1. Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation
- Author
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Kim, Won Sam, Kim, Dong Oh, Yoon, Sung Jin, Kim, Mi Jeong, Yoon, Suk Ran, Park, Young-Jun, Jung, Haiyoung, Kim, Tae-Don, Kwon, Byoung-Mog, and Choi, Inpyo
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INTERLEUKIN-15 , *KILLER cells , *CELL differentiation , *IMMUNE response , *TRANSCRIPTION factors , *MITOGEN-activated protein kinases - Abstract
Abstract: Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors. [Copyright &y& Elsevier]
- Published
- 2012
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