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1. Protection from ischemic liver injury by activation of A[sub 2A] adenosine receptors during reperfusion: inhibition of chemokine induction.

Author

Yuan-Ji Day, Marshall, Melissa A., Liping Huang, McDuffie, Marcia J., Okusa, Mark D., and Linden, Joel

Subjects
CELL receptors, ADENOSINES, LIVER, ISCHEMIA, REPERFUSION, CHEMOKINES
Abstract

Investigates the effect of A[sub 2A] adenosine receptors (A[sub 2A]AR) activation on protection of the liver from ischemia-reperfusion (I/R) injury and determines whether suppression of hepatic inflammatory chemokine production plays a role in this protection. Demonstration that the selective agonist of the A[sub 2a]AR produces a protection of wild-type C57BL/6 mice from liver I/R injury that is absent in congenic animals lacking the A[sub 2A]AR gene.

Published
2004
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