1. Early caloric deprivation in preterm infants affects Bayley-III scales performance at 18-24 months of corrected age.
- Author
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Lithoxopoulou, Maria, Rallis, Dimitrios, Christou, Helen, Goutsiou, Evanthia, Varaklioti, Agoritsa, Karagianni, Paraskevi, Tsakalidis, Christos, Domeyer, Philip, Kuriakeli, Georgia, and Soubasi, Vasiliki
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PREMATURE infants , *BIRTH weight , *BRONCHOPULMONARY dysplasia , *GESTATIONAL age , *COHORT analysis - Abstract
Background: Adequate nutrition is essential for optimal neurodevelopment to preterm infants. Our aim was to evaluate the impact of caloric deprivation on Bayley-III scales performance at 18-24 months of corrected age, in a cohort of preterm infants.Methods: We prospectively enrolled infants with gestational age <30 weeks and birth weight <1500 g. Apart from a whole cohort analysis, we performed a subgroup analysis between infants received inadequate calories (<85 Kcal/kg/day) during the first two weeks of age, compared to a standard nutrition group. All infants underwent a Bayley-III assessment at 18-24 months of corrected age.Results: From the 63 preterm infants analysed, 25% had caloric deprivation compared to 75% with adequate nutrition. Caloric deprived infants were of lower gestational age and birth weight, and received a lower amount of enteral feeding during the first 14 days of age. There were no differences between the two groups regarding the common neonatal co-morbidities. Caloric deprived infants had significantly lower composite index scores at 18-24 months of corrected age. Caloric deprivation, late onset sepsis, necrotizing enterocolitis, and bronchopulmonary dysplasia were significant risk factors of neurodevelopmental impairment.Conclusions: Several neonatal factors affect the neurodevelopmental outcome of preterm infants, and nutrition may pose an important role. [ABSTRACT FROM AUTHOR]- Published
- 2019
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