1. Serendipitous synthesis of 2,3-dihydroquinazolin-4(1H)-ones in ZnCl2/urea deep eutectic solvent.
- Author
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Kumar, Gobind, Khubone, Lungisani, Seboletswe, Pule, Manhas, Neha, Makhanya, Talent, Bhargava, Gaurav, and Singh, Parvesh
- Subjects
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EUTECTICS , *SOLVENTS , *SUSTAINABLE chemistry , *FUNCTIONAL groups , *BENZALDEHYDE , *HETEROCYCLIC compounds - Abstract
A green, sustainable, and efficient one-pot, synthetic strategy for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones (DHQs) was developed. The ZnCl2/urea used as a deep eutectic solvent (DES) not only efficiently promoted the condensation between isatoic anhydride and benzaldehyde but unexpectedly acted as a nitrogen source (like ammonia) in situ to afford DHQs in excellent yields. This approach offers remarkable advantages, involving the triple role of DES in the synthesis of DHQs, atom-economical, green organocatalysts, metal-free conditions, cost-effectiveness, and tolerance to a range of functional groups. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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