7 results on '"enzima convertidora de angiotensina 2"'
Search Results
2. Infección por el SARS-CoV-2 en pacientes hipertensos, revisión no sistemática
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Nilvia Bienvenida Serrano Gámez, Rolando Teruel Ginés, Alejandro Jesús Bermúdez Garcell, and María de los Angeles Leyva Montero
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sars-cov-2 ,covid-19 grave ,hipertensión arterial ,enzima convertidora de angiotensina 2 ,sistema renina-angiotensina-aldosterona ,fármacos antihipertensivos. ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introducción: La hipertensión arterial es la comorbilidad cardiovascular más prevalente, en los pacientes infectados, por la COVID-19. Objetivo: Describir los mecanismos de la hipertensión arterial, con la gravedad de la infección viral por SARS-CoV-2. Métodos: Las bases de datos seleccionadas fueron: PubMed, Scientific Electronic Library Online, Scielo y Google Académico. Se realizó una revisión independiente y se propusieron 50 referencias. No se pusieron restricciones en cuanto al tipo de trabajo, en idioma español e inglés. Se seleccionaron 44 referencias de la propuesta inicial, por mayoría simple. Conclusiones: La hipertensión arterial aumenta el riesgo de hospitalización y muerte, por la COVID-19. Se explica la enfermedad e infección por SARS-CoV-2 que coexiste con la hipertensión, entre los que se destacan el papel de la enzima convertidora de angiotensina 2, los trastornos del sistema renina-angiotensina-aldosterona, la disfunción inmune con excesiva inflamación y la disfunción gastrointestinal.
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- 2023
3. Afectaciones visuales en pacientes con COVID-19.
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González-Aguilar, Vivian, Alberto Pérez-Padilla, Carlos, and del Carmen Herrera-Lazo, Zaihrys
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PREVENTION of infectious disease transmission ,MEDICAL masks ,COVID-19 ,OCULAR manifestations of general diseases ,INFLAMMATION ,BODY fluids ,CELL receptors ,VISION disorders ,ANGIOTENSIN converting enzyme ,CONJUNCTIVITIS - Abstract
Copyright of Revista de Ciencias Médicas de Pinar del Río is the property of Editorial Ciencias Medicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
4. Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
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María Teresa Díaz-Armas, Rolando Sánchez-Artigas, Tamia Zaadé Matute-Respo, and Ronny Alexander Llumiquinga-Achi
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covid-19 ,sars-cov-2 ,proteína de la espícula ,proteína s ,enzima convertidora de angiotensina 2 ,vacunas ,Medicine - Abstract
Introduction: COVID-19 caused by the SARS-CoV-2 virus is a pandemic that has claimed the lives of millions of people and overloaded health services around the world. Objective: to describe the relationship between the spike protein (S) of SARS-CoV-2 and the angiotensin-converting enzyme 2 as the primary trigger of COVID-19 infection. Method: a bibliographic search was carried out in Google Scholar, SciELO and PubMed, with the initial descriptors COVID-19 and SARS-CoV-2. The publication period selected was between the years 2019 to 2021, without restrictions regarding the type of article. The papers had to be available in full text in Spanish and English. Results: the spike protein of SARS-CoV-2, which plays a key role in receptor recognition and in the cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) that binds to the host's receptor, angiotensin-converting enzyme 2, while the S2 subunit is involved in the viral and cellular membrane fusion. The tissue ubiquity of angiotensin converting enzyme 2 explains the multiple clinical manifestations of the disease. Conclusions: the knowledge of the relationship between SARS-CoV-2 and its receptor the angiotensin-converting enzyme 2, allows not only to know the pathophysiology of COVID-19, but also the design of antiviral drugs and vaccines that contribute to the prevention and treatment of this viral disease.
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- 2021
5. Influence of angiotensin receptor and converting enzyme blockers therapy in the respiratory outcome of COVID-19 hospitalized patients.
