembrolizumab therapy, after which complete resolution of the subretinal fluid was seen. Conclusion: Pembrolizumab therapy may cause the development of panuveitis, papillitis, and serous retinal detachment, symptoms which are able to be controlled with lengthy steroid therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. [Extra-intestinal manifestations associated with Crohn's disease].
- Author
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Ayada I, van Wijk MP, de Boer NK, de Hoog J, Kneepkens CMF, and de Meij TJG
- Subjects
- Humans, Eye Diseases etiology, Eye Diseases diagnosis, Quality of Life, Skin Diseases etiology, Skin Diseases diagnosis, Crohn Disease complications, Crohn Disease diagnosis
- Abstract
Extra-intestinal manifestations (EIM) associated with Crohn's disease (CD) are frequently observed and can manifest as either the initial symptom or develop later in the disease course following gastrointestinal symptoms. The most common EIM affect the joints, skin, or eyes, with some correlating with active CD activity while others may occur during periods of inactivity. EIM can affect both pediatric and adult CD patients, potentially reducing their quality of life if not promptly identified and treated. Thus, emphasizing the prevalence and clinical presentation is essential to initiate appropriate diagnostic assessments and effectively treat both EIM and the underlying CD. In this case series, we present two pediatric and one adult case where EIM preceded CD diagnosis, resulting in delayed CD diagnosis. Additionally, we outline the most prevalent EIM, their epidemiology, and associated symptoms.
- Published
- 2024
12. Potential Biomarkers for Noninfectious Scleritis Identified by Serum and Tear Fluid Proteomics.
- Author
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Vergouwen DPC, Kolijn PM, de Hoog J, de Boer JH, Los LI, Gijs M, Erckens RJ, de Jong PHP, Rothova A, Ten Berge JC, and Schreurs MWJ
- Abstract
Purpose: Scleritis is an extremely painful and potentially blinding inflammation of the sclera with unknown pathogenesis and unpredictable course. To gain insight in its disease process and identify biomarker candidates, we performed extensive proteomics in serum and tear fluid., Design: Prospective multicenter cohort study., Participants: A total of 121 patients with noninfectious scleritis (of which 39 active cases), 30 healthy controls, and 23 disease controls (uveitis and rheumatoid arthritis) were enrolled in the Netherlands from 2020 to 2022., Methods: Serum, tear fluid of both eyes, and clinical data were gathered. The level of 368 inflammatory proteins was measured using proximity extension assays. Results were validated in an independent cohort of 15 patients with scleritis, and using addressable laser bead immunoassay, or enzyme-linked immunoassays. In addition, we studied an extended panel of matrix metalloproteinases in tear fluid of necrotizing scleritis with addressable laser bead immunoassay., Main Outcome Measures: Statistically significant differences in the level of inflammatory proteins between patients with scleritis and control groups., Results: Proteomics revealed 18 significantly upregulated or downregulated serum proteins in active scleritis cases compared with all control groups in both the discovery cohort and the validation cohort. The most upregulated protein was nuclear migration protein nudC (NudC; P = 0.0032), a protein involved in neurogenesis. The other significant hits included proteins involved in T-cell activation, apoptosis, epithelial barrier maintenance, and angiogenesis. Our tear fluid analysis showed matrix metalloproteinase 9 (MMP9) to be upregulated in the tear fluid of patients with scleral necrosis., Conclusions: The results of our proteomics analysis suggest a role for neurogenesis, T-cell activation, disruption of epithelial barrier, and angiogenesis in the pathogenesis of scleritis, and highlight MMP9 and NudC as biomarkers with potential clinical relevance., Funding Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article., (© 2023 by the American Academy of Ophthalmology.)
- Published
- 2023
- Full Text
- View/download PDF
13. Vitreous proteomics, a gateway to improved understanding and stratification of diverse uveitis aetiologies.
- Author
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Schrijver B, Kolijn PM, Ten Berge JCEM, Nagtzaam NMA, van Rijswijk ALCT, Swagemakers SMA, van der Spek PJ, Missotten TOAR, van Velthoven MEJ, de Hoog J, van Hagen PM, Langerak AW, and Dik WA
- Subjects
- Biomarkers, Tumor metabolism, Humans, Interleukin-10 metabolism, Interleukin-6 metabolism, Proteomics, Vitreous Body pathology, Eye Neoplasms pathology, Intraocular Lymphoma diagnosis, Intraocular Lymphoma metabolism, Intraocular Lymphoma pathology, Retinal Neoplasms diagnosis, Uveitis diagnosis, Uveitis etiology, Uveitis metabolism
- Abstract
Purpose: The vitreous proteome might provide an attractive gateway to discriminate between various uveitis aetiologies and gain novel insights into the underlying pathophysiological processes. Here, we investigated 180 vitreous proteins to discover novel biomarkers and broaden disease insights by comparing (1). primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies, (2). sarcoid uveitis versus tuberculosis (TB)-associated uveitis and (3). granulomatous (sarcoid and TB) uveitis versus other aetiologies., Methods: Vitreous protein levels were determined by proximity extension assay in 47 patients with intraocular inflammation and a prestudy diagnosis (cohort 1; training) and 22 patients with a blinded diagnosis (cohort 2; validation). Differentially expressed proteins identified by t-tests on cohort 1 were used to calculate Youden's indices. Pathway and network analysis was performed by ingenuity pathway analysis. A random forest classifier was trained to predict the diagnosis of blinded patients., Results: For (P)VRL stratification, the previously reported combined diagnostic value of IL-10 and IL-6 was confirmed. Additionally, CD70 was identified as potential novel marker for (P)VRL. However, the classifier trained on the entire cohort (cohort 1 and 2) relied primarily on the interleukin score for intraocular lymphoma diagnosis (ISOLD) or IL-10/IL-6 ratio and only showed a supportive role for CD70. Furthermore, sarcoid uveitis displayed increased levels of vitreous CCL17 as compared to TB-associated uveitis., Conclusion: We underline the previously reported value of the ISOLD and the IL-10/IL-6 ratio for (P)VRL identification and present CD70 as a potentially valuable target for (P)VRL stratification. Finally, we also show that increased CCL17 levels might help to distinguish sarcoid uveitis from TB-associated uveitis., (© 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
- Published
- 2022
- Full Text
- View/download PDF
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