5 results on '"Novo, Giuseppina"'
Search Results
2. Magnetic resonance in isolated noncompaction of the ventricular myocardium
- Author
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Fazio, Giovanni, Novo, Giuseppina, D'angelo, Luciana, Visconti, Claudia, Sutera, Loredana, Grassedonio, Emanuele, Galia, Massimo, Ferrara, Filippo, Midiri, Massimo, and Novo, Salvatore
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CARDIAC magnetic resonance imaging , *RARE diseases , *CARDIAC imaging , *CARDIOMYOPATHIES , *LEFT heart ventricle , *ECHOCARDIOGRAPHY , *DIAGNOSIS - Abstract
Abstract: Non-compaction of the ventricular myocardium (LCVM) is a rare disorder of myocardial morphogenesis usually diagnosed in paediatric age. The diagnosis was echocardiographically made on the basis of a reported spongeous/compacted ratio >2 in one or more segments of the left ventricle during the diastolic period. We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction. Methods: We collected a consecutive series of 8 patients, 5 males and 3 females, with a mean age of 14.9 years with non-compaction of left ventricular myocardium. All patients were admitted in our divisions of cardiology. In all cases the diagnosis was performed by echocardiography. The diagnosis was obtained when the spongeous/compacted ratio was >2 in one or more segments of left ventricle, evaluated in systolic and diastolic period. In the end we completed the diagnosis by scanning with a Signa HD 1.5 T (GE, Milwaukee, USA) the same 8 patients affected by non compaction of ventricular myocardium. In all patients cardiac-gated T1 and T2 black-blood FSE images in short axis and in four-chamber horizontal long axis were obtained. Breath hold cine MR sequences (FIESTA) were performed, covering the whole left ventricle in short-axis plane and in four-chamber view. A segmented inversion-recovery fast gradient echo sequence (IR-FGE) was performed in the short-axis plane of the LV and in four-chamber-view after Gadolinium injection in 8 patients affected by non compaction of left ventricle. At the end of examination the spongeous/compacted ratio >2 was calculated in all involved segments of the left ventricle in diastole. Results: In all cases we demonstrated by echocardiography an involvement of the ventricular apex. In 3 cases the structural alterations involved also lateral wall of left ventricle. Magnetic resonance evaluation showed that involvement demonstrated by the echocardiogram was the same: ventricular apex involved in every patient, lateral wall in 3 and all segments in 2. However the spongeous/compacted ratio was >>2 in all patients, with a mean value of 3,1. Conclusions: Although our data refer to a small population of patients and need further confirmation, they suggest that it seems reasonable increase the cut-off for spongeous/compacted ratio from a value of 2 to 2.5 for non-compaction diagnosis when high-resolution magnetic resonance is used. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
3. Neuromuscular disorders and non compaction: How much is the strength of the association and how can it be suspected?
- Author
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Fazio, Giovanni, Novo, Giuseppina, Visconti, Claudia, D'angelo, Luciana, Sutera, Loredana, and Novo, Salvatore
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NEUROMUSCULAR diseases , *LEFT heart ventricle , *HEART ventricle abnormalities , *JUVENILE diseases , *CARDIOMYOPATHIES , *CREATINE kinase - Abstract
Abstract: In many reports Finsterer and Stöllberger reported a strong association between non compaction of the left ventricle and neuromuscular disorders. In the same report the authors described a neurological involvement in more than 50%. Recently we published our personal experience, about 21 paediatric patients: only 4 patients (19%) showed a neuromuscular disorder, and only 1 of them showed an increased plasmatic level of CK, and in particular of MM isoform, with a normal level of CK-MB. None presented high levels of troponine. Through the experience of 3 centres we collected 61 patients affected by non compaction that performed a neurological control, and only 14 (21%) were affected by neuromuscular disorders. A correlation between neuromuscular disorders and cardiac non compaction is present, even if, until today, genetic involvement has not been identified clearly. However, in our opinion, an estimated incidence of 50% of neuromuscular disorders in this population of patients could be too exaggerated. About the prognostic value of the CK elevation, it is interesting to consider that an increasing of CK plasmatic level is an expression of muscular disorders and not of cardiac alterations. In our experience only 1 patient in 21 patients (4%) with neuromuscular disorders showed an increasing of CK-MM plasmatic value. [Copyright &y& Elsevier]
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- 2009
- Full Text
- View/download PDF
4. Transient mid-ventricular dyskinesia: A variant of Takotsubo syndrome
- Author
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Fazio, Giovanni, Novo, Giuseppina, Azzarelli, Salvatore, Evola, Salvatore, Barbaro, Giuseppe, Sutera, Loredana, Di Gesaro, Gabriele, Akashi, Yoshihiro J., and Novo, Salvatore
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CARDIOMYOPATHIES , *MOVEMENT disorders , *LEFT heart ventricle , *ANGIOGRAPHY , *CEREBRAL ventriculography , *CORONARY artery stenosis , *CONTRACTILITY (Biology) - Abstract
Abstract: Takotsubo Cardiomyopathy is characterized by a reversible systolic left ventricular apical ballooning. A new pattern of dyskinesia in the absence of angiographic evidence of coronary artery stenosis has been indicated like a variant of takotsubo cardiomiopathy: mid-ventricular akinesis with preservation of apical and basal contractilities revealed at echocardiograms and ventriculographies. We report the case of a 65 years old patient with this pattern, reverted in 4 weeks. [Copyright &y& Elsevier]
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- 2008
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5. Reduced regional systolic function evolved compacted segments in noncompaction
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Fazio, Giovanni, Novo, Giuseppina, D'angelo, Luciana, Lunetta, Monica, Sutera, Loredana, di Gesaro, Gabriele, Indovina, Giuseppe, Ferrara, Filippo, and Novo, Salvatore
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CARDIOMYOPATHIES , *LEFT heart ventricle , *ECHOCARDIOGRAPHY , *MICROCIRCULATION disorders , *RADIONUCLIDE imaging , *HEART diseases - Abstract
Abstract: In a recent report about noncompaction Nemes et al. reported that systolic left ventricular (LV) dysfunction assessed using the wall motion score during 2D echocardiography in noncompaction is not confined to noncompacted LV segments. These results confirmed some published reports of our group. Recently we analyzed a population of 238 patients affected by noncompaction, and demonstrated that the number of noncompacted segment is uncorrelated with the degree of systolic dysfunction. It is an attractive hypothesis that the systolic dysfunction could be depend on the fibrosis of the left ventricle, itself a consequence of microcirculatory dysfunction, which has been confirmed by reports that describe microvascular dysfunction using myocardial scintigraphy. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
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