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Lima FB, Muniz FWMG, Meneses GC, Bezerra KC, Moreira CN, Aguiar AP, Nascimento JCR, Veras de S Freitas T, de Bruin PFC, Pereira EDB, Daher EF, and Oriá RB
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- Humans, Angiotensin-Converting Enzyme Inhibitors adverse effects, Angiotensin Receptor Antagonists adverse effects, SARS-CoV-2, Retrospective Studies, Receptors, Angiotensin therapeutic use, COVID-19 complications, Hypertension drug therapy, Hypertension epidemiology
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Objectives: COVID-19, caused by SARS-CoV-2, has spread around the world since 2019. In severe cases, COVID-19 can lead to hospitalization and death. Systemic arterial hypertension and other comorbidities are associated with serious COVID-19 infection. Literature is unclear whether antihypertensive therapy with angiotensin receptor blockers (ARBs) and angiotensin converting enzyme (ACE) inhibitors affect COVID-19 outcomes. We aim to assess whether ACEI/ARB therapy is a risk factor for worse respiratory outcomes related to COVID-19 in hospitalized patients., Methods: Retrospective study enrolling admitted COVID-19-diagnosed patients by RT-PCR at the Hospital Geral de Fortaleza, Brazil, during 2021. Patient medical records, sociodemographic, and clinical data were analyzed. Chest CT images were analyzed using CAD4COVID-CT/Thirona™ software., Results: A total of 294 patients took part in the study. A cut-off point of 66% of pulmonary involvement was found by ROC curve, with patients having higher risk of death and intubation and lower 60-day survival. Advanced age (RR 1.025, P=0.001) and intubation (RR 16.747, P<0.001) were significantly associated with a higher risk of death. Advanced age (RR 1.023, P=0.001) and the use of noninvasive ventilation (RR 1.548, P=0.037) were associated with a higher risk of intubation. Lung involvement (>66%) increased the risk of death by almost 2.5-fold (RR 2.439, P<0.001) and by more than 2.3-fold the risk of intubation (RR 2.317, P<0.001)., Conclusions: Altogether, our findings suggest that ACEI or ARB therapy does not affect the risk of death and disease course during hospitalization., (Copyright © 2023 Elsevier España, S.L.U. All rights reserved.)
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- 2024
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6. Afecções tireoidianas e Covid-19: uma revisão de literatura
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Pinheiro, Flávia Coelho Mohana, Pinheiro, Hugo Coelho Mohana, Pinheiro, José Delfim Mohana, Abreu, Joana D´Arc Matos França de, and Sobral, Carla Souza Pereira
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Thyroid gland diseases ,Thyroid gland ,Glândula tireoide ,Subacute thyroiditis ,Tiroiditis subaguda ,Enzima convertidora de angiotensina 2 ,Tireoidite subaguda ,Angiotensin 2 converting enzyme ,Covid-19 ,Tiroides ,Enzima de conversão de angiotensina 2 ,Enfermedades de la glándula tiroides ,Doenças da glândula tireoide - Abstract
COVID-19 is a highly contagious disease caused by SARS-CoV-2, a single-stranded, enveloped RNA virus belonging to the beta-coronavirus family. SARS-CoV-2 is phylogenetically related to SARS-CoV-1, the virus that causes severe acute respiratory syndrome (SARS). Like SARS-CoV-1, SARS-CoV-2 infects human tissues by entering cells via the angiotensin-converting enzyme 2 (ACE2) receptor. It was alarming that, during the SARS-CoV-1 outbreak, many infected patients had thyroid gland disorders, even causing severe cellular damage. As SARS-CoV-2 is similar to SARS-CoV-1, researchers began to assess the possibility of developing thyroid diseases, especially subacute thyroiditis, in infected patients. Objective: