Search

Your search keyword '"van den Broek, Tim"' showing total 16 results
Start Over Author "van den Broek, Tim" Publication Year Range Last 3 years
16 results on '"van den Broek, Tim"'

4. Impact of Microbiota and Metabolites on Intestinal Integrity and Inflammation in Severe Obesity.

Author

Custers, Emma, Vreeken, Debby, Schuren, Frank, van den Broek, Tim J., van Dongen, Lieke, Geenen, Bram, de Blaauw, Ivo, Wiesmann, Maximilian, Hazebroek, Eric J., Kleemann, Robert, and Kiliaan, Amanda J.

Subjects
CYTOTOXIC T cells, GUT microbiome, TIGHT junctions, CELL junctions, MAST cells
Abstract

Obesity is a multifactorial disease associated with low-grade inflammation. The gut is thought to be involved in obesity-related inflammation, as it is continuously exposed to antigens from food, microbiota and metabolites. However, the exact underlying mechanisms are still unknown. Therefore, we examined the relation between gut pathology, microbiota, its metabolites and cytokines in adults with severe obesity. Individuals eligible for bariatric surgery were included. Fecal and plasma samples were collected at surgery timepoint, to assess microbiota and metabolite composition. Jejunal biopsies were collected during surgery and stained for cytotoxic T cells, macrophages, mast cells and tight junction component zonula occludens-1. Based on these stainings, the cohort was divided into four groups: high versus low intestinal inflammation and high versus low intestinal integrity. We found no significant differences in microbiota diversity between groups, nor for individual bacterial species. No significant differences in metabolites were observed between the intestinal inflammatory groups. However, some metabolites and cytokines differed between the intestinal integrity groups. Higher plasma levels of interleukin-8 and tauro-chenodeoxycholic acid were found, whereas isovaleric acid and acetic acid were lower in the high intestinal integrity group. As the results were very subtle, we suggest that our cohort shows very early and minor intestinal pathology. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. The entero-endocrine response following a mixed-meal tolerance test with a non-nutritive pre-load in participants with pre-diabetes and type 2 diabetes: A crossover randomized controlled trial proof of concept study

Author

Muilwijk, Mirthe, primary, Beulens, Joline W. J., additional, Groeneveld, Lenka, additional, Rutters, Femke, additional, Blom, Marieke T., additional, Agamennone, Valeria, additional, van den Broek, Tim, additional, Keijser, Bart J. F., additional, and Hoevenaars, Femke, additional

Published
2023
Full Text
View/download PDF

11. 2’-Fucosyllactose inhibits proliferation of Clostridioides difficile ATCC 43599 in the CDi-screen, an in vitro model simulating Clostridioides difficile infection

Author

Wiese, Maria, primary, Schuren, Frank H. J., additional, Smits, Wiep Klaas, additional, Kuijper, Ed J., additional, Ouwens, Anita, additional, Heerikhuisen, Margreet, additional, Vigsnaes, Louise, additional, van den Broek, Tim J., additional, de Boer, Paulo, additional, Montijn, Roy C., additional, and van der Vossen, Jos M. B. M., additional

Published
2022
Full Text
View/download PDF

13. Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial

Author

Rafiq, Rachida, primary, Aleva, Floor E, additional, Schrumpf, Jasmijn A, additional, Daniels, Johannes M, additional, Bet, Pierre M, additional, Boersma, Wim G, additional, Bresser, Paul, additional, Spanbroek, Michiel, additional, Lips, Paul, additional, van den Broek, Tim J, additional, Keijser, Bart JF, additional, van der Ven, André JAM, additional, Hiemstra, Pieter S, additional, den Heijer, Martin, additional, and de Jongh, Renate T, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results