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• Table grape supplementation influence the expression of more than 900 human genes. • Microarray analysis supports grape antithrombotic and anti-inflammatory effects. • Grape intake stimulates protective processes such as autophagy and DNA repair. • Mitochondrial biogenesis and cell homeostasis are positively regulated by grape. • Long ncRNAs might be pivotal in regulation of human genes induced by grape. Using a transcriptomic approach, we performed a pilot study in healthy subjects to evaluate the changes in gene expression induced by grape consumption. Blood from twenty subjects was collected at baseline (T0), after 21 days of grape-rich diet (T1) and after one-month washout (T2). Gene expression profiling of peripheral blood mononuclear cells from six subjects identified 930 differentially expressed transcripts. Gene functional analysis revealed changes (at T1 and/or T2) suggestive of antithrombotic and anti-inflammatory effects, confirming and extending previous finding on the same subjects. Moreover, we observed several other favourable changes in the transcription of genes involved in crucial processes such as immune response, DNA and protein repair, autophagy and mitochondrial biogenesis. Finally, we detected significant changes in many long non-coding RNAs genes, whose regulatory functions are being increasingly appreciated. Altogether, our data suggest that a grape diet may exert its beneficial effects by targeting different strategic pathways. [ABSTRACT FROM AUTHOR]

Children and adolescents with neurodevelopmental disorders generally show adaptive, cognitive and motor skills impairments associated with behavioral problems, i.e., alterations in attention, anxiety and stress regulation, emotional and social relationships, which strongly limit their quality of life. This narrative review aims at providing a critical overview of the current knowledge in the field of serious games (SGs), known as digital instructional interactive videogames, applied to neurodevelopmental disorders. Indeed, a growing number of studies is drawing attention to SGs as innovative and promising interventions in managing neurobehavioral and cognitive disturbs in children with neurodevelopmental disorders. Accordingly, we provide a literature overview of the current evidence regarding the actions and the effects of SGs. In addition, we describe neurobehavioral alterations occurring in some specific neurodevelopmental disorders for which a possible therapeutic use of SGs has been suggested. Finally, we discuss findings obtained in clinical trials using SGs as digital therapeutics in neurodevelopment disorders and suggest new directions and hypotheses for future studies to bridge the gaps between clinical research and clinical practice. • Neurodevelopmental disorders have impairment in emotional, social and cognitive skills. • Serious games (SGs) are designed for therapeutic purpose not for pure entertainment. • SGs development for digital therapeutic purpose in children requires a multimodal approach. • SGs is proposed as non-pharmacological-assisted therapy for behavioral disorder in children. • Randomized controlled trials are necessary to validate a SG efficacy in neurobehavior. [ABSTRACT FROM AUTHOR]