To establish a possible relationship between the development of thyroid disorders and the infectious process caused by SARS-CoV-2 infection. Method: Literature review, supported by results obtained in studies related to the topic. Results: Studies carried out in the different stages of SARS-COV-2 infection suggest the existence of an association between SARS-CoV-2 infection and changes in thyroid function. Conclusion: Although most patients are euthyroid or have subacute thyroiditis, other thyroid diseases can manifest during SARS-CoV-2 infection, indicating the importance of assessing thyroid function in hospitalized, symptomatic and asymptomatic patients. El COVID-19 es una enfermedad altamente contagiosa causada por el SARS-CoV-2, un virus de ARN monocatenario con envoltura que pertenece a la familia de los beta-coronavirus. El SARS-CoV-2 está relacionado filogenéticamente con el SARS-CoV-1, el virus que causa el síndrome respiratorio agudo severo (SARS). Al igual que el SARS-CoV-1, el SARS-CoV-2 infecta los tejidos humanos al ingresar a las células a través del receptor de la enzima convertidora de angiotensina 2 (ACE2). Fue alarmante que, durante el brote de SARS-CoV-1, muchos pacientes infectados tuvieran trastornos de la glándula tiroides, causando incluso daño celular severo. Como el SARS-CoV-2 es similar al SARS-CoV-1, los investigadores comenzaron a evaluar la posibilidad de desarrollar enfermedades de la tiroides, especialmente tiroiditis subaguda, en pacientes infectados. Objetivo: Establecer una posible relación entre el desarrollo de trastornos tiroideos y el proceso infeccioso provocado por la infección por SARS-CoV-2. Método: Revisión de literatura, sustentada en resultados obtenidos en estudios relacionados al tema. Resultados: Los estudios realizados en las diferentes etapas de la infección por SARS-CoV-2 sugieren la existencia de una asociación entre la infección por SARS-CoV-2 y cambios en la función tiroidea. Conclusión: Aunque la mayoría de los pacientes son eutiroideos o tienen tiroiditis subaguda, otras enfermedades tiroideas pueden manifestarse durante la infección por SARS-CoV-2, lo que indica la importancia de evaluar la función tiroidea en pacientes hospitalizados, sintomáticos y asintomáticos. COVID-19 é uma doença altamente contagiosa causada pelo SARS-CoV-2, um vírus de RNA envelopado de fita simples pertencente à família beta-coronavírus. O SARS-CoV-2 está filogeneticamente relacionado ao SARS-CoV-1, o vírus que causa a síndrome respiratória aguda grave (SARS). Assim como o SARS-CoV-1, o SARS-CoV-2 infecta tecidos humanos entrando nas células por meio do receptor da enzima conversora de angiotensina 2 (ACE2). Foi alarmante que, durante o surto de SARS-CoV-1, muitos pacientes infectados tivessem distúrbios da glândula tireoide, causando até danos celulares graves. Como o SARS-CoV-2 é semelhante ao SARS-CoV-1, os pesquisadores começaram a avaliar a possibilidade de desenvolver doenças da tireoide, especialmente a tireoidite subaguda, em pacientes infectados. Objetivo: Estabelecer uma possível relação entre o desenvolvimento de distúrbios da tireoide e o processo infeccioso causado pela infecção por SARS-CoV-2. Método: Revisão de literatura, apoiada em resultados obtidos em estudos relacionados ao tema. Resultados: Estudos realizados nas diferentes fases da infecção por SARS-COV-2 sugerem a existência de associação entre a infecção por SARS-CoV-2 e alterações na função tireoidiana. Conclusão: Embora a maioria dos pacientes seja eutireoidiana ou tenha tireoidite subaguda, outras doenças tireoidianas podem se manifestar durante a infecção por SARS-CoV-2, indicando a importância da avaliação da função tireoidiana em pacientes hospitalizados, sintomáticos e assintomáticos.
