1. Improving Prognostic and Chronicity Evaluation of Chronic Kidney Disease with Contrast-Enhanced Ultrasound Index-Derived Peak Intensity.
- Author
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Xu, Yao, Li, Hongli, Wang, Chunlin, Zhang, Minfang, Wang, Qin, Xie, Yuanyuan, Shao, Xinghua, Tian, Lei, Yuan, Yanhong, Yan, Wei, Feng, Tienan, Li, Fenghua, Ni, Zhaohui, and Mou, Shan
- Subjects
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CONTRAST-enhanced ultrasound , *CHRONIC kidney failure , *LOGISTIC regression analysis , *GLOMERULAR filtration rate , *RENAL biopsy , *HIGH-intensity focused ultrasound - Abstract
The capability of contrast-enhanced ultrasound (CEUS) to assess the prognosis and chronicity of chronic kidney disease (CKD) was evaluated in patients diagnosed with CKD in 2014 at Ren Ji Hospital, Shanghai, China. Time-intensity curves and quantitative indexes were created using QLab quantification software. Kidney biopsies were analyzed with α-smooth muscle actin immunohistochemistry. According to the renal chronicity score, patients were divided into four groups: minimal (n = 14), mild (n = 73), moderate (n = 49) and severe (n = 31). Multivariate logistic regression analysis revealed that the derived peak intensity (DPI) was independently associated with the renal chronicity score. Of 167 CKD patients (median follow-up: 30.4 ± 18.7 mo), 31 (18.6%) exhibited CKD progression, with a decline in the glomerular filtration rate of more than 25% or end-stage renal disease. Multivariate Cox regression analysis revealed that a lower DPI was independently associated with CKD progression. This study indicates that DPI is a reliable CEUS parameter for evaluating chronic renal changes and an independent prognostic factor of CKD. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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