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- 2022
7. Alterações do sistema reprodutor masculino pelo SARS-CoV-2 e sua fisiopatologia: Uma revisão
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Carvalho, Matheus dos Santos do Nascimento, Carvalho, Marcelo do Nascimento, Lima, Jefferson Cavalcante de, Silva, Juliane Cabral, and Cabral, Adriane Borges
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Coronavirus ,Fertilidade masculina ,Coronavírus ,Pandemia ,Fertilidad masculina ,Male fertility ,Enzima convertidora de angiotensina 2 ,Enzima conversora de angiotensina 2 ,Angiotensin-converting enzyme 2 ,Pandemics - Abstract
This integrative literature review aimed to analyze the findings about the SARS-CoV-2 action on the male genital tract. The database used in the search was PubMed, Scielo and Google Scholar with the following descriptors: “Male fertility”, “COVID-19”, “Infertility”, in addition to the use of the Boolean operator (AND). The final sample was 25 baseline studies. The entry of the coronavirus takes place through the interaction of its proteins with ACE-2 and TMPRSS2. Such proteins were identified in the male reproductive system, which explains several clinical findings in patients who were infected. This interaction of the virus with cells prevents the formation of Ang 1-7, which has anti-inflammatory properties, so its reduction would cause local tissue damage in the testicular tissue. Such findings ranged from histological changes with the formation of an inflammatory infiltrate to possible autoimmune orchitis. In addition, there are controversies on certain topics, such as the carriage of the virus in semen and its potential to cause embryological damage. The study showed the different pathophysiological possibilities of the virus in causing changes in male fertility, through the inflammatory effect, direct cytopathological action of the virus, fever, infections of other structures of the reproductive system, direct alterations in the hypothalamic pituitary axis and use of drugs as a treatment. All these results show the complexity of this virus in other systems and its mechanisms, which requires further studies for its full understanding. Esta revisión integrativa de la literatura tuvo como objetivo analizar los hallazgos sobre la acción del SARS-CoV-2 en el tracto genital masculino. La base de datos utilizada en la búsqueda fue PubMed, Scielo e Google Scholar con los siguientes descriptores: “Male fertility”, “COVID-19”, “Infertility”, además del uso del operador booleano (AND). La muestra final fue de 25 estudios de referencia. La entrada del coronavirus se produce por la interacción de sus proteínas con ACE-2 y TMPRSS2. Estas proteínas se han identificado en el sistema reproductor masculino, lo que explica varios hallazgos clínicos en pacientes infectados. Esta interacción del virus con las células impide la formación de Ang 1-7, que tiene propiedades antiinflamatorias, por lo que su reducción provocaría un daño tisular local en el tejido testicular. Los hallazgos fueron desde cambios histológicos con la formación de un infiltrado inflamatorio hasta una posible orquitis autoinmune. Además, existen controversias sobre ciertos temas, como la presencia del virus en el semen y su potencial para causar daño embriológico. El estudio mostró las diferentes posibilidades fisiopatológicas del virus en causar cambios en la fertilidad masculina, por medio del efecto inflamatorio, acción citopatológica directa del virus, fiebre, infecciones de otras estructuras del aparato reproductor, alteraciones directas en el eje hipotálamo hipofisario y uso de drogas como tratamiento. Todos estos resultados muestran la complejidad de este virus en otros sistemas y sus mecanismos, lo que requiere más estudios para su total comprensión. Esta revisão integrativa da literatura teve como objetivo analisar os achados sobre a ação do SARS-CoV-2 no trato genital masculino. A base de dados utilizada na busca foi o PubMed, Scielo e Google Scholar com os seguintes descritores: “Male fertility”, “COVID-19”, “Infertility”, além do uso do operador booleano (AND). A amostra final foi de 25 estudos de linha de base. A entrada do coronavírus ocorre por meio da interação de suas proteínas com ACE-2 e TMPRSS2. Tais proteínas foram identificadas no sistema reprodutor masculino, o que explica vários achados clínicos em pacientes que foram infectados. Essa interação do vírus com as células impede a formação de Ang 1-7, que possui propriedades anti-inflamatórias, de modo que sua redução causaria dano tecidual local no tecido testicular. Tais achados variaram desde alterações histológicas com formação de infiltrado inflamatório até possível orquite autoimune. Além disso, há controvérsias sobre determinados temas, como a presença do vírus no sêmen e seu potencial de causar danos embriológicos. O estudo mostrou as diferentes possibilidades fisiopatológicas do vírus em causar alterações na fertilidade masculina, através do efeito inflamatório, ação citopatológica direta do vírus, febre, infecções de outras estruturas do sistema reprodutor, alterações diretas no eixo hipotalâmico-hipofisário e uso de drogas como tratamento. Todos esses resultados mostram a complexidade desse vírus em outros sistemas e seus mecanismos, o que requer mais estudos para seu completo entendimento.
- Published
- 2022
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